RS54234B2 - Indukujući agensi apoptoze za lečenje kancera i imunih i autoimunih oboljenja - Google Patents

Indukujući agensi apoptoze za lečenje kancera i imunih i autoimunih oboljenja

Info

Publication number
RS54234B2
RS54234B2 RS20150592A RSP20150592A RS54234B2 RS 54234 B2 RS54234 B2 RS 54234B2 RS 20150592 A RS20150592 A RS 20150592A RS P20150592 A RSP20150592 A RS P20150592A RS 54234 B2 RS54234 B2 RS 54234B2
Authority
RS
Serbia
Prior art keywords
apoptosis
immune
cancer
treatment
autoimmune diseases
Prior art date
Application number
RS20150592A
Other languages
English (en)
Inventor
Milan Bruncko
Hong Ding
George Doherty
Steven Elmore
Lisa Hasvold
Laura Hexamer
Aaron R Kunzer
Xiaohong Song
Andrew J Souers
Gerard Sullivan
Zhi-Fu Tao
Gary T Wang
Le Wang
Xilu Wang
Michael Wendt
Robert Mantei
Todd M Hansen
Original Assignee
Abbvie Ireland Unltd Companyc/O Conyers Corporate Services Bermuda Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42677657&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RS54234(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbvie Ireland Unltd Companyc/O Conyers Corporate Services Bermuda Ltd filed Critical Abbvie Ireland Unltd Companyc/O Conyers Corporate Services Bermuda Ltd
Publication of RS54234B1 publication Critical patent/RS54234B1/sr
Publication of RS54234B2 publication Critical patent/RS54234B2/sr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • C07D491/044Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
RS20150592A 2009-05-26 2010-05-26 Indukujući agensi apoptoze za lečenje kancera i imunih i autoimunih oboljenja RS54234B2 (sr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18120309P 2009-05-26 2009-05-26
PCT/US2010/036198 WO2010138588A2 (en) 2009-05-26 2010-05-26 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
EP10721246.6A EP2435432B3 (en) 2009-05-26 2010-05-26 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases

Publications (2)

Publication Number Publication Date
RS54234B1 RS54234B1 (sr) 2015-12-31
RS54234B2 true RS54234B2 (sr) 2024-02-29

Family

ID=42677657

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20150592A RS54234B2 (sr) 2009-05-26 2010-05-26 Indukujući agensi apoptoze za lečenje kancera i imunih i autoimunih oboljenja

Country Status (43)

Country Link
US (1) US8580794B2 (sr)
EP (4) EP4474383A3 (sr)
JP (8) JP5747025B2 (sr)
KR (8) KR101723378B1 (sr)
CN (5) CN109897038B (sr)
AR (2) AR076705A1 (sr)
AU (1) AU2010254160C1 (sr)
BR (2) BRPI1014359B1 (sr)
CA (4) CA3052016A1 (sr)
CL (1) CL2011002949A1 (sr)
CO (1) CO6480950A2 (sr)
CR (2) CR20170019A (sr)
CY (2) CY1117423T1 (sr)
DK (1) DK2435432T6 (sr)
DO (1) DOP2011000367A (sr)
EC (1) ECSP11011554A (sr)
ES (1) ES2546294T7 (sr)
FI (1) FI2435432T6 (sr)
HK (1) HK1215576A1 (sr)
HR (1) HRP20151001T4 (sr)
HU (2) HUE027698T2 (sr)
IL (6) IL319747A (sr)
LT (1) LTC2435432I2 (sr)
ME (1) ME02205B (sr)
MX (2) MX339469B (sr)
MY (1) MY155645A (sr)
NL (1) NL300873I2 (sr)
NO (1) NO2017023I2 (sr)
NZ (1) NZ595708A (sr)
PE (1) PE20120345A1 (sr)
PH (1) PH12015500297B1 (sr)
PL (1) PL2435432T6 (sr)
PT (1) PT2435432E (sr)
RS (1) RS54234B2 (sr)
RU (3) RU2573832C2 (sr)
SG (2) SG10201704742YA (sr)
SI (1) SI2435432T2 (sr)
SM (1) SMT201500225B (sr)
TW (3) TWI537269B (sr)
UA (1) UA106079C2 (sr)
UY (3) UY32668A (sr)
WO (1) WO2010138588A2 (sr)
ZA (1) ZA201108616B (sr)

Families Citing this family (114)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100160322A1 (en) 2008-12-04 2010-06-24 Abbott Laboratories Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US8557983B2 (en) 2008-12-04 2013-10-15 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US8563735B2 (en) 2008-12-05 2013-10-22 Abbvie Inc. Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
KR101692705B1 (ko) * 2008-12-05 2017-01-04 애브비 인코포레이티드 암 및 면역 질환의 치료를 위한 Bcl­2­선택적 아폽토시스-유도제로서의 설폰아미드 유도체
US8586754B2 (en) 2008-12-05 2013-11-19 Abbvie Inc. BCL-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
SG193849A1 (en) * 2009-01-19 2013-10-30 Abbott Lab Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US9034875B2 (en) 2009-05-26 2015-05-19 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
RU2573832C2 (ru) * 2009-05-26 2016-01-27 Эббви Бахамаз Лтд. Индуцирующие апоптоз средства для лечения злокачественной опухоли и иммунных и аутоиммунных заболеваний
US8546399B2 (en) 2009-05-26 2013-10-01 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
US20220315555A1 (en) 2009-05-26 2022-10-06 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
TWI520960B (zh) * 2010-05-26 2016-02-11 艾伯維有限公司 用於治療癌症及免疫及自體免疫疾病之細胞凋亡誘導劑
EP2575818A4 (en) 2010-06-03 2013-11-06 Pharmacyclics Inc USE OF BRUTON TYROSINE KINASE INHIBITORS (BTK)
TWI535712B (zh) 2010-08-06 2016-06-01 阿斯特捷利康公司 化合物
JP6068352B2 (ja) * 2010-10-29 2017-01-25 アッヴィ・インコーポレイテッド アポトーシス誘発剤を含む固体分散体
UA113500C2 (xx) 2010-10-29 2017-02-10 Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб
ES2701603T3 (es) 2010-11-23 2019-02-25 Abbvie Ireland Unlimited Co Métodos de tratamiento que utilizan inhibidores selectivos de Bcl-2
CN107266435A (zh) 2010-11-23 2017-10-20 Abbvie 公司 细胞凋亡诱导剂的盐和晶形
EP2675785B1 (en) 2011-02-15 2018-04-11 Ube Industries, Ltd. Industrial methods for producing arylsulfur pentafluorides
CN102241649A (zh) * 2011-07-08 2011-11-16 陈飞 3-四氢呋喃甲醇的制备方法
CN103958508B (zh) 2011-10-14 2019-02-12 艾伯维公司 用于治疗癌症以及免疫与自身免疫性疾病的细胞凋亡诱导剂
WO2013185202A1 (en) * 2012-06-14 2013-12-19 Beta Pharma Canada Inc Apoptosis inducers
EP3550031A1 (en) 2012-07-24 2019-10-09 Pharmacyclics, LLC Mutations associated with resistance to inhibitors of bruton's tyrosine kinase (btk)
CA2879332C (en) * 2012-08-13 2022-08-30 Abbvie Inc. 1,2,3,4- tetrahydroisoquinoline-8-carboxamide compounds and their use as apoptosis-inducing agents
MX2015002947A (es) 2012-09-07 2015-09-23 Genentech Inc Terapia de combinacion de un anticuerpo ant-cd20 tipo ii con un inhibidor blc-2 selectivo.
LT6064B (lt) 2012-10-15 2014-08-25 Vilniaus Universitetas Fluorinti benzensulfonamidai kaip karboanhidrazės inhibitoriai
US20150283142A1 (en) * 2013-03-15 2015-10-08 Infinity Pharmaceuticals, Inc. Treatment of cancers using pi3 kinase isoform modulators
PL2914296T5 (pl) 2012-11-01 2022-01-17 Infinity Pharmaceuticals, Inc. Leczenie nowotworu z zastosowaniem modulatorów izoform kinazy PI3
US9006438B2 (en) 2013-03-13 2015-04-14 Abbvie Inc. Processes for the preparation of an apoptosis-inducing agent
US20140275082A1 (en) 2013-03-14 2014-09-18 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
MX369503B (es) * 2013-04-08 2019-11-11 Pharmacyclics Llc Combinaciones que comprenden ibrutinib y abt-199 para tratar trastornos proliferativos de células b y métodos de uso de las mismas.
TWI594975B (zh) 2013-04-24 2017-08-11 第一三共股份有限公司 二羧酸化合物
US9238652B2 (en) 2014-03-04 2016-01-19 Abbvie Inc. Processes for the preparation of an apoptosis-inducing agent
WO2015171591A1 (en) 2014-05-05 2015-11-12 Board Of Trustees Of The University Of Arkansas COMPOSITIONS AND METHODS FOR INHIBITING ANTIAPOPTOTIC Bcl-2 PROTEINS AS ANTI-AGING AGENTS
CA2955972A1 (en) 2014-07-22 2016-01-28 Bioventures, Llc. Compositions and methods for selectively depleting senescent cells
CN104163798A (zh) * 2014-07-29 2014-11-26 苏州康润医药有限公司 3-氨基-8-三氟甲基喹啉的合成方法
SI3179991T1 (sl) 2014-08-11 2022-04-29 Acerta Pharma B.V. Terapevtske kombinacije zaviralca BTK in zaviralca BCL-2
NZ768373A (en) 2014-10-06 2024-03-22 Vertex Pharma Modulators of cystic fibrosis transmembrane conductance regulator
US10195213B2 (en) 2015-03-13 2019-02-05 Unity Biotechnology, Inc. Chemical entities that kill senescent cells for use in treating age-related disease
CN113607945B (zh) 2015-07-07 2025-01-28 豪夫迈·罗氏有限公司 抗HER2抗体-药物缀合物和Bcl-2抑制剂的组合疗法
WO2017063572A1 (zh) * 2015-10-13 2017-04-20 苏州晶云药物科技有限公司 细胞凋亡诱导剂的新晶型及其制备方法
CN108367006B (zh) 2015-12-04 2021-12-31 博尔托拉制药公司 用于治疗血液癌症的赛度替尼
EP3426655A1 (en) 2016-03-10 2019-01-16 Assia Chemical Industries Ltd. Solid state forms of venetoclax and processes for preparation of venetoclax
JP7082263B2 (ja) 2016-03-15 2022-06-08 オリソン ヘノミクス エセ. アー. 造血器悪性腫瘍の治療のための、lsd1阻害剤の組合せ
JP7158023B2 (ja) 2016-03-15 2022-10-21 オリソン ヘノミクス エセ. アー. 固形腫瘍の治療における使用のための、lsd1阻害剤の組合せ
EP3442584B1 (en) 2016-03-15 2021-07-28 Seagen Inc. Combinations of pbd-based antibody drug conjugates with bcl-2 inhibitors
AU2017240685B2 (en) 2016-03-31 2021-08-12 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
KR102447884B1 (ko) 2016-04-21 2022-09-27 바이오벤처스, 엘엘씨 항-세포자멸적 bcl-2 계열 단백질의 열화를 유도하는 화합물 및 이의 용도
EP3569601B1 (en) * 2016-08-05 2022-06-22 The Regents of The University of Michigan N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors
CN109641897B (zh) * 2016-09-01 2021-12-07 北京赛林泰医药技术有限公司 Bcl-2选择性抑制剂及其制备和用途
HUE056716T2 (hu) 2016-09-30 2022-03-28 Vertex Pharma Cisztás firbrózis transzmembrán konduktancia regulátor modulátora, gyógyszerészeti készítmények, kezelési eljárások, és eljárások a modulátor elõállítására
CN106749233B (zh) * 2016-11-24 2020-04-21 中山大学 一类磺酰胺衍生物及其应用
HUE064609T2 (hu) 2016-12-01 2024-04-28 Arvinas Operations Inc Tetrahidronaftalin és tetrahidroizokinolin származékok mint ösztrogénreceptor-lebontó anyagok
LT3551622T (lt) 2016-12-09 2021-02-25 Vertex Pharmaceuticals Incorporated Cistinės fibrozės transmembraninio laidumo reguliatoriaus moduliatorius, farmacinė kompozicija, gydymo būdai, ir moduliatoriaus gamybos būdas
US11053239B2 (en) 2017-01-07 2021-07-06 Fochon Pharmaceuticals, Ltd. Compounds as BLC-2-selective apoptosis-inducing agents
JOP20190191A1 (ar) 2017-02-22 2019-08-08 Astrazeneca Ab وحدات شجرية علاجية
WO2018167652A1 (en) * 2017-03-13 2018-09-20 Laurus Labs Limited Process for preparation of amorphous form of venetoclax
KR102630069B1 (ko) * 2017-04-18 2024-01-26 포천 파마슈티컬즈, 엘티디. 아폽토시스-유도제
CN107089981A (zh) * 2017-04-24 2017-08-25 杭州科耀医药科技有限公司 一种BCL‑2抑制剂Venetoclax的合成方法
WO2018227049A1 (en) 2017-06-08 2018-12-13 Vertex Pharmaceuticals Incorporated Methods of treatment for cystic fibrosis
CN108658983B (zh) * 2017-06-26 2019-12-20 深圳市塔吉瑞生物医药有限公司 用于抑制Bcl-2蛋白的N-苯磺酰基苯甲酰胺类化合物及其组合物及应用
WO2019018395A1 (en) 2017-07-17 2019-01-24 Vertex Pharmaceuticals Incorporated METHODS OF TREATING CYSTIC FIBROSIS
CN110869391A (zh) 2017-07-26 2020-03-06 豪夫迈·罗氏有限公司 用BET抑制剂,Bcl-2抑制剂和抗CD20抗体的组合疗法
WO2019020610A1 (en) 2017-07-26 2019-01-31 F. Hoffmann-La Roche Ag POLYTHERAPY USING BET INHIBITOR AND BCL-2 INHIBITOR
TWI799435B (zh) 2017-08-02 2023-04-21 美商維泰克斯製藥公司 製備化合物之製程
JP7467332B2 (ja) 2017-08-23 2024-04-15 グアンジョウ・ルペン・ファーマシューティカル・カンパニー・リミテッド 新生物疾患の治療のためのbcl-2阻害剤としての縮合複素環式誘導体
EP3697774B1 (en) 2017-10-19 2025-09-24 Vertex Pharmaceuticals Incorporated Crystalline forms and compositions of cftr modulators
CN108037196B (zh) * 2017-11-23 2020-06-23 中山奕安泰医药科技有限公司 一种3-硝基-4-[[(四氢-2h-吡喃-4-基)甲基]氨基]苯磺酰胺的检测方法
CN111757874B (zh) 2017-12-08 2024-03-08 弗特克斯药品有限公司 用于制备囊性纤维化跨膜传导调节因子的调节剂的方法
EP3740487B1 (en) 2018-01-10 2025-01-08 Recurium IP Holdings, LLC Benzamide compounds as bci inhibitors for the treatment of hiv
WO2019144117A1 (en) 2018-01-22 2019-07-25 Bioventures, Llc Bcl-2 proteins degraders for cancer treatment
TWI810243B (zh) 2018-02-05 2023-08-01 美商維泰克斯製藥公司 用於治療囊腫纖化症之醫藥組合物
MX2020008569A (es) 2018-02-16 2020-09-21 Abbvie Inc Inhibidores selectivos de bcl-2 en combinacion con un anticuerpo anti-pd-1 o anti-pd-l1 para el tratamiento de tipos de cancer.
WO2019178433A1 (en) 2018-03-15 2019-09-19 Abbvie Inc. Abbv-621 in combination with anti-cancer agents for the treatment of pancreatic cancer
CN111868059B (zh) * 2018-03-30 2021-12-03 正大天晴药业集团股份有限公司 三氟甲基取代的磺酰胺类选择性bcl-2抑制剂
EP3774825A1 (en) 2018-04-13 2021-02-17 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
SG11202009933WA (en) * 2018-04-29 2020-11-27 Beigene Ltd Bcl-2 INHIBITORS
WO2019213606A2 (en) 2018-05-04 2019-11-07 Portola Pharmaceuticals, Inc. Solid forms of cerdulatinib
WO2019221755A1 (en) 2018-05-18 2019-11-21 Bioventures, Llc Piperlongumine analogues and uses thereof
WO2020023435A1 (en) 2018-07-24 2020-01-30 Albany Molecular Research, Inc. Venetoclax basic salts and processes for the purification of venetoclax
TW202023568A (zh) 2018-07-30 2020-07-01 瑞典商阿斯特捷利康公司 用於治療癌症之組合療法
CN110772639B (zh) 2018-07-31 2021-04-13 苏州亚盛药业有限公司 Bcl-2抑制剂与MDM2抑制剂的组合产品及其在预防和/或治疗疾病中的用途
CN114522167A (zh) 2018-07-31 2022-05-24 苏州亚盛药业有限公司 Bcl-2抑制剂或Bcl-2/Bcl-xL抑制剂与BTK抑制剂的组合产品及其用途
AU2019314819A1 (en) 2018-07-31 2020-10-22 Ascentage Pharma (Suzhou) Co., Ltd. Combination product of Bcl-2 inhibitor and chemotherapeutic agent and use thereof in the prevention and/or treatment of diseases
KR20200139139A (ko) 2018-07-31 2020-12-11 어센테지 파마 (쑤저우) 컴퍼니 리미티드 리툭시맙 및/또는 벤다무스틴과 병용된 Bcl-2 억제제 또는 CHOP와 병용된 Bcl-2 억제제의 시너지적 항종양 효과
WO2020041406A1 (en) 2018-08-22 2020-02-27 Newave Pharmaceutical Inc. Bcl-2 inhibitors
JP7473545B2 (ja) 2018-10-29 2024-04-23 チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッド トリフルオロメチル置換スルファミド系選択的bcl-2阻害剤
CN109438441A (zh) * 2018-11-30 2019-03-08 重庆三圣实业股份有限公司 一种维奈妥拉的制备方法及其产品
CN109320516A (zh) * 2018-11-30 2019-02-12 重庆三圣实业股份有限公司 一种维奈妥拉中间体的制备方法及其产品
WO2020232214A1 (en) 2019-05-14 2020-11-19 Abbvie Inc. Treating acute myeloid leukemia (aml) with mivebresib, a bromodomain inhibitor
WO2020234445A1 (en) 2019-05-23 2020-11-26 F. Hoffmann-La Roche Ag Combination therapy with a bet inhibitor and a bcl-2 inhibitor
WO2020238785A1 (zh) * 2019-05-24 2020-12-03 正大天晴药业集团股份有限公司 包括甲基和三氟甲基的双取代磺酰胺类选择性bcl-2抑制剂
US12208095B2 (en) 2019-08-26 2025-01-28 Arvinas Operations, Inc. Methods of treating breast cancer with tetrahydronaphthalene derivatives as estrogen receptor degraders
WO2021037933A1 (en) 2019-08-28 2021-03-04 Astrazeneca Ab Combination of azd2811 nanoparticles, 5-azacitidine and venetoclax for use in the treatment of cancer
CN112661751B (zh) * 2019-10-16 2024-06-14 南京天印健华医药科技有限公司 作为bcl-2抑制剂的杂环化合物
WO2021083135A1 (en) * 2019-10-28 2021-05-06 Beigene, Ltd. Bcl-2 INHIBITORS
WO2021110102A1 (en) * 2019-12-02 2021-06-10 Beigene, Ltd. Methods of cancer treatment using bcl-2 inhibitor
IL296582A (en) 2020-04-15 2022-11-01 Beigene Ltd Bcl-2 inhibitor
US20230174528A1 (en) * 2020-04-29 2023-06-08 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Crystal of trifluoromethyl/chloro disubstituted sulfonamide selective bcl-2 inhibitor
CN111848607B (zh) * 2020-07-22 2023-03-17 长沙创新药物工业技术研究院有限公司 一种新型bcl-2/bcl-xl抑制剂、药物组合物及用途
CN114057728A (zh) * 2020-08-06 2022-02-18 北京诺诚健华医药科技有限公司 作为bcl-2抑制剂的杂环化合物
US20230398110A1 (en) * 2020-08-21 2023-12-14 Ascentage Pharma (Suzhou) Co., Ltd. Compositions and methods for treating non-alcoholic steatohepatitis
WO2022089463A1 (zh) * 2020-10-28 2022-05-05 杭州和正医药有限公司 Bcl-2蛋白凋亡诱导剂及应用
CN114736203A (zh) * 2021-01-07 2022-07-12 南京天印健华医药科技有限公司 作为bcl-2抑制剂的杂环化合物
KR20230159524A (ko) * 2021-03-19 2023-11-21 에일 테라퓨틱스 인코포레이티드 Bcl-2 저해제로서 ((3-나이트로페닐)설포닐)아세트아마이드를 갖는 화합물
US20240239792A1 (en) * 2021-04-13 2024-07-18 Appicine Therapeutics (Hk) Limited Modulators of bcl-2 or bcl-2/bcl-xl and uses thereof
US20240287110A1 (en) 2021-06-04 2024-08-29 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Phosphate of trifluoromethyl-substituted sulfonamide compound
KR20240054327A (ko) * 2021-08-31 2024-04-25 베이진 엘티디 Bcl-2 저해제의 고체 형태, 제조 방법 및 이의 용도
IT202100025976A1 (it) 2021-10-06 2023-04-06 Univ Degli Studi Di Perugia Combinazione di principi attivi per il trattamento della leucemia acuta mieloide (LAM) con mutazione della nucleofosmina (NPM1)
CN118660886A (zh) 2021-12-09 2024-09-17 佛罗里达大学研究基金公司 用于治疗癌症的bcl-xl/bcl-2双重降解剂
WO2024012557A1 (en) * 2022-07-15 2024-01-18 Berrybio (Hong Kong) Limited Anti-apoptotic bcl-2 family protein degraders, pharmaceutical compositions, and therapeutic applications
KR20250079128A (ko) * 2022-07-21 2025-06-04 베이진 스위찰랜드 게엠베하 Bcl-2 저해제를 사용한 다발성 골수종의 치료 방법
CN115260191B (zh) * 2022-09-29 2022-12-27 上海睿跃生物科技有限公司 哌啶类化合物及其制备方法和应用
KR102598137B1 (ko) 2022-11-24 2023-11-06 율촌화학 주식회사 고차단성 생분해 필름 및 이의 제조방법
EP4421075A1 (en) 2023-02-27 2024-08-28 KRKA, d.d., Novo mesto Process for the preparation of venetoclax and intermediates used therein

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2579596B1 (fr) * 1985-03-26 1987-11-20 Inst Nat Sante Rech Med (imidazolyl-4) piperidines, leur preparation et leur application en therapeutique
CA1338238C (en) * 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
EP0400835A1 (en) * 1989-05-15 1990-12-05 Merck & Co. Inc. Substituted benzimidazoles as angiotensin II antagonists
GB9110625D0 (en) * 1991-05-16 1991-07-03 Glaxo Group Ltd Chemical compounds
PT672031E (pt) * 1992-12-02 2003-06-30 Pfizer Dieteres de catecol como inibidores selectivos de pde iv
MY115155A (en) 1993-09-09 2003-04-30 Upjohn Co Substituted oxazine and thiazine oxazolidinone antimicrobials.
DE69631347T2 (de) 1995-09-15 2004-10-07 Upjohn Co Aminoaryl oxazolidinone n-oxide
EP1019399A1 (en) * 1997-10-03 2000-07-19 Merck Frosst Canada & Co. Aryl thiophene derivatives as pde iv inhibitors
US20030220234A1 (en) 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
EP2002837A1 (en) 1998-07-06 2008-12-17 Bristol-Myers Squibb Company Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
DE19830430A1 (de) * 1998-07-08 2000-01-13 Hoechst Marion Roussel De Gmbh Schwefelsubstituierte Sulfonylamino-carbonsäure-N-arylamide, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
GB9918037D0 (en) 1999-07-30 1999-09-29 Biochemie Gmbh Organic compounds
KR100641802B1 (ko) * 1999-12-28 2006-11-02 에자이 가부시키가이샤 술폰아미드 함유 복소환 화합물
GB2361003A (en) * 2000-04-07 2001-10-10 Astrazeneca Ab Novel compounds
US20020055631A1 (en) 2000-09-20 2002-05-09 Augeri David J. N-acylsulfonamide apoptosis promoters
US6720338B2 (en) 2000-09-20 2004-04-13 Abbott Laboratories N-acylsulfonamide apoptosis promoters
AR031130A1 (es) * 2000-09-20 2003-09-10 Abbott Lab N-acilsulfonamidas promotoras de la apoptosis
US6995162B2 (en) 2001-01-12 2006-02-07 Amgen Inc. Substituted alkylamine derivatives and methods of use
HRP20031000A2 (en) 2001-06-06 2004-04-30 Lilly Co Eli Benzoylsulfonamides and sulfonylbenzamidines as antitumour agents
US20030059489A1 (en) 2001-09-24 2003-03-27 Canolio Inc. Genital lubricating compositions and uses thereof
WO2003026587A2 (en) * 2001-09-26 2003-04-03 Bristol-Myers Squibb Company Compounds useful for treating hepatitus c virus
FR2836914B1 (fr) 2002-03-11 2008-03-14 Aventis Pharma Sa Indazoles substitues, compositions les contenant, procede de fabrication et utilisation
GB0215650D0 (en) * 2002-07-05 2002-08-14 Cyclacel Ltd Bisarylsufonamide compounds
US6995787B2 (en) 2002-08-21 2006-02-07 Adams Steven L Sports projectile and camera apparatus
WO2005024636A1 (ja) 2003-09-04 2005-03-17 Hitachi Ulsi Systems Co., Ltd. 半導体装置
US8614318B2 (en) * 2003-11-13 2013-12-24 Abbvie Inc. Apoptosis promoters
US7642260B2 (en) 2003-11-13 2010-01-05 Abbott Laboratories, Inc. Apoptosis promoters
US7973161B2 (en) * 2003-11-13 2011-07-05 Abbott Laboratories Apoptosis promoters
US7767684B2 (en) 2003-11-13 2010-08-03 Abbott Laboratories Apoptosis promoters
WO2005049593A2 (en) 2003-11-13 2005-06-02 Abbott Laboratories N-acylsulfonamide apoptosis promoters
US7307163B2 (en) 2004-04-19 2007-12-11 Symed Labs Limited Process for the preparation of linezolid and related compounds
CN101006065B (zh) * 2004-06-17 2012-07-11 英菲尼蒂发现公司 抑制bcl蛋白与结合伴侣的相互作用的化合物和方法
US7429661B2 (en) 2004-07-20 2008-09-30 Symed Labs Limited Intermediates for linezolid and related compounds
US7361764B2 (en) * 2004-07-27 2008-04-22 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
EP1804823A4 (en) 2004-09-29 2010-06-09 Amr Technology Inc NEW CYCLOSPORIN ANALOGUE AND ITS PHARMACEUTICAL APPLICATIONS
US8624027B2 (en) 2005-05-12 2014-01-07 Abbvie Inc. Combination therapy for treating cancer and diagnostic assays for use therein
CA2606147C (en) * 2005-05-12 2011-07-05 Abbott Laboratories Apoptosis promoters
DE602006014540D1 (en) 2005-05-16 2010-07-08 Irm Llc Pyrrolopyridinderivate als proteinkinaseinhibitoren
TW200716636A (en) 2005-05-31 2007-05-01 Speedel Experimenta Ag Heterocyclic spiro-compounds
UA95244C2 (ru) 2005-06-22 2011-07-25 Плексикон, Инк. Соединения и способ модулирования активности киназ, и показания для их применения
US7514068B2 (en) 2005-09-14 2009-04-07 Concert Pharmaceuticals Inc. Biphenyl-pyrazolecarboxamide compounds
US20070115787A1 (en) * 2005-11-23 2007-05-24 Seagate Technology Llc Planar optical device for generating optical nanojets
CN101534904B (zh) * 2006-09-05 2013-11-06 Abbvie公司 治疗血小板过量的bcl抑制剂
US8796267B2 (en) 2006-10-23 2014-08-05 Concert Pharmaceuticals, Inc. Oxazolidinone derivatives and methods of use
US20080182845A1 (en) 2006-11-16 2008-07-31 Abbott Laboratories Method of preventing or treating organ, hematopoietic stem cell or bone marrow transplant rejection
RU2460725C2 (ru) 2007-02-15 2012-09-10 Ф. Хоффманн-Ля Рош Аг Новые 2-аминооксазолины в качестве лигандов taar1
US8536157B2 (en) 2007-04-13 2013-09-17 The University Of Melbourne Non-steroidal compounds
BRPI0810362A2 (pt) 2007-04-19 2014-10-29 Concert Pharmaceuticals Inc Compostos de morfolinila deuterados
US7531685B2 (en) 2007-06-01 2009-05-12 Protia, Llc Deuterium-enriched oxybutynin
US20090131485A1 (en) 2007-09-10 2009-05-21 Concert Pharmaceuticals, Inc. Deuterated pirfenidone
US20090118238A1 (en) 2007-09-17 2009-05-07 Protia, Llc Deuterium-enriched alendronate
US20090088416A1 (en) 2007-09-26 2009-04-02 Protia, Llc Deuterium-enriched lapaquistat
US20090082471A1 (en) 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched fingolimod
JP2010540635A (ja) 2007-10-02 2010-12-24 コンサート ファーマシューティカルズ インコーポレイテッド ピリミジンジオン誘導体
US20090098118A1 (en) * 2007-10-15 2009-04-16 Thomas Friess Combination therapy of a type ii anti-cd20 antibody with an anti-bcl-2 active agent
US8410124B2 (en) 2007-10-18 2013-04-02 Concert Pharmaceuticals Inc. Deuterated etravirine
US20090105338A1 (en) 2007-10-18 2009-04-23 Protia, Llc Deuterium-enriched gabexate mesylate
CA2703591C (en) 2007-10-26 2013-05-07 Concert Pharmaceuticals, Inc. Deuterated darunavir
US8168784B2 (en) * 2008-06-20 2012-05-01 Abbott Laboratories Processes to make apoptosis promoters
US8557983B2 (en) 2008-12-04 2013-10-15 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US20100160322A1 (en) 2008-12-04 2010-06-24 Abbott Laboratories Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
UA108193C2 (uk) 2008-12-04 2015-04-10 Апоптозіндукуючий засіб для лікування раку і імунних і аутоімунних захворювань
US8563735B2 (en) 2008-12-05 2013-10-22 Abbvie Inc. Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
KR101692705B1 (ko) * 2008-12-05 2017-01-04 애브비 인코포레이티드 암 및 면역 질환의 치료를 위한 Bcl­2­선택적 아폽토시스-유도제로서의 설폰아미드 유도체
US8586754B2 (en) 2008-12-05 2013-11-19 Abbvie Inc. BCL-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
US20110245156A1 (en) 2008-12-09 2011-10-06 Cytokine Pharmasciences, Inc. Novel antiviral compounds, compositions, and methods of use
WO2010072734A2 (en) 2008-12-23 2010-07-01 The Provost Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin Targeting prodrugs and compositions for the treatment of gastrointestinal diseases
SG193849A1 (en) 2009-01-19 2013-10-30 Abbott Lab Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
RU2538965C2 (ru) 2009-01-19 2015-01-10 Эббви Инк. Вызывающие апоптоз средства для лечения рака и иммунных и аутоиммунных заболеваний
RU2573832C2 (ru) 2009-05-26 2016-01-27 Эббви Бахамаз Лтд. Индуцирующие апоптоз средства для лечения злокачественной опухоли и иммунных и аутоиммунных заболеваний
US8546399B2 (en) 2009-05-26 2013-10-01 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
TWI520960B (zh) * 2010-05-26 2016-02-11 艾伯維有限公司 用於治療癌症及免疫及自體免疫疾病之細胞凋亡誘導劑

Also Published As

Publication number Publication date
PE20120345A1 (es) 2012-05-17
SMT201500225B (it) 2015-10-30
EP2435432B3 (en) 2023-10-25
WO2010138588A3 (en) 2011-04-07
KR101659583B1 (ko) 2016-09-29
HK1163099A1 (en) 2012-09-07
CN102448959A (zh) 2012-05-09
WO2010138588A9 (en) 2011-05-05
EP4474383A2 (en) 2024-12-11
NO2017023I1 (no) 2017-05-29
JP2020023545A (ja) 2020-02-13
AU2010254160B2 (en) 2015-02-12
CY2017019I1 (el) 2018-01-10
LTPA2017015I1 (lt) 2017-06-12
RU2011152973A (ru) 2013-07-10
RU2535347C3 (ru) 2019-05-14
SG10201704742YA (en) 2017-07-28
KR102001418B1 (ko) 2019-07-19
KR101920202B1 (ko) 2018-11-21
JP2023040165A (ja) 2023-03-22
LTC2435432I2 (lt) 2018-06-11
UY37825A (es) 2020-02-28
IL215644A (en) 2017-08-31
WO2010138588A2 (en) 2010-12-02
KR20230128571A (ko) 2023-09-05
EP2944638A1 (en) 2015-11-18
BRPI1014359A2 (pt) 2016-04-05
IL299019A (en) 2023-02-01
JP2017048219A (ja) 2017-03-09
RU2573832C2 (ru) 2016-01-27
AU2010254160C1 (en) 2023-07-06
CY1117423T1 (el) 2017-04-26
JP2025072583A (ja) 2025-05-09
KR20170037683A (ko) 2017-04-04
EP3656771A1 (en) 2020-05-27
RU2535347C2 (ru) 2014-12-10
HUS1700021I1 (hu) 2017-06-28
CA2759182C (en) 2016-06-07
DOP2011000367A (es) 2017-07-31
KR20150065947A (ko) 2015-06-15
KR20180124164A (ko) 2018-11-20
CA2759182A1 (en) 2010-12-02
HRP20151001T4 (hr) 2024-02-16
IL286036A (en) 2021-10-31
TW201607946A (zh) 2016-03-01
RU2628885C2 (ru) 2017-08-22
SI2435432T1 (sl) 2015-10-30
CR20170019A (es) 2017-05-12
TW201506025A (zh) 2015-02-16
PH12015500297B1 (en) 2023-10-20
IL319747A (en) 2025-05-01
UY32668A (es) 2010-12-31
JP5747025B2 (ja) 2015-07-08
US20110124628A1 (en) 2011-05-26
CN109897038A (zh) 2019-06-18
TWI561523B (en) 2016-12-11
KR20120034671A (ko) 2012-04-12
CN109966294A (zh) 2019-07-05
ECSP11011554A (es) 2012-01-31
KR20180049164A (ko) 2018-05-10
EP2435432B1 (en) 2015-06-24
JP2015110605A (ja) 2015-06-18
HUE027698T2 (en) 2016-10-28
KR20190086591A (ko) 2019-07-22
IL253891A0 (en) 2017-10-31
CN102448959B (zh) 2015-06-17
AR109974A2 (es) 2019-02-13
JP6038195B2 (ja) 2016-12-07
UA106079C2 (uk) 2014-07-25
BR122019016429B1 (pt) 2020-03-24
JP2018138577A (ja) 2018-09-06
PH12015500297A1 (en) 2015-12-07
EP4474383A3 (en) 2025-02-19
CO6480950A2 (es) 2012-07-16
JP2022033939A (ja) 2022-03-02
CN104876927A (zh) 2015-09-02
CA3206963A1 (en) 2010-12-02
US8580794B2 (en) 2013-11-12
CN104906100A (zh) 2015-09-16
BRPI1014359B1 (pt) 2019-11-05
CN104876927B (zh) 2017-06-23
CA2929347A1 (en) 2010-12-02
MX2011012257A (es) 2011-12-16
HRP20151001T1 (hr) 2015-10-23
JP6353506B2 (ja) 2018-07-04
SG175253A1 (en) 2011-11-28
CL2011002949A1 (es) 2012-05-25
NO2017023I2 (no) 2017-05-29
TW201107323A (en) 2011-03-01
TWI537269B (zh) 2016-06-11
IL215644A0 (en) 2012-01-31
NZ595708A (en) 2014-03-28
AR076705A1 (es) 2011-06-29
ES2546294T7 (es) 2024-06-06
KR20190130676A (ko) 2019-11-22
IL269092A (en) 2019-11-28
CA3052016A1 (en) 2010-12-02
CY2017019I2 (el) 2018-01-10
KR101723378B1 (ko) 2017-04-06
ES2546294T3 (es) 2015-09-22
CN109897038B (zh) 2022-04-05
AU2010254160A1 (en) 2011-11-24
RU2014132884A (ru) 2015-12-27
PL2435432T3 (pl) 2015-12-31
MX2019012154A (es) 2019-11-21
UY33047A (es) 2011-09-30
RU2015154494A (ru) 2017-06-22
DK2435432T6 (da) 2023-12-18
JP2012528178A (ja) 2012-11-12
PT2435432E (pt) 2015-10-13
DK2435432T3 (en) 2015-08-31
CR20110632A (es) 2012-02-15
MY155645A (en) 2015-11-13
MX339469B (es) 2016-05-27
EP2435432A2 (en) 2012-04-04
ME02205B (me) 2016-02-20
FI2435432T6 (fi) 2023-11-21
TWI476195B (zh) 2015-03-11
HK1215576A1 (en) 2016-09-02
ZA201108616B (en) 2015-12-23
NL300873I2 (nl) 2017-10-24
PL2435432T6 (pl) 2024-02-12
RS54234B1 (sr) 2015-12-31
SI2435432T2 (sl) 2024-04-30

Similar Documents

Publication Publication Date Title
RS54234B2 (sr) Indukujući agensi apoptoze za lečenje kancera i imunih i autoimunih oboljenja
IL247183A0 (en) Secretory-apoptosis factors for the treatment of cancer and immune and autoimmune diseases
IL238607A0 (en) Apoptosis-inducing factors for the treatment of cancer and immune and autoimmune diseases
HRP20160714T1 (hr) Sredstva za induciranje apoptoze namijenjena liječenju raka i imunih i autoimunih bolesti
IL219991A0 (en) Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
ZA201104671B (en) Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
IL231702A0 (en) Factors that induce programmed cell death for the treatment of cancer and immune and auto-immune diseases
ZA201208832B (en) Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases