RU2011133335A - Способы и композиции для лечения персистирующих инфекций - Google Patents

Способы и композиции для лечения персистирующих инфекций Download PDF

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RU2011133335A
RU2011133335A RU2011133335/15A RU2011133335A RU2011133335A RU 2011133335 A RU2011133335 A RU 2011133335A RU 2011133335/15 A RU2011133335/15 A RU 2011133335/15A RU 2011133335 A RU2011133335 A RU 2011133335A RU 2011133335 A RU2011133335 A RU 2011133335A
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composition
antibody
antigen
composition according
activity
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RU2011133335/15A
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RU2596491C2 (ru
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Гордан ФРИМАН
Эрлин ШАРП
Дэвид М. ДОРФМАН
Рафи Ахмед
Дэниел БАРЬЕР
Е. Джонсон УИРРИ
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Дана-Фарбер Кэнсер Инститьют
Дзе Брихэм Энд Уимен'З Хоспитал, Инк.
Эмори Юниверсити
Президент Энд Феллоуз Оф Гарвард Колледж
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37499143&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RU2011133335(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Дана-Фарбер Кэнсер Инститьют, Дзе Брихэм Энд Уимен'З Хоспитал, Инк., Эмори Юниверсити, Президент Энд Феллоуз Оф Гарвард Колледж filed Critical Дана-Фарбер Кэнсер Инститьют
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Abstract

1. Композиция для смягчения или предотвращения персистирующей инфекции, ангиоиммунобластической лимфомы или нодулярной с лимфоидным преобладанием лимфомы Ходжкина, содержащая ингибитор активности или экспрессии PD-1.2. Композиция по п.1, где указанный ингибитор активности или экспрессии PD-1 понижает экспрессию или активность PD-L1.3. Композиция по п.2, где указанный ингибитор активности или экспрессии PD-1 представляет собой антитело к PD-L1.4. Композиция по п.3, где указанная персистирующая инфекция представляет собой вирус иммунодефицита человека, Т-лимфотрофический вирус человека, вирус герпеса, вирус Эпштейна-Барр или вирус папилломы человека.5. Композиция по п.3, где указанная персистирующая инфекция представляет собой инфекцию вирусом иммунодефицита человека.6. Композиция по п.5, дополнительно содержащая вакцину.7. Композиция по п.6, где указанная вакцина вызывает иммунный ответ в отношении вируса иммунодефицита человека.8. Композиция по п.1, приготовленная для имплантации.9. Композиция по п.1, приготовленная для системного введения.10. Композиция по п.1, приготовленная для парентерального введения.11. Композиция по п.1, дополнительно содержащая противовирусный агент.12. Композиция по п.1, где указанный ингибитор PD-1 представляет собой антитело к PD-1, антитело к PD-L1, антитело к PD-L2, анти-PD-1-РНКи, анти-PD-L1-РНКи, анти-PD-L2-РНКи, анти-PD-1-антисмысловая РНК, анти-PD-L1-антисмысловая РНК, анти-PD-L2-антисмысловая РНК, доминантно-негативный белок PD-1, доминантно-негативный белок PD-L1 или доминантно-негативный белок PD-L2.13. Композиция по п.3, где указанное антитело к PD-L1 представляет собой моноклональное антитело или гуманизированное моноклональн

Claims (21)

1. Композиция для смягчения или предотвращения персистирующей инфекции, ангиоиммунобластической лимфомы или нодулярной с лимфоидным преобладанием лимфомы Ходжкина, содержащая ингибитор активности или экспрессии PD-1.
2. Композиция по п.1, где указанный ингибитор активности или экспрессии PD-1 понижает экспрессию или активность PD-L1.
3. Композиция по п.2, где указанный ингибитор активности или экспрессии PD-1 представляет собой антитело к PD-L1.
4. Композиция по п.3, где указанная персистирующая инфекция представляет собой вирус иммунодефицита человека, Т-лимфотрофический вирус человека, вирус герпеса, вирус Эпштейна-Барр или вирус папилломы человека.
5. Композиция по п.3, где указанная персистирующая инфекция представляет собой инфекцию вирусом иммунодефицита человека.
6. Композиция по п.5, дополнительно содержащая вакцину.
7. Композиция по п.6, где указанная вакцина вызывает иммунный ответ в отношении вируса иммунодефицита человека.
8. Композиция по п.1, приготовленная для имплантации.
9. Композиция по п.1, приготовленная для системного введения.
10. Композиция по п.1, приготовленная для парентерального введения.
11. Композиция по п.1, дополнительно содержащая противовирусный агент.
12. Композиция по п.1, где указанный ингибитор PD-1 представляет собой антитело к PD-1, антитело к PD-L1, антитело к PD-L2, анти-PD-1-РНКи, анти-PD-L1-РНКи, анти-PD-L2-РНКи, анти-PD-1-антисмысловая РНК, анти-PD-L1-антисмысловая РНК, анти-PD-L2-антисмысловая РНК, доминантно-негативный белок PD-1, доминантно-негативный белок PD-L1 или доминантно-негативный белок PD-L2.
13. Композиция по п.3, где указанное антитело к PD-L1 представляет собой моноклональное антитело или гуманизированное моноклональное антитело.
14. Композиция по п.3, где указанная композиция повышает вирусный клиренс.
15. Композиция по п.3, дополнительно содержащая антитело к CTLA-4, антитело к BTLA, антитело к CD28, антитело к ICOS, антитело к ICOS-L, антитело к B7-H3 или антитело к B7-H4.
16. Композиция для использования в способе смягчения или предотвращения персистирующей инфекции, ангиоиммунобластической лимфомы или нодулярной с лимфоидным преобладанием лимфомы Ходжкина, содержащая антиген-специфичную Т-клетку, приведенную в контакт с соединением, которое понижает экспрессию или активность PD-1, для понижения экспрессии или активности PD-1 в указанной антиген-специфичной Т-клетке.
17. Композиция по п.16, дополнительно содержащая антиген-специфичную В-клетку, приведенную в контакт с соединением, которое понижает экспрессию или активность PD-1, для понижения экспрессии или активности PD-1 в указанной антиген-специфичной В-клетке.
18. Композиция по п.16, где указанная антиген-специфичная Т-клетка является специфичной в отношении вирусного антигена.
19. Композиция по п.16, где указанная антиген-специфичная Т-клетка является специфичной в отношении антигена ангиоиммунобластической лимфомы или нодулярной с лимфоидным преобладанием лимфомы Ходжкина.
20. Композиция по п.18, где указанный вирусный антиген представляет собой антиген вируса иммунодефицита человека (ВИЧ), Т-лимфотрофического вируса человека, вируса герпеса, вируса Эпштейна-Барр или вируса папилломы человека.
21. Композиция по п.20, где указанный вирусный антиген представляет собой антиген вируса иммунодефицита человека.
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