ES2195409T3 - Purificacion de moleculas. - Google Patents

Purificacion de moleculas.

Info

Publication number
ES2195409T3
ES2195409T3 ES98953320T ES98953320T ES2195409T3 ES 2195409 T3 ES2195409 T3 ES 2195409T3 ES 98953320 T ES98953320 T ES 98953320T ES 98953320 T ES98953320 T ES 98953320T ES 2195409 T3 ES2195409 T3 ES 2195409T3
Authority
ES
Spain
Prior art keywords
contaminants
molecules
molecule
purification
column
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98953320T
Other languages
English (en)
Inventor
Robert L Fahrner
David Reifsnyder
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ES2195409T3 publication Critical patent/ES2195409T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

Procedimiento para la purificación de una molécula seleccionada de entre el grupo que consiste en un péptido, un polipéptido y un compuesto no peptidil biológicamente activo, que comprende cargar una mezcla que contiene la molécula en una columna de cromatografía líquida en fase inversa y eluir la molécula de la columna con un tampón que contiene hexilenglicol.
ES98953320T 1997-10-24 1998-10-08 Purificacion de moleculas. Expired - Lifetime ES2195409T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95776097A 1997-10-24 1997-10-24

Publications (1)

Publication Number Publication Date
ES2195409T3 true ES2195409T3 (es) 2003-12-01

Family

ID=25500093

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98953320T Expired - Lifetime ES2195409T3 (es) 1997-10-24 1998-10-08 Purificacion de moleculas.

Country Status (13)

Country Link
EP (1) EP1025126B1 (es)
JP (1) JP4239131B2 (es)
AT (1) ATE237636T1 (es)
AU (1) AU740665B2 (es)
CA (1) CA2306447C (es)
DE (1) DE69813599T2 (es)
DK (1) DK1025126T3 (es)
ES (1) ES2195409T3 (es)
HK (1) HK1031387A1 (es)
IL (1) IL135087A (es)
PT (1) PT1025126E (es)
WO (1) WO1999021889A1 (es)
ZA (1) ZA989424B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1412384T3 (da) 2001-06-28 2008-04-28 Novo Nordisk As Stabil formulering af modificeret GLP-1
JP2007524592A (ja) 2003-06-03 2007-08-30 ノボ・ノルデイスク・エー／エス 安定化された薬学的ペプチド組成物
KR101308912B1 (ko) 2003-06-03 2013-09-23 노보 노르디스크 에이/에스 안정화된 약학적 펩티드 조성물
KR101243648B1 (ko) 2003-11-20 2013-03-14 노보 노르디스크 에이/에스 제조 및 주사 장치용에 최적인 프로필렌 글리콜 함유펩티드 제제
EP1789434B1 (en) * 2004-08-31 2013-11-20 Novo Nordisk A/S Use of tris(hydroxymethyl) aminomethane for the stabilization of peptides, polypeptides and proteins
EP1817048B1 (en) 2004-11-12 2014-02-12 Novo Nordisk A/S Stable formulations of insulinoptropic peptides
JP5401097B2 (ja) * 2005-12-23 2014-01-29 ノボ・ノルデイスク・エー／エス 分取逆相クロマトグラフィー（ｒｐｃ）を使用するタンパク質精製
WO2012082933A1 (en) 2010-12-15 2012-06-21 Baxter International, Inc. Eluate collection using conductivity gradient
HRP20240485T1 (hr) 2017-08-24 2024-07-05 Novo Nordisk A/S Pripravci glp-1 i njihova upotreba
US20230082544A1 (en) 2020-02-18 2023-03-16 Novo Nordisk A/S Pharmaceutical formulations

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4743680A (en) * 1985-02-01 1988-05-10 New York University Method for purifying antihemophilic factor
US5446024A (en) * 1993-12-17 1995-08-29 Genentech, Inc. Purification of insulin-like growth factor

Also Published As

Publication number Publication date
DE69813599T2 (de) 2004-04-08
EP1025126B1 (en) 2003-04-16
HK1031387A1 (en) 2001-06-15
ATE237636T1 (de) 2003-05-15
WO1999021889A1 (en) 1999-05-06
ZA989424B (en) 2000-04-17
DE69813599D1 (de) 2003-05-22
DK1025126T3 (da) 2003-08-04
CA2306447A1 (en) 1999-05-06
CA2306447C (en) 2009-04-07
IL135087A (en) 2005-05-17
EP1025126A1 (en) 2000-08-09
PT1025126E (pt) 2003-09-30
JP2001521044A (ja) 2001-11-06
JP4239131B2 (ja) 2009-03-18
AU1072599A (en) 1999-05-17
AU740665B2 (en) 2001-11-08

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