CN1337968A - 蓝刺菌素环肽化合物的纯化 - Google Patents

蓝刺菌素环肽化合物的纯化 Download PDF

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Publication number
CN1337968A
CN1337968A CN99815515A CN99815515A CN1337968A CN 1337968 A CN1337968 A CN 1337968A CN 99815515 A CN99815515 A CN 99815515A CN 99815515 A CN99815515 A CN 99815515A CN 1337968 A CN1337968 A CN 1337968A
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CN
China
Prior art keywords
product
mixture
ecbn
hydrogen
iii
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN99815515A
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English (en)
Chinese (zh)
Inventor
J·R·杜宾斯
E·P·克罗夫
J·T·维森吉
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
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Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of CN1337968A publication Critical patent/CN1337968A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN99815515A 1998-12-09 1999-12-08 蓝刺菌素环肽化合物的纯化 Pending CN1337968A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11152498P 1998-12-09 1998-12-09
US60/111,524 1998-12-09

Publications (1)

Publication Number Publication Date
CN1337968A true CN1337968A (zh) 2002-02-27

Family

ID=22339024

Family Applications (1)

Application Number Title Priority Date Filing Date
CN99815515A Pending CN1337968A (zh) 1998-12-09 1999-12-08 蓝刺菌素环肽化合物的纯化

Country Status (17)

Country Link
US (1) US6506726B1 (https=)
EP (1) EP1137663B1 (https=)
JP (1) JP2003511345A (https=)
KR (1) KR20010101151A (https=)
CN (1) CN1337968A (https=)
AT (1) ATE338059T1 (https=)
AU (1) AU766091B2 (https=)
BR (1) BR9916101A (https=)
CA (1) CA2353930A1 (https=)
DE (1) DE69933046T2 (https=)
DK (1) DK1137663T3 (https=)
ES (1) ES2272096T3 (https=)
IL (1) IL143563A0 (https=)
PT (1) PT1137663E (https=)
RU (1) RU2001118849A (https=)
WO (1) WO2000034315A2 (https=)
ZA (1) ZA200104621B (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102153616A (zh) * 2010-12-27 2011-08-17 浙江海正药业股份有限公司 一种环己肽类化合物及其盐的分离纯化方法
CN103483427A (zh) * 2012-06-09 2014-01-01 浙江海正药业股份有限公司 一种棘白菌素类化合物的纯化方法
CN103533995A (zh) * 2011-04-20 2014-01-22 赛利亚医药公司 提纯米卡芬净的方法

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US6743777B1 (en) * 1992-03-19 2004-06-01 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
HK1040062A1 (zh) * 1999-03-03 2002-05-24 Eli Lilly And Company 含有成胶束表面活性剂的棘白菌素药物配方
ATE248187T1 (de) 1999-03-03 2003-09-15 Lilly Co Eli Echinocandin-kohlenhydrate-komplexe
HK1040369A1 (zh) 1999-03-03 2002-06-07 Eli Lilly And Company 制备药物口服ecb配方和组合物的方法
AU767956B2 (en) 1999-03-03 2003-11-27 Eli Lilly And Company Formation and anion-exchange of crystalline echinocandin ammonium salts
US6991800B2 (en) * 2002-06-13 2006-01-31 Vicuron Pharmaceuticals Inc. Antifungal parenteral products
JP5112060B2 (ja) * 2004-06-29 2013-01-09 リライアンス ライフ サイエンシーズ プライベイト リミテッド ウイルス安全性生物学的流体の調製のための方法
DE102004060750A1 (de) 2004-12-15 2006-07-13 Sanofi-Aventis Deutschland Gmbh Verfahren zur Deacylierung von Lipopeptiden
TW200826957A (en) * 2006-10-16 2008-07-01 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Purification processes for echinocandin-type compounds
US9394340B2 (en) 2009-03-24 2016-07-19 Cadila Healthcare Limited Purification process for lipopeptides
CN102219832B (zh) 2010-04-15 2013-08-21 上海天伟生物制药有限公司 一种氮杂环六肽或其盐的纯化方法
CN102336817B (zh) * 2010-07-16 2016-06-15 浙江震元制药有限公司 棘球白素b母核的分离方法
ES2581562T3 (es) 2010-09-29 2016-09-06 Shanghai Techwell Biopharmaceutical Co., Ltd Procedimiento para purificar compuestos lipopeptídicos cíclicos o sales de los mismos
CN102443050B (zh) * 2010-09-30 2014-06-04 上海天伟生物制药有限公司 一种环脂肽化合物或其盐的纯化方法
WO2012119065A2 (en) 2011-03-03 2012-09-07 Seachaid Pharmaceuticals, Inc. Antifungal agents and uses thereof
CN102952178B (zh) * 2011-08-24 2016-04-27 华北制药集团新药研究开发有限责任公司 一种高纯度棘白霉素类化合物的制备方法
SI3677252T1 (sl) 2012-03-19 2024-02-29 Cidara Therapeutics, Inc. Sheme odmerjanja za spojine iz razreda ehinokandinov
CN103910783B (zh) * 2014-04-23 2016-07-06 华北制药集团新药研究开发有限责任公司 一种高纯度棘白霉素b母核的制备方法
PL3058958T3 (pl) 2015-02-23 2019-02-28 Selectchemie Ag Kompozycja anidulafunginy
CN108883152A (zh) 2016-01-08 2018-11-23 奇达拉治疗公司 防止和治疗肺孢子虫感染的方法
MA43825A (fr) 2016-03-16 2021-04-07 Cidara Therapeutics Inc Schémas posologiques pour le traitement d'infections fongiques
CN106248857A (zh) * 2016-07-15 2016-12-21 广西医科大学 利用薄层层析快速检测植物环肽的方法
JP7779651B2 (ja) 2017-07-12 2025-12-03 ナップ ファーマシューティカル グループ リミテッド 真菌感染症の処置のための組成物及び方法

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US4304716A (en) 1979-12-13 1981-12-08 Eli Lilly And Company S 31794/F-1 Nucleus
US4293489A (en) 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912A nucleus
US4320052A (en) 1979-12-13 1982-03-16 Eli Lilly And Company Derivatives of A-30912A nucleus
US4293482A (en) 1979-12-13 1981-10-06 Eli Lilly And Company A-30912A Nucleus
US4874843A (en) 1987-12-03 1989-10-17 Eli Lilly And Company Chromatographic purification process
EP0294990A3 (en) 1987-06-10 1990-05-09 Eli Lilly And Company Chromatographic purification process
US5166135A (en) 1988-09-12 1992-11-24 Merck & Company, Inc. Method for the control of pneumocystis carinii
DK173802B1 (da) 1988-09-12 2001-11-05 Merck & Co Inc Præparat til behandling af Pneumocystis carinii infeksioner og anvendelse af et cyclohexapeptid til fremstilling af et lægemiddel mod Pneumocystis carinii infektioner
US5310726A (en) 1990-03-19 1994-05-10 Merck & Co., Inc. Lipopeptide compounds
IL98349A (en) 1990-06-07 1995-05-26 Lilly Co Eli Diphylase lipopeptide
IL98506A (en) 1990-06-18 1996-09-12 Fujisawa Pharmaceutical Co Cyclic peptide antibiotics processes for the preparation thereof and pharmaceutical compositions containing them
US5965525A (en) 1992-03-19 1999-10-12 Eli Lilly And Company Cyclic peptide antifungal agents
MY136593A (en) 1992-03-19 2008-10-31 Lilly Co Eli Cyclic peptide antifungal agents and process for preparation thereof
US5541160A (en) 1994-04-04 1996-07-30 Merck & Co., Inc. Antifungal and anti-pneumocystis compounds, compositions containing such compounds, and methods of use
US5646111A (en) 1995-04-07 1997-07-08 Eli Lilly And Company Cyclic peptide antifungal Agents
US5618787A (en) 1995-05-26 1997-04-08 Eli Lilly And Company Cyclic peptide antifungal agents
US5786325A (en) 1995-05-26 1998-07-28 Eli Lilly And Company Cyclic peptide antifungal agents and methods of making and using
US5652213A (en) 1995-05-26 1997-07-29 Eli Lilly And Company Cyclic peptide antifungal agents
US5629290A (en) 1995-05-26 1997-05-13 Eli Lilly And Company Cyclic peptide antifungal agents
US5629289A (en) 1995-07-25 1997-05-13 Eli Lilly And Company Cyclic peptide antifungal agents
EP0881907A4 (en) 1996-02-01 2000-05-10 Lilly Co Eli FUNGICIDES IN THE FORM OF CYCLIC PEPTIDES
US5696084A (en) 1996-08-16 1997-12-09 Abbott Laboratories Amino-lipopetide antifungal agents
WO1999006062A1 (en) 1997-08-04 1999-02-11 Eli Lilly And Company Cyclic peptide antifungal agents
CA2255140A1 (en) 1997-12-23 1999-06-23 Eli Lilly And Company Echinocandin binding domain of 1,3-.beta.-glucan synthase
US6323176B1 (en) 1998-02-25 2001-11-27 Eli Lilly And Company Cyclic peptide antifungal agents
ATE287899T1 (de) 1998-08-20 2005-02-15 Lilly Co Eli Verfahren zur herstellung von ring-modifizierten zyklischen peptidanalogen
CA2340647A1 (en) 1998-08-28 2000-03-09 Eli Lilly And Company Reversible boronate complexes of 1,2-cis-diol cyclic-peptides
WO2000024694A1 (en) 1998-10-28 2000-05-04 Eli Lilly And Company Photochemical process for making 1-deoxy-2-keto derivatives
AU767357B2 (en) 1998-12-16 2003-11-06 Eli Lilly And Company Cyclic peptide antifungal agents
AU2189500A (en) 1998-12-16 2000-07-03 Eli Lilly And Company Cyclic peptide antifungal agents having a sugar substituent
HK1040369A1 (zh) 1999-03-03 2002-06-07 Eli Lilly And Company 制备药物口服ecb配方和组合物的方法
ATE248187T1 (de) 1999-03-03 2003-09-15 Lilly Co Eli Echinocandin-kohlenhydrate-komplexe
AU767956B2 (en) 1999-03-03 2003-11-27 Eli Lilly And Company Formation and anion-exchange of crystalline echinocandin ammonium salts
HK1040062A1 (zh) 1999-03-03 2002-05-24 Eli Lilly And Company 含有成胶束表面活性剂的棘白菌素药物配方

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102153616A (zh) * 2010-12-27 2011-08-17 浙江海正药业股份有限公司 一种环己肽类化合物及其盐的分离纯化方法
TWI488862B (zh) * 2010-12-27 2015-06-21 Shanghai Inst Pharm Industry Separation and Purification of Cyclohexyl Compounds and Their Salts
CN103533995A (zh) * 2011-04-20 2014-01-22 赛利亚医药公司 提纯米卡芬净的方法
CN103533995B (zh) * 2011-04-20 2016-03-02 赛利亚医药公司 提纯米卡芬净的方法
CN103483427A (zh) * 2012-06-09 2014-01-01 浙江海正药业股份有限公司 一种棘白菌素类化合物的纯化方法

Also Published As

Publication number Publication date
EP1137663B1 (en) 2006-08-30
ES2272096T3 (es) 2007-04-16
IL143563A0 (en) 2002-04-21
KR20010101151A (ko) 2001-11-14
RU2001118849A (ru) 2003-08-10
EP1137663A2 (en) 2001-10-04
BR9916101A (pt) 2002-06-04
US6506726B1 (en) 2003-01-14
ZA200104621B (en) 2002-06-06
DE69933046D1 (de) 2006-10-12
PT1137663E (pt) 2006-12-29
CA2353930A1 (en) 2000-06-15
WO2000034315A3 (en) 2000-12-28
WO2000034315A2 (en) 2000-06-15
AU3113200A (en) 2000-06-26
WO2000034315A8 (en) 2000-10-26
ATE338059T1 (de) 2006-09-15
DE69933046T2 (de) 2007-09-13
DK1137663T3 (da) 2007-01-08
JP2003511345A (ja) 2003-03-25
AU766091B2 (en) 2003-10-09

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