JP2003511345A - Ｅｃｈｉｎｏｃａｎｄｉｎシクロペプチド化合物の精製 - Google Patents

Ｅｃｈｉｎｏｃａｎｄｉｎシクロペプチド化合物の精製

Info

Publication number
JP2003511345A
JP2003511345A JP2000586757A JP2000586757A JP2003511345A JP 2003511345 A JP2003511345 A JP 2003511345A JP 2000586757 A JP2000586757 A JP 2000586757A JP 2000586757 A JP2000586757 A JP 2000586757A JP 2003511345 A JP2003511345 A JP 2003511345A
Authority
JP
Japan
Prior art keywords
acetic acid
group
product
mixture
column
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
JP2000586757A
Other languages
English (en)
Japanese (ja)
Other versions
JP2003511345A5 (https=
Inventor
ジョン ロバート ドビンズ，
ヨージェン ポール クロエフ，
ジェフレイ トーマス ヴィチェンツィ，
Original Assignee
イーライ リリー アンド カンパニー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by イーライ リリー アンド カンパニー filed Critical イーライ リリー アンド カンパニー
Publication of JP2003511345A publication Critical patent/JP2003511345A/ja
Publication of JP2003511345A5 publication Critical patent/JP2003511345A5/ja
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2000586757A 1998-12-09 1999-12-08 Ｅｃｈｉｎｏｃａｎｄｉｎシクロペプチド化合物の精製 Abandoned JP2003511345A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11152498P 1998-12-09 1998-12-09
US60/111,524 1998-12-09
PCT/US1999/029008 WO2000034315A2 (en) 1998-12-09 1999-12-08 Purification of echinocandin cyclopeptide compounds

Publications (2)

Publication Number Publication Date
JP2003511345A true JP2003511345A (ja) 2003-03-25
JP2003511345A5 JP2003511345A5 (https=) 2006-01-05

Family

ID=22339024

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000586757A Abandoned JP2003511345A (ja) 1998-12-09 1999-12-08 Ｅｃｈｉｎｏｃａｎｄｉｎシクロペプチド化合物の精製

Country Status (17)

Country Link
US (1) US6506726B1 (https=)
EP (1) EP1137663B1 (https=)
JP (1) JP2003511345A (https=)
KR (1) KR20010101151A (https=)
CN (1) CN1337968A (https=)
AT (1) ATE338059T1 (https=)
AU (1) AU766091B2 (https=)
BR (1) BR9916101A (https=)
CA (1) CA2353930A1 (https=)
DE (1) DE69933046T2 (https=)
DK (1) DK1137663T3 (https=)
ES (1) ES2272096T3 (https=)
IL (1) IL143563A0 (https=)
PT (1) PT1137663E (https=)
RU (1) RU2001118849A (https=)
WO (1) WO2000034315A2 (https=)
ZA (1) ZA200104621B (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008505065A (ja) * 2004-06-29 2008-02-21 リライアンス ライフ サイエンシーズ ピーヴィーティー エルティーディー ウイルス安全性生物学的流体の調製のための方法
JP2009519245A (ja) * 2006-10-16 2009-05-14 テバ ジョジセルジャール ザ−トケルエン ムケド レ−スベニュタ−ルシャシャ−グ エキノカンジン型化合物の精製方法
JP2013538833A (ja) * 2010-09-30 2013-10-17 上海天偉生物制薬有限公司 環状リポペプチド化合物又はその塩の精製方法
JP2013538832A (ja) * 2010-09-29 2013-10-17 上海天偉生物制薬有限公司 環状リポペプチド化合物又はその塩の精製方法

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6743777B1 (en) * 1992-03-19 2004-06-01 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
KR20020003864A (ko) * 1999-03-03 2002-01-15 피터 지. 스트링거 에키노칸딘/탄수화물 착물
AU767956B2 (en) 1999-03-03 2003-11-27 Eli Lilly And Company Formation and anion-exchange of crystalline echinocandin ammonium salts
EP1582204B1 (en) * 1999-03-03 2013-09-25 Eli Lilly & Company Echinocandin pharmaceutical formulations containing micelle-forming surfactants
WO2000051567A1 (en) 1999-03-03 2000-09-08 Eli Lilly And Company Processes for making pharmaceutical oral ecb formulations and compositions
US6991800B2 (en) * 2002-06-13 2006-01-31 Vicuron Pharmaceuticals Inc. Antifungal parenteral products
DE102004060750A1 (de) * 2004-12-15 2006-07-13 Sanofi-Aventis Deutschland Gmbh Verfahren zur Deacylierung von Lipopeptiden
US9394340B2 (en) 2009-03-24 2016-07-19 Cadila Healthcare Limited Purification process for lipopeptides
CN102219832B (zh) * 2010-04-15 2013-08-21 上海天伟生物制药有限公司 一种氮杂环六肽或其盐的纯化方法
CN102336817B (zh) * 2010-07-16 2016-06-15 浙江震元制药有限公司 棘球白素b母核的分离方法
CN102153616A (zh) * 2010-12-27 2011-08-17 浙江海正药业股份有限公司 一种环己肽类化合物及其盐的分离纯化方法
ES2645074T3 (es) 2011-03-03 2017-12-04 Cidara Therapeutics, Inc. Agentes antifúngicos y sus usos
BR112013026420A2 (pt) * 2011-04-20 2020-11-03 Xellia Pharmaceuticals Aps método de produção de um sal de micafungina farmaceuticamente aceitável
CN102952178B (zh) * 2011-08-24 2016-04-27 华北制药集团新药研究开发有限责任公司 一种高纯度棘白霉素类化合物的制备方法
RU2639483C2 (ru) 2012-03-19 2017-12-21 Сидара Терапьютикс, Инк. Режимы дозирования для соединений класса эхинокандинов
CN103483427A (zh) * 2012-06-09 2014-01-01 浙江海正药业股份有限公司 一种棘白菌素类化合物的纯化方法
CN103910783B (zh) * 2014-04-23 2016-07-06 华北制药集团新药研究开发有限责任公司 一种高纯度棘白霉素b母核的制备方法
ES2694561T3 (es) 2015-02-23 2018-12-21 Selectchemie Ag Composición de anidulafungina
CN108883152A (zh) 2016-01-08 2018-11-23 奇达拉治疗公司 防止和治疗肺孢子虫感染的方法
WO2017161016A1 (en) 2016-03-16 2017-09-21 Cidara Therapeutics, Inc. Dosing regimens for treatment of fungal infections
CN106248857A (zh) * 2016-07-15 2016-12-21 广西医科大学 利用薄层层析快速检测植物环肽的方法
US11197909B2 (en) 2017-07-12 2021-12-14 Cidara Therapeutics, Inc. Compositions and methods for the treatment of fungal infections

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4320052A (en) 1979-12-13 1982-03-16 Eli Lilly And Company Derivatives of A-30912A nucleus
US4293489A (en) 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912A nucleus
US4304716A (en) 1979-12-13 1981-12-08 Eli Lilly And Company S 31794/F-1 Nucleus
US4293482A (en) 1979-12-13 1981-10-06 Eli Lilly And Company A-30912A Nucleus
US4874843A (en) 1987-12-03 1989-10-17 Eli Lilly And Company Chromatographic purification process
EP0294990A3 (en) * 1987-06-10 1990-05-09 Eli Lilly And Company Chromatographic purification process
US5166135A (en) 1988-09-12 1992-11-24 Merck & Company, Inc. Method for the control of pneumocystis carinii
DK173802B1 (da) 1988-09-12 2001-11-05 Merck & Co Inc Præparat til behandling af Pneumocystis carinii infeksioner og anvendelse af et cyclohexapeptid til fremstilling af et lægemiddel mod Pneumocystis carinii infektioner
US5310726A (en) 1990-03-19 1994-05-10 Merck & Co., Inc. Lipopeptide compounds
ES2089133T3 (es) 1990-06-07 1996-10-01 Lilly Co Eli Desacilasa de lipopeptidos.
IE990233A1 (en) 1990-06-18 2000-11-15 Fujisawa Pharmaceutical Co New Polypeptide Compound and a Process for Preparation thereof
US5965525A (en) 1992-03-19 1999-10-12 Eli Lilly And Company Cyclic peptide antifungal agents
NZ247149A (en) 1992-03-19 1996-10-28 Lilly Co Eli Cyclic peptide antifungal agents and compositions thereof
US5541160A (en) 1994-04-04 1996-07-30 Merck & Co., Inc. Antifungal and anti-pneumocystis compounds, compositions containing such compounds, and methods of use
US5646111A (en) 1995-04-07 1997-07-08 Eli Lilly And Company Cyclic peptide antifungal Agents
US5652213A (en) 1995-05-26 1997-07-29 Eli Lilly And Company Cyclic peptide antifungal agents
US5629290A (en) 1995-05-26 1997-05-13 Eli Lilly And Company Cyclic peptide antifungal agents
US5618787A (en) 1995-05-26 1997-04-08 Eli Lilly And Company Cyclic peptide antifungal agents
US5786325A (en) 1995-05-26 1998-07-28 Eli Lilly And Company Cyclic peptide antifungal agents and methods of making and using
US5629289A (en) 1995-07-25 1997-05-13 Eli Lilly And Company Cyclic peptide antifungal agents
WO1997027864A1 (en) 1996-02-01 1997-08-07 Eli Lilly And Company Cyclic peptide antifungal agents
US5696084A (en) 1996-08-16 1997-12-09 Abbott Laboratories Amino-lipopetide antifungal agents
WO1999006062A1 (en) 1997-08-04 1999-02-11 Eli Lilly And Company Cyclic peptide antifungal agents
CA2255140A1 (en) 1997-12-23 1999-06-23 Eli Lilly And Company Echinocandin binding domain of 1,3-.beta.-glucan synthase
US6323176B1 (en) 1998-02-25 2001-11-27 Eli Lilly And Company Cyclic peptide antifungal agents
ES2233070T3 (es) 1998-08-20 2005-06-01 ELI LILLY & COMPANY Sintesis de analogos peptidicos ciclicos modificados en el anillo.
WO2000012540A1 (en) 1998-08-28 2000-03-09 Eli Lilly And Company Reversible boronate complexes of 1,2-cis-diol cyclic-peptides
AU1517900A (en) 1998-10-28 2000-05-15 Eli Lilly And Company Photochemical process for making 1-deoxy-2-keto derivatives
JP2002532513A (ja) 1998-12-16 2002-10-02 イーライ リリー アンド カンパニー 糖置換基を有する環式ペプチド抗真菌剤
AU767357B2 (en) 1998-12-16 2003-11-06 Eli Lilly And Company Cyclic peptide antifungal agents
AU767956B2 (en) 1999-03-03 2003-11-27 Eli Lilly And Company Formation and anion-exchange of crystalline echinocandin ammonium salts
WO2000051567A1 (en) 1999-03-03 2000-09-08 Eli Lilly And Company Processes for making pharmaceutical oral ecb formulations and compositions
KR20020003864A (ko) 1999-03-03 2002-01-15 피터 지. 스트링거 에키노칸딘/탄수화물 착물
EP1582204B1 (en) 1999-03-03 2013-09-25 Eli Lilly & Company Echinocandin pharmaceutical formulations containing micelle-forming surfactants

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008505065A (ja) * 2004-06-29 2008-02-21 リライアンス ライフ サイエンシーズ ピーヴィーティー エルティーディー ウイルス安全性生物学的流体の調製のための方法
JP2009519245A (ja) * 2006-10-16 2009-05-14 テバ ジョジセルジャール ザ−トケルエン ムケド レ−スベニュタ−ルシャシャ−グ エキノカンジン型化合物の精製方法
JP2013538832A (ja) * 2010-09-29 2013-10-17 上海天偉生物制薬有限公司 環状リポペプチド化合物又はその塩の精製方法
JP2013538833A (ja) * 2010-09-30 2013-10-17 上海天偉生物制薬有限公司 環状リポペプチド化合物又はその塩の精製方法

Also Published As

Publication number Publication date
WO2000034315A3 (en) 2000-12-28
BR9916101A (pt) 2002-06-04
DE69933046T2 (de) 2007-09-13
PT1137663E (pt) 2006-12-29
ES2272096T3 (es) 2007-04-16
WO2000034315A8 (en) 2000-10-26
EP1137663A2 (en) 2001-10-04
RU2001118849A (ru) 2003-08-10
AU3113200A (en) 2000-06-26
CA2353930A1 (en) 2000-06-15
EP1137663B1 (en) 2006-08-30
KR20010101151A (ko) 2001-11-14
ZA200104621B (en) 2002-06-06
IL143563A0 (en) 2002-04-21
ATE338059T1 (de) 2006-09-15
AU766091B2 (en) 2003-10-09
DK1137663T3 (da) 2007-01-08
WO2000034315A2 (en) 2000-06-15
US6506726B1 (en) 2003-01-14
CN1337968A (zh) 2002-02-27
DE69933046D1 (de) 2006-10-12

Similar Documents

Publication Publication Date Title
JP2003511345A (ja) Ｅｃｈｉｎｏｃａｎｄｉｎシクロペプチド化合物の精製
JP4063497B2 (ja) エキノカンジンアンモニウム塩結晶の形成およびアニオン交換
CA1315229C (en) Chromatographic purification process
JP5882219B2 (ja) コリスチンの精製方法および精製コリスチン成分
CN101305018B (zh) 合成卡泊芬净的方法和中间体
KR101479389B1 (ko) 아자시클로헥사펩타이드 또는 그 염의 정제방법
CN102947327B (zh) 卡泊芬净中间体的纯化
US4874843A (en) Chromatographic purification process
JPS6038389A (ja) 精製したバンコマイシン群抗生物質の製法
AU613640B2 (en) Chromatographic purification process
AU2004200026A1 (en) Purification of echinocandin cyclopeptide compounds
MXPA01005688A (en) Purification of echinocandin cyclopeptide compounds
MXPA01008787A (en) Formation and anion-exchange of crystalline echinocandin ammonium salts
AU2004200741A1 (en) Formation and anion-exchange of crystalline echinocandin ammonium salts
JPS6052753B2 (ja) ７−アミノセフエム化合物の精製法

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20050204

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20050822

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20060612

RD02 Notification of acceptance of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7422

Effective date: 20060612

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20060613

A762 Written abandonment of application

Free format text: JAPANESE INTERMEDIATE CODE: A762

Effective date: 20080407