ATE150791T1 - Proteinstruktur des pflanzlichen toxins gelonin - Google Patents

Proteinstruktur des pflanzlichen toxins gelonin

Info

Publication number
ATE150791T1
ATE150791T1 AT91917004T AT91917004T ATE150791T1 AT E150791 T1 ATE150791 T1 AT E150791T1 AT 91917004 T AT91917004 T AT 91917004T AT 91917004 T AT91917004 T AT 91917004T AT E150791 T1 ATE150791 T1 AT E150791T1
Authority
AT
Austria
Prior art keywords
gelonin
protein structure
plant toxin
dna
toxic fragments
Prior art date
Application number
AT91917004T
Other languages
English (en)
Inventor
Michael Rosenblum
Bharat Aggarwal
William J Kohr
Original Assignee
Res Dev Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Res Dev Foundation filed Critical Res Dev Foundation
Application granted granted Critical
Publication of ATE150791T1 publication Critical patent/ATE150791T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Plant Substances (AREA)
AT91917004T 1990-08-14 1991-08-14 Proteinstruktur des pflanzlichen toxins gelonin ATE150791T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US56722090A 1990-08-14 1990-08-14

Publications (1)

Publication Number Publication Date
ATE150791T1 true ATE150791T1 (de) 1997-04-15

Family

ID=24266242

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91917004T ATE150791T1 (de) 1990-08-14 1991-08-14 Proteinstruktur des pflanzlichen toxins gelonin

Country Status (22)

Country Link
US (2) US5631348A (de)
EP (1) EP0546087B1 (de)
JP (1) JPH06502847A (de)
KR (1) KR100220502B1 (de)
CN (1) CN1055123C (de)
AT (1) ATE150791T1 (de)
CA (1) CA2088068C (de)
DE (1) DE69125381T2 (de)
DK (1) DK0546087T3 (de)
ES (1) ES2100960T3 (de)
FI (1) FI112492B (de)
GR (1) GR3023593T3 (de)
HK (1) HK1006727A1 (de)
IE (1) IE912716A1 (de)
IL (1) IL99079A (de)
NO (1) NO309656B1 (de)
NZ (1) NZ239249A (de)
PT (1) PT98669B (de)
RU (1) RU2104285C1 (de)
SA (1) SA92130322B1 (de)
WO (1) WO1992003144A1 (de)
ZA (1) ZA916171B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA912490B (en) * 1990-04-19 1992-12-30 Res Dev Foundation Antibody conjugates for treatment of neoplastic disease
IE912716A1 (en) 1990-08-14 1992-02-26 Res Dev Foundation Protein Structure of the Plant Toxin Gelonin
RU2142015C1 (ru) * 1991-09-06 1999-11-27 Рисерч Дивелопмент Фаундейшн Фрагмент днк, кодирующий белок гелонина, и способ его получения, вектор, обеспечивающий экспрессию белка гелонина, рекомбинантный штамм e.coli - продуцент белка гелонина
US6146850A (en) * 1991-11-04 2000-11-14 Xoma Corporation Proteins encoding gelonin sequences
US5621083A (en) * 1991-11-04 1997-04-15 Xoma Corporation Immunotoxins comprising ribosome-inactivating proteins
US5837491A (en) * 1991-11-04 1998-11-17 Xoma Corporation Polynucleotides encoding gelonin sequences
US6599505B1 (en) * 1992-04-10 2003-07-29 Research Development Foundation Immunotoxins directed against CD33 related surface antigens
US5684129A (en) * 1992-07-07 1997-11-04 Fish; Eleanor N. Interferon receptor binding peptides
ZA200305980B (en) * 2001-02-12 2007-01-31 Res Dev Foundation Modified proteins, designer toxins, and methods of making thereof
IL159894A0 (en) * 2001-07-17 2004-06-20 Res Dev Foundation Therapeutic agents comprising pro-apoptotic proteins
US20040013691A1 (en) * 2002-06-12 2004-01-22 Rosenblum Michael G. Immunotoxin as a therapeutic agent and uses thereof
AU2006210769A1 (en) * 2005-02-01 2006-08-10 Research Development Foundation BLyS fusion proteins for targeting BLyS receptor and methods for treatment of B-cell proliferative disorders
WO2014127211A1 (en) 2013-02-15 2014-08-21 Research Development Foundation Deimmunized gelonin molecules and therapies

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4446240A (en) * 1981-01-30 1984-05-01 Nerenberg Samuel T Pancreas specific protein systems
US4921802A (en) * 1983-05-05 1990-05-01 Pioneer Hi-Bred International, Inc. Plant virus cDNA
US4888415A (en) * 1985-03-04 1989-12-19 Dana-Farber Cancer Institute, Inc. Gelonin immunotoxin
US4810648A (en) * 1986-01-08 1989-03-07 Rhone Poulenc Agrochimie Haloarylnitrile degrading gene, its use, and cells containing the gene
EP0341304A4 (en) 1987-11-24 1991-01-30 Genetics Institute, Inc. Improved ricin molecules and ricin toxin conjugates
GB8801877D0 (en) * 1988-01-28 1988-02-24 Erba Carlo Spa Nucleotide sequence encoding plant ribosome inactivating protein
IE62463B1 (en) * 1988-07-07 1995-02-08 Res Dev Foundation Immunoconjugates for cancer diagnosis and therapy
IE912716A1 (en) 1990-08-14 1992-02-26 Res Dev Foundation Protein Structure of the Plant Toxin Gelonin

Also Published As

Publication number Publication date
SA92130322B1 (ar) 2004-05-25
ZA916171B (en) 1992-04-29
FI112492B (fi) 2003-12-15
PT98669A (pt) 1992-07-31
WO1992003144A1 (en) 1992-03-05
HK1006727A1 (en) 1999-03-12
NO930428L (no) 1993-03-29
JPH06502847A (ja) 1994-03-31
CA2088068C (en) 1999-06-15
IL99079A (en) 1998-09-24
CN1055123C (zh) 2000-08-02
IL99079A0 (en) 1992-07-15
US5631348A (en) 1997-05-20
PT98669B (pt) 1999-01-29
USRE37462E1 (en) 2001-12-04
ES2100960T3 (es) 1997-07-01
RU2104285C1 (ru) 1998-02-10
AU8624091A (en) 1992-03-17
NO309656B1 (no) 2001-03-05
CN1058990A (zh) 1992-02-26
FI930626A0 (fi) 1993-02-12
EP0546087A1 (de) 1993-06-16
EP0546087A4 (de) 1994-01-05
EP0546087B1 (de) 1997-03-26
GR3023593T3 (en) 1997-08-29
NZ239249A (en) 1992-10-28
KR100220502B1 (ko) 1999-10-01
FI930626A (fi) 1993-02-12
DE69125381T2 (de) 1997-07-03
AU653365B2 (en) 1994-09-29
NO930428D0 (no) 1993-02-08
CA2088068A1 (en) 1992-02-15
DK0546087T3 (da) 1997-09-22
IE912716A1 (en) 1992-02-26
KR930701487A (ko) 1993-06-11
DE69125381D1 (de) 1997-04-30

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Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee