ATE249244T1 - Aktivierte verbindungen und verfahren zur herstellung und reiningung - Google Patents
Aktivierte verbindungen und verfahren zur herstellung und reiningungInfo
- Publication number
- ATE249244T1 ATE249244T1 AT96944251T AT96944251T ATE249244T1 AT E249244 T1 ATE249244 T1 AT E249244T1 AT 96944251 T AT96944251 T AT 96944251T AT 96944251 T AT96944251 T AT 96944251T AT E249244 T1 ATE249244 T1 AT E249244T1
- Authority
- AT
- Austria
- Prior art keywords
- pegs
- production
- purification
- methods
- activated compounds
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 4
- 238000004191 hydrophobic interaction chromatography Methods 0.000 abstract 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Road Signs Or Road Markings (AREA)
- Thermistors And Varistors (AREA)
- Separation Of Suspended Particles By Flocculating Agents (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/611,918 US5747639A (en) | 1996-03-06 | 1996-03-06 | Use of hydrophobic interaction chromatography to purify polyethylene glycols |
| PCT/US1996/019459 WO1997032607A2 (en) | 1996-03-06 | 1996-12-06 | Activated linkers and methods for making and purifying the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE249244T1 true ATE249244T1 (de) | 2003-09-15 |
Family
ID=24450930
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96944251T ATE249244T1 (de) | 1996-03-06 | 1996-12-06 | Aktivierte verbindungen und verfahren zur herstellung und reiningung |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US5747639A (de) |
| EP (1) | EP0906122B1 (de) |
| JP (1) | JP2000506851A (de) |
| AT (1) | ATE249244T1 (de) |
| AU (1) | AU720399B2 (de) |
| CA (1) | CA2248006C (de) |
| DE (1) | DE69629949T2 (de) |
| DK (1) | DK0906122T3 (de) |
| ES (1) | ES2206616T3 (de) |
| PT (1) | PT906122E (de) |
| WO (1) | WO1997032607A2 (de) |
Families Citing this family (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6552170B1 (en) * | 1990-04-06 | 2003-04-22 | Amgen Inc. | PEGylation reagents and compounds formed therewith |
| US5932462A (en) * | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| US5747639A (en) * | 1996-03-06 | 1998-05-05 | Amgen Boulder Inc. | Use of hydrophobic interaction chromatography to purify polyethylene glycols |
| TW555765B (en) | 1996-07-09 | 2003-10-01 | Amgen Inc | Low molecular weight soluble tumor necrosis factor type-I and type-II proteins |
| ATE247974T1 (de) | 1996-12-06 | 2003-09-15 | Amgen Inc | Kombinationtherapie mit einem tnf-bindendem protein zür behandlung von durch tnf verursachten erkrangungen |
| DK1007082T3 (da) * | 1997-01-15 | 2007-02-19 | Phoenix Pharmacologics Inc | Modificeret tumor nekrose faktor |
| US6448369B1 (en) | 1997-11-06 | 2002-09-10 | Shearwater Corporation | Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation |
| US7642323B2 (en) | 1997-11-06 | 2010-01-05 | Nektar Therapeutics | Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation |
| DK1656952T3 (da) * | 1998-10-16 | 2014-01-20 | Biogen Idec Inc | Polyalkylenglycolkonjugater af interferon beta-1A og anvendelser deraf |
| AU766190B2 (en) | 1998-10-16 | 2003-10-09 | Biogen Idec Ma Inc. | Interferon-beta fusion proteins and uses |
| US6660843B1 (en) * | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| US6924264B1 (en) * | 1999-04-30 | 2005-08-02 | Amylin Pharmaceuticals, Inc. | Modified exendins and exendin agonists |
| HUP0203751A3 (en) | 2000-01-10 | 2005-01-28 | Maxygen Holdings Ltd Redwood C | G-csf conjugates |
| WO2001058935A2 (en) | 2000-02-11 | 2001-08-16 | Maxygen Aps | FACTOR VII OR VIIa-LIKE MOLECULES |
| EP1806144A3 (de) * | 2000-12-06 | 2008-04-23 | Laboratoires Serono SA | Verwendung von SARP-1 zur Behandlung und/oder Vorbeugung von Scleroderma |
| EP1366075B1 (de) | 2001-02-27 | 2009-05-27 | Maxygen Aps | Neue interferon-beta-ähnliche moleküle |
| KR20050040832A (ko) * | 2001-10-29 | 2005-05-03 | 넥타르 테라퓨틱스 에이엘, 코포레이션 | 단백질 키나아제 ｃ 억제제의 중합체 공액 |
| PT3025726T (pt) * | 2002-01-18 | 2020-01-09 | Biogen Ma Inc | Compostos do polímero polialquileno e utilizações dos mesmos |
| ES2363205T3 (es) | 2002-06-21 | 2011-07-26 | Novo Nordisk Health Care Ag | Glicoformas del factor vii pegilado. |
| US8129330B2 (en) * | 2002-09-30 | 2012-03-06 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof |
| GEP20084486B (en) * | 2002-12-26 | 2008-09-25 | Mountain View Pharmaceuticals | Polymer conjugates of interferon-beta with enhanced biological potency |
| RS20050501A (sr) * | 2002-12-26 | 2007-08-03 | Mountain View Pharmaceuticals Inc., | Polimerni konjugati citokina,hemokina,faktora rasta, polipeptidnih hormona i njihovih antagonista sa očuvanom aktivnošću vezivanja receptora |
| DE602004029173D1 (de) | 2003-10-10 | 2010-10-28 | Novo Nordisk As | Il-21-derivate |
| ES2428358T3 (es) | 2003-10-17 | 2013-11-07 | Novo Nordisk A/S | Terapia de combinación |
| BRPI0507169A (pt) | 2004-02-02 | 2007-06-26 | Ambrx Inc | polipeptìdeos do hormÈnio de crescimento humano modificados e seu usos |
| EP1771205B1 (de) | 2004-06-18 | 2016-10-26 | Ambrx, Inc. | Neuartige antigen-bindende polypeptide und ihre verwendungen |
| JP2008507280A (ja) | 2004-07-21 | 2008-03-13 | アンブレツクス・インコーポレイテツド | 非天然コードアミノ酸を用いた生合成ポリペプチド |
| BRPI0519170A8 (pt) | 2004-12-22 | 2018-05-08 | Ambrx Inc | formulações de hormônio de crescimento humano que compreendem um aminoácido não naturalmente codificado |
| JP4990792B2 (ja) | 2004-12-22 | 2012-08-01 | アンブレツクス・インコーポレイテツド | アミノアシル−ｔＲＮＡシンテターゼの組成物およびこの使用 |
| JP2008525032A (ja) | 2004-12-22 | 2008-07-17 | アンブレツクス・インコーポレイテツド | 組換えヒト成長ホルモンを発現及び精製するための方法 |
| CA2594557C (en) | 2004-12-22 | 2016-04-26 | Ambrx, Inc. | Modified human growth hormone |
| KR20080026135A (ko) | 2005-06-03 | 2008-03-24 | 암브룩스, 인코포레이티드 | 개선된 인간 인터페론 분자 및 이의 용도 |
| US8633300B2 (en) | 2005-06-17 | 2014-01-21 | Novo Nordisk Healthcare Ag | Selective reduction and derivatization of engineered proteins comprising at least one non-native cysteine |
| WO2007021297A1 (en) | 2005-08-18 | 2007-02-22 | Ambrx, Inc. | COMPOSITIONS OF tRNA AND USES THEREOF |
| EP1951890A4 (de) | 2005-11-16 | 2009-06-24 | Ambrx Inc | Verfahren und zusammensetzungen mit nichtnatürlichen aminosäuren |
| DE602007008074D1 (de) | 2006-02-28 | 2010-09-09 | Reddy S Lab Eu Ltd Dr | Verfahren zur herstellung von polyethylen-glycol-carbonaten |
| AU2007253264A1 (en) | 2006-05-24 | 2007-11-29 | Novo Nordisk Health Care Ag | Factor IX analogues having prolonged in vivo half life |
| CN101511856B (zh) | 2006-09-08 | 2016-01-20 | Ambrx公司 | 脊椎动物细胞中抑制因子trna的转录 |
| AU2007292892B9 (en) | 2006-09-08 | 2013-02-28 | Ambrx, Inc. | Hybrid suppressor tRNA for vertebrate cells |
| KR20090060294A (ko) | 2006-09-08 | 2009-06-11 | 암브룩스, 인코포레이티드 | 변형된 인간 혈장 폴리펩티드 또는 Ｆｃ 스캐폴드 및 그의 용도 |
| WO2008101311A1 (en) * | 2007-02-22 | 2008-08-28 | Biovectra Inc. | Process for purification of water soluble polymers |
| CA2682147C (en) | 2007-03-30 | 2017-08-08 | Ambrx, Inc. | Modified fgf-21 polypeptides and their uses |
| CN101675071B (zh) | 2007-05-02 | 2014-06-18 | Ambrx公司 | 经修饰干扰素β多肽和其用途 |
| CA2703830A1 (en) | 2007-11-20 | 2009-05-28 | Ambrx, Inc. | Modified insulin polypeptides and their uses |
| SG188143A1 (en) | 2008-02-08 | 2013-03-28 | Ambrx Inc | Modified leptin polypeptides and their uses |
| EP2318029B1 (de) | 2008-07-23 | 2017-11-01 | Ambrx, Inc. | Modifizierte bovine g-csf-polypeptide und ihre verwendung |
| US8278418B2 (en) | 2008-09-26 | 2012-10-02 | Ambrx, Inc. | Modified animal erythropoietin polypeptides and their uses |
| PE20110480A1 (es) | 2008-09-26 | 2011-07-01 | Ambrx Inc | Microorganismos y vacunas dependientes de replicacion de aminoacidos no naturales |
| EA201290541A1 (ru) | 2009-12-21 | 2013-05-30 | Амбркс, Инк. | Модифицированные бычьи соматотропиновые полипептиды и их применение |
| JP2013515081A (ja) | 2009-12-21 | 2013-05-02 | アンブルックス，インコーポレイテッド | 修飾されているブタのソマトトロピンポリペプチドおよびそれらの使用 |
| AU2011222883B2 (en) | 2010-03-05 | 2016-05-26 | Omeros Corporation | Chimeric inhibitor molecules of complement activation |
| EP2569331A1 (de) | 2010-05-10 | 2013-03-20 | Perseid Therapeutics LLC | Polypeptid-inhibitoren von vla4 |
| PE20140160A1 (es) | 2010-08-17 | 2014-02-08 | Ambrx Inc | Polipeptidos de relaxina modificados y sus usos |
| US9567386B2 (en) | 2010-08-17 | 2017-02-14 | Ambrx, Inc. | Therapeutic uses of modified relaxin polypeptides |
| TWI480288B (zh) | 2010-09-23 | 2015-04-11 | Lilly Co Eli | 牛顆粒細胞群落刺激因子及其變體之調配物 |
| AU2012280474A1 (en) | 2011-07-01 | 2014-01-16 | Bayer Intellectual Property Gmbh | Relaxin fusion polypeptides and uses thereof |
| US9738724B2 (en) | 2012-06-08 | 2017-08-22 | Sutro Biopharma, Inc. | Antibodies comprising site-specific non-natural amino acid residues, methods of their preparation and methods of their use |
| EP3135690A1 (de) | 2012-06-26 | 2017-03-01 | Sutro Biopharma, Inc. | Modifizierte fc-proteine mit stellenspezifischen nichtnatürlichen aminosäureresten, konjugate daraus, verfahren zu deren herstellung und verfahren zu deren verwendung |
| US9395468B2 (en) | 2012-08-27 | 2016-07-19 | Ocular Dynamics, Llc | Contact lens with a hydrophilic layer |
| SI2890402T1 (sl) | 2012-08-31 | 2019-07-31 | Sutro Biopharma, Inc. | Modificirane aminokisline vsebujoče acido skupino |
| EP2964610A4 (de) * | 2013-03-08 | 2016-11-23 | Univ Southern California Usc Stevens | Vinylsulfonbasierte 18f-labeling-zusammensetzungen sowie verfahren und verwendungen davon |
| WO2015006555A2 (en) | 2013-07-10 | 2015-01-15 | Sutro Biopharma, Inc. | Antibodies comprising multiple site-specific non-natural amino acid residues, methods of their preparation and methods of their use |
| WO2015054658A1 (en) | 2013-10-11 | 2015-04-16 | Sutro Biopharma, Inc. | Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use |
| EP3570093B1 (de) | 2013-11-15 | 2021-09-15 | Tangible Science, Inc. | Kontaktlinse mit hydrophiler schicht |
| MX2017004947A (es) | 2014-10-24 | 2017-06-29 | Bristol Myers Squibb Co | Polipeptidos del factor de crecimiento de fibroblastos 2 (fgf-21) modificados y usos de los mismos. |
| CN107206119B (zh) | 2014-12-09 | 2021-01-29 | 实体科学公司 | 具有生物相容性层的医疗设备涂层 |
| SG10201912034UA (en) | 2017-02-08 | 2020-02-27 | Bristol Myers Squibb Co | Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof |
| KR20210057124A (ko) | 2018-09-11 | 2021-05-20 | 암브룩스, 인코포레이티드 | 인터류킨-2 폴리펩타이드 접합체 및 그의 용도 |
| JP2022512746A (ja) | 2018-10-19 | 2022-02-07 | アンブルックス，インコーポレイテッド | インターロイキン－１０ポリペプチド複合体、その二量体、およびそれらの使用 |
| CN119455003A (zh) | 2019-02-12 | 2025-02-18 | Ambrx公司 | 包含抗体-tlr激动剂缀合物的组合物、方法和用途 |
| CN114555204A (zh) | 2019-09-10 | 2022-05-27 | 皮尔斯生物科技有限公司 | 样品制备组合物、装置、系统和方法 |
| EP4117732A1 (de) | 2020-03-11 | 2023-01-18 | Ambrx, Inc. | Interleukin-2-polypeptidkonjugate und verfahren zur verwendung davon |
| WO2022040596A1 (en) | 2020-08-20 | 2022-02-24 | Ambrx, Inc. | Antibody-tlr agonist conjugates, methods and uses thereof |
| WO2022212899A1 (en) | 2021-04-03 | 2022-10-06 | Ambrx, Inc. | Anti-her2 antibody-drug conjugates and uses thereof |
| WO2026043823A2 (en) | 2024-08-19 | 2026-02-26 | Sutro Biopharma, Inc. | Antibodies comprising site-specific non-natural amino acid residues, methods of preparation and uses thereof |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1336077C (en) * | 1987-11-10 | 1995-06-27 | Ruben G. Carbonell | Chromatography apparatus and method and material for making the same |
| US5094960A (en) * | 1988-10-07 | 1992-03-10 | New York Blood Center, Inc. | Removal of process chemicals from labile biological mixtures by hydrophobic interaction chromatography |
| US5349052A (en) * | 1988-10-20 | 1994-09-20 | Royal Free Hospital School Of Medicine | Process for fractionating polyethylene glycol (PEG)-protein adducts and an adduct for PEG and granulocyte-macrophage colony stimulating factor |
| US5645717A (en) * | 1989-01-13 | 1997-07-08 | Bio-Rad Laboratories, Inc. | Hydrophobic polymers from water-soluble monomers and their use as chromatography media |
| IL95031A (en) * | 1989-07-18 | 2007-03-08 | Amgen Inc | Method for the production of a human recombinant tumor necrosis factor inhibitor |
| US6552170B1 (en) * | 1990-04-06 | 2003-04-22 | Amgen Inc. | PEGylation reagents and compounds formed therewith |
| AU1674292A (en) * | 1991-03-15 | 1992-10-21 | Synergen, Inc. | Pegylation of polypeptides |
| WO1993001498A1 (en) * | 1991-07-04 | 1993-01-21 | Immunodex K/S | Water-soluble, polymer-based reagents and conjugates comprising moieties derived from divinyl sulfone |
| US5424063A (en) * | 1992-01-09 | 1995-06-13 | The Dow Chemical Company | Narrow poly- and mono-dispersed anionic oligomers, and their uses, formulations and process |
| ZA933926B (en) * | 1992-06-17 | 1994-01-03 | Amgen Inc | Polyoxymethylene-oxyethylene copolymers in conjuction with blomolecules |
| EP0622394A1 (de) * | 1993-04-30 | 1994-11-02 | S.A. Laboratoires S.M.B. | Umkehrbare Modifikation von Verbindungen, Schwefel enthaltend, mit Polyalkylengycol und ihre Verwendung |
| EP0708919B1 (de) * | 1993-07-16 | 1998-09-16 | MERCK PATENT GmbH | Trennmaterialien für die hydrophobe chromatographie |
| US5446090A (en) * | 1993-11-12 | 1995-08-29 | Shearwater Polymers, Inc. | Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules |
| US5476643A (en) * | 1993-11-19 | 1995-12-19 | Bernel Chemical Co. | Method of dispersing micronized TIo2, ZnO and other pigments |
| DE19517848A1 (de) * | 1995-05-16 | 1996-11-21 | Merck Patent Gmbh | Fluorhaltige Benzoylguanidine |
| US5747639A (en) * | 1996-03-06 | 1998-05-05 | Amgen Boulder Inc. | Use of hydrophobic interaction chromatography to purify polyethylene glycols |
-
1996
- 1996-03-06 US US08/611,918 patent/US5747639A/en not_active Expired - Lifetime
- 1996-12-06 PT PT96944251T patent/PT906122E/pt unknown
- 1996-12-06 CA CA002248006A patent/CA2248006C/en not_active Expired - Fee Related
- 1996-12-06 EP EP96944251A patent/EP0906122B1/de not_active Expired - Lifetime
- 1996-12-06 AU AU14108/97A patent/AU720399B2/en not_active Ceased
- 1996-12-06 WO PCT/US1996/019459 patent/WO1997032607A2/en not_active Ceased
- 1996-12-06 JP JP9531747A patent/JP2000506851A/ja active Pending
- 1996-12-06 ES ES96944251T patent/ES2206616T3/es not_active Expired - Lifetime
- 1996-12-06 DK DK96944251T patent/DK0906122T3/da active
- 1996-12-06 AT AT96944251T patent/ATE249244T1/de not_active IP Right Cessation
- 1996-12-06 DE DE69629949T patent/DE69629949T2/de not_active Expired - Fee Related
-
1997
- 1997-09-18 US US08/936,478 patent/US5935564A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US5935564A (en) | 1999-08-10 |
| WO1997032607A2 (en) | 1997-09-12 |
| AU720399B2 (en) | 2000-06-01 |
| DE69629949T2 (de) | 2004-07-22 |
| ES2206616T3 (es) | 2004-05-16 |
| PT906122E (pt) | 2003-12-31 |
| CA2248006A1 (en) | 1997-09-12 |
| US5747639A (en) | 1998-05-05 |
| DK0906122T3 (da) | 2004-01-19 |
| EP0906122A2 (de) | 1999-04-07 |
| CA2248006C (en) | 2002-05-28 |
| EP0906122B1 (de) | 2003-09-10 |
| WO1997032607A3 (en) | 1997-11-13 |
| DE69629949D1 (de) | 2003-10-16 |
| AU1410897A (en) | 1997-09-22 |
| JP2000506851A (ja) | 2000-06-06 |
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