KR930701487A - 식물성 독소 겔로닌의 단백질 구조물 - Google Patents

식물성 독소 겔로닌의 단백질 구조물

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Publication number
KR930701487A
KR930701487A KR1019930700412A KR930700412A KR930701487A KR 930701487 A KR930701487 A KR 930701487A KR 1019930700412 A KR1019930700412 A KR 1019930700412A KR 930700412 A KR930700412 A KR 930700412A KR 930701487 A KR930701487 A KR 930701487A
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South Korea
Prior art keywords
gelonin
fragments
dna
protein structure
derivatives
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KR1019930700412A
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English (en)
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KR100220502B1 (ko
Inventor
로젠블룸 마이클
악가랄 브하라트
제이. 코어 윌리암
Original Assignee
제임스 에프,와일러
리서치 디벨롭먼트 파운데이션
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Publication of KR930701487A publication Critical patent/KR930701487A/ko
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Publication of KR100220502B1 publication Critical patent/KR100220502B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

본 발명은 겔로닌 또는 세포성 단백질 합성을 억제하지만 세포 표면 수용체와 결합하지 않는 활성을 갖는 폴리펩타이드를 암호화하는 cDNA 및 아미노산 서열에 관한 것이다.

Description

식물성 독소 겔로닌의 단백질 구조물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 겔로닌의 아미노산 서열을 도시한다.
제2도는 겔로닌에 대한 cDNA 암호화를 나타낸다,
제3도는 겔로닌 아미노산 서열과 트리코산틴, 리신 A 쇄, 파마자로 부터 분리한 아글루티닌 전구체 및 아브린 A쇄의 서열가의 호몰로지(homology)를 나타낸다.

Claims (8)

  1. [1992년 2월 14일자로 국제사무국에 의해 수령됨 :최초 출원된 특허청구의 범위 제1항 및 제2항이 보정된 특허청구의 범위 제1항 및 제2항으로 대체됨]
  2. 세포성 단백질 합성을 억제하지만 세포 표면 수용체와는 결합하지 않는 활성을 갖는 폴리펩타이드를 암호화하는 하기 아미노산 서열을 갖는 실질적으로 순수한 겔로닌 독소, 이의 단편 및 유도체.
  4. 겔로닌을 암호화하거나 세포성 단백질 합성을 억제하지만 세포 표면 수용체와는 결합하지 않는 활성을 갖는 폴리펩타이드를 암호화하는 하기 서열식의 DNA, 이의 단편 및 유도체.
  7. 여기서, R은 A 또는 G이고, K는 G 또는 T이고, N은 모든 염기이고, Y는 C 또는 T이고, M은 A 또는 C이고, S는 C 또는 G이고, B는 C, G 또는 T이고, V는 A, C 또는 G이고, W는 A 또는 T이고, D는 A, G 또는 T이고, H는 A, C 또는 T이고, X는 미지의 염기이다.
  8. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019930700412A 1990-08-14 1991-08-14 식물성 독소 겔로닌의 단백질 구조물 KR100220502B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US56722090A 1990-08-14 1990-08-14
US7/567,220 1990-08-14
US07/567,220 1990-08-14
PCT/US1991/005766 WO1992003144A1 (en) 1990-08-14 1991-08-14 Protein structure of the plant toxin gelonin

Publications (2)

Publication Number Publication Date
KR930701487A true KR930701487A (ko) 1993-06-11
KR100220502B1 KR100220502B1 (ko) 1999-10-01

Family

ID=24266242

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019930700412A KR100220502B1 (ko) 1990-08-14 1991-08-14 식물성 독소 겔로닌의 단백질 구조물

Country Status (22)

Country Link
US (2) US5631348A (ko)
EP (1) EP0546087B1 (ko)
JP (1) JPH06502847A (ko)
KR (1) KR100220502B1 (ko)
CN (1) CN1055123C (ko)
AT (1) ATE150791T1 (ko)
CA (1) CA2088068C (ko)
DE (1) DE69125381T2 (ko)
DK (1) DK0546087T3 (ko)
ES (1) ES2100960T3 (ko)
FI (1) FI112492B (ko)
GR (1) GR3023593T3 (ko)
HK (1) HK1006727A1 (ko)
IE (1) IE912716A1 (ko)
IL (1) IL99079A (ko)
NO (1) NO309656B1 (ko)
NZ (1) NZ239249A (ko)
PT (1) PT98669B (ko)
RU (1) RU2104285C1 (ko)
SA (1) SA92130322B1 (ko)
WO (1) WO1992003144A1 (ko)
ZA (1) ZA916171B (ko)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE62496B1 (en) * 1990-04-19 1995-02-08 Res Dev Foundation Antibody conjugates for treatment of neoplastic disease
IE912716A1 (en) 1990-08-14 1992-02-26 Res Dev Foundation Protein Structure of the Plant Toxin Gelonin
CA2115049C (en) * 1991-09-06 2003-10-21 Michael G. Rosenblum Dna sequences encoding gelonin polypeptide
US6146850A (en) * 1991-11-04 2000-11-14 Xoma Corporation Proteins encoding gelonin sequences
US5837491A (en) * 1991-11-04 1998-11-17 Xoma Corporation Polynucleotides encoding gelonin sequences
US5621083A (en) 1991-11-04 1997-04-15 Xoma Corporation Immunotoxins comprising ribosome-inactivating proteins
US6599505B1 (en) * 1992-04-10 2003-07-29 Research Development Foundation Immunotoxins directed against CD33 related surface antigens
US5684129A (en) * 1992-07-07 1997-11-04 Fish; Eleanor N. Interferon receptor binding peptides
ZA200305980B (en) * 2001-02-12 2007-01-31 Res Dev Foundation Modified proteins, designer toxins, and methods of making thereof
DK1414471T3 (da) 2001-07-17 2012-07-16 Res Dev Foundation Terapeutiske midler omfattende pro-apoptotiske proteiner
AU2003275985A1 (en) * 2002-06-12 2003-12-31 Research Development Foundation Immunotoxin as a therapeutic agent and uses thereof
AU2006210769A1 (en) * 2005-02-01 2006-08-10 Research Development Foundation BLyS fusion proteins for targeting BLyS receptor and methods for treatment of B-cell proliferative disorders
WO2014127211A1 (en) 2013-02-15 2014-08-21 Research Development Foundation Deimmunized gelonin molecules and therapies

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4446240A (en) * 1981-01-30 1984-05-01 Nerenberg Samuel T Pancreas specific protein systems
US4921802A (en) * 1983-05-05 1990-05-01 Pioneer Hi-Bred International, Inc. Plant virus cDNA
US4888415A (en) * 1985-03-04 1989-12-19 Dana-Farber Cancer Institute, Inc. Gelonin immunotoxin
US4810648A (en) * 1986-01-08 1989-03-07 Rhone Poulenc Agrochimie Haloarylnitrile degrading gene, its use, and cells containing the gene
JPH02502287A (ja) 1987-11-24 1990-07-26 ジェネティックス・インスティテュート・インコーポレイテッド 改良されたリシン分子およびリシン毒素コンジュゲート
GB8801877D0 (en) * 1988-01-28 1988-02-24 Erba Carlo Spa Nucleotide sequence encoding plant ribosome inactivating protein
IE62463B1 (en) * 1988-07-07 1995-02-08 Res Dev Foundation Immunoconjugates for cancer diagnosis and therapy
IE912716A1 (en) 1990-08-14 1992-02-26 Res Dev Foundation Protein Structure of the Plant Toxin Gelonin

Also Published As

Publication number Publication date
IL99079A (en) 1998-09-24
NO309656B1 (no) 2001-03-05
NO930428D0 (no) 1993-02-08
EP0546087A4 (ko) 1994-01-05
DE69125381T2 (de) 1997-07-03
ZA916171B (en) 1992-04-29
FI112492B (fi) 2003-12-15
PT98669A (pt) 1992-07-31
EP0546087B1 (en) 1997-03-26
NO930428L (no) 1993-03-29
CA2088068C (en) 1999-06-15
FI930626A0 (fi) 1993-02-12
WO1992003144A1 (en) 1992-03-05
ES2100960T3 (es) 1997-07-01
CN1055123C (zh) 2000-08-02
DK0546087T3 (da) 1997-09-22
US5631348A (en) 1997-05-20
RU2104285C1 (ru) 1998-02-10
GR3023593T3 (en) 1997-08-29
IE912716A1 (en) 1992-02-26
NZ239249A (en) 1992-10-28
SA92130322B1 (ar) 2004-05-25
HK1006727A1 (en) 1999-03-12
ATE150791T1 (de) 1997-04-15
EP0546087A1 (en) 1993-06-16
KR100220502B1 (ko) 1999-10-01
DE69125381D1 (de) 1997-04-30
IL99079A0 (en) 1992-07-15
FI930626A (fi) 1993-02-12
PT98669B (pt) 1999-01-29
USRE37462E1 (en) 2001-12-04
AU653365B2 (en) 1994-09-29
CA2088068A1 (en) 1992-02-15
JPH06502847A (ja) 1994-03-31
AU8624091A (en) 1992-03-17
CN1058990A (zh) 1992-02-26

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