ATE215968T1 - Verfahren zur reinigung von thrombomodulin - Google Patents

Verfahren zur reinigung von thrombomodulin

Info

Publication number
ATE215968T1
ATE215968T1 AT96117071T AT96117071T ATE215968T1 AT E215968 T1 ATE215968 T1 AT E215968T1 AT 96117071 T AT96117071 T AT 96117071T AT 96117071 T AT96117071 T AT 96117071T AT E215968 T1 ATE215968 T1 AT E215968T1
Authority
AT
Austria
Prior art keywords
thrombomodulin
purified
purifying
purifying thrombomodulin
content
Prior art date
Application number
AT96117071T
Other languages
English (en)
Inventor
Jun-Ichi Kajihara
Aki Asada
Kozue Shibata
Kazuo Katoh
Original Assignee
Japan Chem Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Chem Res filed Critical Japan Chem Res
Application granted granted Critical
Publication of ATE215968T1 publication Critical patent/ATE215968T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/7455—Thrombomodulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
AT96117071T 1995-10-24 1996-10-24 Verfahren zur reinigung von thrombomodulin ATE215968T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP30068295A JP3745805B2 (ja) 1995-10-24 1995-10-24 トロンボモジュリンの精製方法

Publications (1)

Publication Number Publication Date
ATE215968T1 true ATE215968T1 (de) 2002-04-15

Family

ID=17887810

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96117071T ATE215968T1 (de) 1995-10-24 1996-10-24 Verfahren zur reinigung von thrombomodulin

Country Status (7)

Country Link
US (1) US5753123A (de)
EP (1) EP0770626B1 (de)
JP (1) JP3745805B2 (de)
CN (1) CN1151406A (de)
AT (1) ATE215968T1 (de)
DE (1) DE69620539T2 (de)
TW (1) TW408129B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1781778A4 (de) * 2004-06-16 2007-09-12 Ciphergen Biosystems Inc Multichemiefraktionierung
WO2006067230A1 (en) * 2004-12-23 2006-06-29 Novo Nordisk Health Care Ag Reduction of the content of protein contaminants in compositions comprising a vitamin k-dependent protein of interest
CN101522206B (zh) 2006-10-06 2013-03-27 旭化成制药株式会社 弥散性血管内凝血综合征的治疗剂和/或改善剂
US8258269B2 (en) * 2007-03-23 2012-09-04 Asahi Kasei Pharma Corporation Method for producing high-purity soluble thrombomodulin
JP5722314B2 (ja) * 2010-04-30 2015-05-20 旭化成ファーマ株式会社 高純度可溶性トロンボモジュリン及びその製造方法
EP2781221B9 (de) 2011-11-15 2020-09-02 Asahi Kasei Pharma Corporation Medizin zur behandlung und/oder linderung von sepsis
HUE045997T2 (hu) 2012-05-31 2020-01-28 Univ Kinki Hatóanyag rákellenes szer által okozott perifériás neuropátiás fájdalom megelõzésére és/vagy kezelésére
CN107987157A (zh) * 2017-12-19 2018-05-04 江苏艾迪药业有限公司 一种可工业化生产的人来源血凝调节蛋白的制备方法
MX2021003288A (es) 2018-09-28 2021-05-13 Asahi Kasei Pharma Corp Medicacion para aliviar los sintomas de la neuropatia periferica causada por farmacos anticancerigenos y/o suprimir el inicio de la neuropatia periferica.
KR20210060574A (ko) 2018-10-22 2021-05-26 아사히 가세이 파마 가부시키가이샤 응고 이상을 수반하는 패혈증의 치료 및/또는 개선을 위한 의약

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USH1148H (en) * 1987-04-17 1993-03-02 Method of separating activated human protein C
US5202421A (en) * 1988-12-27 1993-04-13 Mochida Pharmaceutical Co., Ltd. Anticoagulant substance obtained from urine and process for the preparation thereof
FR2658517B2 (fr) * 1989-04-12 1992-06-19 Fondation Nale Transfusion San Preparation de la proteine c activee et solution de proteine c activee ainsi obtenue.
GB9007657D0 (en) * 1990-04-04 1990-05-30 Connaught Lab Purification of a pertussis outer membrane protein(omp69)
US5378816A (en) * 1992-12-16 1995-01-03 Berlex Laboratories, Inc. Methods for high purity chromatographic separation of proteins having EGF-like binding domains

Also Published As

Publication number Publication date
JPH09110900A (ja) 1997-04-28
DE69620539T2 (de) 2002-08-08
EP0770626A3 (de) 1998-04-08
CN1151406A (zh) 1997-06-11
DE69620539D1 (de) 2002-05-16
EP0770626B1 (de) 2002-04-10
US5753123A (en) 1998-05-19
TW408129B (en) 2000-10-11
JP3745805B2 (ja) 2006-02-15
EP0770626A2 (de) 1997-05-02

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