ZA200402262B - Human coagulation factor VII polypeptides. - Google Patents
Human coagulation factor VII polypeptides. Download PDFInfo
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- ZA200402262B ZA200402262B ZA200402262A ZA200402262A ZA200402262B ZA 200402262 B ZA200402262 B ZA 200402262B ZA 200402262 A ZA200402262 A ZA 200402262A ZA 200402262 A ZA200402262 A ZA 200402262A ZA 200402262 B ZA200402262 B ZA 200402262B
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- amino acid
- factor vii
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- 101150080369 tpiA gene Proteins 0.000 description 1
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- 238000001890 transfection Methods 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 238000011830 transgenic mouse model Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
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- 230000002792 vascular Effects 0.000 description 1
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- 230000003612 virological effect Effects 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6437—Coagulation factor VIIa (3.4.21.21)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21021—Coagulation factor VIIa (3.4.21.21)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200101413 | 2001-09-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200402262B true ZA200402262B (en) | 2004-06-02 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| ZA200402262A ZA200402262B (en) | 2001-09-27 | 2004-03-23 | Human coagulation factor VII polypeptides. |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP1432794B1 (hu) |
| JP (1) | JP4537059B2 (hu) |
| KR (1) | KR20040039444A (hu) |
| CN (1) | CN1602354A (hu) |
| AT (1) | ATE532858T1 (hu) |
| AU (1) | AU2002333211B2 (hu) |
| BR (1) | BR0212818A (hu) |
| CA (1) | CA2461003A1 (hu) |
| CZ (1) | CZ2004427A3 (hu) |
| ES (1) | ES2376694T3 (hu) |
| HU (1) | HUP0500060A3 (hu) |
| IL (1) | IL160897A0 (hu) |
| MX (1) | MXPA04002833A (hu) |
| NO (1) | NO20041700L (hu) |
| PL (1) | PL368619A1 (hu) |
| RU (1) | RU2325401C2 (hu) |
| UA (1) | UA82177C2 (hu) |
| WO (1) | WO2003027147A2 (hu) |
| ZA (1) | ZA200402262B (hu) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US7247708B2 (en) | 1997-10-23 | 2007-07-24 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
| US6747003B1 (en) | 1997-10-23 | 2004-06-08 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
| US7220837B1 (en) | 2000-04-28 | 2007-05-22 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
| US7812132B2 (en) | 2000-04-28 | 2010-10-12 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
| US6905683B2 (en) | 2000-05-03 | 2005-06-14 | Novo Nordisk Healthcare A/G | Human coagulation factor VII variants |
| US20030211094A1 (en) | 2001-06-26 | 2003-11-13 | Nelsestuen Gary L. | High molecular weight derivatives of vitamin k-dependent polypeptides |
| US7176288B2 (en) | 2000-09-13 | 2007-02-13 | Novo Nordisk Healthcare A/G | Human coagulation factor VII variants |
| AU2002218029A1 (en) | 2000-11-09 | 2002-05-21 | The Scripps Research Institute | Modified factor viia |
| US7052868B2 (en) | 2001-09-27 | 2006-05-30 | Novo Nordisk Healthcare A/G | Human coagulation factor VII polypeptides |
| US6960657B2 (en) | 2001-11-02 | 2005-11-01 | Novo Nordisk Healthcare A/G | Human coagulation factor VII polypeptides |
| DK1499719T3 (da) | 2002-04-30 | 2011-02-28 | Bayer Healthcare Llc | Faktor VII- eller VIIa-polypeptidvarianter |
| JP4634145B2 (ja) | 2002-06-21 | 2011-02-16 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | ペジル化されたｖｉｉ因子糖形体 |
| US6911323B2 (en) | 2002-09-25 | 2005-06-28 | Novo Nordisk Healthcare A/G | Human coagulation factor VII polypeptides |
| AU2003266214A1 (en) * | 2002-09-25 | 2004-04-19 | Novo Nordisk A/S | Human coagulation factor vii polypeptides |
| ES2386010T3 (es) | 2003-03-20 | 2012-08-07 | Bayer Healthcare Llc | Variantes de FVII o FVIIa |
| US8791070B2 (en) | 2003-04-09 | 2014-07-29 | Novo Nordisk A/S | Glycopegylated factor IX |
| JP2006527216A (ja) * | 2003-06-13 | 2006-11-30 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 新規調合物 |
| SI1644504T1 (sl) | 2003-06-19 | 2010-06-30 | Bayer Healthcare Llc | Variante Gla domene faktorja VII ali VIIa |
| CN101870729A (zh) | 2003-09-09 | 2010-10-27 | 诺和诺德医疗保健公司 | 凝固因子ⅶ多肽 |
| EP1673453A2 (en) | 2003-10-07 | 2006-06-28 | Novo Nordisk Health Care AG | Hybrid molecules having factor vii/viia activity |
| CN1890257A (zh) | 2003-12-01 | 2007-01-03 | 诺和诺德医疗保健公司 | 液体因子ⅶ组合物的病毒过滤 |
| US20060040856A1 (en) | 2003-12-03 | 2006-02-23 | Neose Technologies, Inc. | Glycopegylated factor IX |
| JP2007522805A (ja) * | 2004-02-03 | 2007-08-16 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 新規化合物 |
| WO2006014253A2 (en) * | 2004-07-02 | 2006-02-09 | Genentech, Inc. | Factor viia variants |
| EP1831242B1 (en) * | 2004-12-23 | 2012-09-26 | Novo Nordisk Health Care AG | Reduction of the content of protein contaminants in compositions comprising a vitamin k-dependent protein of interest |
| JP5216580B2 (ja) | 2005-05-25 | 2013-06-19 | ノヴォ ノルディスク アー／エス | グリコペグ化第ｉｘ因子 |
| JP5335422B2 (ja) | 2005-06-17 | 2013-11-06 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 少なくとも１つの非天然のシステインを含んでいる操作されたタンパク質の選択的な還元および誘導体化 |
| US7696318B2 (en) | 2005-07-13 | 2010-04-13 | Novo Nordisk Health Care Ag | Host cell protein knock-out cells for production of therapeutic proteins |
| CN101268185B (zh) | 2005-09-01 | 2013-03-27 | 诺沃-诺迪斯克保健股份有限公司 | 因子ⅶ多肽的疏水作用色谱纯化 |
| EP2316930A1 (en) | 2005-09-14 | 2011-05-04 | Novo Nordisk Health Care AG | Human coagulation factor VII polypeptides |
| WO2007115953A1 (en) * | 2006-04-07 | 2007-10-18 | Novo Nordisk Health Care Ag | Covalent factor vii-tissue factor complex |
| WO2008025856A2 (en) | 2006-09-01 | 2008-03-06 | Novo Nordisk Health Care Ag | Modified glycoproteins |
| EP1952822A1 (en) * | 2007-01-26 | 2008-08-06 | Novo Nordisk A/S | Factor VII polypeptides with increased affinity to platelets |
| WO2008127702A2 (en) | 2007-04-13 | 2008-10-23 | Catalyst Biosciences, Inc. | Modified factor vii polypetides and uses thereof |
| WO2008154639A2 (en) | 2007-06-12 | 2008-12-18 | Neose Technologies, Inc. | Improved process for the production of nucleotide sugars |
| PT2235197T (pt) | 2007-12-27 | 2017-10-11 | Baxalta Inc | Processos para cultura de células |
| TWI465247B (zh) | 2008-04-11 | 2014-12-21 | Catalyst Biosciences Inc | 經修飾的因子ｖｉｉ多肽和其用途 |
| CN103080135B (zh) | 2010-06-30 | 2017-06-13 | 诺沃—诺迪斯克有限公司 | 能够特异性结合组织因子途径抑制剂的抗体 |
| JP6309273B2 (ja) | 2011-03-02 | 2018-04-11 | ノヴォ・ノルディスク・ヘルス・ケア・アーゲー | 活性化血小板上のｔｌｔ−１に対する凝固因子の標的化 |
| SI2717898T1 (sl) | 2011-06-10 | 2019-07-31 | Bioverativ Therapeutics Inc. | Spojine prokoagulantov in metode za njihovo uporabo |
| CN104717973A (zh) | 2012-10-10 | 2015-06-17 | 诺和诺德保健Ag（股份有限公司） | 因子vii多肽的液体药物组合物 |
| CN109385443B (zh) * | 2017-08-07 | 2022-08-02 | 北京睿诚海汇健康科技有限公司 | 生菜作为宿主在表达凝血因子中的应用 |
| WO2021030787A1 (en) | 2019-08-15 | 2021-02-18 | Catalyst Biosciences, Inc. | Modified factor vii polypeptides for subcutaneous administration and on-demand treatment |
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| US4203570A (en) | 1978-08-23 | 1980-05-20 | The Western States Machine Company | Power-operated loading gate for centrifugal machines incorporating an auxiliary drive device |
| US4873191A (en) | 1981-06-12 | 1989-10-10 | Ohio University | Genetic transformation of zygotes |
| US4456591A (en) | 1981-06-25 | 1984-06-26 | Baxter Travenol Laboratories, Inc. | Therapeutic method for activating factor VII |
| US4546082A (en) | 1982-06-17 | 1985-10-08 | Regents Of The Univ. Of California | E. coli/Saccharomyces cerevisiae plasmid cloning vector containing the alpha-factor gene for secretion and processing of hybrid proteins |
| US4599311A (en) | 1982-08-13 | 1986-07-08 | Kawasaki Glenn H | Glycolytic promotersfor regulated protein expression: protease inhibitor |
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| NZ207926A (en) | 1983-04-25 | 1988-04-29 | Genentech Inc | Use of yeast #a#-factor to assist in expression of proteins heterologus to yeast |
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| GR860984B (en) | 1985-04-17 | 1986-08-18 | Zymogenetics Inc | Expression of factor vii and ix activities in mammalian cells |
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| DE3650202T3 (de) | 1985-08-29 | 2004-06-03 | Genencor International, Inc., South San Francisco | Expression von heterologen Polypeptiden in filamentösen Pilzen, Verfahren zu deren Herstellung und Vektoren zu deren Herstellung. |
| HU206897B (en) | 1985-10-25 | 1993-01-28 | Zymogenetics Inc | Process for utilizing bar-1 gen for selecting strange proteins |
| DK122686D0 (da) | 1986-03-17 | 1986-03-17 | Novo Industri As | Fremstilling af proteiner |
| GB8610600D0 (en) | 1986-04-30 | 1986-06-04 | Novo Industri As | Transformation of trichoderma |
| GB8615942D0 (en) | 1986-06-30 | 1986-08-06 | Animal & Food Research Council | Peptide production |
| NZ221259A (en) | 1986-07-31 | 1990-05-28 | Calgene Inc | Seed specific transcriptional regulation |
| DK323587D0 (da) * | 1987-06-25 | 1987-06-25 | Novo Industri As | Protein |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| GB8700458D0 (en) | 1987-01-09 | 1987-02-11 | Unvala Ltd | Communications systems |
| EP0832981A1 (en) | 1987-02-17 | 1998-04-01 | Pharming B.V. | DNA sequences to target proteins to the mammary gland for efficient secretion |
| US4873316A (en) | 1987-06-23 | 1989-10-10 | Biogen, Inc. | Isolation of exogenous recombinant proteins from the milk of transgenic mammals |
| EP0383779B2 (en) | 1987-09-04 | 2000-05-31 | Novo Nordisk A/S | PROCESS FOR THE PRODUCTION OF PROTEIN PRODUCTS IN $i(ASPERGILLUS) AND PROMOTERS FOR USE IN $i(ASPERGILLUS) |
| DK463887D0 (da) | 1987-09-07 | 1987-09-07 | Novo Industri As | Gaerleader |
| GB8826446D0 (en) | 1988-11-11 | 1988-12-14 | Agricultural & Food Res | Peptide production |
| AU4647889A (en) | 1988-11-18 | 1990-06-12 | Cetus Corporation | Insect signal peptide mediated secretion of recombinant proteins |
| GB8910962D0 (en) | 1989-05-12 | 1989-06-28 | Natural Environment Res | Novel baculovirus expression vectors and use thereof in the expression of foreign proteins in insects or insect cells |
| US5162222A (en) | 1989-07-07 | 1992-11-10 | Guarino Linda A | Use of baculovirus early promoters for expression of foreign genes in stably transformed insect cells or recombinant baculoviruses |
| US5155037A (en) | 1989-08-04 | 1992-10-13 | The Texas A&M University System | Insect signal sequences useful to improve the efficiency of processing and secretion of foreign genes in insect systems |
| US5023328A (en) | 1989-08-04 | 1991-06-11 | The Texas A&M University System | Lepidopteran AKH signal sequence |
| JP3330932B2 (ja) | 1990-01-29 | 2002-10-07 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 抗凝固剤タンパク質 |
| DK300090D0 (da) | 1990-12-19 | 1990-12-19 | Novo Nordisk As | Fremgangsmaade til fremstilling af leadersekvenser |
| AU1228592A (en) | 1991-01-11 | 1992-08-17 | American Red Cross | Expression of active human protein c in mammary tissue of transgenic animals |
| JP4451514B2 (ja) * | 1999-08-24 | 2010-04-14 | 財団法人化学及血清療法研究所 | 血液凝固第ｖｉｉ因子改変体 |
| WO2001058935A2 (en) * | 2000-02-11 | 2001-08-16 | Maxygen Aps | FACTOR VII OR VIIa-LIKE MOLECULES |
| AU2001254624A1 (en) * | 2000-05-03 | 2001-11-12 | Novo-Nordisk A/S | Human coagulation factor vii variants |
| IL156842A0 (en) * | 2001-02-05 | 2004-02-08 | Novo Nordisk Healthcare Ag | Combined use of factor vii polypeptides and factor ix polypeptides |
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2002
- 2002-09-26 WO PCT/DK2002/000635 patent/WO2003027147A2/en active Application Filing
- 2002-09-26 AU AU2002333211A patent/AU2002333211B2/en not_active Ceased
- 2002-09-26 RU RU2004112768/13A patent/RU2325401C2/ru not_active IP Right Cessation
- 2002-09-26 IL IL16089702A patent/IL160897A0/xx unknown
- 2002-09-26 PL PL02368619A patent/PL368619A1/xx unknown
- 2002-09-26 AT AT02799394T patent/ATE532858T1/de active
- 2002-09-26 JP JP2003530733A patent/JP4537059B2/ja not_active Expired - Fee Related
- 2002-09-26 ES ES02799394T patent/ES2376694T3/es not_active Expired - Lifetime
- 2002-09-26 MX MXPA04002833A patent/MXPA04002833A/es active IP Right Grant
- 2002-09-26 CA CA002461003A patent/CA2461003A1/en not_active Abandoned
- 2002-09-26 EP EP02799394A patent/EP1432794B1/en not_active Expired - Lifetime
- 2002-09-26 BR BR0212818-7A patent/BR0212818A/pt not_active IP Right Cessation
- 2002-09-26 UA UA2004031982A patent/UA82177C2/uk unknown
- 2002-09-26 CZ CZ2004427A patent/CZ2004427A3/cs unknown
- 2002-09-26 KR KR10-2004-7004600A patent/KR20040039444A/ko not_active Application Discontinuation
- 2002-09-26 CN CNA028206096A patent/CN1602354A/zh active Pending
- 2002-09-26 HU HU0500060A patent/HUP0500060A3/hu unknown
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2004
- 2004-03-23 ZA ZA200402262A patent/ZA200402262B/en unknown
- 2004-04-26 NO NO20041700A patent/NO20041700L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP4537059B2 (ja) | 2010-09-01 |
| AU2002333211B2 (en) | 2008-05-08 |
| IL160897A0 (en) | 2004-08-31 |
| WO2003027147A3 (en) | 2003-11-27 |
| HUP0500060A3 (en) | 2010-01-28 |
| ES2376694T3 (es) | 2012-03-16 |
| ATE532858T1 (de) | 2011-11-15 |
| CZ2004427A3 (cs) | 2004-08-18 |
| HUP0500060A2 (hu) | 2005-04-28 |
| JP2005509413A (ja) | 2005-04-14 |
| CA2461003A1 (en) | 2003-04-03 |
| RU2325401C2 (ru) | 2008-05-27 |
| RU2004112768A (ru) | 2006-01-10 |
| CN1602354A (zh) | 2005-03-30 |
| MXPA04002833A (es) | 2004-07-15 |
| WO2003027147A2 (en) | 2003-04-03 |
| PL368619A1 (en) | 2005-04-04 |
| BR0212818A (pt) | 2004-10-05 |
| KR20040039444A (ko) | 2004-05-10 |
| EP1432794A2 (en) | 2004-06-30 |
| UA82177C2 (uk) | 2008-03-25 |
| EP1432794B1 (en) | 2011-11-09 |
| NO20041700L (no) | 2004-04-26 |
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