HUP0302477A2 - Szubsztituált indolszármazékok, ezeket tartalmazó gyógyszerkészítmények és ezek alkalmazása PPAR-gamma kötő szerként - Google Patents

Szubsztituált indolszármazékok, ezeket tartalmazó gyógyszerkészítmények és ezek alkalmazása PPAR-gamma kötő szerként

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Publication number
HUP0302477A2
HUP0302477A2 HU0302477A HUP0302477A HUP0302477A2 HU P0302477 A2 HUP0302477 A2 HU P0302477A2 HU 0302477 A HU0302477 A HU 0302477A HU P0302477 A HUP0302477 A HU P0302477A HU P0302477 A2 HUP0302477 A2 HU P0302477A2
Authority
HU
Hungary
Prior art keywords
group
optionally substituted
heterocycloalkyl
cycloalkenyl
cycloalkyl
Prior art date
Application number
HU0302477A
Other languages
English (en)
Inventor
Jeremy L. Baryza
William H. Bullock
Anne-Marie Campbell
William Carley
Phillip D.G. Coish
James H. Cook
Jacques P. Dumas
Derek B. Lowe
Steven R. Magnuson
Dhanapalan Nagarathnam
Ning Qi
Andreas Stolle
Ning Su
Yamin Wang
Original Assignee
Smithkline Beecham Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp. filed Critical Smithkline Beecham Corp.
Publication of HUP0302477A2 publication Critical patent/HUP0302477A2/hu

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    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D491/04—Ortho-condensed systems

Abstract

A találmány szerinti vegyületek (I) általános képletében R1 jelentéseegyenként alkilcsoporton, alkenilcsoporton, alkinilcsoporton,alkilszulfonilcsoport vagy alkilkarbonilcsoporton keresztül kapcsolódóés egyenként adott esetben szubsztituált fenilcsoport,cikloalkilcsoport, heterocikloalkilcsoport, cikloalkenilcsoport vagyheterocikloalkenilcsoport, X jelentése adott esetben szubsztituáltiminocsoport, oxigénatom vagy kénatom, R2 jelentése hidrogénatom,alkilcsoport, halogénalkilcsoport vagy egyenkéntalkilszulfonilcsoporton keresztül kapcsolódó és egyenként adottesetben szubsztituált arilcsoport vagy heteroarilcsoport, R3 jelentéseegyenként adott esetben alkilcsoporton, alkenilcsoporton,alkinilcsoporton vagy karbonilcsoporton keresztül kapcsolódó ésegyenként adott esetben szubsztituált cikloalkilcsoport,cikloalkenilcsoport, heterocikloalkilcsoport vagyheterocikloalkenilcsoport vagy adott esetben szubsztituált arilcsoportvagy heteroarilcsoport, R4 jelentése egyenként adott esetbenszubsztituált iminocsoporton, kénatomon vagy oxigénatomon keresztülkapcsolódó és egyenként adott esetben szubsztituált alkilcsoport,cikloalkilcsoport, heterocikloalkilcsoport, cikloalkenilcsoport vagyheterocikloalkenilcsoport, R5 jelentése hidrogénatom, karboxilcsoport,alkilkarboxicsoport, egyenként karbonilcsoporton keresztül kapcsolódóalkilcsoport, cikloalkilcsoport, heterocikloalkilcsoport,cikloalkenilcsoport, heterocikloalkenilcsoport, arilcsoport vagyheteroarilcsoport, cikloalkilcsoport, heterocikloalkilcsoport,cikloalkenilcsoport vagy heterocikloalkenilcsoport, egyenként adottesetben szubsztituált iminocsoporton, kénatomon vagy oxigénatomonkeresztül kapcsolódó és egyenként adott esetben szubsztituáltalkilcsoport, alkenilcsoport, alkinilcsoport,cikloalkilkarbonilcsoport, heterocikloalkilkarbonilcsoport,cikloalkenilkarbonilcsoport, heterocikloalkenilkarbonilcsoport vagyaminokarbonilcsoport, vagy R5 és R6 jelentése együtt két végénegymástól függetlenül adott esetben szubsztituált iminocsoporton,kénatomon vagy oxigénatomon keresztül kapcsolódó alkilénlánc, R6jelentése hidrogénatom, hidroxilcsoport, egyenként adott esetbenszubsztituált iminocsoporton kénatomon vagy oxigénatomon keresztülkapcsolódó és egyenként adott esetben szubsztituált alkilcsoport,cikloalkilcsoport, heterocikloalkilcsoport, cikloalkenilcsoport,heterocikloalkenilcsoport, arilcsoport vagy heteroarilcsoport, R7jelentése hidrogénatom, egyenként karbonilcsoporton keresztülkapcsolódó alkilcsoport, cikloalkilcsoport, heterocikloalkilcsoport,cikloalkenilcsoport, heterocikloalkenilcsoport, arilcsoport vagyheteroarilcsoport, egyenként adott esetben szubsztituáltiminocsoporton, kénatomon vagy oxigénatomon keresztül ka
HU0302477A 2000-10-10 2001-10-09 Szubsztituált indolszármazékok, ezeket tartalmazó gyógyszerkészítmények és ezek alkalmazása PPAR-gamma kötő szerként HUP0302477A2 (hu)

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