RU2005111256A - Производные фенола и их применение в качестве ингибиторов ротамаз - Google Patents

Производные фенола и их применение в качестве ингибиторов ротамаз Download PDF

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Publication number
RU2005111256A
RU2005111256A RU2005111256/04A RU2005111256A RU2005111256A RU 2005111256 A RU2005111256 A RU 2005111256A RU 2005111256/04 A RU2005111256/04 A RU 2005111256/04A RU 2005111256 A RU2005111256 A RU 2005111256A RU 2005111256 A RU2005111256 A RU 2005111256A
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Russia
Prior art keywords
hydroxyphenyl
chloro
dichloro
phenol
urea
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RU2005111256/04A
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English (en)
Russian (ru)
Inventor
Йохен КНОЛЛЕ (DE)
Йохен Кнолле
Мике ШУТКОВСКИ (DE)
Мике ШУТКОВСКИ
Герд ХУММЕЛЬ (DE)
Герд ХУММЕЛЬ
Томас ТРАДЛЕР (DE)
Томас ТРАДЛЕР
Лоранс ЖОБРОН (DE)
Лоранс ЖОБРОН
Клаудиа КРИСТНЕР (DE)
Клаудиа КРИСТНЕР
Дирк ШАРН (DE)
Дирк ШАРН
Роланд ШТРАГИС (DE)
Роланд ШТРАГИС
Кристоф ГИБСОН (DE)
Кристоф ГИБСОН
Франк ОСТЕРКАМП (DE)
Франк ОСТЕРКАМП
Original Assignee
Йерини Аг (De)
Йерини Аг
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Application filed by Йерини Аг (De), Йерини Аг filed Critical Йерини Аг (De)
Publication of RU2005111256A publication Critical patent/RU2005111256A/ru

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    • C07C275/28Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/32Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • C07C275/34Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
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RU2005111256/04A 2002-09-18 2003-09-18 Производные фенола и их применение в качестве ингибиторов ротамаз RU2005111256A (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20020020987 EP1402888A1 (en) 2002-09-18 2002-09-18 The use of substituted carbocyclic compounds as rotamases inhibitors
EP02020987.0 2002-09-18

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RU2010136779/04A Division RU2010136779A (ru) 2002-09-18 2010-09-02 Производные фенола и их применение в качестве ингибиторов ротамаз

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RU2010136779/04A RU2010136779A (ru) 2002-09-18 2010-09-02 Производные фенола и их применение в качестве ингибиторов ротамаз

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US (2) US20070054904A1 (enExample)
EP (3) EP1402888A1 (enExample)
JP (2) JP2005539072A (enExample)
KR (1) KR20050053673A (enExample)
CN (1) CN100546977C (enExample)
AU (1) AU2003271619A1 (enExample)
BR (1) BR0314544A (enExample)
CA (1) CA2498662A1 (enExample)
MX (1) MXPA05003084A (enExample)
PL (1) PL374846A1 (enExample)
RU (2) RU2005111256A (enExample)
SG (1) SG165995A1 (enExample)
WO (1) WO2004026815A2 (enExample)
ZA (1) ZA200501913B (enExample)

Families Citing this family (47)

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Publication number Priority date Publication date Assignee Title
JP2006518738A (ja) * 2003-02-12 2006-08-17 トランス テック ファーマ,インコーポレイテッド 治療薬としての置換アゾール誘導体
WO2004089296A2 (en) 2003-04-03 2004-10-21 The Regents Of The University Of California Improved inhibitors for the soluble epoxide hydrolase
JP4090491B2 (ja) * 2003-12-23 2008-05-28 ハー・ルンドベック・アクチエゼルスカベット 2−(1h−インドリルスルファニル)−ベンジルアミン誘導体
EP1713780B1 (en) * 2004-02-05 2012-01-18 Probiodrug AG Novel inhibitors of glutaminyl cyclase
CA2559665A1 (en) 2004-03-16 2005-09-29 The Regents Of The University Of California Reducing nephropathy with inhibitors of soluble epoxide hydrolase and epoxyeicosanoids
US7550499B2 (en) 2004-05-12 2009-06-23 Bristol-Myers Squibb Company Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
CN1984899B (zh) * 2004-05-12 2011-07-27 先灵公司 Cxcr1和cxcr2趋化因子拮抗剂
AR052308A1 (es) * 2004-07-16 2007-03-14 Lundbeck & Co As H Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto
NZ554555A (en) 2004-10-20 2011-09-30 Univ California Cyclohexyl-urea derivatives as improved inhibitors for the soluble epoxide hydrolase
AU2006206611A1 (en) 2005-01-19 2006-07-27 Bristol-Myers Squibb Company 2-phenoxy-N- (1, 3 , 4-thiadizol-2-yl) pyridin-3-amine derivatives and related compounds as P2Y1 receptor inhibitors for the treatment of thromboembolic disorders
EP1888052A2 (en) * 2005-05-12 2008-02-20 Wisconsin Alumni Research Foundation Blockade of pin1 prevents cytokine production by activated immune cells
US7629473B2 (en) * 2005-06-17 2009-12-08 H. Lundbeck A/S 2-(1H-indolylsulfanyl)-aryl amine derivatives
AR054393A1 (es) * 2005-06-17 2007-06-20 Lundbeck & Co As H Derivados de benzo(b)furano y benzo(b)tiofeno, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por la inhibicion de la reabsorcion de neurotransmisores de amina biogenicos.
EP1899299B1 (en) 2005-06-27 2010-10-20 Bristol-Myers Squibb Company C-linked cyclic antagonists of p2y1 receptor useful in the treatment of thrombotic conditions
US7714002B2 (en) 2005-06-27 2010-05-11 Bristol-Myers Squibb Company Carbocycle and heterocycle antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
MX2007016501A (es) 2005-06-27 2008-03-06 Squibb Bristol Myers Co Antagonistas heterociclicos n-enlazados del receptor de p2y1, utiles en el tratamiento de condiciones tromboticas.
ES2360818T3 (es) 2005-06-27 2011-06-09 Bristol-Myers Squibb Company Miméticos de urea lineal antagonistas del receptor p2y, útiles en el tratamiento de afecciones trombóticas.
US7723369B2 (en) 2006-01-30 2010-05-25 Transtech Pharma, Inc. Substituted imidazole derivatives, compositions, and methods of use as PTPase inhibitors
US20080081913A1 (en) * 2006-09-29 2008-04-03 General Electric Company Benzoxazole and benzothiazole compounds and methods therefor
US20080081210A1 (en) 2006-09-29 2008-04-03 General Electric Company Authenticatable articles and methods therefor
US7960569B2 (en) 2006-10-17 2011-06-14 Bristol-Myers Squibb Company Indole antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
JP2010523476A (ja) * 2007-03-08 2010-07-15 ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ ミトコンドリアアルデヒドデヒドロゲナーゼ−2モジュレーター及びその使用方法
US20110110958A1 (en) * 2007-09-11 2011-05-12 University Of Florida Research Foundation Compositions and methods for the treatment of neoplasia
EP2062578A1 (en) * 2007-11-12 2009-05-27 Institut National De La Sante Et De La Recherche Medicale (Inserm) Novel use of chemical compounds for the treatment of AIDS
CN102209541B (zh) 2008-09-08 2016-05-18 小利兰·斯坦福大学托管委员会 醛脱氢酶活性调节剂和其使用方法
JP2012506856A (ja) 2008-10-28 2012-03-22 ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティ アルデヒドデヒドロゲナーゼのモジュレーターおよびその使用方法
WO2010057101A2 (en) * 2008-11-17 2010-05-20 Schering Corporation Compounds useful as hiv blockers
RU2571662C2 (ru) 2009-03-25 2015-12-20 Эббви Инк. Противовирусные соединения и их применения
DK2417972T3 (en) * 2009-04-06 2017-08-14 Neurotech Pharmaceuticals Co Ltd PHARMACEUTICAL COMPOSITION FOR TREATMENT OR PREVENTION OF COMBUSTION DAMAGE
EP2712655B1 (en) 2011-04-28 2019-12-18 The Broad Institute, Inc. Inhibitors of histone deacetylase
US10457659B2 (en) 2011-04-29 2019-10-29 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for increasing proliferation of adult salivary stem cells
EP2750671A2 (en) * 2011-05-19 2014-07-09 Oryzon Genomics, S.A. Lysine demethylase inhibitors for thrombosis and cardiovascular diseases
EP2741741A2 (en) * 2011-05-19 2014-06-18 Oryzon Genomics, S.A. Lysine demethylase inhibitors for inflammatory diseases or conditions
KR20150002713A (ko) * 2012-03-28 2015-01-07 뉴로포레 테라피스, 인코포레이티드 단백질 응집 저해제로서의 페닐-우레아 및 페닐-카바메이트 유도체
KR20130118612A (ko) * 2012-04-20 2013-10-30 (주)네오믹스 신규한 아미노피리딘 유도체 및 이의 용도
WO2014018979A1 (en) 2012-07-27 2014-01-30 The Broad Institute, Inc. Inhibitors of histone deacetylase
WO2014100438A1 (en) 2012-12-20 2014-06-26 The Broad Institute, Inc. Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors
KR20150135332A (ko) 2013-03-14 2015-12-02 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 미토콘드리아 알데히드 탈수소효소-2 조절인자들 및 이들의 사용 방법
WO2016049774A1 (en) * 2014-10-03 2016-04-07 The Royal Institution For The Advancement Of Learning/Mcgill University Urea and bis-urea based compounds and analogues thereof useful in the treatment of androgen receptor mediated diseases or disorders
SMT202400213T1 (it) 2015-07-06 2024-07-09 Turning Point Therapeutics Inc Polimorfo di diaril macrociclo
CN107417578B (zh) * 2017-08-23 2020-02-07 沈阳海诺威医药科技有限公司 N-(3,5-二甲基金刚烷-1-基)-n’-取代苯基脲类化合物及其制备方法和用途
US12128018B2 (en) 2018-01-12 2024-10-29 KDAc Therapeutics, Inc. Combination of a selective histone deacetylase 3 (HDAC3) inhibitor and an immunotherapy agent for the treatment of cancer
CN111233692A (zh) * 2020-01-19 2020-06-05 江西农业大学 一种香茅酸酰胺类衍生物及其制备方法与应用
WO2023003468A1 (en) 2021-07-23 2023-01-26 Rijksuniversiteit Groningen Novel inhibitors of histone deacetylase (hdac), and methods, compositions and uses related thereto.
CN117682973A (zh) * 2022-09-26 2024-03-12 中国药科大学 磺酰胺类化合物及其医药用途
CN116942649B (zh) * 2023-08-01 2025-09-16 华中农业大学 一种苯基脲类化合物作为巴贝斯虫生长抑制剂的应用
CN117224515A (zh) * 2023-10-31 2023-12-15 首都医科大学附属北京朝阳医院 Coh-sr4在制备预防和/或治疗缺血性心脏病的药物中的应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK41193D0 (da) * 1993-04-07 1993-04-07 Neurosearch As Ionkanalaabnere
US5744485A (en) * 1994-03-25 1998-04-28 Vertex Pharmaceuticals Incorporated Carbamates and ureas as modifiers of multi-drug resistance
US5696135A (en) * 1995-06-07 1997-12-09 Gpi Nil Holdings, Inc. Inhibitors of rotamase enzyme activity effective at stimulating neuronal growth
SK57899A3 (en) * 1996-12-31 2000-05-16 Guilford Pharm Inc N-linked ureas and carbamates of heterocyclic thioesters
US6242468B1 (en) * 1997-02-27 2001-06-05 Jia-He Li Carbamate and urea compositions and neurotrophic uses
ZA98825B (en) * 1997-02-27 1998-10-19 Guilford Pharm Inc Method of using neurotrophic carbamates and ureas
US6093742A (en) * 1997-06-27 2000-07-25 Vertex Pharmaceuticals, Inc. Inhibitors of p38
JP2003508512A (ja) * 1999-09-08 2003-03-04 ギルフォード ファーマシュウティカルズ インコーポレイテッド 非ペプチド性サイクロフィリン結合化合物とその用途
JP2004523490A (ja) * 2000-11-28 2004-08-05 ギルフォード ファーマシュウティカルズ インコーポレイテッド 二置換カルボサイクリックサイクロフィリン結合化合物とその用途
WO2002059080A2 (en) * 2001-01-25 2002-08-01 Guilford Pharmaceuticals Inc. Trisubstituted carbocyclic cyclophilin binding compounds and their use
JP2002241273A (ja) * 2001-02-13 2002-08-28 Sumitomo Pharmaceut Co Ltd ベンズアミド誘導体およびその利用
WO2002064139A1 (en) * 2001-02-15 2002-08-22 Neurosearch A/S Treatment of parkinson's disease by the combined action of a compound with neurotrophic activity and a compound enhancing the dopamine activity
JP2004520396A (ja) * 2001-02-15 2004-07-08 ニューロサーチ、アクティーゼルスカブ 過剰な又は不十分な細胞死によって特徴づけられる疾患の治療

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