NO309656B1 - DNA-sekvens kodende for gelonintoksin samt fremgangsmåte for fremstilling av vesentlig ren gelonintoksin eller fragmenter eller derivater derav - Google Patents

DNA-sekvens kodende for gelonintoksin samt fremgangsmåte for fremstilling av vesentlig ren gelonintoksin eller fragmenter eller derivater derav Download PDF

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Publication number
NO309656B1
NO309656B1 NO930428A NO930428A NO309656B1 NO 309656 B1 NO309656 B1 NO 309656B1 NO 930428 A NO930428 A NO 930428A NO 930428 A NO930428 A NO 930428A NO 309656 B1 NO309656 B1 NO 309656B1
Authority
NO
Norway
Prior art keywords
gelonin
amino acid
gelonin toxin
toxin
fragments
Prior art date
Application number
NO930428A
Other languages
English (en)
Norwegian (no)
Other versions
NO930428L (no
NO930428D0 (no
Inventor
Michael Rosenblum
Bharat Aggarwal
William J Kohr
Original Assignee
Res Dev Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Res Dev Foundation filed Critical Res Dev Foundation
Publication of NO930428D0 publication Critical patent/NO930428D0/no
Publication of NO930428L publication Critical patent/NO930428L/no
Publication of NO309656B1 publication Critical patent/NO309656B1/no

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/55Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Plant Pathology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
NO930428A 1990-08-14 1993-02-08 DNA-sekvens kodende for gelonintoksin samt fremgangsmåte for fremstilling av vesentlig ren gelonintoksin eller fragmenter eller derivater derav NO309656B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56722090A 1990-08-14 1990-08-14
PCT/US1991/005766 WO1992003144A1 (en) 1990-08-14 1991-08-14 Protein structure of the plant toxin gelonin

Publications (3)

Publication Number Publication Date
NO930428D0 NO930428D0 (no) 1993-02-08
NO930428L NO930428L (no) 1993-03-29
NO309656B1 true NO309656B1 (no) 2001-03-05

Family

ID=24266242

Family Applications (1)

Application Number Title Priority Date Filing Date
NO930428A NO309656B1 (no) 1990-08-14 1993-02-08 DNA-sekvens kodende for gelonintoksin samt fremgangsmåte for fremstilling av vesentlig ren gelonintoksin eller fragmenter eller derivater derav

Country Status (22)

Country Link
US (2) US5631348A (xx)
EP (1) EP0546087B1 (xx)
JP (1) JPH06502847A (xx)
KR (1) KR100220502B1 (xx)
CN (1) CN1055123C (xx)
AT (1) ATE150791T1 (xx)
CA (1) CA2088068C (xx)
DE (1) DE69125381T2 (xx)
DK (1) DK0546087T3 (xx)
ES (1) ES2100960T3 (xx)
FI (1) FI112492B (xx)
GR (1) GR3023593T3 (xx)
HK (1) HK1006727A1 (xx)
IE (1) IE912716A1 (xx)
IL (1) IL99079A (xx)
NO (1) NO309656B1 (xx)
NZ (1) NZ239249A (xx)
PT (1) PT98669B (xx)
RU (1) RU2104285C1 (xx)
SA (1) SA92130322B1 (xx)
WO (1) WO1992003144A1 (xx)
ZA (1) ZA916171B (xx)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA912490B (en) * 1990-04-19 1992-12-30 Res Dev Foundation Antibody conjugates for treatment of neoplastic disease
IE912716A1 (en) 1990-08-14 1992-02-26 Res Dev Foundation Protein Structure of the Plant Toxin Gelonin
AU679427B2 (en) * 1991-09-06 1997-07-03 Research Development Foundation DNA sequences encoding gelonin polypeptide
US6146850A (en) * 1991-11-04 2000-11-14 Xoma Corporation Proteins encoding gelonin sequences
US5621083A (en) 1991-11-04 1997-04-15 Xoma Corporation Immunotoxins comprising ribosome-inactivating proteins
US5837491A (en) * 1991-11-04 1998-11-17 Xoma Corporation Polynucleotides encoding gelonin sequences
US6599505B1 (en) * 1992-04-10 2003-07-29 Research Development Foundation Immunotoxins directed against CD33 related surface antigens
CA2139571C (en) * 1992-07-07 2006-11-14 Eleanor N. Fish Interferon receptor binding peptides
ZA200305980B (en) * 2001-02-12 2007-01-31 Res Dev Foundation Modified proteins, designer toxins, and methods of making thereof
US7101977B2 (en) 2001-07-17 2006-09-05 Research Development Foundation Therapeutic agents comprising pro-apoptotic proteins
AU2003275985A1 (en) * 2002-06-12 2003-12-31 Research Development Foundation Immunotoxin as a therapeutic agent and uses thereof
JP2008528633A (ja) * 2005-02-01 2008-07-31 リサーチ ディベロップメント ファウンデーション Blysレセプターを標的化するためのblys融合タンパク質およびb細胞増殖性疾患の処置方法
WO2014127211A1 (en) 2013-02-15 2014-08-21 Research Development Foundation Deimmunized gelonin molecules and therapies

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4446240A (en) * 1981-01-30 1984-05-01 Nerenberg Samuel T Pancreas specific protein systems
US4921802A (en) * 1983-05-05 1990-05-01 Pioneer Hi-Bred International, Inc. Plant virus cDNA
US4888415A (en) * 1985-03-04 1989-12-19 Dana-Farber Cancer Institute, Inc. Gelonin immunotoxin
US4810648A (en) * 1986-01-08 1989-03-07 Rhone Poulenc Agrochimie Haloarylnitrile degrading gene, its use, and cells containing the gene
WO1989004839A1 (en) 1987-11-24 1989-06-01 Genetics Institute, Inc. Improved ricin molecules and ricin toxin conjugates
GB8801877D0 (en) * 1988-01-28 1988-02-24 Erba Carlo Spa Nucleotide sequence encoding plant ribosome inactivating protein
IE62463B1 (en) * 1988-07-07 1995-02-08 Res Dev Foundation Immunoconjugates for cancer diagnosis and therapy
IE912716A1 (en) 1990-08-14 1992-02-26 Res Dev Foundation Protein Structure of the Plant Toxin Gelonin

Also Published As

Publication number Publication date
FI930626A (fi) 1993-02-12
DE69125381D1 (de) 1997-04-30
CN1055123C (zh) 2000-08-02
RU2104285C1 (ru) 1998-02-10
ZA916171B (en) 1992-04-29
SA92130322B1 (ar) 2004-05-25
EP0546087B1 (en) 1997-03-26
PT98669A (pt) 1992-07-31
DK0546087T3 (da) 1997-09-22
EP0546087A1 (en) 1993-06-16
WO1992003144A1 (en) 1992-03-05
CA2088068C (en) 1999-06-15
CN1058990A (zh) 1992-02-26
DE69125381T2 (de) 1997-07-03
PT98669B (pt) 1999-01-29
GR3023593T3 (en) 1997-08-29
NO930428L (no) 1993-03-29
CA2088068A1 (en) 1992-02-15
IE912716A1 (en) 1992-02-26
IL99079A (en) 1998-09-24
NZ239249A (en) 1992-10-28
HK1006727A1 (en) 1999-03-12
FI112492B (fi) 2003-12-15
AU653365B2 (en) 1994-09-29
ES2100960T3 (es) 1997-07-01
ATE150791T1 (de) 1997-04-15
EP0546087A4 (xx) 1994-01-05
KR930701487A (ko) 1993-06-11
USRE37462E1 (en) 2001-12-04
US5631348A (en) 1997-05-20
JPH06502847A (ja) 1994-03-31
IL99079A0 (en) 1992-07-15
KR100220502B1 (ko) 1999-10-01
AU8624091A (en) 1992-03-17
NO930428D0 (no) 1993-02-08
FI930626A0 (fi) 1993-02-12

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