RU2001118849A - Очистка циклопептидных соединений эхинокандина - Google Patents
Очистка циклопептидных соединений эхинокандина Download PDFInfo
- Publication number
- RU2001118849A RU2001118849A RU2001118849/04A RU2001118849A RU2001118849A RU 2001118849 A RU2001118849 A RU 2001118849A RU 2001118849/04 A RU2001118849/04 A RU 2001118849/04A RU 2001118849 A RU2001118849 A RU 2001118849A RU 2001118849 A RU2001118849 A RU 2001118849A
- Authority
- RU
- Russia
- Prior art keywords
- mixture
- product
- group
- iii
- acetic acid
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract 8
- 108010069514 Cyclic Peptides Proteins 0.000 title claims abstract 6
- 102000001189 Cyclic Peptides Human genes 0.000 title claims abstract 6
- 238000004140 cleaning Methods 0.000 title 1
- 238000000034 method Methods 0.000 claims abstract 26
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims abstract 18
- 239000000203 mixture Substances 0.000 claims abstract 8
- 239000000047 product Substances 0.000 claims abstract 7
- 125000003277 amino group Chemical group 0.000 claims abstract 4
- 239000006227 byproduct Substances 0.000 claims abstract 4
- 239000003795 chemical substances by application Substances 0.000 claims abstract 4
- 230000002209 hydrophobic effect Effects 0.000 claims abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract 3
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
- 239000002594 sorbent Substances 0.000 claims 4
- 229920000620 organic polymer Polymers 0.000 claims 3
- 238000000926 separation method Methods 0.000 claims 3
- MYRTYDVEIRVNKP-UHFFFAOYSA-N 1,2-Divinylbenzene Chemical compound C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 claims 2
- CHRJZRDFSQHIFI-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;styrene Chemical group C=CC1=CC=CC=C1.C=CC1=CC=CC=C1C=C CHRJZRDFSQHIFI-UHFFFAOYSA-N 0.000 claims 2
- 108010049047 Echinocandins Proteins 0.000 claims 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- 239000011148 porous material Substances 0.000 claims 2
- UJTTUOLQLCQZEA-UHFFFAOYSA-N 9h-fluoren-9-ylmethyl n-(4-hydroxybutyl)carbamate Chemical compound C1=CC=C2C(COC(=O)NCCCCO)C3=CC=CC=C3C2=C1 UJTTUOLQLCQZEA-UHFFFAOYSA-N 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims 1
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical group [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 238000010828 elution Methods 0.000 claims 1
- 230000002255 enzymatic effect Effects 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 claims 1
- -1 sodium hydroxylamine sodium bisulfite Chemical compound 0.000 claims 1
- 238000001179 sorption measurement Methods 0.000 claims 1
- 238000000855 fermentation Methods 0.000 abstract 3
- 230000004151 fermentation Effects 0.000 abstract 3
- 235000010633 broth Nutrition 0.000 abstract 1
- 239000012501 chromatography medium Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11152498P | 1998-12-09 | 1998-12-09 | |
| US60/111,524 | 1998-12-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2001118849A true RU2001118849A (ru) | 2003-08-10 |
Family
ID=22339024
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2001118849/04A RU2001118849A (ru) | 1998-12-09 | 1999-12-08 | Очистка циклопептидных соединений эхинокандина |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6506726B1 (https=) |
| EP (1) | EP1137663B1 (https=) |
| JP (1) | JP2003511345A (https=) |
| KR (1) | KR20010101151A (https=) |
| CN (1) | CN1337968A (https=) |
| AT (1) | ATE338059T1 (https=) |
| AU (1) | AU766091B2 (https=) |
| BR (1) | BR9916101A (https=) |
| CA (1) | CA2353930A1 (https=) |
| DE (1) | DE69933046T2 (https=) |
| DK (1) | DK1137663T3 (https=) |
| ES (1) | ES2272096T3 (https=) |
| IL (1) | IL143563A0 (https=) |
| PT (1) | PT1137663E (https=) |
| RU (1) | RU2001118849A (https=) |
| WO (1) | WO2000034315A2 (https=) |
| ZA (1) | ZA200104621B (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2583262C2 (ru) * | 2011-04-20 | 2016-05-10 | Кселлия Фармасьютикалз Апс | Способ очистки микафунгина |
| CN106248857A (zh) * | 2016-07-15 | 2016-12-21 | 广西医科大学 | 利用薄层层析快速检测植物环肽的方法 |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6743777B1 (en) * | 1992-03-19 | 2004-06-01 | Eli Lilly And Company | Cyclic peptide antifungal agents and process for preparation thereof |
| HK1040062A1 (zh) * | 1999-03-03 | 2002-05-24 | Eli Lilly And Company | 含有成胶束表面活性剂的棘白菌素药物配方 |
| ATE248187T1 (de) | 1999-03-03 | 2003-09-15 | Lilly Co Eli | Echinocandin-kohlenhydrate-komplexe |
| HK1040369A1 (zh) | 1999-03-03 | 2002-06-07 | Eli Lilly And Company | 制备药物口服ecb配方和组合物的方法 |
| AU767956B2 (en) | 1999-03-03 | 2003-11-27 | Eli Lilly And Company | Formation and anion-exchange of crystalline echinocandin ammonium salts |
| US6991800B2 (en) * | 2002-06-13 | 2006-01-31 | Vicuron Pharmaceuticals Inc. | Antifungal parenteral products |
| JP5112060B2 (ja) * | 2004-06-29 | 2013-01-09 | リライアンス ライフ サイエンシーズ プライベイト リミテッド | ウイルス安全性生物学的流体の調製のための方法 |
| DE102004060750A1 (de) | 2004-12-15 | 2006-07-13 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Deacylierung von Lipopeptiden |
| TW200826957A (en) * | 2006-10-16 | 2008-07-01 | Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag | Purification processes for echinocandin-type compounds |
| US9394340B2 (en) | 2009-03-24 | 2016-07-19 | Cadila Healthcare Limited | Purification process for lipopeptides |
| CN102219832B (zh) | 2010-04-15 | 2013-08-21 | 上海天伟生物制药有限公司 | 一种氮杂环六肽或其盐的纯化方法 |
| CN102336817B (zh) * | 2010-07-16 | 2016-06-15 | 浙江震元制药有限公司 | 棘球白素b母核的分离方法 |
| ES2581562T3 (es) | 2010-09-29 | 2016-09-06 | Shanghai Techwell Biopharmaceutical Co., Ltd | Procedimiento para purificar compuestos lipopeptídicos cíclicos o sales de los mismos |
| CN102443050B (zh) * | 2010-09-30 | 2014-06-04 | 上海天伟生物制药有限公司 | 一种环脂肽化合物或其盐的纯化方法 |
| CN102153616A (zh) * | 2010-12-27 | 2011-08-17 | 浙江海正药业股份有限公司 | 一种环己肽类化合物及其盐的分离纯化方法 |
| WO2012119065A2 (en) | 2011-03-03 | 2012-09-07 | Seachaid Pharmaceuticals, Inc. | Antifungal agents and uses thereof |
| CN102952178B (zh) * | 2011-08-24 | 2016-04-27 | 华北制药集团新药研究开发有限责任公司 | 一种高纯度棘白霉素类化合物的制备方法 |
| SI3677252T1 (sl) | 2012-03-19 | 2024-02-29 | Cidara Therapeutics, Inc. | Sheme odmerjanja za spojine iz razreda ehinokandinov |
| CN103483427A (zh) * | 2012-06-09 | 2014-01-01 | 浙江海正药业股份有限公司 | 一种棘白菌素类化合物的纯化方法 |
| CN103910783B (zh) * | 2014-04-23 | 2016-07-06 | 华北制药集团新药研究开发有限责任公司 | 一种高纯度棘白霉素b母核的制备方法 |
| PL3058958T3 (pl) | 2015-02-23 | 2019-02-28 | Selectchemie Ag | Kompozycja anidulafunginy |
| CN108883152A (zh) | 2016-01-08 | 2018-11-23 | 奇达拉治疗公司 | 防止和治疗肺孢子虫感染的方法 |
| MA43825A (fr) | 2016-03-16 | 2021-04-07 | Cidara Therapeutics Inc | Schémas posologiques pour le traitement d'infections fongiques |
| JP7779651B2 (ja) | 2017-07-12 | 2025-12-03 | ナップ ファーマシューティカル グループ リミテッド | 真菌感染症の処置のための組成物及び方法 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4304716A (en) | 1979-12-13 | 1981-12-08 | Eli Lilly And Company | S 31794/F-1 Nucleus |
| US4293489A (en) | 1979-12-13 | 1981-10-06 | Eli Lilly And Company | Derivatives of A-30912A nucleus |
| US4320052A (en) | 1979-12-13 | 1982-03-16 | Eli Lilly And Company | Derivatives of A-30912A nucleus |
| US4293482A (en) | 1979-12-13 | 1981-10-06 | Eli Lilly And Company | A-30912A Nucleus |
| US4874843A (en) | 1987-12-03 | 1989-10-17 | Eli Lilly And Company | Chromatographic purification process |
| EP0294990A3 (en) | 1987-06-10 | 1990-05-09 | Eli Lilly And Company | Chromatographic purification process |
| US5166135A (en) | 1988-09-12 | 1992-11-24 | Merck & Company, Inc. | Method for the control of pneumocystis carinii |
| DK173802B1 (da) | 1988-09-12 | 2001-11-05 | Merck & Co Inc | Præparat til behandling af Pneumocystis carinii infeksioner og anvendelse af et cyclohexapeptid til fremstilling af et lægemiddel mod Pneumocystis carinii infektioner |
| US5310726A (en) | 1990-03-19 | 1994-05-10 | Merck & Co., Inc. | Lipopeptide compounds |
| IL98349A (en) | 1990-06-07 | 1995-05-26 | Lilly Co Eli | Diphylase lipopeptide |
| IL98506A (en) | 1990-06-18 | 1996-09-12 | Fujisawa Pharmaceutical Co | Cyclic peptide antibiotics processes for the preparation thereof and pharmaceutical compositions containing them |
| US5965525A (en) | 1992-03-19 | 1999-10-12 | Eli Lilly And Company | Cyclic peptide antifungal agents |
| MY136593A (en) | 1992-03-19 | 2008-10-31 | Lilly Co Eli | Cyclic peptide antifungal agents and process for preparation thereof |
| US5541160A (en) | 1994-04-04 | 1996-07-30 | Merck & Co., Inc. | Antifungal and anti-pneumocystis compounds, compositions containing such compounds, and methods of use |
| US5646111A (en) | 1995-04-07 | 1997-07-08 | Eli Lilly And Company | Cyclic peptide antifungal Agents |
| US5618787A (en) | 1995-05-26 | 1997-04-08 | Eli Lilly And Company | Cyclic peptide antifungal agents |
| US5786325A (en) | 1995-05-26 | 1998-07-28 | Eli Lilly And Company | Cyclic peptide antifungal agents and methods of making and using |
| US5652213A (en) | 1995-05-26 | 1997-07-29 | Eli Lilly And Company | Cyclic peptide antifungal agents |
| US5629290A (en) | 1995-05-26 | 1997-05-13 | Eli Lilly And Company | Cyclic peptide antifungal agents |
| US5629289A (en) | 1995-07-25 | 1997-05-13 | Eli Lilly And Company | Cyclic peptide antifungal agents |
| EP0881907A4 (en) | 1996-02-01 | 2000-05-10 | Lilly Co Eli | FUNGICIDES IN THE FORM OF CYCLIC PEPTIDES |
| US5696084A (en) | 1996-08-16 | 1997-12-09 | Abbott Laboratories | Amino-lipopetide antifungal agents |
| WO1999006062A1 (en) | 1997-08-04 | 1999-02-11 | Eli Lilly And Company | Cyclic peptide antifungal agents |
| CA2255140A1 (en) | 1997-12-23 | 1999-06-23 | Eli Lilly And Company | Echinocandin binding domain of 1,3-.beta.-glucan synthase |
| US6323176B1 (en) | 1998-02-25 | 2001-11-27 | Eli Lilly And Company | Cyclic peptide antifungal agents |
| ATE287899T1 (de) | 1998-08-20 | 2005-02-15 | Lilly Co Eli | Verfahren zur herstellung von ring-modifizierten zyklischen peptidanalogen |
| CA2340647A1 (en) | 1998-08-28 | 2000-03-09 | Eli Lilly And Company | Reversible boronate complexes of 1,2-cis-diol cyclic-peptides |
| WO2000024694A1 (en) | 1998-10-28 | 2000-05-04 | Eli Lilly And Company | Photochemical process for making 1-deoxy-2-keto derivatives |
| AU767357B2 (en) | 1998-12-16 | 2003-11-06 | Eli Lilly And Company | Cyclic peptide antifungal agents |
| AU2189500A (en) | 1998-12-16 | 2000-07-03 | Eli Lilly And Company | Cyclic peptide antifungal agents having a sugar substituent |
| HK1040369A1 (zh) | 1999-03-03 | 2002-06-07 | Eli Lilly And Company | 制备药物口服ecb配方和组合物的方法 |
| ATE248187T1 (de) | 1999-03-03 | 2003-09-15 | Lilly Co Eli | Echinocandin-kohlenhydrate-komplexe |
| AU767956B2 (en) | 1999-03-03 | 2003-11-27 | Eli Lilly And Company | Formation and anion-exchange of crystalline echinocandin ammonium salts |
| HK1040062A1 (zh) | 1999-03-03 | 2002-05-24 | Eli Lilly And Company | 含有成胶束表面活性剂的棘白菌素药物配方 |
-
1999
- 1999-12-08 DK DK99965156T patent/DK1137663T3/da active
- 1999-12-08 AT AT99965156T patent/ATE338059T1/de not_active IP Right Cessation
- 1999-12-08 JP JP2000586757A patent/JP2003511345A/ja not_active Abandoned
- 1999-12-08 DE DE69933046T patent/DE69933046T2/de not_active Expired - Fee Related
- 1999-12-08 CA CA002353930A patent/CA2353930A1/en not_active Abandoned
- 1999-12-08 ES ES99965156T patent/ES2272096T3/es not_active Expired - Lifetime
- 1999-12-08 KR KR1020017007161A patent/KR20010101151A/ko not_active Withdrawn
- 1999-12-08 PT PT99965156T patent/PT1137663E/pt unknown
- 1999-12-08 US US09/857,924 patent/US6506726B1/en not_active Expired - Fee Related
- 1999-12-08 WO PCT/US1999/029008 patent/WO2000034315A2/en not_active Ceased
- 1999-12-08 EP EP99965156A patent/EP1137663B1/en not_active Expired - Lifetime
- 1999-12-08 AU AU31132/00A patent/AU766091B2/en not_active Ceased
- 1999-12-08 RU RU2001118849/04A patent/RU2001118849A/ru not_active Application Discontinuation
- 1999-12-08 CN CN99815515A patent/CN1337968A/zh active Pending
- 1999-12-08 IL IL14356399A patent/IL143563A0/xx unknown
- 1999-12-08 BR BR9916101-0A patent/BR9916101A/pt not_active IP Right Cessation
-
2001
- 2001-06-06 ZA ZA200104621A patent/ZA200104621B/en unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2583262C2 (ru) * | 2011-04-20 | 2016-05-10 | Кселлия Фармасьютикалз Апс | Способ очистки микафунгина |
| CN106248857A (zh) * | 2016-07-15 | 2016-12-21 | 广西医科大学 | 利用薄层层析快速检测植物环肽的方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1137663B1 (en) | 2006-08-30 |
| ES2272096T3 (es) | 2007-04-16 |
| IL143563A0 (en) | 2002-04-21 |
| KR20010101151A (ko) | 2001-11-14 |
| CN1337968A (zh) | 2002-02-27 |
| EP1137663A2 (en) | 2001-10-04 |
| BR9916101A (pt) | 2002-06-04 |
| US6506726B1 (en) | 2003-01-14 |
| ZA200104621B (en) | 2002-06-06 |
| DE69933046D1 (de) | 2006-10-12 |
| PT1137663E (pt) | 2006-12-29 |
| CA2353930A1 (en) | 2000-06-15 |
| WO2000034315A3 (en) | 2000-12-28 |
| WO2000034315A2 (en) | 2000-06-15 |
| AU3113200A (en) | 2000-06-26 |
| WO2000034315A8 (en) | 2000-10-26 |
| ATE338059T1 (de) | 2006-09-15 |
| DE69933046T2 (de) | 2007-09-13 |
| DK1137663T3 (da) | 2007-01-08 |
| JP2003511345A (ja) | 2003-03-25 |
| AU766091B2 (en) | 2003-10-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA94 | Acknowledgement of application withdrawn (non-payment of fees) |
Effective date: 20050317 |