HK1006727A1 - Protein structure of the plant toxin gelonin - Google Patents

Protein structure of the plant toxin gelonin

Info

Publication number
HK1006727A1
HK1006727A1 HK98106041A HK98106041A HK1006727A1 HK 1006727 A1 HK1006727 A1 HK 1006727A1 HK 98106041 A HK98106041 A HK 98106041A HK 98106041 A HK98106041 A HK 98106041A HK 1006727 A1 HK1006727 A1 HK 1006727A1
Authority
HK
Hong Kong
Prior art keywords
gelonin
protein structure
plant toxin
dna
toxic fragments
Prior art date
Application number
HK98106041A
Other languages
English (en)
Inventor
Michael Rosenblum
Bharat Aggarwal
William J Kohr
Original Assignee
Res Dev Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Res Dev Foundation filed Critical Res Dev Foundation
Publication of HK1006727A1 publication Critical patent/HK1006727A1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/55Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
HK98106041A 1990-08-14 1998-06-23 Protein structure of the plant toxin gelonin HK1006727A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56722090A 1990-08-14 1990-08-14
PCT/US1991/005766 WO1992003144A1 (en) 1990-08-14 1991-08-14 Protein structure of the plant toxin gelonin

Publications (1)

Publication Number Publication Date
HK1006727A1 true HK1006727A1 (en) 1999-03-12

Family

ID=24266242

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98106041A HK1006727A1 (en) 1990-08-14 1998-06-23 Protein structure of the plant toxin gelonin

Country Status (22)

Country Link
US (2) US5631348A (xx)
EP (1) EP0546087B1 (xx)
JP (1) JPH06502847A (xx)
KR (1) KR100220502B1 (xx)
CN (1) CN1055123C (xx)
AT (1) ATE150791T1 (xx)
CA (1) CA2088068C (xx)
DE (1) DE69125381T2 (xx)
DK (1) DK0546087T3 (xx)
ES (1) ES2100960T3 (xx)
FI (1) FI112492B (xx)
GR (1) GR3023593T3 (xx)
HK (1) HK1006727A1 (xx)
IE (1) IE912716A1 (xx)
IL (1) IL99079A (xx)
NO (1) NO309656B1 (xx)
NZ (1) NZ239249A (xx)
PT (1) PT98669B (xx)
RU (1) RU2104285C1 (xx)
SA (1) SA92130322B1 (xx)
WO (1) WO1992003144A1 (xx)
ZA (1) ZA916171B (xx)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE62496B1 (en) * 1990-04-19 1995-02-08 Res Dev Foundation Antibody conjugates for treatment of neoplastic disease
IE912716A1 (en) 1990-08-14 1992-02-26 Res Dev Foundation Protein Structure of the Plant Toxin Gelonin
KR100270195B1 (ko) * 1991-09-06 2001-03-02 와일러 제임스 에프. 겔로닌 폴리펩타이드를 암호화하는 dna 서열
US5621083A (en) * 1991-11-04 1997-04-15 Xoma Corporation Immunotoxins comprising ribosome-inactivating proteins
US6146850A (en) * 1991-11-04 2000-11-14 Xoma Corporation Proteins encoding gelonin sequences
US5837491A (en) * 1991-11-04 1998-11-17 Xoma Corporation Polynucleotides encoding gelonin sequences
US6599505B1 (en) * 1992-04-10 2003-07-29 Research Development Foundation Immunotoxins directed against CD33 related surface antigens
US5684129A (en) * 1992-07-07 1997-11-04 Fish; Eleanor N. Interferon receptor binding peptides
ZA200305980B (en) * 2001-02-12 2007-01-31 Res Dev Foundation Modified proteins, designer toxins, and methods of making thereof
EP1414471B1 (en) * 2001-07-17 2012-06-13 Research Development Foundation Therapeutic agents comprising pro-apoptotic proteins
WO2003105761A2 (en) * 2002-06-12 2003-12-24 Research Development Foundation Immunotoxin as a therapeutic agent and uses thereof
CN101132813A (zh) * 2005-02-01 2008-02-27 研究发展基金会 靶向blys受体的blys融合蛋白和用于治疗b细胞增殖性疾病的方法
US9388397B2 (en) * 2013-02-15 2016-07-12 Research Development Foundation Deimmunized gelonin molecules and therapies

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4446240A (en) * 1981-01-30 1984-05-01 Nerenberg Samuel T Pancreas specific protein systems
US4921802A (en) * 1983-05-05 1990-05-01 Pioneer Hi-Bred International, Inc. Plant virus cDNA
US4888415A (en) * 1985-03-04 1989-12-19 Dana-Farber Cancer Institute, Inc. Gelonin immunotoxin
US4810648A (en) * 1986-01-08 1989-03-07 Rhone Poulenc Agrochimie Haloarylnitrile degrading gene, its use, and cells containing the gene
JPH02502287A (ja) 1987-11-24 1990-07-26 ジェネティックス・インスティテュート・インコーポレイテッド 改良されたリシン分子およびリシン毒素コンジュゲート
GB8801877D0 (en) * 1988-01-28 1988-02-24 Erba Carlo Spa Nucleotide sequence encoding plant ribosome inactivating protein
IE62463B1 (en) * 1988-07-07 1995-02-08 Res Dev Foundation Immunoconjugates for cancer diagnosis and therapy
IE912716A1 (en) 1990-08-14 1992-02-26 Res Dev Foundation Protein Structure of the Plant Toxin Gelonin

Also Published As

Publication number Publication date
ZA916171B (en) 1992-04-29
ATE150791T1 (de) 1997-04-15
IE912716A1 (en) 1992-02-26
IL99079A (en) 1998-09-24
CN1055123C (zh) 2000-08-02
CA2088068C (en) 1999-06-15
NO309656B1 (no) 2001-03-05
NZ239249A (en) 1992-10-28
PT98669B (pt) 1999-01-29
AU8624091A (en) 1992-03-17
JPH06502847A (ja) 1994-03-31
EP0546087B1 (en) 1997-03-26
SA92130322B1 (ar) 2004-05-25
WO1992003144A1 (en) 1992-03-05
EP0546087A1 (en) 1993-06-16
CN1058990A (zh) 1992-02-26
NO930428L (no) 1993-03-29
FI930626A (fi) 1993-02-12
ES2100960T3 (es) 1997-07-01
US5631348A (en) 1997-05-20
AU653365B2 (en) 1994-09-29
FI112492B (fi) 2003-12-15
KR100220502B1 (ko) 1999-10-01
RU2104285C1 (ru) 1998-02-10
GR3023593T3 (en) 1997-08-29
PT98669A (pt) 1992-07-31
DE69125381D1 (de) 1997-04-30
USRE37462E1 (en) 2001-12-04
IL99079A0 (en) 1992-07-15
EP0546087A4 (xx) 1994-01-05
NO930428D0 (no) 1993-02-08
DE69125381T2 (de) 1997-07-03
KR930701487A (ko) 1993-06-11
FI930626A0 (fi) 1993-02-12
DK0546087T3 (da) 1997-09-22
CA2088068A1 (en) 1992-02-15

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20100814