RU2005116225A - Антитела, специфичные к фактору некроза опухолей, и их применение - Google Patents
Антитела, специфичные к фактору некроза опухолей, и их применение Download PDFInfo
- Publication number
- RU2005116225A RU2005116225A RU2005116225/13A RU2005116225A RU2005116225A RU 2005116225 A RU2005116225 A RU 2005116225A RU 2005116225/13 A RU2005116225/13 A RU 2005116225/13A RU 2005116225 A RU2005116225 A RU 2005116225A RU 2005116225 A RU2005116225 A RU 2005116225A
- Authority
- RU
- Russia
- Prior art keywords
- monoclonal antibody
- human monoclonal
- amino acid
- acid sequence
- hypervariable region
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (53)
1. Моноклональное антитело человека, которое специфическим образом связывается с фактором некроза опухолей альфа и содержит гипервариабельный участок 1 (CDR1) тяжелой цепи, который имеет последовательность аминокислот "Ser Tyr Asp Met His".
2. Моноклональное антитело человека по п.1, содержащее гипервариабельный участок 2 (CDR2) тяжелой цепи, который имеет последовательность аминокислот "Val Ile Trp Ser Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ser Val Lys Gly".
3. Моноклональное антитело человека по п.2, содержащее гипервариабельный участок 3 (CDR3) тяжелой цепи, который имеет последовательность аминокислот "Glu Val Glu Ser Ala Met Gly Gly Phe Tyr Tyr Asn Gly Met Asp Val".
4. Моноклональное антитело человека по п.1, последовательность аминокислот тяжелой цепи которого содержит последовательность аминокислот SEQ ID NO:70.
5. Моноклональное антитело человека по п.1, последовательность аминокислот тяжелой цепи которого содержит последовательность аминокислот SEQ ID NO:74.
6. Моноклональное антитело человека по п.1, содержащее гипервариабельный участок 1 (CDR1) легкой цепи, который имеет последовательность аминокислот "Arg Ala Ser Gln Gly Ile Arg He Asp Leu Gly".
7. Моноклональное антитело человека по п.6, содержащее гипервариабельный участок 2 (CDR2) легкой цепи, который имеет последовательность аминокислот "Ala Ala Ser Thr Leu Gln Ser".
8. Моноклональное антитело человека по п.7, содержащее гипервариабельный участок 3 (CDR3) легкой цепи, который имеет последовательность аминокислот "Leu Gln His Lys Ser Tyr Pro Leu Thr".
9. Моноклональное антитело человека по п.6, последовательность аминокислот легкой цепи которого содержит последовательность аминокислот SEQ ID NO:72.
10. Моноклональное антитело человека, которое специфическим образом связывается с фактором некроза опухолей альфа и содержит гипервариабельный участок 1 (CDR1) легкой цепи, который имеет последовательность аминокислот "Arg Ala Ser Gln Gly Ile Arg Ile Asp Leu Gly".
11. Моноклональное антитело человека по п.10, содержащее гипервариабельный участок 2 (CDR2) легкой цепи, который имеет аминокислотную последовательность "Ala Ala Ser Thr Leu Gln Ser".
12. Моноклональное антитело человека по п.11, содержащее гипервариабельный участок 3 (CDR3) легкой цепи, который имеет аминокислотную последовательность "Leu Gln His Lys Ser Tyr Pro Leu Thr".
13. Моноклональное антитело человека по п.10, содержащее гипервариабельный участок 1 (CDR1) тяжелой цепи, который имеет последовательность аминокислот "Ser Tyr Asp Met His".
14. Моноклональное антитело человека по п.13, содержащее гипервариабельный участок 2 (CDR2) тяжелой цепи, который имеет аминокислотную последовательность "Val Ile Trp Ser Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ser Val Lys Gly".
15. Моноклональное антитело человека по п.14, содержащее гипервариабельный участок 3 (CDR3) тяжелой цепи, который имеет аминокислотную последовательность "Glu Val Glu Ser Ala Met Gly Gly Phe Tyr Tyr Asn Gly Met Asp Val".
16. Моноклональное антитело человека, которое специфически связывает фактор некроза опухолей альфа и содержит последовательность тяжелой цепи, кодируемую геном VH3-33 или его консервативным вариантом.
17. Моноклональное антитело человека по п.16, которое содержит последовательность легкой цепи, кодируемую геном A30VK1.
18. Моноклональное антитело человека, которое специфическим образом связывается с фактором некроза опухолей альфа и содержит гипервариабельный участок 1 (CDR1) легкой цепи, который относится к каноническому классу 1.
19. Моноклональное антитело человека по п.18, которое содержит гипервариабельный участок 2 (CDR2) тяжелой цепи, который относится к каноническому классу 3.
20. Моноклональное антитело человека по п.19, которое содержит гипервариабельный участок 1 (CDR1) легкой цепи, который относится к каноническому классу 2.
21. Моноклональное антитело человека по п.20, которое содержит гипервариабельный участок 2 (CDR2) легкой цепи, который относится к каноническому классу 1.
22. Моноклональное антитело человека по п.21, которое содержит гипервариабельный участок 3(CDR3) легкой цепи, который относится к каноническому классу 1.
23. Моноклональное антитело человека, которое специфическим образом связывается с фактором некроза опухолей альфа и содержит гипервариабельный участок 1 (CDR1) тяжелой цепи, который имеет последовательность аминокислот "Arg Asn Tyr Met Ser".
24. Моноклональное антитело человека по п.23, содержащее гипервариабельный участок 2 (CDR2) тяжелой цепи, который имеет последовательность аминокислот "Val Ile Туг Ser Gly Asp Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly".
25. Моноклональное антитело человека по п.24, содержащее гипервариабельный участок 3 (CDR3) тяжелой цепи, который имеет последовательность аминокислот "Gly Glu Gly Gly Phe Asp Tyr".
26. Моноклональное антитело человека по п.23, последовательность аминокислот тяжелой цепи которого содержит последовательность аминокислот SEQ ID NO:50.
27. Моноклональное антитело человека по п.23, содержащее гипервариабельный участок 1 (CDR1) легкой цепи, который имеет последовательность аминокислот "Arg Ala Ser Gln Ser Val Ser Ser Asn Leu Ala".
28. Моноклональное антитело человека по п.27, содержащее гипервариабельный участок 2 (CDR2) легкой цепи, который имеет последовательность аминокислот "Gly Ala Ser Ile Arg Ala Thr".
29. Моноклональное антитело человека по п.28, содержащее гипервариабельный участок 3 (CDR3) легкой цепи, который имеет последовательность аминокислот "Gln Gln Tyr Asn Tyr Trp Trp Thr".
30. Моноклональное антитело человека по п.23, последовательность аминокислот легкой цепи которого содержит последовательность аминокислот SEQ ID NO:52.
31. Моноклональное антитело человека, которое специфическим образом связывается с фактором некроза опухолей альфа и содержат гипервариабельный участок 1 (CDR1) легкой цепи, который имеет последовательность аминокислот "Arg Ala Ser Gln Ser Val Ser Ser Asn Leu Ala".
32. Моноклональное антитело человека по п.31, содержащее гипервариабельный участок 2 (CDR2) легкой цепи, который имеет последовательность аминокислот "Gly Ala Ser Ile Arg Ala Thr".
33. Моноклональное антитело человека по п.32, содержащее гипервариабельный участок 3 (CDR3) легкой цепи, который имеет последовательность аминокислот "Gln Gln Tyr Asn Tyr Trp Trp Thr".
34. Моноклональное антитело человека по п.31, содержащее гипервариабельный участок 1 (CDR1) тяжелой цепи, который имеет последовательность аминокислот "Arg Asn Tyr Met Ser".
35. Моноклональное антитело человека по п.34, содержащее гипервариабельный участок 2 (CDR2) тяжелой цепи, который имеет последовательность аминокислот "Val Ile Tyr Ser Gly Asp Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly".
36. Моноклональное антитело человека по п.35, содержащее гипервариабельный участок 3 (CDR3) тяжелой цепи, который имеет последовательность аминокислот "Gly Glu Gly Gly Phe Asp Tyr".
37. Моноклональное антитело человека, которое специфически связывает фактор некроза опухолей альфа и содержит последовательность тяжелой цепи, кодируемую геном VH3-53 или его консервативными вариантами.
38. Моноклональное антитело человека по п.37, которое содержит последовательность легкой цепи, кодируемую геном L2VK3.
39. Моноклональное антитело человека по п.18, которое содержит гипервариабельный участок 2 (CDR2) тяжелой цепи, который относится к каноническому классу 1.
40. Моноклональное антитело человека по п.40, которое содержит гипервариабельный участок 1 (CDR1) легкой цепи, который относится к каноническому классу 2.
41. Моноклональное антитело человека по п.41, которое содержит гипервариабельный участок 2 (CDR2) легкой цепи, который относится к каноническому классу 1.
42. Моноклональное антитело человека по п.42, которое содержит гипервариабельный участок 3 (CDR3) легкой цепи, который относится к каноническому классу 3.
43. Способ оценки содержания фактора некроза опухолей альфа (ФНОа) в образце, взятом у пациента, включающий контакт антитела против ФНОа по п.1 или 23 с биологическим образцом, взятым у пациента и определение степени связывания указанного антитела с ФНОа в указанном образце.
44. Способ по п.44, где биологический образец представляет собой кровь.
45. Состав, содержащий антитело по п.1 или 23 или его функциональный фрагмент и фармацевтически приемлемый носитель.
46. Применение антитела по п.1 или 23 в приготовлении лекарственного препарата для эффективного лечения опухолевых заболеваний или иммунно-опосредованных воспалительных заболеваний или апоптоза, индуцированного фактором некроза опухолей, у животных, в котором указанное моноклональное антитело специфически связывается с фактором некроза опухолей альфа (ФНОа).
47. Применение по п.46, где указанное опухолевое заболевание выбирают из следующей группы: рак груди, рак яичников, рак желчного пузыря, рак легких, глиобластома, рак желудка, рак эндометрия, рак почек, рак толстой кишки, рак поджелудочной железы, рак простаты.
48. Применение по п.46, где указанное иммунно-опосредованное воспалительное заболевание выбирают из следующей группы: ревматоидный артрит, гламерулонефрит, атеросклероз, псориаз, рестеноз, аутоиммунная болезнь, болезнь Крона, отторжение трансплантата, септический шок, кахексия, анорексия, анкилозный спондилит, множественный склероз.
49. Способ эффективного лечения животных, страдающих опухолевыми заболеваниями, включающий выбор животного нуждающегося в лечении опухолевого заболевания/ новообразования, и введение выбранному животному терапевтически эффективного количества антитела человека по п.1 или п.23, которое специфически связывается с фактором некроза опухолей альфа (ФНОа).
50. Способ по п.49, где опухолевое заболевание выбирают из следующей группы: рак груди, рак яичников, рак желчного пузыря, рак легких, глиобластома, рак желудка, рак эндометрия, рак почек, рак толстой кишки, рак поджелудочной железы, рак простаты.
51. Способ эффективного лечения иммунно-опосредованных воспалительных заболеваний, включающий выбор животного, нуждающегося в лечении воспаления, и введение выбранному животному терапевтически эффективного количества антитела человека по п.1 или 23, которое специфически связывает фактор некроза опухолей альфа (ФНОа).
52. Способ по п.51, где иммунно-опосредованное воспалительное заболевание выбирают из следующей группы: ревматоидный артрит, гламерулонефрит, атеросклероз, псориаз, рестеноз, аутоиммунная болезнь, болезнь Крона, отторжение трансплантанта, септический шок, кахексия, анорексия, анкилозный спондилит, множественный склероз.
53. Способ ингибирования у животных апоптоза, индуцированного фактором некроза опухолей альфа (ФНОа), включающий выбор животного, нуждающегося в лечении апоптоза, индуцированного ФНО, введение выбранному животному терапевтически эффективного количества антитела человека по п.1 или 23, которое специфически связывается с фактором некроза опухолей альфа (ФНОа).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43072902P | 2002-12-02 | 2002-12-02 | |
US60/430,729 | 2002-12-02 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU2005116225A true RU2005116225A (ru) | 2006-02-27 |
RU2377253C2 RU2377253C2 (ru) | 2009-12-27 |
Family
ID=32469516
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2005116225/13A RU2377253C2 (ru) | 2002-12-02 | 2003-12-02 | Антитела, специфичные к фактору некроза опухолей, и их применение |
Country Status (13)
Country | Link |
---|---|
US (2) | US7285269B2 (ru) |
EP (1) | EP1578799B8 (ru) |
JP (1) | JP4754219B2 (ru) |
CN (1) | CN100434440C (ru) |
AT (1) | ATE472556T1 (ru) |
AU (1) | AU2003298816C1 (ru) |
CA (1) | CA2508375C (ru) |
DE (1) | DE60333228D1 (ru) |
ES (1) | ES2347239T3 (ru) |
HK (1) | HK1083023A1 (ru) |
MX (1) | MXPA05005921A (ru) |
RU (1) | RU2377253C2 (ru) |
WO (1) | WO2004050683A2 (ru) |
Families Citing this family (161)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7192584B2 (en) | 1991-03-18 | 2007-03-20 | Centocor, Inc. | Methods of treating psoriasis with anti-TNF antibodies |
US20050249735A1 (en) * | 2000-08-07 | 2005-11-10 | Centocor, Inc. | Methods of treating ankylosing spondylitis using anti-TNF antibodies and peptides of human tumor necrosis factor |
US7658924B2 (en) * | 2001-10-11 | 2010-02-09 | Amgen Inc. | Angiopoietin-2 specific binding agents |
AU2003202297C1 (en) | 2002-01-25 | 2006-05-18 | G2 Therapies Ltd | Anti-C5aR antibodies and uses thereof |
MY150740A (en) * | 2002-10-24 | 2014-02-28 | Abbvie Biotechnology Ltd | Low dose methods for treating disorders in which tnf? activity is detrimental |
RU2377253C2 (ru) * | 2002-12-02 | 2009-12-27 | Амген Фремонт,Инк. | Антитела, специфичные к фактору некроза опухолей, и их применение |
KR20130065723A (ko) | 2003-06-27 | 2013-06-19 | 암젠 프레몬트 인코포레이티드 | 상피 성장 인자 수용체의 결실 돌연변이체 지향 항체 및 그 용도 |
WO2005007800A2 (ja) * | 2003-07-18 | 2005-01-27 | Mochida Pharm Co Ltd | 抗血小板膜糖蛋白質ⅵモノクローナル抗体 |
FR2859725B1 (fr) * | 2003-09-16 | 2006-03-10 | Neovacs | Procede a haut rendement pour l'obtention d'anticorps humains neutralisant l'activite biologique d'une cytokine humaine |
US20050142137A1 (en) * | 2003-11-07 | 2005-06-30 | Curagen Corporation | Antibodies against secretoryleukocyte protease inhibitor |
AU2004317819A1 (en) * | 2003-11-12 | 2005-10-13 | Patrys, Limited | Methods of identifying neoplasm-specific antibodies and uses thereof |
AU2005320349C1 (en) * | 2004-02-06 | 2019-06-13 | E. R. Squibb & Sons, L.L.C. | Antibodies against clostridium difficile toxins and uses thereof |
AR049390A1 (es) | 2004-06-09 | 2006-07-26 | Wyeth Corp | Anticuerpos contra la interleuquina-13 humana y usos de los mismos |
US7501121B2 (en) | 2004-06-17 | 2009-03-10 | Wyeth | IL-13 binding agents |
US7501119B2 (en) | 2004-06-30 | 2009-03-10 | Mayo Foundation For Medical Education And Research | Methods and molecules for modulating an immune response |
US20060099203A1 (en) | 2004-11-05 | 2006-05-11 | Pease Larry R | B7-DC binding antibody |
ES2427147T3 (es) * | 2004-06-30 | 2013-10-29 | Mayo Foundation For Medical Education And Research | Anticuerpo sHlgM12 útil para tratar esclerosis múltiple |
GB0425972D0 (en) * | 2004-11-25 | 2004-12-29 | Celltech R&D Ltd | Biological products |
EP1819731A4 (en) * | 2004-12-08 | 2013-02-13 | Immunomedics Inc | METHOD AND COMPOSITION FOR IMMUNOTHERAPY AND FOR THE DETECTION OF INFLAMMATORY AND DYSEGRATIVE IMMUNE DISEASES, INFECTION DISEASES, PATHOLOGICAL ANGIOGENESIS AND CANCER |
JP5096167B2 (ja) | 2005-01-24 | 2012-12-12 | メドイミューン リミテッド | Ngfに対する特異的結合メンバー |
US7807159B2 (en) * | 2005-04-25 | 2010-10-05 | Amgen Fremont Inc. | Antibodies to myostatin |
PT2447283E (pt) * | 2005-09-07 | 2015-10-08 | Pfizer | Anticorpos monoclonais humanos para cinase-1 tipo recetor de activina (alk-1) |
CN1954882A (zh) * | 2005-10-14 | 2007-05-02 | 李海 | 长效人重组可溶性肿瘤坏死因子α受体在制备防治肝衰竭药物中的用途 |
EP3069731A1 (en) | 2005-11-14 | 2016-09-21 | Labrys Biologics Inc. | Antagonist antibodies directed against calcitonin gene-related peptide and methods using same |
EA035459B1 (ru) * | 2005-12-29 | 2020-06-19 | Сентокор, Инк. | Антитело против il-23p19 |
JP2009522302A (ja) | 2005-12-30 | 2009-06-11 | ダイアックス コーポレーション | マトリックスメタロプロテイナーゼ結合タンパク質 |
AR056857A1 (es) * | 2005-12-30 | 2007-10-24 | U3 Pharma Ag | Anticuerpos dirigidos hacia her-3 (receptor del factor de crecimiento epidérmico humano-3) y sus usos |
WO2007100937A2 (en) * | 2006-01-19 | 2007-09-07 | The Regents Of The University Of Michigan | System and method for spectroscopic photoacoustic tomography |
CL2007002668A1 (es) * | 2006-09-20 | 2008-05-09 | Amgen Inc | Proteina de union a antigeno que se une al receptor de glucagon humano; acido nucleico que la codifica; metodo de produccion; composicion farmaceutica que la comprende; y su uso para tratar o prevenir la diabetes tipo 2. |
WO2008067438A2 (en) * | 2006-11-29 | 2008-06-05 | The Regents Of University Of Michigan | System and method for photoacoustic guided diffuse optical imaging |
EP2450369A1 (en) * | 2007-01-30 | 2012-05-09 | Epivax, Inc. | Regulatory t cell epitopes, compositions and uses thereof |
US7807168B2 (en) * | 2007-04-10 | 2010-10-05 | Vaccinex, Inc. | Selection of human TNFα specific antibodies |
WO2008144763A2 (en) | 2007-05-21 | 2008-11-27 | Alder Biopharmaceuticals, Inc. | Antibodies to il-6 and use thereof |
US8404235B2 (en) | 2007-05-21 | 2013-03-26 | Alderbio Holdings Llc | Antagonists of IL-6 to raise albumin and/or lower CRP |
US8178101B2 (en) | 2007-05-21 | 2012-05-15 | Alderbio Holdings Inc. | Use of anti-IL-6 antibodies having specific binding properties to treat cachexia |
US8252286B2 (en) | 2007-05-21 | 2012-08-28 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
US7906117B2 (en) * | 2007-05-21 | 2011-03-15 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever |
US8062864B2 (en) | 2007-05-21 | 2011-11-22 | Alderbio Holdings Llc | Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies |
US9056905B2 (en) * | 2007-05-21 | 2015-06-16 | Alderbio Holdings Llc | Antibodies to TNF-α and use thereof |
US9701747B2 (en) | 2007-05-21 | 2017-07-11 | Alderbio Holdings Llc | Method of improving patient survivability and quality of life by anti-IL-6 antibody administration |
WO2008141511A1 (fr) * | 2007-05-22 | 2008-11-27 | Human Antibodomics (Shanghai) Inc. | ANTICORPS MONOCLONAL HUMAIN ANTI-TNFα ET SON UTILISATION |
WO2009018429A2 (en) * | 2007-07-31 | 2009-02-05 | The Government Of The United States Of America, Asrepresented By The Secretary, Department Of Healt Of Human Services, National Institutes Of Healt | TREATMENT OF CANCER VIA TARGETING OF IL-13 RECEPTOR-α2 |
WO2009079585A2 (en) | 2007-12-17 | 2009-06-25 | Dyax Corp. | Compositions and methods for treating osteolytic disorders comprising mmp-14 binding proteins |
JO2913B1 (en) | 2008-02-20 | 2015-09-15 | امجين إنك, | Antibodies directed towards angiopoietin-1 and angiopoietin-2 proteins and their uses |
RU2010138612A (ru) | 2008-02-20 | 2012-03-27 | Джи2 ИНФЛЕММЕЙШН ПТИ ЛТД (AU) | ГУМАНИЗИРОВАННЫЕ АНТИТЕЛА ПРОТИВ C5аR |
RU2522493C2 (ru) | 2008-03-04 | 2014-07-20 | Пфайзер Лимитед | Способы лечения хронической боли |
CA2722466A1 (en) | 2008-04-29 | 2009-11-05 | Tariq Ghayur | Dual variable domain immunoglobulins and uses thereof |
TW201006485A (en) | 2008-06-03 | 2010-02-16 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
WO2009149189A2 (en) | 2008-06-03 | 2009-12-10 | Abbott Laboratories | Dual variable domain immunoglobulins and uses thereof |
JP5674654B2 (ja) | 2008-07-08 | 2015-02-25 | アッヴィ・インコーポレイテッド | プロスタグランジンe2二重可変ドメイン免疫グロブリンおよびその使用 |
US8420089B2 (en) | 2008-11-25 | 2013-04-16 | Alderbio Holdings Llc | Antagonists of IL-6 to raise albumin and/or lower CRP |
US8992920B2 (en) | 2008-11-25 | 2015-03-31 | Alderbio Holdings Llc | Anti-IL-6 antibodies for the treatment of arthritis |
US8337847B2 (en) | 2008-11-25 | 2012-12-25 | Alderbio Holdings Llc | Methods of treating anemia using anti-IL-6 antibodies |
US9212223B2 (en) | 2008-11-25 | 2015-12-15 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
US9452227B2 (en) | 2008-11-25 | 2016-09-27 | Alderbio Holdings Llc | Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments |
US8323649B2 (en) | 2008-11-25 | 2012-12-04 | Alderbio Holdings Llc | Antibodies to IL-6 and use thereof |
CN101896502B (zh) * | 2009-03-20 | 2012-10-17 | 刘庆法 | 抗人TNFα单抗、分子进化及其应用 |
SG177689A1 (en) | 2009-07-31 | 2012-02-28 | Organon Nv | Fully human antibodies to btla |
WO2011015919A1 (en) * | 2009-08-03 | 2011-02-10 | Avesthagen Limited | A highly efficient process of purification and production of recombinant infliximab |
US8623366B2 (en) | 2009-08-28 | 2014-01-07 | Labrys Biologics, Inc. | Methods for treating visceral pain by administering antagonist antibodies directed against calcitonin gene-related peptide |
UY32979A (es) * | 2009-10-28 | 2011-02-28 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
NO2719708T3 (ru) | 2009-11-13 | 2018-03-24 | ||
US9775921B2 (en) | 2009-11-24 | 2017-10-03 | Alderbio Holdings Llc | Subcutaneously administrable composition containing anti-IL-6 antibody |
US9724410B2 (en) | 2009-11-24 | 2017-08-08 | Alderbio Holdings Llc | Anti-IL-6 antibodies or fragments thereof to treat or inhibit cachexia, associated with chemotherapy toxicity |
CN102167741B (zh) * | 2010-02-25 | 2014-05-14 | 上海百迈博制药有限公司 | 一种全人源抗TNF-α单克隆抗体、其制备方法及用途 |
MX2012011629A (es) * | 2010-04-07 | 2013-03-05 | Abbvie Inc | Proteinas de union a tnf-alfa. |
BR112013002578A2 (pt) | 2010-08-03 | 2019-05-14 | Abbvie Inc. | imunoglobinas de domínio variável duplo e usos das mesmas |
TW201211252A (en) | 2010-08-26 | 2012-03-16 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
EP2613797B1 (en) | 2010-09-09 | 2015-11-04 | University Of Southern California | Compositions and methods for the removal of biofilms |
CA2812430C (en) * | 2010-09-30 | 2019-01-15 | Chengdu Kanghong Biotechnologies Co., Ltd. | Humanized anti-tnf-.alpha. antibody and antigen-binding fragment (fab) thereof and use of the same |
CA2818813C (en) | 2010-11-23 | 2020-10-06 | Alder Biopharmaceuticals, Inc. | Anti-il-6 antibodies for the treatment of oral mucositis |
AR084210A1 (es) * | 2010-12-08 | 2013-05-02 | Abbott Lab | PROTEINAS DE UNION AL TNF-a |
KR20140059168A (ko) | 2011-04-21 | 2014-05-15 | 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트 | 시신경 척수염 치료용 조성물 및 치료 방법 |
SG194973A1 (en) | 2011-05-20 | 2013-12-30 | Alderbio Holdings Llc | Use of anti-cgrp antibodies and antibody fragments to prevent or inhibit photophobia or light aversion in subjects in need thereof, especially migraine sufferers |
US9855332B2 (en) | 2011-05-20 | 2018-01-02 | Alderbio Holdings Llc | Use of anti-CGRP antibodies and antibody fragments to treat diarrhea in subjects with diseases or treatments that result in elevated CGRP levels |
HUE054437T2 (hu) | 2011-05-20 | 2021-09-28 | H Lundbeck As | Anti-CGRP készítmények és alkalmazásuk |
EP3424953B1 (en) | 2011-06-06 | 2020-08-05 | Novo Nordisk A/S | Therapeutic antibodies |
US20140314784A1 (en) * | 2011-07-20 | 2014-10-23 | Medlmmune Limited | Anti-cxcr4 antibodies and methods of use |
US10314909B2 (en) | 2011-10-21 | 2019-06-11 | Dyax Corp. | Combination therapy comprising an MMP-14 binding protein |
BR112014009810A2 (pt) | 2011-10-24 | 2017-04-25 | Abbvie Inc | imunoligantes biespecíficos dirigidos contra tnf e il-17 |
TW201323440A (zh) | 2011-10-24 | 2013-06-16 | Abbvie Inc | 抗骨硬化素(sclerostin)之免疫結合物 |
BR112014009799A2 (pt) * | 2011-10-24 | 2017-06-13 | Abbvie Inc | imunoligantes dirigidos conra tnf |
CN106831985A (zh) | 2011-12-21 | 2017-06-13 | 诺华股份有限公司 | 用于抗体靶定p因子的组合物和方法 |
EP2915818A3 (en) * | 2011-12-30 | 2015-11-11 | AbbVie Inc. | Dual variable domain immunoglobulins and uses thereof |
WO2013102042A2 (en) | 2011-12-30 | 2013-07-04 | Abbvie Inc. | Dual specific binding proteins directed against il-13 and/or il-17 |
WO2013165972A2 (en) * | 2012-04-30 | 2013-11-07 | Cell Signaling Technology, Inc. | Anti-hepatitis b virus antibodies and use thereof |
CN104520328B (zh) | 2012-08-13 | 2019-06-07 | 霍夫曼-拉罗奇有限公司 | 抗锯齿蛋白抗体及使用方法 |
RU2017137740A (ru) | 2012-11-01 | 2019-02-11 | Эббви Инк. | Анти-vegf/dll4-иммуноглобулины с двойными вариабельными доменами и их применения |
UY35148A (es) | 2012-11-21 | 2014-05-30 | Amgen Inc | Immunoglobulinas heterodiméricas |
EP2970459A2 (en) | 2013-03-15 | 2016-01-20 | AbbVie Inc. | Dual specific binding proteins directed against il-1beta and il-17 |
US9708375B2 (en) | 2013-03-15 | 2017-07-18 | Amgen Inc. | Inhibitory polypeptides specific to WNT inhibitors |
US11274144B2 (en) | 2013-06-13 | 2022-03-15 | Research Institute At Nationwide Children's Hospital | Compositions and methods for the removal of biofilms |
TWI646230B (zh) | 2013-08-05 | 2019-01-01 | 扭轉生物科技有限公司 | 重新合成之基因庫 |
AU2014318017B2 (en) | 2013-09-05 | 2020-02-06 | Amgen Inc. | Fc-containing molecules exhibiting predictable, consistent, and reproducible glycoform profiles |
US20150086561A1 (en) * | 2013-09-26 | 2015-03-26 | Trellis Bioscience, Llc | Binding moieties for biofilm remediation |
US10233234B2 (en) | 2014-01-13 | 2019-03-19 | Trellis Bioscience, Llc | Binding moieties for biofilm remediation |
US11248040B2 (en) | 2013-09-26 | 2022-02-15 | Trellis Bioscience, Llc | Binding moieties for biofilm remediation |
EP3094973B1 (en) | 2013-11-07 | 2020-07-29 | Diagnodus Limited | Biomarkers |
BR112016018754A2 (pt) | 2014-02-14 | 2017-10-10 | S Chi Andrew | método de tratamento de um câncer com vascularização |
CN104892760B (zh) * | 2014-03-04 | 2018-04-17 | 北京安保康生物医药科技有限公司 | 抗TNFα的全人源单克隆抗体及其应用 |
US10556945B2 (en) | 2014-03-21 | 2020-02-11 | Teva Pharmaceuticals International Gmbh | Antagonist antibodies directed against calcitonin gene-related peptide and methods using same |
CN106456759A (zh) | 2014-03-21 | 2017-02-22 | 泰华制药国际有限公司 | 针对降钙素基因相关肽的拮抗剂抗体及其使用方法 |
MX2016014761A (es) | 2014-05-16 | 2017-05-25 | Amgen Inc | Ensayo para detectar poblaciones celulares linfocitos t colaboradores 1 (th1) y linfocitos t colaboradores (th2). |
JP6709215B2 (ja) | 2014-10-27 | 2020-06-10 | エージェンシー フォー サイエンス,テクノロジー アンド リサーチ | 抗tim−3抗体 |
GB201419094D0 (en) | 2014-10-27 | 2014-12-10 | Agency Science Tech & Res | Anti-TIM-3-antibodies |
CA3005158A1 (en) | 2014-11-06 | 2016-05-12 | Scholar Rock, Inc. | Anti-pro/latent-myostatin antibodies and uses thereof |
WO2016094881A2 (en) | 2014-12-11 | 2016-06-16 | Abbvie Inc. | Lrp-8 binding proteins |
CA2975852A1 (en) | 2015-02-04 | 2016-08-11 | Twist Bioscience Corporation | Methods and devices for de novo oligonucleic acid assembly |
ES2882157T3 (es) * | 2015-02-13 | 2021-12-01 | Sorrento Therapeutics Inc | Productos terapéuticos de anticuerpos que se unen a CTLA4 |
US10100118B2 (en) * | 2015-04-08 | 2018-10-16 | Sorrento Therapeutics, Inc. | Antibody therapeutics that bind CD123 |
US9981239B2 (en) | 2015-04-21 | 2018-05-29 | Twist Bioscience Corporation | Devices and methods for oligonucleic acid library synthesis |
FI3447075T3 (fi) * | 2015-05-15 | 2023-11-07 | Massachusetts Gen Hospital | Antagonistisia anti-tuumorinekroositekijäreseptorin superperheen vasta-aineita |
TW201710286A (zh) | 2015-06-15 | 2017-03-16 | 艾伯維有限公司 | 抗vegf、pdgf及/或其受體之結合蛋白 |
CA2993009A1 (en) | 2015-07-31 | 2017-02-09 | Research Institute At Nationwide Children's Hospital | Peptides and antibodies for the removal of biofilms |
IL258121B2 (en) | 2015-09-15 | 2024-01-01 | Scholar Rock Inc | Antipro/latent myostatin antibodies and their uses |
CA2998169A1 (en) | 2015-09-18 | 2017-03-23 | Twist Bioscience Corporation | Oligonucleic acid variant libraries and synthesis thereof |
CN108698012A (zh) | 2015-09-22 | 2018-10-23 | 特韦斯特生物科学公司 | 用于核酸合成的柔性基底 |
CR20180365A (es) | 2015-12-16 | 2018-09-28 | Amgen Inc | PROTEÍNAS DE UNIÓN AL ANTÍGENO BISPECÍFICO DE ANTI-TL1A/ANTI-TNF-a Y SUS USOS |
MX2018008369A (es) | 2016-01-08 | 2019-05-15 | Scholar Rock Inc | Anticuerpos de anti-miostatina pro/latente y metodo de uso de los mismos. |
EP3400013A4 (en) * | 2016-01-09 | 2019-09-11 | Arbele Limited | CADHERIN-17 SPECIFIC ANTIBODIES AND CYTOTOXIC CELL TREATMENT CELLS |
CA3016870A1 (en) * | 2016-03-17 | 2017-09-21 | Numab Innovation Ag | Anti-tnf.alpha.-antibodies and functional fragments thereof |
EP3785728A3 (en) | 2016-06-13 | 2021-04-28 | Scholar Rock, Inc. | Use of myostatin inhibitors and combination therapies |
EP3497122A2 (en) * | 2016-08-08 | 2019-06-19 | Sorrento Therapeutics, Inc. | Anti-ox40 binding proteins |
US10417457B2 (en) | 2016-09-21 | 2019-09-17 | Twist Bioscience Corporation | Nucleic acid based data storage |
CN109952314A (zh) | 2016-09-23 | 2019-06-28 | 泰瓦制药国际有限公司 | 治疗难治性偏头痛 |
CA3046387A1 (en) | 2016-12-21 | 2018-06-28 | David Jose Simon LAINE | Antibodies that specifically bind to human il-15 and uses thereof |
JP2020513838A (ja) | 2017-01-04 | 2020-05-21 | リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル | Dnabiiワクチンおよび強化された活性を有する抗体 |
DK3565592T3 (da) | 2017-01-06 | 2023-05-01 | Scholar Rock Inc | Behandling af stofskiftesygdomme ved inhibering af myostatinaktivering |
US11550939B2 (en) | 2017-02-22 | 2023-01-10 | Twist Bioscience Corporation | Nucleic acid based data storage using enzymatic bioencryption |
MA47775A (fr) | 2017-03-14 | 2020-01-22 | Amgen Inc | Contrôle des glycoformes afucosylées totales d'anticorps produits en culture cellulaire |
EP3638782A4 (en) | 2017-06-12 | 2021-03-17 | Twist Bioscience Corporation | SEALLESS NUCLEIC ACID ASSEMBLY METHODS |
WO2018231864A1 (en) | 2017-06-12 | 2018-12-20 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
JP7356970B2 (ja) * | 2017-06-25 | 2023-10-05 | システィミューン, インク. | 多重特異性抗体とその作製及び使用方法 |
CN111566125A (zh) | 2017-09-11 | 2020-08-21 | 特韦斯特生物科学公司 | Gpcr结合蛋白及其合成 |
KR20240024357A (ko) | 2017-10-20 | 2024-02-23 | 트위스트 바이오사이언스 코포레이션 | 폴리뉴클레오타이드 합성을 위한 가열된 나노웰 |
US11142579B2 (en) | 2017-12-06 | 2021-10-12 | Sorrento Therapeutics, Inc. | Variant antibodies that bind OX40 |
MA52186A (fr) | 2018-03-26 | 2021-02-17 | Amgen Inc | Glycoformes afucosylées totales d'anticorps produits en culture cellulaire |
EP3814497A4 (en) | 2018-05-18 | 2022-03-02 | Twist Bioscience Corporation | POLYNUCLEOTIDES, REAGENTS, AND METHODS FOR NUCLEIC ACID HYBRIDIZATION |
CA3108915A1 (en) * | 2018-08-08 | 2020-02-13 | Dragonfly Therapeutics, Inc. | Proteins binding nkg2d, cd16 and a tumor-associated antigen |
AU2019383017A1 (en) | 2018-11-20 | 2021-06-03 | Janssen Biotech, Inc. | Safe and effective method of treating psoriasis with anti-IL-23 specific antibody |
BR112020018192A2 (pt) | 2019-01-08 | 2021-08-24 | H. Lundbeck A/S | Tratamento agudo e tratamento rápido de dor de cabeça com o uso de anticorpos anti-cgrp |
SG11202109283UA (en) | 2019-02-26 | 2021-09-29 | Twist Bioscience Corp | Variant nucleic acid libraries for antibody optimization |
MA55551A (fr) * | 2019-04-04 | 2022-02-09 | Janssen Biotech Inc | Anticorps anti-hla-c et leurs utilisations |
BR112021023295A2 (pt) | 2019-05-23 | 2022-02-08 | Janssen Biotech Inc | Método de tratamento de doença inflamatória intestinal com uma terapia de combinação de anticorpos para il-23 e tnf-alfa |
EP3987019A4 (en) | 2019-06-21 | 2023-04-19 | Twist Bioscience Corporation | BARCODE-BASED NUCLEIC ACID SEQUENCE ARRANGEMENT |
WO2021015237A1 (ja) * | 2019-07-24 | 2021-01-28 | 国立研究開発法人科学技術振興機構 | 抗体酵素の革新的製造技術 |
EP4034566A4 (en) * | 2019-09-23 | 2024-01-24 | Twist Bioscience Corp | VARIANT NUCLEIC ACID LIBRARIES FOR CRTH2 |
BR112022005583A2 (pt) | 2019-09-26 | 2022-09-20 | Amgen Inc | Métodos para a produção de composições de anticorpos |
CN111153994B (zh) * | 2019-12-31 | 2021-10-15 | 武汉班科生物技术股份有限公司 | 人肿瘤坏死因子的人源单克隆抗体 |
WO2021154530A1 (en) * | 2020-01-27 | 2021-08-05 | Vanderbilt University | Human anti-dengue antibodies and methods of use therefor |
WO2021222128A1 (en) * | 2020-04-27 | 2021-11-04 | Fred Hutchinson Cancer Research Center | Neutralizing monoclonal antibodies against covid-19 |
US20230273126A1 (en) | 2020-06-04 | 2023-08-31 | Amgen Inc. | Assessment of cleaning procedures of a biotherapeutic manufacturing process |
KR20220012826A (ko) * | 2020-07-23 | 2022-02-04 | (주)셀트리온 | 사스-코로나바이러스-2 스파이크 단백질의 에피토프에 결합하는 사스-코로나바이러스-2 중화 결합 분자 |
CA3190667A1 (en) * | 2020-08-26 | 2022-03-03 | Aaron Sato | Methods and compositions relating to glp1r variants |
CA3197930A1 (en) | 2020-10-15 | 2022-04-21 | Amgen Inc. | Relative unpaired glycans in antibody production methods |
AU2020480890A1 (en) | 2020-12-09 | 2023-07-27 | Hk Inno.N Corporation | ANTI-OX40L ANTIBODY, ANTI-OX40L/ANTI-TNFα BISPECIFIC ANTIBODY, AND USES THEREOF |
AU2022289365A1 (en) | 2021-06-07 | 2023-12-14 | Amgen Inc. | Using fucosidase to control afucosylation level of glycosylated proteins |
AU2022361382A1 (en) | 2021-10-05 | 2024-03-28 | Amgen Inc. | Fc-gamma receptor ii binding and glycan content |
WO2023215725A1 (en) | 2022-05-02 | 2023-11-09 | Fred Hutchinson Cancer Center | Compositions and methods for cellular immunotherapy |
CN114702578B (zh) * | 2022-06-06 | 2022-09-27 | 百斯医学诊断科技(北京)有限公司 | 新型冠状病毒Omicron突变株特异性抗体及其应用 |
CN116789813B (zh) * | 2023-06-27 | 2024-04-26 | 重庆原伦生物科技有限公司 | 一种抗金黄色葡萄球菌α-溶血素的单克隆抗体及其应用 |
Family Cites Families (239)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
US4263428A (en) | 1978-03-24 | 1981-04-21 | The Regents Of The University Of California | Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same |
US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
US4309418A (en) * | 1980-03-25 | 1982-01-05 | Sloan-Kettering Research Institute For Cancer | Anti-tumor agent from human serum and process |
ATE12348T1 (de) | 1980-11-10 | 1985-04-15 | Gersonde Klaus Prof Dr | Verfahren zur herstellung von lipid-vesikeln durch ultraschallbehandlung, anwendung des verfahrens und vorrichtung zur durchfuehrung des verfahrens. |
IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
SE8204382L (sv) * | 1981-07-21 | 1983-01-22 | Hayashibara Biochem Lab | Sett att framstella malcellysfaktor och anvendning derav |
US6419927B1 (en) | 1981-09-08 | 2002-07-16 | Anthony Cerami | Method for reducing adverse effects of a human 70kDa mediator which results from endotoxin stimulation of macrophages |
US6309640B1 (en) | 1981-09-08 | 2001-10-30 | The Rockefeller University | Lipoprotein lipase suppression by endotoxin-induced mediator (shock assay) |
US4603106A (en) * | 1982-02-22 | 1986-07-29 | The Rockefeller University | Lipoprotein lipase suppression by endotoxin-induced mediator (shock assay) |
US5700466A (en) | 1981-09-08 | 1997-12-23 | The Rockefeller University | Method of ameliorating or preventing septic shock using a monoclonal antibody specific to cachectin/tumor necrosis factor |
US4822776A (en) * | 1981-09-08 | 1989-04-18 | The Rockefeller University | Lipoprotein lipase suppression by endotoxin-induced mediator (shock assay) |
US5833975A (en) | 1989-03-08 | 1998-11-10 | Virogenetics Corporation | Canarypox virus expressing cytokine and/or tumor-associated antigen DNA sequence |
JPS58118008A (ja) | 1982-01-06 | 1983-07-13 | Nec Corp | デ−タ処理装置 |
DE3374837D1 (en) | 1982-02-17 | 1988-01-21 | Ciba Geigy Ag | Lipids in the aqueous phase |
JPS58166634A (ja) | 1982-03-29 | 1983-10-01 | Toshiba Corp | 有機溶媒電池用正極 |
JPS58166633A (ja) | 1982-03-29 | 1983-10-01 | Toshiba Corp | 有機溶媒電池用正極 |
HU189251B (en) * | 1982-04-07 | 1986-06-30 | Asahi Kasei Kogyo Kk,Jp | Process for stabilizing tumor necrosis factor |
DE3218121A1 (de) | 1982-05-14 | 1983-11-17 | Leskovar, Peter, Dr.-Ing., 8000 München | Arzneimittel zur tumorbehandlung |
EP0102324A3 (de) | 1982-07-29 | 1984-11-07 | Ciba-Geigy Ag | Lipide und Tenside in wässriger Phase |
US4390468A (en) * | 1982-08-04 | 1983-06-28 | Maruzen Oil Co., Ltd. | Preparation of antitumor agent from shellfish |
US4457916A (en) * | 1982-08-31 | 1984-07-03 | Asahi Kasei Kogyo Kabushiki Kaisha | Method for stabilizing Tumor Necrosis Factor and a stable aqueous solution or powder containing the same |
GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
JPS6019719A (ja) * | 1983-07-15 | 1985-01-31 | Asahi Chem Ind Co Ltd | 抗腫瘍活性を有する蛋白質 |
HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
US4678773A (en) * | 1983-08-26 | 1987-07-07 | Chugai Seiyaku Kabushiki Kaisha | Antitumor agent |
EP0350973B1 (de) | 1983-09-26 | 1997-11-05 | Udo Dr. Ehrenfeld | Mittel und Erzeugnis für die Diagnose und Therapie von Tumoren sowie zur Behandlung von Schwächen der zelligen und humoralen Immunabwehr |
DE3474511D1 (en) | 1983-11-01 | 1988-11-17 | Terumo Corp | Pharmaceutical composition containing urokinase |
JPS60112718A (ja) | 1983-11-21 | 1985-06-19 | Kyorin Pharmaceut Co Ltd | 抗腫瘍作用を示す蛋白性物質及びその製造方法 |
JPH0695939B2 (ja) | 1983-12-02 | 1994-11-30 | 大日本製薬株式会社 | ウサギ癌壊死因子をコ−ドするクロ−ン化dνa |
US4681581A (en) | 1983-12-05 | 1987-07-21 | Coates Fredrica V | Adjustable size diaper and folding method therefor |
US4740461A (en) | 1983-12-27 | 1988-04-26 | Genetics Institute, Inc. | Vectors and methods for transformation of eucaryotic cells |
US5288852A (en) * | 1984-03-06 | 1994-02-22 | Dainippon Pharmaceutical Co., Ltd. | Human tumor necrosis factor polypeptides |
US4656132A (en) * | 1984-03-28 | 1987-04-07 | Cetus Corporation | Method of improving the yield of heterologous protein produced by cultivating recombinant bacteria |
US4894334A (en) * | 1984-03-28 | 1990-01-16 | Cetus Corporation | Method of improving the yield of heterologous protein produced by cultivating recombinant bacteria |
US4879226A (en) | 1984-04-06 | 1989-11-07 | Asahi Kasei Kogyo Kabushiki Kaisha | Novel human physiologically active polypeptide |
DE3423234A1 (de) | 1984-06-23 | 1986-02-06 | Boehringer Ingelheim International GmbH, 6507 Ingelheim | Synergistische mischungen von interferonen und tumor-nekrose-faktor |
US4650674A (en) * | 1984-07-05 | 1987-03-17 | Genentech, Inc. | Synergistic cytotoxic composition |
US5672347A (en) | 1984-07-05 | 1997-09-30 | Genentech, Inc. | Tumor necrosis factor antagonists and their use |
WO1986002068A1 (en) | 1984-09-26 | 1986-04-10 | Takeda Chemical Industries, Ltd. | Mutual separation of proteins |
US4677064A (en) * | 1984-11-09 | 1987-06-30 | Cetus Corporation | Human tumor necrosis factor |
US4677063A (en) * | 1985-05-02 | 1987-06-30 | Cetus Corporation | Human tumor necrosis factor |
JPS61124392A (ja) | 1984-11-22 | 1986-06-12 | Asahi Chem Ind Co Ltd | 遺伝子組換体の産生する生理活性物質の精製法 |
IL73883A (en) | 1984-12-20 | 1990-12-23 | Yeda Res & Dev | Monoclonal antibodies against tnf-alpha,hybridomas producing them and method for the purification of tnf-alpha |
DE3585690D1 (de) * | 1984-12-21 | 1992-04-23 | Biogen Inc | Reinigung, herstellung und verwendung von tumor-nekrosisfaktoren. |
WO1986005204A1 (en) * | 1985-03-04 | 1986-09-12 | Sawai Pharmaceutical Co., Ltd. | Novel tumor necrosis factor-inducing substance originating in acid-fast bacteria |
US4684623A (en) | 1985-05-02 | 1987-08-04 | The Board Of Trustees Of The Cetus Corporation | Use of tumor necrosis factor as a weight regulator |
US5776093A (en) | 1985-07-05 | 1998-07-07 | Immunomedics, Inc. | Method for imaging and treating organs and tissues |
US4735210A (en) | 1985-07-05 | 1988-04-05 | Immunomedics, Inc. | Lymphographic and organ imaging method and kit |
US5101827A (en) | 1985-07-05 | 1992-04-07 | Immunomedics, Inc. | Lymphographic and organ imaging method and kit |
DE3526096A1 (de) * | 1985-07-22 | 1987-01-22 | Basf Ag | Verfahren zur reinigung von htnf |
US4870163A (en) | 1985-08-29 | 1989-09-26 | New York Blood Center, Inc. | Preparation of pure human tumor necrosis factor and hybridomas producing monoclonal antibodies to human tumor necrosis factor |
US4770995A (en) | 1985-08-29 | 1988-09-13 | New York Blood Center, Inc | Detection of the sensitivity of cells to the effects of tumor necrosis factor and lymphotoxin |
JPH0698004B2 (ja) | 1985-09-30 | 1994-12-07 | サントリー株式会社 | Tnf発現用新規プラスミド |
US5059530A (en) | 1985-09-30 | 1991-10-22 | Suntory Ltd. | Expression vector for human TNF |
US5182196A (en) * | 1985-10-09 | 1993-01-26 | Biogen, Inc. | Expression systems for overproduction of desired proteins |
US4677197A (en) * | 1985-10-30 | 1987-06-30 | Cetus Corporation | Purification method for tumor necrosis factor |
US4894439A (en) * | 1986-05-22 | 1990-01-16 | Cetus Corporation | N-terminal derivatives of tumor necrosis factor purified by microporous PTFE membranes |
JPS62170639A (ja) | 1986-01-22 | 1987-07-27 | 株式会社システムメンテナンス | 防蟻板の取付け工法 |
US5081021A (en) * | 1986-02-04 | 1992-01-14 | Mizuno Den Ichi | DNA encoding HTNF variants exhibiting enhanced activity |
US4822605A (en) * | 1986-02-18 | 1989-04-18 | Exovir, Inc. | Compositions and methods employing the same for the treatment of viral and cancerous skin lesions and the like |
US5425940A (en) | 1986-04-09 | 1995-06-20 | Cetus Oncology Corporation | Combination therapy using interleukin-2 and tumor necrosis factor |
US4863727A (en) | 1986-04-09 | 1989-09-05 | Cetus Corporation | Combination therapy using interleukin-2 and tumor necrosis factor |
CA1310924C (en) * | 1986-04-24 | 1992-12-01 | Francis P. Mccormick | Infective drug delivery system |
DE3750056T2 (de) * | 1986-06-20 | 1995-04-06 | Dainippon Pharmaceutical Co | Polypeptid-Mutanten des menschlichen TNF und für diese Mutanten codierende DNS. |
US4959455A (en) | 1986-07-14 | 1990-09-25 | Genetics Institute, Inc. | Primate hematopoietic growth factors IL-3 and pharmaceutical compositions |
US5866136A (en) * | 1986-08-01 | 1999-02-02 | Commonwealth Scientific And Industrial Organisation | Recombinant vaccine |
DE3631229A1 (de) | 1986-09-13 | 1988-03-24 | Basf Ag | Monoklonale antikoerper gegen humanen tumornekrosefaktor (tnf) und deren verwendung |
US5002876A (en) * | 1986-09-22 | 1991-03-26 | Phillips Petroleum Company | Yeast production of human tumor necrosis factor |
US4777242A (en) | 1986-10-10 | 1988-10-11 | Phillips Petroleum Company | Purification of recombinant tumor necrosis factor |
US4912040A (en) | 1986-11-14 | 1990-03-27 | Genetics Institute, Inc. | Eucaryotic expression system |
JPH07106158B2 (ja) | 1986-12-04 | 1995-11-15 | サントリー株式会社 | 抗腫瘍活性を有する新規ポリペプチドおよびその製造法 |
US5504005A (en) * | 1987-03-02 | 1996-04-02 | Albert Einstein College Of Medicine Of Yeshiva University | Recombinant mycobacterial vaccine |
US4894225A (en) * | 1987-03-02 | 1990-01-16 | Cetus Corporation | Combination therapy using antitumor immunotoxins with tumor necrosis factor |
CA1340953C (en) * | 1987-04-08 | 2000-04-11 | David W. Barnes | Non-tumorigenic cell lines for expression of genes |
DE3888224T2 (de) | 1987-04-24 | 1994-07-21 | Teijin Ltd | Bestimmung vom Tumornekrosefaktor; monoklonaler Antikörper und Zusammensetzung. |
DE3716513A1 (de) * | 1987-05-16 | 1988-11-24 | Basf Ag | Proteine mit tnf-wirkung |
US6410033B1 (en) * | 1987-07-27 | 2002-06-25 | Syntro Corporation | Recombinant infectious bovine rhinotracheitis virus |
IL87737A (en) * | 1987-09-11 | 1993-08-18 | Genentech Inc | Method for culturing polypeptide factor dependent vertebrate recombinant cells |
US5648471A (en) | 1987-12-03 | 1997-07-15 | Centocor, Inc. | One vial method for labeling antibodies with Technetium-99m |
US5158871A (en) | 1988-02-12 | 1992-10-27 | University Of Connecticut | Method of using magnetic particles for isolating, collecting and assaying diagnostic ligates |
US5183657A (en) * | 1988-03-11 | 1993-02-02 | Celltech Limited | Antibodies for use in antilymphocyte antibody therapy |
US5215743A (en) * | 1988-04-13 | 1993-06-01 | Maninder Singh | Tumor necrosis factor formulations |
US5424940A (en) * | 1988-04-25 | 1995-06-13 | Ousborne; Jeffrey J. | Computer controlled system providing functions within a laundromat facility |
JPH0797997B2 (ja) | 1988-04-28 | 1995-10-25 | 帝人株式会社 | 新規生理活性ポリペプチド |
DE3823804A1 (de) | 1988-07-14 | 1990-01-18 | Basf Ag | Neutralisation der in vitro und in vivo toxischen eigenschaften von tnf-(alpha) durch monoklonale antikoerper und den davon abgeleiteten fragmenten |
AU626572B2 (en) | 1988-07-18 | 1992-08-06 | Chiron Corporation | Monoclonal antibodies reactive with cachectin |
DE68926679T2 (de) | 1988-09-22 | 1996-10-17 | Teijin Ltd | Physiologisch aktives polypeptid, rekombinantes plasmid, rekombinante mikrobielle zellen, medizinisches präparat sowie verfahren zur gewinnung des gereinigten polypeptids |
GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
US5360716A (en) | 1988-10-24 | 1994-11-01 | Otsuka Pharmaceutical Co., Ltd. | Human tumor necrosis factor αspecific monoclonal antibody and method for detecting human tumor necrosis factor α |
US5162430A (en) | 1988-11-21 | 1992-11-10 | Collagen Corporation | Collagen-polymer conjugates |
US5510418A (en) | 1988-11-21 | 1996-04-23 | Collagen Corporation | Glycosaminoglycan-synthetic polymer conjugates |
US5223395A (en) * | 1988-12-01 | 1993-06-29 | Centocor, Inc. | Immunometric assays for tumor necrosis factor-alpha and methods for preventing the loss of biological activity of tumor necrosis factor-alpha in biological samples |
US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
ATE289350T1 (de) | 1989-04-21 | 2005-03-15 | Amgen Inc | Tnf-rezeptor, tnf bindende proteine und dafür kodierende dnas |
US6262239B1 (en) | 1989-05-18 | 2001-07-17 | Yeda Research And Development Co., Ltd. | TNF receptor-specific antibodies |
US6232446B1 (en) * | 1989-05-18 | 2001-05-15 | Yeda Research And Development Co. Ltd. | TNF ligands |
US5959087A (en) | 1989-08-07 | 1999-09-28 | Peptide Technology, Ltd. | Tumour necrosis factor binding ligands |
US6498237B2 (en) | 1989-08-07 | 2002-12-24 | Peptech Limited | Tumor necrosis factor antibodies |
US5644034A (en) | 1989-08-07 | 1997-07-01 | Peptide Technology Ltd. | Tumour necrosis factor binding ligands |
EP0486622B1 (en) | 1989-08-09 | 1998-11-04 | Rhomed, Incorporated | Direct radiolabeling of antibodies and other proteins with technetium or rhenium |
US6315999B1 (en) | 1989-08-10 | 2001-11-13 | Solvay, S.A. | Pharmaceutical product for the treatment of sepsis |
DE69033457T2 (de) | 1989-08-16 | 2000-09-14 | Chiron Corp | Prohormonspaltungsplatzblockierungsantikörper |
US6541610B1 (en) * | 1989-09-05 | 2003-04-01 | Immunex Corporation | Fusion proteins comprising tumor necrosis factor receptor |
US5395760A (en) * | 1989-09-05 | 1995-03-07 | Immunex Corporation | DNA encoding tumor necrosis factor-α and -β receptors |
ATE199398T1 (de) * | 1989-10-24 | 2001-03-15 | Chiron Corp | Sekretion vom mit gamma-interferon signalpeptid gebundenen humänen protein |
US5859205A (en) * | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
US6673986B1 (en) | 1990-01-12 | 2004-01-06 | Abgenix, Inc. | Generation of xenogeneic antibodies |
US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
SG48759A1 (en) | 1990-01-12 | 2002-07-23 | Abgenix Inc | Generation of xenogenic antibodies |
US6075181A (en) | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
US5672510A (en) | 1990-01-19 | 1997-09-30 | Genetic Therapy, Inc. | Retroviral vectors |
US5151510A (en) | 1990-04-20 | 1992-09-29 | Applied Biosystems, Inc. | Method of synethesizing sulfurized oligonucleotide analogs |
US5110913A (en) * | 1990-05-25 | 1992-05-05 | Miles Inc. | Antibody purification method |
CA2090126C (en) | 1990-08-02 | 2002-10-22 | John W. Schrader | Methods for the production of proteins with a desired function |
CA2090401A1 (en) | 1990-08-27 | 1992-02-28 | Deborah A. Rathjen | Method of treating viral infection |
US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US5877397A (en) | 1990-08-29 | 1999-03-02 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
KR100272077B1 (ko) | 1990-08-29 | 2000-11-15 | 젠팜인터내셔날,인코포레이티드 | 이종 항체를 생산할 수 있는 전이유전자를 가진 인간이외의 동물 |
US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US6300129B1 (en) | 1990-08-29 | 2001-10-09 | Genpharm International | Transgenic non-human animals for producing heterologous antibodies |
US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
US5814318A (en) | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
US6255458B1 (en) | 1990-08-29 | 2001-07-03 | Genpharm International | High affinity human antibodies and human antibodies against digoxin |
US5874299A (en) | 1990-08-29 | 1999-02-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
WO1992003917A1 (en) | 1990-08-29 | 1992-03-19 | Genpharm International | Homologous recombination in mammalian cells |
US5789650A (en) | 1990-08-29 | 1998-08-04 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
US5194594A (en) | 1990-09-07 | 1993-03-16 | Techniclone, Inc. | Modified antibodies |
JPH05255393A (ja) | 1990-09-21 | 1993-10-05 | Ishihara Sangyo Kaisha Ltd | ポリペプチド |
US5519119A (en) * | 1990-09-21 | 1996-05-21 | Ishihara Sangyo Kaisha Ltd. | Muteins of TNF pharmaceutical compositions and a method of making |
GB9022648D0 (en) * | 1990-10-18 | 1990-11-28 | Charing Cross Sunley Research | Polypeptide and its use |
US5653974A (en) | 1990-10-18 | 1997-08-05 | Board Of Regents,The University Of Texas System | Preparation and characterization of liposomal formulations of tumor necrosis factor |
US5650150A (en) | 1990-11-09 | 1997-07-22 | Gillies; Stephen D. | Recombinant antibody cytokine fusion proteins |
CA2055168A1 (en) | 1990-11-21 | 1992-05-22 | Walter Fiers | Tnf-muteins |
ATE164395T1 (de) | 1990-12-03 | 1998-04-15 | Genentech Inc | Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften |
US5994510A (en) | 1990-12-21 | 1999-11-30 | Celltech Therapeutics Limited | Recombinant antibodies specific for TNFα |
GB9109645D0 (en) | 1991-05-03 | 1991-06-26 | Celltech Ltd | Recombinant antibodies |
GB9028123D0 (en) | 1990-12-28 | 1991-02-13 | Erba Carlo Spa | Monoclonal antibodies against human tumor necrosis factor alpha |
US5656272A (en) | 1991-03-18 | 1997-08-12 | New York University Medical Center | Methods of treating TNF-α-mediated Crohn's disease using chimeric anti-TNF antibodies |
US5919452A (en) | 1991-03-18 | 1999-07-06 | New York University | Methods of treating TNFα-mediated disease using chimeric anti-TNF antibodies |
US6284471B1 (en) | 1991-03-18 | 2001-09-04 | New York University Medical Center | Anti-TNFa antibodies and assays employing anti-TNFa antibodies |
CA2106299C (en) | 1991-03-18 | 2001-02-06 | Junming Le | Monoclonal and chimeric antibodies specific for human tumor necrosis factor |
US5698195A (en) | 1991-03-18 | 1997-12-16 | New York University Medical Center | Methods of treating rheumatoid arthritis using chimeric anti-TNF antibodies |
US6277969B1 (en) | 1991-03-18 | 2001-08-21 | New York University | Anti-TNF antibodies and peptides of human tumor necrosis factor |
US5160483A (en) | 1991-05-07 | 1992-11-03 | The University Of Tennessee Research Corporation | Fragment of TNF-α for promoting wound healing |
WO1992022670A1 (en) | 1991-06-12 | 1992-12-23 | Genpharm International, Inc. | Early detection of transgenic embryos |
AU2235992A (en) | 1991-06-14 | 1993-01-12 | Genpharm International, Inc. | Transgenic immunodeficient non-human animals |
FR2677654B1 (fr) | 1991-06-17 | 1995-11-17 | Pasteur Merieux Serums Vacc | Composes a effet immunogene anti-cytokine, a effet immunogene anticytostatique ou a effet vaccinal anti-infection a hiv. |
US5633146A (en) | 1991-07-02 | 1997-05-27 | Rhone-Poulenc Rorer S.A. | Method for producing recombinant proteins and host cells used therein |
US5223408A (en) * | 1991-07-11 | 1993-06-29 | Genentech, Inc. | Method for making variant secreted proteins with altered properties |
US5965379A (en) | 1991-07-19 | 1999-10-12 | Cytimmune Sciences Inc. | Method for measuring endogenous cytokines |
IE922437A1 (en) | 1991-07-25 | 1993-01-27 | Idec Pharma Corp | Recombinant antibodies for human therapy |
FR2679920A1 (fr) * | 1991-08-02 | 1993-02-05 | Rhone Poulenc Rorer Sa | Levures recombinantes hautement stables pour la production de proteines recombinantes, leur preparation et leur utilisation. |
AU2515992A (en) | 1991-08-20 | 1993-03-16 | Genpharm International, Inc. | Gene targeting in animal cells using isogenic dna constructs |
US5334380A (en) | 1991-09-27 | 1994-08-02 | Board Of Regents, The University Of Texas System | Anti-endotoxin, interleukin-1 receptor antagonist and anti-tumor necrosis factor antibody with arginine-free formulations for the treatment of hypotension |
US5641670A (en) * | 1991-11-05 | 1997-06-24 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
US5252479A (en) | 1991-11-08 | 1993-10-12 | Research Corporation Technologies, Inc. | Safe vector for gene therapy |
US6261834B1 (en) | 1991-11-08 | 2001-07-17 | Research Corporation Technologies, Inc. | Vector for gene therapy |
PT1696031E (pt) * | 1991-12-02 | 2010-06-25 | Medical Res Council | Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos |
EP0746609A4 (en) | 1991-12-17 | 1997-12-17 | Genpharm Int | NON-HUMAN TRANSGENIC ANIMALS CAPABLE OF PRODUCING HETEROLOGOUS ANTIBODIES |
US5447851B1 (en) | 1992-04-02 | 1999-07-06 | Univ Texas System Board Of | Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells |
SK376492A3 (en) * | 1992-04-02 | 1995-06-07 | Hoffmann La Roche | Tnf - muteins and method of their production |
US5278284A (en) * | 1992-05-14 | 1994-01-11 | Miller Brewing Company | Protein purification method |
EP0648265A4 (en) | 1992-06-18 | 1996-12-04 | Genpharm Int | PROCESS FOR THE PRODUCTION OF NON-HUMAN TRANSGENIC ANIMALS HAVING AN ARTIFICIAL YEAST CHROMOSOME. |
WO1994002602A1 (en) | 1992-07-24 | 1994-02-03 | Cell Genesys, Inc. | Generation of xenogeneic antibodies |
ATE172880T1 (de) * | 1992-08-28 | 1998-11-15 | Bayer Ag | Verwendung von monoklonalen anti-tnf-antikörpern für die behandlung von bakteriellen meningitiden |
US6270766B1 (en) | 1992-10-08 | 2001-08-07 | The Kennedy Institute Of Rheumatology | Anti-TNF antibodies and methotrexate in the treatment of arthritis and crohn's disease |
WO1994008619A1 (en) * | 1992-10-08 | 1994-04-28 | The Kennedy Institute Of Rheumatology | Treatment of autoimmune and inflammatory disorders |
WO1994008609A1 (en) * | 1992-10-15 | 1994-04-28 | Dana-Farber Cancer Institute, Inc. | TREATMENT OF INSULIN RESISTANCE IN OBESITY LINKED TYPE II DIABETES USING ANTAGONISTS TO TNF-α FUNCTION |
US5968735A (en) | 1992-11-12 | 1999-10-19 | Max Delbruck-Centrum Fur Molekular Medizin Berlin | Vector for the expression of therapy-relevant genes |
GB9225448D0 (en) * | 1992-12-04 | 1993-01-27 | Erba Carlo Spa | Improved synthesis of polymer bioactive conjugates |
GB9225453D0 (en) | 1992-12-04 | 1993-01-27 | Medical Res Council | Binding proteins |
US5837242A (en) | 1992-12-04 | 1998-11-17 | Medical Research Council | Multivalent and multispecific binding proteins, their manufacture and use |
US5981175A (en) | 1993-01-07 | 1999-11-09 | Genpharm Internation, Inc. | Methods for producing recombinant mammalian cells harboring a yeast artificial chromosome |
CA2155103A1 (en) * | 1993-02-03 | 1994-08-18 | Rudolph Lucas | Tnf-alpha muteins and a process for preparing them |
KR970005042B1 (ko) * | 1993-02-09 | 1997-04-11 | 한일합성섬유공업 주식회사 | 종양괴사인자-알파 뮤테인 |
US5626843A (en) * | 1993-02-26 | 1997-05-06 | Advanced Biotherapy Concepts, Inc. | Treatment of autoimmune diseases, including AIDS, by removel of interferons, TNFs and receptors therefor |
DK0614984T4 (da) | 1993-03-05 | 2010-12-20 | Bayer Healthcare Llc | Humane monoklonale anti-TNF-alfa-antistoffer |
CA2119089A1 (en) * | 1993-03-29 | 1994-09-30 | David Banner | Tumor necrosis factor muteins |
EP0754225A4 (en) | 1993-04-26 | 2001-01-31 | Genpharm Int | HETEROLOGIC ANTIBODY-PRODUCING TRANSGENIC NON-HUMAN ANIMALS |
DK0701571T3 (da) * | 1993-06-03 | 1997-09-15 | Therapeutic Antibodies Inc | Antistoffragmenter til terapi |
EP0710121B1 (en) | 1993-07-30 | 2000-10-11 | Kennedy Institute Of Rheumatology | Method for treating multiple sclerosis |
FR2709309B1 (fr) * | 1993-08-25 | 1995-11-10 | Centre Nat Rech Scient | Compositions cellulaires, préparation et utilisations thérapeutiques. |
US6268212B1 (en) | 1993-10-18 | 2001-07-31 | Amgen Inc. | Tissue specific transgene expression |
US5625825A (en) | 1993-10-21 | 1997-04-29 | Lsi Logic Corporation | Random number generating apparatus for an interface unit of a carrier sense with multiple access and collision detect (CSMA/CD) ethernet data network |
US5959085A (en) | 1993-11-23 | 1999-09-28 | Schering Corporation | Human monoclonal antibodies against human cytokines and methods of making and using such antibodies |
GB9324807D0 (en) * | 1993-12-03 | 1994-01-19 | Cancer Res Campaign Tech | Tumour antibody |
NZ278607A (en) * | 1994-02-07 | 1999-05-28 | Knoll Ag | Use of tnf antagonists for treating disorders involving elevated serum levels of il-6 wherein the serum levels are 500pg/ml or above |
ATE410518T1 (de) * | 1994-03-23 | 2008-10-15 | Univ Ohio | Kompaktnukleinsäure und ihre verabreichung in zellen |
DK0760010T3 (da) | 1994-05-17 | 2002-02-25 | Cedars Sinai Medical Center | Fremgangsmåder til screening for Crohn's sygdom under anvendelse af TNF-mikrosatellit-alleler |
US5606023A (en) * | 1994-05-24 | 1997-02-25 | Thomas Jefferson University | Mutant tumor necrosis factor proteins |
US5888814A (en) * | 1994-06-06 | 1999-03-30 | Chiron Corporation | Recombinant host cells encoding TNF proteins |
US5989808A (en) | 1994-06-14 | 1999-11-23 | American Cyanamid Company | Identification of compounds affecting specific interaction of peptide binding pairs |
DE4435612A1 (de) | 1994-10-05 | 1996-04-11 | Braun Melsungen Ag | Verfahren zur simultanen Entfernung von Tumor-Nekrose-Faktor alpha und bakteriellen Lipopolysacchariden aus einer wäßrigen Flüssigkeit |
US5763733A (en) * | 1994-10-13 | 1998-06-09 | Enzon, Inc. | Antigen-binding fusion proteins |
US5643763A (en) | 1994-11-04 | 1997-07-01 | Genpharm International, Inc. | Method for making recombinant yeast artificial chromosomes by minimizing diploid doubling during mating |
US5753499A (en) * | 1994-12-23 | 1998-05-19 | New York University | Viral vector complexes having adapters of predefined valence |
US6127528A (en) | 1995-02-16 | 2000-10-03 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Process for adsorbing and removing tumor necrosis factor-α |
AU5004196A (en) * | 1995-03-10 | 1996-10-02 | Boehringer Mannheim Gmbh | Polypeptide-containing pharmaceutical forms of administration in the form of microparticles and method for the preparation thereof |
CA2219486A1 (en) | 1995-04-28 | 1996-10-31 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
US5705364A (en) * | 1995-06-06 | 1998-01-06 | Genentech, Inc. | Mammalian cell culture process |
DK0843961T3 (da) | 1995-08-29 | 2007-05-21 | Kirin Brewery | Kimærisk mus og fremgangsmåde til at producere samme |
US6022737A (en) * | 1995-11-02 | 2000-02-08 | Amgen Inc. | Formulations for non-viral in vivo transfection in the lungs |
FR2741262B1 (fr) * | 1995-11-20 | 1999-03-05 | Oreal | Utilisation d'un antagoniste de tnf-alpha pour le traitement des rougeurs cutanees d'origine neurogene |
US6090382A (en) * | 1996-02-09 | 2000-07-18 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
US5789442A (en) * | 1996-01-18 | 1998-08-04 | Schering Aktiengesellschaft | Treatment of urinary incontinence with nitric oxide synthase substrates and/or nitric oxide donors alone or in combination with estrogen or progesterone and/or other agents |
CN101712720A (zh) | 1996-02-09 | 2010-05-26 | 艾博特生物技术有限公司 | 结合人TNFα的人抗体 |
EP0792083B1 (en) * | 1996-02-23 | 1999-07-28 | Samsung Electronics Co., Ltd. | A method for controlling a microwave oven to prevent overcooking of small food portions |
EP0791360A3 (en) | 1996-02-29 | 1997-09-24 | Bayer Corporation | Treatment of septic shock with anti-TNF antibodies |
US5952221A (en) * | 1996-03-06 | 1999-09-14 | Avigen, Inc. | Adeno-associated virus vectors comprising a first and second nucleic acid sequence |
DK0912738T3 (da) * | 1996-05-22 | 2008-11-17 | Viventia Biotech Inc | Antigen-bindende-fragmenter der specifikt detekterer cancerceller, nukleotider der koder fragmenterne og anvendelse deraf til profylakse og detektion af cancere |
US6277368B1 (en) | 1996-07-25 | 2001-08-21 | The Regents Of The University Of California | Cancer immunotherapy using autologous tumor cells combined with cells expressing a membrane cytokine |
US5916771A (en) | 1996-10-11 | 1999-06-29 | Abgenix, Inc. | Production of a multimeric protein by cell fusion method |
KR20080059467A (ko) | 1996-12-03 | 2008-06-27 | 아브게닉스, 인크. | 복수의 vh 및 vk 부위를 함유하는 사람 면역글로불린유전자좌를 갖는 형질전환된 포유류 및 이로부터 생성된항체 |
BR9714127A (pt) * | 1996-12-31 | 2000-02-29 | Chevron Usa Inc | Zeólito, e, processo para preparação de um material cristalino, para conversão de hidrocarbonetos, para conversão de álcoois inferiores e outros hidrocarbonetos oxigenados, e, para redução de óxidos de nitrogênio contidos em um fluxo de gás em presença de oxigênio. |
US5917123A (en) * | 1997-03-14 | 1999-06-29 | University Of Pittsburgh | Transgenic mice containing a nucleic acid encoding tumor necrosis factor-α under the control of a cardiac specific regulatory region |
US6099847A (en) | 1997-05-15 | 2000-08-08 | The United States Of America As Represented By The Department Of Health And Human Services | Chimeric Gag pseudovirions |
AU7590198A (en) * | 1997-06-10 | 1998-12-30 | Medlyte Diagnostics, Inc. | Methods for early detection of heart disease |
GB9713412D0 (en) * | 1997-06-26 | 1997-08-27 | Delta Biotechnology Ltd | Improved protein expression strains |
US6407218B1 (en) * | 1997-11-10 | 2002-06-18 | Cytimmune Sciences, Inc. | Method and compositions for enhancing immune response and for the production of in vitro mabs |
EP1038017A2 (en) * | 1997-12-11 | 2000-09-27 | Pangene Corporation | The use of consensus sequences for targeted homologous gene isolation and recombination in gene families |
AU764629B2 (en) | 1998-01-22 | 2003-08-28 | Btg International Limited | Inhibition of cytokine production |
MXPA01000271A (es) * | 1998-07-13 | 2002-10-17 | Expression Genetics Inc | Analogo de poliester de poli-lisina como un portador para el suministro de genes, soluble, biodegradable. |
US6136599A (en) | 1998-12-10 | 2000-10-24 | Bayer Corporation | Human hybrid host cell for mammalian gene expression |
US6376246B1 (en) | 1999-02-05 | 2002-04-23 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
US6015557A (en) * | 1999-02-24 | 2000-01-18 | Tobinick; Edward L. | Tumor necrosis factor antagonists for the treatment of neurological disorders |
US6177077B1 (en) * | 1999-02-24 | 2001-01-23 | Edward L. Tobinick | TNT inhibitors for the treatment of neurological disorders |
US6287588B1 (en) | 1999-04-29 | 2001-09-11 | Macromed, Inc. | Agent delivering system comprised of microparticle and biodegradable gel with an improved releasing profile and methods of use thereof |
ES2225156T3 (es) * | 1999-06-03 | 2005-03-16 | Maxim Pharmaceuticals, Inc. | Composiciones oftalmicas que contienen histamina y usos de las mismas. |
US6833268B1 (en) | 1999-06-10 | 2004-12-21 | Abgenix, Inc. | Transgenic animals for producing specific isotypes of human antibodies via non-cognate switch regions |
NZ518401A (en) * | 1999-10-29 | 2004-01-30 | Nektar Therapeutics | Dry powder compositions having improved dispersivity |
US6524572B1 (en) * | 2000-06-26 | 2003-02-25 | Rainbow Therapeutic Company | Targeting recombinant virus with a bispecific fusion protein ligand in coupling with an antibody to cells for gene therapy |
US7754433B2 (en) | 2001-12-03 | 2010-07-13 | Amgen Fremont Inc. | Identification of high affinity molecules by limited dilution screening |
RU2377253C2 (ru) * | 2002-12-02 | 2009-12-27 | Амген Фремонт,Инк. | Антитела, специфичные к фактору некроза опухолей, и их применение |
US11284893B2 (en) | 2019-04-02 | 2022-03-29 | Covidien Lp | Stapling device with articulating tool assembly |
-
2003
- 2003-12-02 RU RU2005116225/13A patent/RU2377253C2/ru active
- 2003-12-02 EP EP03796574A patent/EP1578799B8/en not_active Expired - Lifetime
- 2003-12-02 ES ES03796574T patent/ES2347239T3/es not_active Expired - Lifetime
- 2003-12-02 DE DE60333228T patent/DE60333228D1/de not_active Expired - Lifetime
- 2003-12-02 CN CNB2003801094561A patent/CN100434440C/zh not_active Expired - Lifetime
- 2003-12-02 JP JP2004557489A patent/JP4754219B2/ja not_active Expired - Lifetime
- 2003-12-02 AU AU2003298816A patent/AU2003298816C1/en not_active Expired
- 2003-12-02 AT AT03796574T patent/ATE472556T1/de not_active IP Right Cessation
- 2003-12-02 MX MXPA05005921A patent/MXPA05005921A/es active IP Right Grant
- 2003-12-02 WO PCT/US2003/038281 patent/WO2004050683A2/en active Application Filing
- 2003-12-02 CA CA2508375A patent/CA2508375C/en not_active Expired - Lifetime
- 2003-12-02 US US10/727,155 patent/US7285269B2/en not_active Expired - Lifetime
-
2006
- 2006-03-09 HK HK06103052.3A patent/HK1083023A1/xx not_active IP Right Cessation
-
2007
- 2007-10-22 US US11/876,669 patent/US8101178B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US8101178B2 (en) | 2012-01-24 |
JP2006508167A (ja) | 2006-03-09 |
WO2004050683A3 (en) | 2005-04-14 |
HK1083023A1 (en) | 2006-06-23 |
AU2003298816B2 (en) | 2010-06-17 |
EP1578799A2 (en) | 2005-09-28 |
AU2003298816A1 (en) | 2004-06-23 |
RU2377253C2 (ru) | 2009-12-27 |
MXPA05005921A (es) | 2005-10-19 |
EP1578799B1 (en) | 2010-06-30 |
EP1578799B8 (en) | 2011-03-23 |
AU2003298816C1 (en) | 2010-12-16 |
ATE472556T1 (de) | 2010-07-15 |
CA2508375A1 (en) | 2004-06-17 |
US20080187531A1 (en) | 2008-08-07 |
US20050049402A1 (en) | 2005-03-03 |
DE60333228D1 (de) | 2010-08-12 |
CN1745101A (zh) | 2006-03-08 |
WO2004050683A2 (en) | 2004-06-17 |
EP1578799A4 (en) | 2007-04-04 |
ES2347239T3 (es) | 2010-10-27 |
US7285269B2 (en) | 2007-10-23 |
CA2508375C (en) | 2014-05-27 |
JP4754219B2 (ja) | 2011-08-24 |
WO2004050683A8 (en) | 2005-07-28 |
CN100434440C (zh) | 2008-11-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
RU2005116225A (ru) | Антитела, специфичные к фактору некроза опухолей, и их применение | |
US8211433B2 (en) | TNFα-neutralizing antibodies | |
RU2492185C2 (ru) | Связывающие протеины, специфичные по отношению к инсулин-подобным факторам роста, и их использование | |
RU2413735C2 (ru) | Антитела и родственные молекулы, связывающиеся с белками 161p2f10b | |
JP6006404B2 (ja) | 抗BLyS抗体 | |
CN109206514B (zh) | Tslp单克隆抗体及其制备方法和应用 | |
RU2010138567A (ru) | Антитела рецептора 1 интерферона альфа и их применение | |
KR20150038556A (ko) | TNF-α 결합 단백질 | |
RU2008129787A (ru) | Фармацевтические композиции с устойчивостью к растворимому сеа | |
RU2008129080A (ru) | Средства и способы лечения опухолевых заболеваний | |
RU2007118670A (ru) | Ангиопоэтин-2-специфические связывающие агенты | |
JP2005518789A5 (ru) | ||
HRP20120701T1 (hr) | Humana monoklonska protutijela protiv fukozil-gm1 i postupci za uporabu antifukozil-gm1 | |
RU2006146666A (ru) | Антитела и родственные молекулы, связывающиеся с белками psca | |
CN101440130B (zh) | 一种抗人IL-13Rα2单克隆抗体的重链和轻链的可变区 | |
CN103201287A (zh) | 成纤维细胞生长因子受体2的致癌异构体的抗体分子及其用途 | |
CN114380910B (zh) | 靶向人b7-h3分子的人源化单克隆抗体及其应用 | |
JP2005528914A5 (ru) | ||
CN109721656A (zh) | 靶向rankl的治疗性抗体 | |
Song et al. | Characterization of a novel anti-human TNF-α murine monoclonal antibody with high binding affinity and neutralizing activity | |
CA3133163A1 (en) | Protein binders for irhom2 | |
DE50013935D1 (de) | Diagnostischer und therapeutischer einsatz von antikörpern gegen den urokinase-rezeptor | |
CN113227148B (zh) | 抗gpc3抗体、其抗原结合片段及其医药用途 | |
CN105683218A (zh) | 针对toso的抗体 | |
CN101585880B (zh) | 一种抗人IL-13Rα2单克隆抗体的重链和轻链的可变区 |