AR035348A1 - Indoles sustituidos, composiciones farmaceuticas que los comprenden, y uso de dichos compuestos en la preparacion de medicamentos - Google Patents

Indoles sustituidos, composiciones farmaceuticas que los comprenden, y uso de dichos compuestos en la preparacion de medicamentos

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Publication number
AR035348A1
AR035348A1 ARP010104758A ARP010104758A AR035348A1 AR 035348 A1 AR035348 A1 AR 035348A1 AR P010104758 A ARP010104758 A AR P010104758A AR P010104758 A ARP010104758 A AR P010104758A AR 035348 A1 AR035348 A1 AR 035348A1
Authority
AR
Argentina
Prior art keywords
compounds
preparation
pharmaceutical compositions
medicines
substituted indoles
Prior art date
Application number
ARP010104758A
Other languages
English (en)
Original Assignee
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Corp filed Critical Bayer Corp
Publication of AR035348A1 publication Critical patent/AR035348A1/es

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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
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    • C07D491/04—Ortho-condensed systems

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  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Indoles sustituidos seleccionados a partir del grupo formado por fórmulas (1) y sales farmacéuticamente aceptables de los mismos. Dichos compuestos modulan procesos mediados por PPAR-gamma, pues actúan como agonistas o antagonistas de PPAR-gamma, y en consecuencia son útiles para el tratamiento o la prevención de enfermedades y trastornos tales como osteopenia, osteoporosis, cáncer, diabetes y arteriosclerosis. También se dan a conocer: composiciones farmacéuticas que los comprenden y el uso de dichos compuestos en la preparación de medicamentos.
ARP010104758A 2000-10-10 2001-10-10 Indoles sustituidos, composiciones farmaceuticas que los comprenden, y uso de dichos compuestos en la preparacion de medicamentos AR035348A1 (es)

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AU2002211901A1 (en) 2002-04-22
WO2002030895A1 (en) 2002-04-18
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CA2427499A1 (en) 2002-04-18
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US6787651B2 (en) 2004-09-07
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IL154981A0 (en) 2003-10-31
MXPA03003174A (es) 2003-07-14
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