DK0906122T3 - Aktiverede linkers og fremgangsmåde til at fremstille og oprense disse - Google Patents

Aktiverede linkers og fremgangsmåde til at fremstille og oprense disse

Info

Publication number
DK0906122T3
DK0906122T3 DK96944251T DK96944251T DK0906122T3 DK 0906122 T3 DK0906122 T3 DK 0906122T3 DK 96944251 T DK96944251 T DK 96944251T DK 96944251 T DK96944251 T DK 96944251T DK 0906122 T3 DK0906122 T3 DK 0906122T3
Authority
DK
Denmark
Prior art keywords
pegs
purify
manufacture
processes
activated linkers
Prior art date
Application number
DK96944251T
Other languages
Danish (da)
English (en)
Inventor
Prabha N Ibrahim
Robert A Baile
James Ervin Seely
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Application granted granted Critical
Publication of DK0906122T3 publication Critical patent/DK0906122T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Road Signs Or Road Markings (AREA)
  • Thermistors And Varistors (AREA)
  • Separation Of Suspended Particles By Flocculating Agents (AREA)
DK96944251T 1996-03-06 1996-12-06 Aktiverede linkers og fremgangsmåde til at fremstille og oprense disse DK0906122T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/611,918 US5747639A (en) 1996-03-06 1996-03-06 Use of hydrophobic interaction chromatography to purify polyethylene glycols
PCT/US1996/019459 WO1997032607A2 (en) 1996-03-06 1996-12-06 Activated linkers and methods for making and purifying the same

Publications (1)

Publication Number Publication Date
DK0906122T3 true DK0906122T3 (da) 2004-01-19

Family

ID=24450930

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96944251T DK0906122T3 (da) 1996-03-06 1996-12-06 Aktiverede linkers og fremgangsmåde til at fremstille og oprense disse

Country Status (11)

Country Link
US (2) US5747639A (de)
EP (1) EP0906122B1 (de)
JP (1) JP2000506851A (de)
AT (1) ATE249244T1 (de)
AU (1) AU720399B2 (de)
CA (1) CA2248006C (de)
DE (1) DE69629949T2 (de)
DK (1) DK0906122T3 (de)
ES (1) ES2206616T3 (de)
PT (1) PT906122E (de)
WO (1) WO1997032607A2 (de)

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US5747639A (en) * 1996-03-06 1998-05-05 Amgen Boulder Inc. Use of hydrophobic interaction chromatography to purify polyethylene glycols
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ATE247974T1 (de) 1996-12-06 2003-09-15 Amgen Inc Kombinationtherapie mit einem tnf-bindendem protein zür behandlung von durch tnf verursachten erkrangungen
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US7642323B2 (en) 1997-11-06 2010-01-05 Nektar Therapeutics Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation
US6448369B1 (en) 1997-11-06 2002-09-10 Shearwater Corporation Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation
PT1121382E (pt) * 1998-10-16 2006-10-31 Biogen Idec Inc Proteinas de fusao do interferao beta e as respectivas utilizacoes
EP2599503B1 (de) * 1998-10-16 2017-05-17 Biogen MA Inc. Polymerkonjugate von Interferon-Beta-1A und Verwendungen dafür
US6660843B1 (en) * 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
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EP1982732A3 (de) 2000-02-11 2011-06-08 Bayer HealthCare LLC Faktor VII- oder VIIA-ähnliche Konjugate
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IL156059A0 (en) 2001-02-27 2003-12-23 Maxygen Aps NEW INTERFERON beta-LIKE MOLECULES
US20030143185A1 (en) * 2001-10-29 2003-07-31 Shearwater Corporation Polymer conjugates of protein kinase C inhibitors
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US8129330B2 (en) * 2002-09-30 2012-03-06 Mountain View Pharmaceuticals, Inc. Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
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PT2061878E (pt) 2006-09-08 2014-04-22 Ambrx Inc Supressor híbrido arnt para células de vertebrados
US8420792B2 (en) 2006-09-08 2013-04-16 Ambrx, Inc. Suppressor tRNA transcription in vertebrate cells
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AU2008232937B2 (en) 2007-03-30 2012-09-27 Ambrx, Inc. Modified FGF-21 polypeptides and their uses
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JP5547083B2 (ja) 2007-11-20 2014-07-09 アンブルックス，インコーポレイテッド 修飾されたインスリンポリペプチドおよびそれらの使用
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AU2009296397B2 (en) 2008-09-26 2012-11-08 Ambrx Inc. Modified animal erythropoietin polypeptides and their uses
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Also Published As

Publication number Publication date
JP2000506851A (ja) 2000-06-06
EP0906122B1 (de) 2003-09-10
US5747639A (en) 1998-05-05
WO1997032607A3 (en) 1997-11-13
AU720399B2 (en) 2000-06-01
PT906122E (pt) 2003-12-31
CA2248006A1 (en) 1997-09-12
US5935564A (en) 1999-08-10
WO1997032607A2 (en) 1997-09-12
ES2206616T3 (es) 2004-05-16
DE69629949D1 (de) 2003-10-16
DE69629949T2 (de) 2004-07-22
CA2248006C (en) 2002-05-28
ATE249244T1 (de) 2003-09-15
AU1410897A (en) 1997-09-22
EP0906122A2 (de) 1999-04-07

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