BR0314544A - Compostos para a inibição de rotamases e seu uso - Google Patents
Compostos para a inibição de rotamases e seu usoInfo
- Publication number
- BR0314544A BR0314544A BR0314544-1A BR0314544A BR0314544A BR 0314544 A BR0314544 A BR 0314544A BR 0314544 A BR0314544 A BR 0314544A BR 0314544 A BR0314544 A BR 0314544A
- Authority
- BR
- Brazil
- Prior art keywords
- substituted
- heterocyclyl
- alkyl
- straight
- branched
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
- C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
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- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/18—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
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- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Psychology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Transplantation (AREA)
- AIDS & HIV (AREA)
- Psychiatry (AREA)
Abstract
"COMPOSTOS PARA A INIBIçãO DE ROTAMASES E SEU USO". A presente invenção se relaciona a um composto da fórmula (I), em que Z~ 1~, Z~ 2~, Z~ 3~ e Z~ 4~ são cada um e independentemente selecionado do grupo compreendendo -C(O)-, -C(S)-, -C(O)-NR~ 10~-, -C(S)-NR~ 11~-, -C(NCN)-NR~ 12~-, -S(O)-, -S(O~ 2~)-, -S(O)-NR~ 13~-, e -S(O~ 2~)-NR~ 14~-, -0-, -S- ou são cada um e individualmente ausente; X é um espaçador e é independentemente selecionado do grupo compreendendo -M1-L1-K-L2-M2-, em que Y é selecionado do grupo compreendendo alquila, alquila substituída, alquila reta, alquila reta substituída, alquila ramificada, alquila ramificada substituída, alquenila reta, alquenila reta substituída, alquenila ramificada, alquenila ramificada substituída, alquinila reta, alquinila reta substituída, alquila ramificada e alquinila ramificada substituída, cicloalquila, cicloalquila substituída, cicloalquenila, cicloalquenila substituída, heterociclila, heterociclila substituída, heterociclila mono-insaturada, heterociclila poli-insaturada, heterociclila mono-substituída poli-insaturada, heterociclila poli-substituída poliinsaturada, heterociclila mono-substituída mono-insaturada, heterociclila poli-substituída mono-insaturada, arila, arila substituída, heteroarila e heteroarila substituída, em que Y é diferente de um peptídeo ou está ausente.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP20020020987 EP1402888A1 (en) | 2002-09-18 | 2002-09-18 | The use of substituted carbocyclic compounds as rotamases inhibitors |
PCT/EP2003/010406 WO2004026815A2 (en) | 2002-09-18 | 2003-09-18 | Phenol derivatives and their use as rotamase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0314544A true BR0314544A (pt) | 2005-08-16 |
Family
ID=31970282
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0314544-1A BR0314544A (pt) | 2002-09-18 | 2003-09-18 | Compostos para a inibição de rotamases e seu uso |
Country Status (14)
Country | Link |
---|---|
US (2) | US20070054904A1 (pt) |
EP (3) | EP1402888A1 (pt) |
JP (2) | JP2005539072A (pt) |
KR (1) | KR20050053673A (pt) |
CN (1) | CN100546977C (pt) |
AU (1) | AU2003271619A1 (pt) |
BR (1) | BR0314544A (pt) |
CA (1) | CA2498662A1 (pt) |
MX (1) | MXPA05003084A (pt) |
PL (1) | PL374846A1 (pt) |
RU (2) | RU2005111256A (pt) |
SG (1) | SG165995A1 (pt) |
WO (1) | WO2004026815A2 (pt) |
ZA (1) | ZA200501913B (pt) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006518738A (ja) * | 2003-02-12 | 2006-08-17 | トランス テック ファーマ,インコーポレイテッド | 治療薬としての置換アゾール誘導体 |
CA2520763A1 (en) * | 2003-04-03 | 2004-10-21 | The Regents Of The University Of California | Improved inhibitors for the soluble epoxide hydrolase |
EP1701940B1 (en) * | 2003-12-23 | 2008-05-28 | H.Lundbeck A/S | 2-(1h-indolylsulfanyl)-benzyl amine derivatives as ssri |
EP1713780B1 (en) * | 2004-02-05 | 2012-01-18 | Probiodrug AG | Novel inhibitors of glutaminyl cyclase |
JP2007532484A (ja) | 2004-03-16 | 2007-11-15 | ザ・レジェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア | 可溶性エポキシド加水分解酵素の阻害剤およびエポキシエイコサノイドを用いて腎症を緩和する方法 |
CA2565519A1 (en) * | 2004-05-12 | 2005-12-01 | Schering Corporation | Cxcr1 and cxcr2 chemokine antagonists |
US7550499B2 (en) | 2004-05-12 | 2009-06-23 | Bristol-Myers Squibb Company | Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
AR052308A1 (es) * | 2004-07-16 | 2007-03-14 | Lundbeck & Co As H | Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto |
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-
2002
- 2002-09-18 EP EP20020020987 patent/EP1402888A1/en not_active Withdrawn
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2003
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- 2003-09-18 BR BR0314544-1A patent/BR0314544A/pt not_active IP Right Cessation
- 2003-09-18 JP JP2004537125A patent/JP2005539072A/ja not_active Withdrawn
- 2003-09-18 RU RU2005111256/04A patent/RU2005111256A/ru not_active Application Discontinuation
- 2003-09-18 CN CNB038252651A patent/CN100546977C/zh not_active Expired - Fee Related
- 2003-09-18 US US10/528,139 patent/US20070054904A1/en not_active Abandoned
- 2003-09-18 CA CA002498662A patent/CA2498662A1/en not_active Abandoned
- 2003-09-18 EP EP09007837A patent/EP2100876A3/en not_active Withdrawn
- 2003-09-18 SG SG200702382-3A patent/SG165995A1/en unknown
- 2003-09-18 KR KR1020057004693A patent/KR20050053673A/ko not_active Application Discontinuation
- 2003-09-18 MX MXPA05003084A patent/MXPA05003084A/es not_active Application Discontinuation
- 2003-09-18 WO PCT/EP2003/010406 patent/WO2004026815A2/en active Application Filing
- 2003-09-18 EP EP03753427A patent/EP1539683A2/en not_active Ceased
- 2003-09-18 AU AU2003271619A patent/AU2003271619A1/en not_active Abandoned
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2005
- 2005-03-07 ZA ZA2005/01913A patent/ZA200501913B/en unknown
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2009
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2010
- 2010-09-02 RU RU2010136779/04A patent/RU2010136779A/ru not_active Application Discontinuation
- 2010-09-29 JP JP2010219856A patent/JP2011037869A/ja active Pending
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EP2100876A2 (en) | 2009-09-16 |
CN100546977C (zh) | 2009-10-07 |
JP2011037869A (ja) | 2011-02-24 |
EP1539683A2 (en) | 2005-06-15 |
WO2004026815A2 (en) | 2004-04-01 |
RU2010136779A (ru) | 2012-03-10 |
AU2003271619A1 (en) | 2004-04-08 |
RU2005111256A (ru) | 2006-10-27 |
US20110065760A1 (en) | 2011-03-17 |
US20070054904A1 (en) | 2007-03-08 |
EP2100876A3 (en) | 2010-02-24 |
EP1402888A1 (en) | 2004-03-31 |
KR20050053673A (ko) | 2005-06-08 |
CA2498662A1 (en) | 2004-04-01 |
PL374846A1 (en) | 2005-11-14 |
SG165995A1 (en) | 2010-11-29 |
MXPA05003084A (es) | 2005-11-17 |
JP2005539072A (ja) | 2005-12-22 |
CN1701061A (zh) | 2005-11-23 |
WO2004026815A3 (en) | 2004-12-02 |
ZA200501913B (en) | 2005-07-27 |
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