DE69933046D1 - Reinigung von echinocandin cyclopeptiden - Google Patents

Reinigung von echinocandin cyclopeptiden

Info

Publication number
DE69933046D1
DE69933046D1 DE69933046T DE69933046T DE69933046D1 DE 69933046 D1 DE69933046 D1 DE 69933046D1 DE 69933046 T DE69933046 T DE 69933046T DE 69933046 T DE69933046 T DE 69933046T DE 69933046 D1 DE69933046 D1 DE 69933046D1
Authority
DE
Germany
Prior art keywords
acetic acid
fermentation
products
echinocandin
cyclopeptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69933046T
Other languages
English (en)
Other versions
DE69933046T2 (de
Inventor
Robert Dobbins
Paul Kroeff
Thomas Vicenzi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of DE69933046D1 publication Critical patent/DE69933046D1/de
Publication of DE69933046T2 publication Critical patent/DE69933046T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE69933046T 1998-12-09 1999-12-08 Reinigung von echinocandin cyclopeptiden Expired - Fee Related DE69933046T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11152498P 1998-12-09 1998-12-09
US111524P 1998-12-09
PCT/US1999/029008 WO2000034315A2 (en) 1998-12-09 1999-12-08 Purification of echinocandin cyclopeptide compounds

Publications (2)

Publication Number Publication Date
DE69933046D1 true DE69933046D1 (de) 2006-10-12
DE69933046T2 DE69933046T2 (de) 2007-09-13

Family

ID=22339024

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69933046T Expired - Fee Related DE69933046T2 (de) 1998-12-09 1999-12-08 Reinigung von echinocandin cyclopeptiden

Country Status (17)

Country Link
US (1) US6506726B1 (de)
EP (1) EP1137663B1 (de)
JP (1) JP2003511345A (de)
KR (1) KR20010101151A (de)
CN (1) CN1337968A (de)
AT (1) ATE338059T1 (de)
AU (1) AU766091B2 (de)
BR (1) BR9916101A (de)
CA (1) CA2353930A1 (de)
DE (1) DE69933046T2 (de)
DK (1) DK1137663T3 (de)
ES (1) ES2272096T3 (de)
IL (1) IL143563A0 (de)
PT (1) PT1137663E (de)
RU (1) RU2001118849A (de)
WO (1) WO2000034315A2 (de)
ZA (1) ZA200104621B (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6743777B1 (en) * 1992-03-19 2004-06-01 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
DK1155034T3 (da) 1999-03-03 2007-01-08 Lilly Co Eli Dannelse og anionbytning af indre krystallinske echinocandin B-ammoniumsalte
IL145188A0 (en) 1999-03-03 2002-06-30 Lilly Co Eli Processes for making pharmaceutical oral ecb formulations and compositions
PT1157030E (pt) * 1999-03-03 2004-01-30 Lilly Co Eli Complexos equinocandina/hidrato de carbono
ES2433678T3 (es) 1999-03-03 2013-12-12 Eli Lilly & Company Formulaciones farmacéuticas de equinocandina que contienen tensioactivos formadores de micelas
US6991800B2 (en) * 2002-06-13 2006-01-31 Vicuron Pharmaceuticals Inc. Antifungal parenteral products
CN101005859B (zh) * 2004-06-29 2012-08-15 利莱恩斯生命科学有限公司 灭病毒生物液体的制备方法
DE102004060750A1 (de) * 2004-12-15 2006-07-13 Sanofi-Aventis Deutschland Gmbh Verfahren zur Deacylierung von Lipopeptiden
TW200826957A (en) * 2006-10-16 2008-07-01 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Purification processes for echinocandin-type compounds
US9394340B2 (en) 2009-03-24 2016-07-19 Cadila Healthcare Limited Purification process for lipopeptides
CN102219832B (zh) 2010-04-15 2013-08-21 上海天伟生物制药有限公司 一种氮杂环六肽或其盐的纯化方法
CN102336817B (zh) * 2010-07-16 2016-06-15 浙江震元制药有限公司 棘球白素b母核的分离方法
KR101514903B1 (ko) 2010-09-29 2015-04-23 샹하이 테크웰 바이오파마슈티컬 컴퍼니, 리미티드 사이클릭 리포펩타이드 화합물 또는 그의 염의 정제방법
WO2012041220A1 (zh) * 2010-09-30 2012-04-05 上海天伟生物制药有限公司 一种环脂肽化合物或其盐的纯化方法
CN102153616A (zh) * 2010-12-27 2011-08-17 浙江海正药业股份有限公司 一种环己肽类化合物及其盐的分离纯化方法
CA2865791C (en) 2011-03-03 2019-10-08 Cidara Therapeutics, Inc. Antifungal agents and uses thereof
HUE027806T2 (en) * 2011-04-20 2016-11-28 Xellia Pharmaceuticals Aps A method for purifying micafungin
CN102952178B (zh) * 2011-08-24 2016-04-27 华北制药集团新药研究开发有限责任公司 一种高纯度棘白霉素类化合物的制备方法
KR102236462B1 (ko) 2012-03-19 2021-04-08 시다라 세라퓨틱스, 인코포레이티드 에키노칸딘 계열의 화합물에 대한 투여 용법
CN103483427A (zh) * 2012-06-09 2014-01-01 浙江海正药业股份有限公司 一种棘白菌素类化合物的纯化方法
CN103910783B (zh) * 2014-04-23 2016-07-06 华北制药集团新药研究开发有限责任公司 一种高纯度棘白霉素b母核的制备方法
PL3058958T3 (pl) 2015-02-23 2019-02-28 Selectchemie Ag Kompozycja anidulafunginy
EP3399995A4 (de) 2016-01-08 2019-08-21 Cidara Therapeutics, Inc. Verfahren zur vorbeugung und behandlung von pneumocystis-infektionen
EP3430400B1 (de) 2016-03-16 2023-06-21 Cidara Therapeutics, Inc. Dosierpläne zur behandlung von pilzinfektionen
CN106248857A (zh) * 2016-07-15 2016-12-21 广西医科大学 利用薄层层析快速检测植物环肽的方法
US11197909B2 (en) 2017-07-12 2021-12-14 Cidara Therapeutics, Inc. Compositions and methods for the treatment of fungal infections

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4293482A (en) 1979-12-13 1981-10-06 Eli Lilly And Company A-30912A Nucleus
US4320052A (en) 1979-12-13 1982-03-16 Eli Lilly And Company Derivatives of A-30912A nucleus
US4293489A (en) 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912A nucleus
US4304716A (en) 1979-12-13 1981-12-08 Eli Lilly And Company S 31794/F-1 Nucleus
US4874843A (en) 1987-12-03 1989-10-17 Eli Lilly And Company Chromatographic purification process
EP0294990A3 (de) * 1987-06-10 1990-05-09 Eli Lilly And Company Chromatographisches Reinigungsverfahren
US5166135A (en) 1988-09-12 1992-11-24 Merck & Company, Inc. Method for the control of pneumocystis carinii
DK173802B1 (da) 1988-09-12 2001-11-05 Merck & Co Inc Præparat til behandling af Pneumocystis carinii infeksioner og anvendelse af et cyclohexapeptid til fremstilling af et lægemiddel mod Pneumocystis carinii infektioner
US5310726A (en) 1990-03-19 1994-05-10 Merck & Co., Inc. Lipopeptide compounds
DE69121018T2 (de) 1990-06-07 1996-12-19 Lilly Co Eli Lipopeptid Deacylase
IL98506A (en) 1990-06-18 1996-09-12 Fujisawa Pharmaceutical Co Peptides, of antibiotics, processes for their preparation and pharmaceutical preparations containing them
US5965525A (en) 1992-03-19 1999-10-12 Eli Lilly And Company Cyclic peptide antifungal agents
NZ512085A (en) 1992-03-19 2003-08-29 Lilly Co Eli Methods employing cyclic peptide antifungal agents
US5541160A (en) 1994-04-04 1996-07-30 Merck & Co., Inc. Antifungal and anti-pneumocystis compounds, compositions containing such compounds, and methods of use
US5646111A (en) 1995-04-07 1997-07-08 Eli Lilly And Company Cyclic peptide antifungal Agents
US5618787A (en) 1995-05-26 1997-04-08 Eli Lilly And Company Cyclic peptide antifungal agents
US5786325A (en) 1995-05-26 1998-07-28 Eli Lilly And Company Cyclic peptide antifungal agents and methods of making and using
US5652213A (en) 1995-05-26 1997-07-29 Eli Lilly And Company Cyclic peptide antifungal agents
US5629290A (en) 1995-05-26 1997-05-13 Eli Lilly And Company Cyclic peptide antifungal agents
US5629289A (en) 1995-07-25 1997-05-13 Eli Lilly And Company Cyclic peptide antifungal agents
WO1997027864A1 (en) 1996-02-01 1997-08-07 Eli Lilly And Company Cyclic peptide antifungal agents
US5696084A (en) 1996-08-16 1997-12-09 Abbott Laboratories Amino-lipopetide antifungal agents
CA2301184A1 (en) 1997-08-04 1999-02-11 Eli Lilly And Company Cyclic peptide antifungal agents
EP0931834A3 (de) 1997-12-23 2002-06-26 Eli Lilly And Company Echinocandin-bindungsdomäne von 1,3-Beta-glukan Synthase
US6323176B1 (en) 1998-02-25 2001-11-27 Eli Lilly And Company Cyclic peptide antifungal agents
WO2000011023A2 (en) 1998-08-20 2000-03-02 Eli Lilly And Company Ring modified cyclic peptide analogs
CA2340647A1 (en) 1998-08-28 2000-03-09 Eli Lilly And Company Reversible boronate complexes of 1,2-cis-diol cyclic-peptides
AU1517900A (en) 1998-10-28 2000-05-15 Eli Lilly And Company Photochemical process for making 1-deoxy-2-keto derivatives
CA2354056A1 (en) 1998-12-16 2000-06-22 James Andrew Jamison Cyclic peptide antifungal agents
JP2002532513A (ja) 1998-12-16 2002-10-02 イーライ リリー アンド カンパニー 糖置換基を有する環式ペプチド抗真菌剤
DK1155034T3 (da) 1999-03-03 2007-01-08 Lilly Co Eli Dannelse og anionbytning af indre krystallinske echinocandin B-ammoniumsalte
IL145188A0 (en) 1999-03-03 2002-06-30 Lilly Co Eli Processes for making pharmaceutical oral ecb formulations and compositions
PT1157030E (pt) 1999-03-03 2004-01-30 Lilly Co Eli Complexos equinocandina/hidrato de carbono
ES2433678T3 (es) 1999-03-03 2013-12-12 Eli Lilly & Company Formulaciones farmacéuticas de equinocandina que contienen tensioactivos formadores de micelas

Also Published As

Publication number Publication date
ES2272096T3 (es) 2007-04-16
PT1137663E (pt) 2006-12-29
ATE338059T1 (de) 2006-09-15
DE69933046T2 (de) 2007-09-13
CA2353930A1 (en) 2000-06-15
EP1137663B1 (de) 2006-08-30
RU2001118849A (ru) 2003-08-10
AU766091B2 (en) 2003-10-09
WO2000034315A8 (en) 2000-10-26
AU3113200A (en) 2000-06-26
WO2000034315A3 (en) 2000-12-28
US6506726B1 (en) 2003-01-14
JP2003511345A (ja) 2003-03-25
IL143563A0 (en) 2002-04-21
EP1137663A2 (de) 2001-10-04
ZA200104621B (en) 2002-06-06
BR9916101A (pt) 2002-06-04
KR20010101151A (ko) 2001-11-14
CN1337968A (zh) 2002-02-27
DK1137663T3 (da) 2007-01-08
WO2000034315A2 (en) 2000-06-15

Similar Documents

Publication Publication Date Title
DE69933046D1 (de) Reinigung von echinocandin cyclopeptiden
Razafindralambo et al. Purification of antifungal lipopeptides by reversed-phase high-performance liquid chromatography
JP2563726B2 (ja) 本質的に純粋なヒト副甲状腺ホルモン
MX9707909A (es) Purificacion de anticuerpos.
ATE249244T1 (de) Aktivierte verbindungen und verfahren zur herstellung und reiningung
RU2037500C1 (ru) Способ очистки инсулина и/или его производных
SE8402861L (sv) Rening av biologiskt material
Hearn et al. Application of Reversed Phase High Performance Liquid Chromatography in Solid Phase Peptide Synthesis: High Pressure Liquid Chromatography of Amino Acids Peptides and Proteins XIII. Part XII Ref. 2
WO2004026891A3 (en) Protein purification
Bishop et al. High-performance liquid chromatography of amino acids, peptides and proteins: XXI. The application of preparative reversed-phase high-performance liquid chromatography for the purification of a synthetic underivatised peptide
DE69533108D1 (de) Antibiotische cryptdin-peptide und verfahren zur ihrer verwendung
CA2306447A1 (en) Purification of molecules
CA2213577A1 (en) A process for the preparation of factor ix from biological sources
AU4263493A (en) Method for purifying an aqueous solution of raw albumin
DE69408631T2 (de) Verfahren zur reinigung eines hydrophoben polypeptides
ES2126775T3 (es) Procedimiento cromatografico de desplazamiento y producto de hemoglobina purificada.
Bishop et al. The Preparative Separation of Synthetic Peptides on Reversed-Phase Silica Packed in Radially Compressed Flexible-Walled Columns.+
BENSON et al. Isolation and structure elucidation of bovine pineal arginine vasopressin: arginine vasotocin not identified
Dillon et al. HETEROGENEITY OF INSULIN: I. ISOLATION OF A CHROMATOGRAPHICALLY PURIFIED, HIGH-POTENCY INSULIN AND SOME OF ITS PROPERTIES
BR9813522A (pt) Processos para separar e purificar apm e metil éster de n-[n-(3,3-dimetilbutil)-l-alfa-aspartil]-l-fenilalanina e para a produção do derivado de apm, apm ou derivado de apm, e, adoçante
Syu Jr et al. Purification of papain by affinity chromatography
SU767121A1 (ru) Способ выделени и очистки трипсина и химотрипсина
Pedroso et al. Reversed-phase high-performance liquid chromatography of protected peptide segments
Chang et al. Rapid purification of arrowhead proteinase inhibitors by high performance hydrophobic interaction chromatography on a PEG bonded phase column
JPH02222680A (ja) ウシトリプシンの分離精製法

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee