DE69620539D1 - Verfahren zur Reinigung von Thrombomodulin - Google Patents

Verfahren zur Reinigung von Thrombomodulin

Info

Publication number
DE69620539D1
DE69620539D1 DE69620539T DE69620539T DE69620539D1 DE 69620539 D1 DE69620539 D1 DE 69620539D1 DE 69620539 T DE69620539 T DE 69620539T DE 69620539 T DE69620539 T DE 69620539T DE 69620539 D1 DE69620539 D1 DE 69620539D1
Authority
DE
Germany
Prior art keywords
thrombomodulin
purification
purified
content
starting material
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69620539T
Other languages
English (en)
Other versions
DE69620539T2 (de
Inventor
Jun-Ichi Kajihara
Aki Asada
Kozue Shibata
Kazuo Katoh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
JCR Pharmaceuticals Co Ltd
Original Assignee
JCR Pharmaceuticals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by JCR Pharmaceuticals Co Ltd filed Critical JCR Pharmaceuticals Co Ltd
Application granted granted Critical
Publication of DE69620539D1 publication Critical patent/DE69620539D1/de
Publication of DE69620539T2 publication Critical patent/DE69620539T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/7455—Thrombomodulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69620539T 1995-10-24 1996-10-24 Verfahren zur Reinigung von Thrombomodulin Expired - Fee Related DE69620539T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP30068295A JP3745805B2 (ja) 1995-10-24 1995-10-24 トロンボモジュリンの精製方法

Publications (2)

Publication Number Publication Date
DE69620539D1 true DE69620539D1 (de) 2002-05-16
DE69620539T2 DE69620539T2 (de) 2002-08-08

Family

ID=17887810

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69620539T Expired - Fee Related DE69620539T2 (de) 1995-10-24 1996-10-24 Verfahren zur Reinigung von Thrombomodulin

Country Status (7)

Country Link
US (1) US5753123A (de)
EP (1) EP0770626B1 (de)
JP (1) JP3745805B2 (de)
CN (1) CN1151406A (de)
AT (1) ATE215968T1 (de)
DE (1) DE69620539T2 (de)
TW (1) TW408129B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008503725A (ja) * 2004-06-16 2008-02-07 バイオ−ラッド・ラボラトリーズ・インコーポレーテッド マルチケミストリ分画
BRPI0519626A2 (pt) 2004-12-23 2009-02-25 Novo Nordisk Healthcare Ag mÉtodos para a reduÇço do teor de um ou mais contaminantes, do teor de proteÍna s em uma composiÇço, do teor de um ou mais contaminantes de proteÍna em um sobrenadante de cultura de cÉlula, do teor de proteÍna s em um sobrenadante de cultura de cÉlula, composiÇço compreendendo uma proteÍna dependente de vitamina k de interesse
WO2008044631A1 (fr) 2006-10-06 2008-04-17 Asahi Kasei Pharma Corporation Agent thérapeutique et/ou améliorant pour la coagulation intravasculaire disséminée
SG184699A1 (en) * 2007-03-23 2012-10-30 Asahi Kasei Pharma Corp Method for producing high-purity soluble thrombomodulin
EP2565269B1 (de) * 2010-04-30 2016-11-16 Asahi Kasei Pharma Corporation Verfahren zur herstellung von hochreinem löslichen thrombomodulin
CN103974710B (zh) * 2011-11-15 2016-07-06 旭化成制药株式会社 用于败血症的治疗和/或改善的药物
NZ702242A (en) 2012-05-31 2016-03-31 Asahi Kasei Pharma Corp Agent for prophylactic and/or therapeutic treatment of peripheral neuropathic pain caused by anticancer agent
CN107987157A (zh) * 2017-12-19 2018-05-04 江苏艾迪药业有限公司 一种可工业化生产的人来源血凝调节蛋白的制备方法
JP7245844B2 (ja) 2018-09-28 2023-03-24 旭化成ファーマ株式会社 抗悪性腫瘍剤による末梢神経障害の症状軽減及び／又は発症抑制のための医薬
EP3871684B1 (de) 2018-10-22 2024-06-26 Asahi Kasei Pharma Corporation Arzneimittel zur behandlung und/oder verbesserung der septikämie in zusammenhang mit einer gerinnungsstörung

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USH1148H (en) * 1987-04-17 1993-03-02 Method of separating activated human protein C
US5202421A (en) * 1988-12-27 1993-04-13 Mochida Pharmaceutical Co., Ltd. Anticoagulant substance obtained from urine and process for the preparation thereof
FR2658517B2 (fr) * 1989-04-12 1992-06-19 Fondation Nale Transfusion San Preparation de la proteine c activee et solution de proteine c activee ainsi obtenue.
GB9007657D0 (en) * 1990-04-04 1990-05-30 Connaught Lab Purification of a pertussis outer membrane protein(omp69)
US5378816A (en) * 1992-12-16 1995-01-03 Berlex Laboratories, Inc. Methods for high purity chromatographic separation of proteins having EGF-like binding domains

Also Published As

Publication number Publication date
DE69620539T2 (de) 2002-08-08
US5753123A (en) 1998-05-19
EP0770626A3 (de) 1998-04-08
EP0770626B1 (de) 2002-04-10
JP3745805B2 (ja) 2006-02-15
EP0770626A2 (de) 1997-05-02
ATE215968T1 (de) 2002-04-15
TW408129B (en) 2000-10-11
JPH09110900A (ja) 1997-04-28
CN1151406A (zh) 1997-06-11

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee