RU2002113920A - Антигенные пептиды neisseria - Google Patents
Антигенные пептиды neisseriaInfo
- Publication number
- RU2002113920A RU2002113920A RU2002113920/13A RU2002113920A RU2002113920A RU 2002113920 A RU2002113920 A RU 2002113920A RU 2002113920/13 A RU2002113920/13 A RU 2002113920/13A RU 2002113920 A RU2002113920 A RU 2002113920A RU 2002113920 A RU2002113920 A RU 2002113920A
- Authority
- RU
- Russia
- Prior art keywords
- protein
- fragment
- composition
- polypeptide
- fragment according
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title claims 6
- 241000588653 Neisseria Species 0.000 title claims 5
- 102000004196 processed proteins & peptides Human genes 0.000 title claims 5
- 230000000890 antigenic effect Effects 0.000 title claims 2
- 239000012634 fragment Substances 0.000 claims 10
- 102000004169 proteins and genes Human genes 0.000 claims 8
- 108090000623 proteins and genes Proteins 0.000 claims 8
- 229920001184 polypeptide Polymers 0.000 claims 4
- 239000003153 chemical reaction reagent Substances 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000002163 immunogen Effects 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Claims (13)
1. Фрагмент белка, описанного в международной патентной заявке WO99/57280 или WO00/22430, содержащий по меньшей мере одну антигенную детерминанту.
2. Фрагмент по п.1, имеющий длину 100 или менее аминокислот.
3. Фрагмент по п.1 или 2, имеющий длину 5 или более аминокислот.
4. Фрагмент по любому из предыдущих пунктов, имеющий аминокислотную последовательность, представленную в таблице 1.
5. Полипептид, имеющий 50%-ную или более высокую идентичность последовательности относительно фрагмента по любому из предыдущих пунктов.
6. Белок, содержащий один или более фрагментов по любому из пп.1, 2 или 3, при условии, что этот белок не является одной из полных белковых последовательностей, описанных в международной патентной заявке WO99/57280 или WO00/22430.
7. Антитело, которое распознает фрагмент по любому из пп. 1-6.
8. Белок, содержащий пептидную последовательность, которая распознается антителом по п.7.
9. Нуклеиновая кислота, кодирующая фрагмент по любому из пп.1, 2 или 3, полипептид по п.5 или белок по п.6 или 8.
10. Композиция, содержащая фрагмент по любому из пп.1, 2 или 3, полипептид по п.5, белок по п.6 или 8, антитело по п.7 и/или нуклеиновую кислоту по п.9, причем эта композиция является вакциной, диагностическим реагентом или иммуногенной композицией.
11. Композиция по п.10 для использования в качестве лекарственного средства.
12. Применение фрагмента по любому из пп.1, 2 или 3, полипептида по п.5, белка по 8, антитела по п.7 и/или нуклеиновой кислоты по п.9 для получения (i) лекарственного средства для лечения или профилактики инфекции, обусловленной бактериями Neisseria, (ii) диагностического реагента для обнаружения присутствия бактерий Neisseria или антител, индуцированных против бактерий Neisseria, и/или (iii) реагента, который может индуцировать антитела против бактерий Neisseria.
13. Способ лечения пациента, включающий введение пациенту терапевтически эффективного количества композиции по п.10.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16261699P | 1999-10-29 | 1999-10-29 | |
US60/162,616 | 1999-10-29 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU2002113920A true RU2002113920A (ru) | 2004-03-27 |
RU2281956C2 RU2281956C2 (ru) | 2006-08-20 |
Family
ID=22586405
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2002113920/13A RU2281956C2 (ru) | 1999-10-29 | 2000-10-30 | Антигенные пептиды neisseria |
Country Status (14)
Country | Link |
---|---|
US (4) | US8734812B1 (ru) |
EP (7) | EP2275552B1 (ru) |
JP (4) | JP2004508801A (ru) |
CN (3) | CN101613397A (ru) |
AU (1) | AU784203B2 (ru) |
BR (1) | BR0015137A (ru) |
CA (4) | CA2389321A1 (ru) |
DK (3) | DK1801219T3 (ru) |
ES (5) | ES2564463T3 (ru) |
HK (1) | HK1220483A1 (ru) |
MX (1) | MXPA02004283A (ru) |
PT (5) | PT2275553E (ru) |
RU (1) | RU2281956C2 (ru) |
WO (1) | WO2001031019A2 (ru) |
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