MA50400A - Formes cristallines et compositions de modulateurs de cftr - Google Patents

Formes cristallines et compositions de modulateurs de cftr

Info

Publication number
MA50400A
MA50400A MA050400A MA50400A MA50400A MA 50400 A MA50400 A MA 50400A MA 050400 A MA050400 A MA 050400A MA 50400 A MA50400 A MA 50400A MA 50400 A MA50400 A MA 50400A
Authority
MA
Morocco
Prior art keywords
compositions
crystalline forms
cftr modulators
cftr
modulators
Prior art date
Application number
MA050400A
Other languages
English (en)
Inventor
Welchao George Chen
Varsha Dhamankar
Kirk Raymond Dinehart
Eleni Dokou
Lori Ann Ferris
Nishanth Gopinathan
Eric L Haseltine
Katie Mccarty
Catherine Metzler
Samuel Moskowitz
Sarah Robertson
David Waltz
Beili Zhang
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of MA50400A publication Critical patent/MA50400A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
MA050400A 2017-10-19 2018-10-19 Formes cristallines et compositions de modulateurs de cftr MA50400A (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762574677P 2017-10-19 2017-10-19
US201762574670P 2017-10-19 2017-10-19
US201862650057P 2018-03-29 2018-03-29

Publications (1)

Publication Number Publication Date
MA50400A true MA50400A (fr) 2020-08-26

Family

ID=64110267

Family Applications (1)

Application Number Title Priority Date Filing Date
MA050400A MA50400A (fr) 2017-10-19 2018-10-19 Formes cristallines et compositions de modulateurs de cftr

Country Status (8)

Country Link
US (2) US10654829B2 (fr)
EP (1) EP3697774B1 (fr)
AU (1) AU2018351533B2 (fr)
CA (1) CA3078893A1 (fr)
IL (1) IL273831B2 (fr)
MA (1) MA50400A (fr)
TW (1) TWI719349B (fr)
WO (1) WO2019079760A1 (fr)

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HUE052205T2 (hu) 2016-12-09 2021-04-28 Vertex Pharma Cisztás fibrózis transzmembrán vezetõképesség szabályzó modulátora, gyógyszerészeti készítmények, kezelési eljárások és eljárás a modulátor elõállítására
BR112019025801A2 (pt) 2017-06-08 2020-07-07 Vertex Pharmaceuticals Incorporated métodos de tratamento para fibrose cística
BR112020000941A2 (pt) 2017-07-17 2020-07-21 Vertex Pharmaceuticals Incorporated métodos de tratamento para fibrose cística
US11434201B2 (en) 2017-08-02 2022-09-06 Vertex Pharmaceuticals Incorporated Processes for preparing pyrrolidine compounds
CA3078893A1 (fr) 2017-10-19 2019-04-25 Vertex Pharmaceuticals Incorporated Formes cristallines et compositions de modulateurs de cftr
CA3085006A1 (fr) 2017-12-08 2019-06-13 Vertex Pharmaceuticals Incorporated Procedes pour preparer des modulateurs du regulateur de la conductance transmembranaire de la mucoviscidose
TWI810243B (zh) 2018-02-05 2023-08-01 美商維泰克斯製藥公司 用於治療囊腫纖化症之醫藥組合物
HRP20230030T1 (hr) 2018-02-15 2023-03-03 Vertex Pharmaceuticals Incorporated Makrocikli kao modulatori regulatora provodljivosti transmembrane cistične fibroze, njihovi farmaceutski pripravci, njihova uporaba u liječenju cistične fibroze, i postupak za njihovu proizvodnju
EP3774825A1 (fr) 2018-04-13 2021-02-17 Vertex Pharmaceuticals Incorporated Modulateurs du régulateur de la conductance transmembranaire de la fibrose kystique, compositions pharmaceutiques, procédés de traitement et procédé de fabrication du modulateur
AR118555A1 (es) 2019-04-03 2021-10-20 Vertex Pharma Agentes moduladores del regulador de la conductancia transmembrana de la fibrosis quística
WO2020214921A1 (fr) * 2019-04-17 2020-10-22 Vertex Pharmaceuticals Incorporated Formes solides de modulateurs de cftr
CA3150162A1 (fr) 2019-08-14 2021-02-18 Vertex Pharmaceuticals Incorporated Formes cristallines de modulateurs de cftr
TWI867024B (zh) 2019-08-14 2024-12-21 美商維泰克斯製藥公司 囊腫纖維化跨膜傳導調節蛋白之調節劑
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US20250221971A1 (en) 2022-02-03 2025-07-10 Vertex Pharmaceuticals Incorporated Methods of treatment for cystic fibrosis
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EP4525858A1 (fr) 2022-05-16 2025-03-26 Vertex Pharmaceuticals Incorporated Méthodes de traitement de la fibrose kystique

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