BR9813522A - Processos para separar e purificar apm e metil éster de n-[n-(3,3-dimetilbutil)-l-alfa-aspartil]-l-fenilalanina e para a produção do derivado de apm, apm ou derivado de apm, e, adoçante - Google Patents

Processos para separar e purificar apm e metil éster de n-[n-(3,3-dimetilbutil)-l-alfa-aspartil]-l-fenilalanina e para a produção do derivado de apm, apm ou derivado de apm, e, adoçante

Info

Publication number
BR9813522A
BR9813522A BR9813522-8A BR9813522A BR9813522A BR 9813522 A BR9813522 A BR 9813522A BR 9813522 A BR9813522 A BR 9813522A BR 9813522 A BR9813522 A BR 9813522A
Authority
BR
Brazil
Prior art keywords
apm
derivative
dimethylbutyl
phenylalanine
methyl ester
Prior art date
Application number
BR9813522-8A
Other languages
English (en)
Inventor
Kazutaka Nagashima
Akihiro Kishishita
Original Assignee
Ajinomoto Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk
Publication of BR9813522A publication Critical patent/BR9813522A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30—Artificial sweetening agents
    • A23L27/31—Artificial sweetening agents containing amino acids, nucleotides, peptides or derivatives
    • A23L27/32—Artificial sweetening agents containing amino acids, nucleotides, peptides or derivatives containing dipeptides or derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nutrition Science (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

''PROCESSOS PARA SEPARAR E PURIFICAR APM E METIL éSTER DE N-[N-(3,3-DIMETILBUTIL)-L-ALFA-ASPARTIL]-L-FENILALANINA E PARA A PRODUçãO DO DERIVADO DE APM, APM OU DERIVADO DE APM, E, ADOçANTE'' é provido um processo para separar aspartame (APM), de modo fácil e eficiente, a partir de metil éster de N-[N-(3,3-dimetilbutil)-L-<244>-aspartil]-L-fenilalanina e, deste modo, separar e purificar o APM e o derivado de APM acima mencionado, mais especificamente o N-(3,3-dimetilbutil)-APM, cada qual em alta pureza, que compreende submeter uma solução aquosa contendo o APM e o derivado de APM, ou o similar, à cromatografia em coluna com o uso de uma resina à base de polímero altamente poroso não-polar.
BR9813522-8A 1997-12-11 1998-12-07 Processos para separar e purificar apm e metil éster de n-[n-(3,3-dimetilbutil)-l-alfa-aspartil]-l-fenilalanina e para a produção do derivado de apm, apm ou derivado de apm, e, adoçante BR9813522A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP9340939A JPH11171895A (ja) 1997-12-11 1997-12-11 アスパルテームとアスパルテーム誘導体の分離精製方法
PCT/JP1998/005533 WO1999029713A1 (fr) 1997-12-11 1998-12-07 Separation et purification de l'aspartame et d'un derive d'aspartame

Publications (1)

Publication Number Publication Date
BR9813522A true BR9813522A (pt) 2000-10-03

Family

ID=18341698

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9813522-8A BR9813522A (pt) 1997-12-11 1998-12-07 Processos para separar e purificar apm e metil éster de n-[n-(3,3-dimetilbutil)-l-alfa-aspartil]-l-fenilalanina e para a produção do derivado de apm, apm ou derivado de apm, e, adoçante

Country Status (7)

Country Link
US (1) US6613933B1 (pt)
EP (1) EP1048674A1 (pt)
JP (1) JPH11171895A (pt)
KR (1) KR20010032971A (pt)
CN (1) CN1284964A (pt)
BR (1) BR9813522A (pt)
WO (1) WO1999029713A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1317012A (zh) 1998-10-30 2001-10-10 味之素株式会社 稳定性优良的天冬甜素衍生物晶体的结晶方法
AU2158700A (en) * 1998-11-25 2000-06-19 Nutrasweet Company, The Process for purification of N- (N-(3,3-dimethylbutyl) -l-alpha-aspartyl) -l-phenylalanine 1-methyl ester
WO2005001105A1 (ja) 2003-06-26 2005-01-06 Ajinomoto Co., Inc. モナティンの製造方法
JP4046708B2 (ja) * 2004-06-04 2008-02-13 明治製菓株式会社 ３−アルケニルセフェム化合物の製造方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5235660B2 (pt) * 1972-05-25 1977-09-10
DE3733198A1 (de) * 1987-10-01 1989-04-13 Kernforschungsanlage Juelich Enzymatisches verfahren zur herstellung von dipeptiden
FR2697844B1 (fr) * 1992-11-12 1995-01-27 Claude Nofre Nouveaux composés dérivés de dipeptides ou d'analogues dipeptidiques utiles comme agents édulcorants, leur procédé de préparation.
FR2719590B1 (fr) 1994-05-09 1996-07-26 Claude Nofre Procédé perfectionné de préparation d'un composé dérivé de l'aspartame utile comme agent édulcorant.
US5728862A (en) * 1997-01-29 1998-03-17 The Nutrasweet Company Method for preparing and purifying an N-alkylated aspartame derivative
DE69739895D1 (de) * 1997-03-10 2010-07-08 Ajinomoto Kk Süßstoffzusammensetzung mit verbessertem Geschmack, ihre Verwendung und Herstellungsverfahren
JP3651161B2 (ja) 1997-03-10 2005-05-25 味の素株式会社 改善された呈味を有する甘味料組成物
JP3651162B2 (ja) 1997-03-10 2005-05-25 味の素株式会社 甘味料組成物

Also Published As

Publication number Publication date
EP1048674A1 (en) 2000-11-02
CN1284964A (zh) 2001-02-21
KR20010032971A (ko) 2001-04-25
WO1999029713A1 (fr) 1999-06-17
US6613933B1 (en) 2003-09-02
JPH11171895A (ja) 1999-06-29

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Legal Events

Date Code Title Description
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE A 4A,5A,6A,7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1910 DE 14/08/2007.

B15K Others concerning applications: alteration of classification

Ipc: C07K 5/072 (2006.01), A23L 27/30 (2016.0