ATE338059T1 - Reinigung von echinocandin cyclopeptiden - Google Patents

Reinigung von echinocandin cyclopeptiden

Info

Publication number
ATE338059T1
ATE338059T1 AT99965156T AT99965156T ATE338059T1 AT E338059 T1 ATE338059 T1 AT E338059T1 AT 99965156 T AT99965156 T AT 99965156T AT 99965156 T AT99965156 T AT 99965156T AT E338059 T1 ATE338059 T1 AT E338059T1
Authority
AT
Austria
Prior art keywords
acetic acid
fermentation
products
echinocandin
cyclopeptides
Prior art date
Application number
AT99965156T
Other languages
English (en)
Inventor
John Robert Dobbins
Eugene Paul Kroeff
Jeffrey Thomas Vicenzi
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE338059T1 publication Critical patent/ATE338059T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
AT99965156T 1998-12-09 1999-12-08 Reinigung von echinocandin cyclopeptiden ATE338059T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11152498P 1998-12-09 1998-12-09

Publications (1)

Publication Number Publication Date
ATE338059T1 true ATE338059T1 (de) 2006-09-15

Family

ID=22339024

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99965156T ATE338059T1 (de) 1998-12-09 1999-12-08 Reinigung von echinocandin cyclopeptiden

Country Status (17)

Country Link
US (1) US6506726B1 (de)
EP (1) EP1137663B1 (de)
JP (1) JP2003511345A (de)
KR (1) KR20010101151A (de)
CN (1) CN1337968A (de)
AT (1) ATE338059T1 (de)
AU (1) AU766091B2 (de)
BR (1) BR9916101A (de)
CA (1) CA2353930A1 (de)
DE (1) DE69933046T2 (de)
DK (1) DK1137663T3 (de)
ES (1) ES2272096T3 (de)
IL (1) IL143563A0 (de)
PT (1) PT1137663E (de)
RU (1) RU2001118849A (de)
WO (1) WO2000034315A2 (de)
ZA (1) ZA200104621B (de)

Families Citing this family (26)

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US6743777B1 (en) * 1992-03-19 2004-06-01 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
ATE338060T1 (de) 1999-03-03 2006-09-15 Lilly Co Eli Bildung und anionenaustausch von inneren kristallinen ammoniumsalzen des echinocandins b
JP4272359B2 (ja) * 1999-03-03 2009-06-03 イーライ リリー アンド カンパニー エキノカンジン／炭水化物複合体
AU771727B2 (en) 1999-03-03 2004-04-01 Eli Lilly And Company Processes for making pharmaceutical oral ECB formulations and compositions
IL145185A0 (en) 1999-03-03 2002-06-30 Lilly Co Eli Echinocandin pharmaceutical formulations containing micelle-forming surfactants
US6991800B2 (en) * 2002-06-13 2006-01-31 Vicuron Pharmaceuticals Inc. Antifungal parenteral products
AU2005265960B8 (en) * 2004-06-29 2012-01-12 Reliance Life Sciences Pvt Ltd Process for improvement of virus-safe biological fluids
DE102004060750A1 (de) 2004-12-15 2006-07-13 Sanofi-Aventis Deutschland Gmbh Verfahren zur Deacylierung von Lipopeptiden
TW200826957A (en) 2006-10-16 2008-07-01 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Purification processes for echinocandin-type compounds
US9394340B2 (en) 2009-03-24 2016-07-19 Cadila Healthcare Limited Purification process for lipopeptides
CN102219832B (zh) * 2010-04-15 2013-08-21 上海天伟生物制药有限公司 一种氮杂环六肽或其盐的纯化方法
CN102336817B (zh) * 2010-07-16 2016-06-15 浙江震元制药有限公司 棘球白素b母核的分离方法
US8927690B2 (en) 2010-09-29 2015-01-06 Shanghai Techwell Biopharmaceutical Co., Ltd. Process for purifying cyclolipopeptide compounds or the salts thereof
JP6000255B2 (ja) * 2010-09-30 2016-09-28 上海天偉生物制薬有限公司 環状リポペプチド化合物又はその塩の精製方法
CN102153616A (zh) * 2010-12-27 2011-08-17 浙江海正药业股份有限公司 一种环己肽类化合物及其盐的分离纯化方法
CA2865791C (en) 2011-03-03 2019-10-08 Cidara Therapeutics, Inc. Antifungal agents and uses thereof
AU2012244435B2 (en) 2011-04-20 2017-06-15 Xellia Pharmaceuticals Aps Method for purification of Micafungin
CN102952178B (zh) * 2011-08-24 2016-04-27 华北制药集团新药研究开发有限责任公司 一种高纯度棘白霉素类化合物的制备方法
LT3677252T (lt) 2012-03-19 2023-10-10 Cidara Therapeutics, Inc. Dozavimo režimas, skirtas echinokandino klasės junginiams
CN103483427A (zh) * 2012-06-09 2014-01-01 浙江海正药业股份有限公司 一种棘白菌素类化合物的纯化方法
CN103910783B (zh) * 2014-04-23 2016-07-06 华北制药集团新药研究开发有限责任公司 一种高纯度棘白霉素b母核的制备方法
PL3058958T3 (pl) 2015-02-23 2019-02-28 Selectchemie Ag Kompozycja anidulafunginy
EP3399995A4 (de) 2016-01-08 2019-08-21 Cidara Therapeutics, Inc. Verfahren zur vorbeugung und behandlung von pneumocystis-infektionen
EP4268896A3 (de) 2016-03-16 2024-01-03 Cidara Therapeutics, Inc. Dosierpläne zur behandlung von pilzinfektionen
CN106248857A (zh) * 2016-07-15 2016-12-21 广西医科大学 利用薄层层析快速检测植物环肽的方法
CA3069423A1 (en) 2017-07-12 2019-01-17 Cidara Therapeutics, Inc. Formulations for the treatment of fungal infections

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US4304716A (en) 1979-12-13 1981-12-08 Eli Lilly And Company S 31794/F-1 Nucleus
US4320052A (en) 1979-12-13 1982-03-16 Eli Lilly And Company Derivatives of A-30912A nucleus
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EP0294990A3 (de) * 1987-06-10 1990-05-09 Eli Lilly And Company Chromatographisches Reinigungsverfahren
US4874843A (en) 1987-12-03 1989-10-17 Eli Lilly And Company Chromatographic purification process
DK173802B1 (da) 1988-09-12 2001-11-05 Merck & Co Inc Præparat til behandling af Pneumocystis carinii infeksioner og anvendelse af et cyclohexapeptid til fremstilling af et lægemiddel mod Pneumocystis carinii infektioner
US5166135A (en) 1988-09-12 1992-11-24 Merck & Company, Inc. Method for the control of pneumocystis carinii
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IE912046A1 (en) 1990-06-18 1991-12-18 Fujisawa Pharmaceutical Co New polypeptide compound and a process for preparation¹thereof
US5965525A (en) 1992-03-19 1999-10-12 Eli Lilly And Company Cyclic peptide antifungal agents
TW264477B (de) 1992-03-19 1995-12-01 Lilly Co Eli
US5541160A (en) 1994-04-04 1996-07-30 Merck & Co., Inc. Antifungal and anti-pneumocystis compounds, compositions containing such compounds, and methods of use
US5646111A (en) 1995-04-07 1997-07-08 Eli Lilly And Company Cyclic peptide antifungal Agents
US5629290A (en) 1995-05-26 1997-05-13 Eli Lilly And Company Cyclic peptide antifungal agents
US5652213A (en) 1995-05-26 1997-07-29 Eli Lilly And Company Cyclic peptide antifungal agents
US5618787A (en) 1995-05-26 1997-04-08 Eli Lilly And Company Cyclic peptide antifungal agents
US5786325A (en) 1995-05-26 1998-07-28 Eli Lilly And Company Cyclic peptide antifungal agents and methods of making and using
US5629289A (en) 1995-07-25 1997-05-13 Eli Lilly And Company Cyclic peptide antifungal agents
CA2244238A1 (en) 1996-02-01 1997-08-07 Eli Lilly And Company Cyclic peptide antifungal agents
US5696084A (en) 1996-08-16 1997-12-09 Abbott Laboratories Amino-lipopetide antifungal agents
CA2301184A1 (en) 1997-08-04 1999-02-11 Eli Lilly And Company Cyclic peptide antifungal agents
EP0931834A3 (de) 1997-12-23 2002-06-26 Eli Lilly And Company Echinocandin-bindungsdomäne von 1,3-Beta-glukan Synthase
US6323176B1 (en) 1998-02-25 2001-11-27 Eli Lilly And Company Cyclic peptide antifungal agents
WO2000011023A2 (en) 1998-08-20 2000-03-02 Eli Lilly And Company Ring modified cyclic peptide analogs
AU763351B2 (en) 1998-08-28 2003-07-17 Eli Lilly And Company Reversible boronate complexes of 1,2-(cis)-diol cyclic-peptides
WO2000024694A1 (en) 1998-10-28 2000-05-04 Eli Lilly And Company Photochemical process for making 1-deoxy-2-keto derivatives
EP1140991A1 (de) 1998-12-16 2001-10-10 Eli Lilly And Company Fungizide in form zyklischer peptide
AU2189500A (en) 1998-12-16 2000-07-03 Eli Lilly And Company Cyclic peptide antifungal agents having a sugar substituent
JP4272359B2 (ja) 1999-03-03 2009-06-03 イーライ リリー アンド カンパニー エキノカンジン／炭水化物複合体
IL145185A0 (en) 1999-03-03 2002-06-30 Lilly Co Eli Echinocandin pharmaceutical formulations containing micelle-forming surfactants
ATE338060T1 (de) 1999-03-03 2006-09-15 Lilly Co Eli Bildung und anionenaustausch von inneren kristallinen ammoniumsalzen des echinocandins b
AU771727B2 (en) 1999-03-03 2004-04-01 Eli Lilly And Company Processes for making pharmaceutical oral ECB formulations and compositions

Also Published As

Publication number Publication date
RU2001118849A (ru) 2003-08-10
PT1137663E (pt) 2006-12-29
KR20010101151A (ko) 2001-11-14
DE69933046T2 (de) 2007-09-13
DE69933046D1 (de) 2006-10-12
AU766091B2 (en) 2003-10-09
ES2272096T3 (es) 2007-04-16
DK1137663T3 (da) 2007-01-08
EP1137663A2 (de) 2001-10-04
IL143563A0 (en) 2002-04-21
BR9916101A (pt) 2002-06-04
CN1337968A (zh) 2002-02-27
WO2000034315A8 (en) 2000-10-26
WO2000034315A2 (en) 2000-06-15
AU3113200A (en) 2000-06-26
EP1137663B1 (de) 2006-08-30
ZA200104621B (en) 2002-06-06
JP2003511345A (ja) 2003-03-25
WO2000034315A3 (en) 2000-12-28
CA2353930A1 (en) 2000-06-15
US6506726B1 (en) 2003-01-14

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