SG10201704742YA - Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases - Google Patents

Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases

Info

Publication number
SG10201704742YA
SG10201704742YA SG10201704742YA SG10201704742YA SG10201704742YA SG 10201704742Y A SG10201704742Y A SG 10201704742YA SG 10201704742Y A SG10201704742Y A SG 10201704742YA SG 10201704742Y A SG10201704742Y A SG 10201704742YA SG 10201704742Y A SG10201704742Y A SG 10201704742YA
Authority
SG
Singapore
Prior art keywords
apoptosis
immune
cancer
treatment
autoimmune diseases
Prior art date
Application number
SG10201704742YA
Inventor
Milan Bruncko
Hong Ding
George Doherty
Steven Elmore
Lisa Hasvold
Laura Hexamer
Aaron R Kunzer
Xiaohong Song
Andrew J Souers
Gerard Sullivan
Zhi-Fu Tao
Gary T Wang
Le Wang
Xilu Wang
Michael Wendt
Robert Mantei
Todd M Hansen
Original Assignee
Abbvie Ireland Unlimited Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42677657&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG10201704742Y(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbvie Ireland Unlimited Co filed Critical Abbvie Ireland Unlimited Co
Publication of SG10201704742YA publication Critical patent/SG10201704742YA/en

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • C07D491/044Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
SG10201704742YA 2009-05-26 2010-05-26 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases SG10201704742YA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18120309P 2009-05-26 2009-05-26

Publications (1)

Publication Number Publication Date
SG10201704742YA true SG10201704742YA (en) 2017-07-28

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ID=42677657

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SG2011075843A SG175253A1 (en) 2009-05-26 2010-05-26 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
SG10201704742YA SG10201704742YA (en) 2009-05-26 2010-05-26 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases

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US (1) US8580794B2 (en)
EP (3) EP3656771A1 (en)
JP (7) JP5747025B2 (en)
KR (8) KR102001418B1 (en)
CN (5) CN109897038B (en)
AR (2) AR076705A1 (en)
AU (1) AU2010254160C1 (en)
BR (2) BR122019016429B1 (en)
CA (4) CA3206963A1 (en)
CL (1) CL2011002949A1 (en)
CO (1) CO6480950A2 (en)
CR (2) CR20170019A (en)
CY (2) CY1117423T1 (en)
DK (1) DK2435432T6 (en)
DO (1) DOP2011000367A (en)
EC (1) ECSP11011554A (en)
ES (1) ES2546294T3 (en)
FI (1) FI2435432T6 (en)
HK (2) HK1163099A1 (en)
HR (1) HRP20151001T4 (en)
HU (2) HUE027698T2 (en)
IL (5) IL299019A (en)
LT (1) LTC2435432I2 (en)
ME (1) ME02205B (en)
MX (2) MX339469B (en)
MY (1) MY155645A (en)
NL (1) NL300873I2 (en)
NO (1) NO2017023I2 (en)
NZ (1) NZ595708A (en)
PE (1) PE20120345A1 (en)
PH (1) PH12015500297A1 (en)
PL (1) PL2435432T6 (en)
PT (1) PT2435432E (en)
RS (1) RS54234B2 (en)
RU (3) RU2573832C2 (en)
SG (2) SG175253A1 (en)
SI (1) SI2435432T1 (en)
SM (1) SMT201500225B (en)
TW (3) TWI561523B (en)
UA (1) UA106079C2 (en)
UY (3) UY32668A (en)
WO (1) WO2010138588A2 (en)
ZA (1) ZA201108616B (en)

Families Citing this family (108)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8557983B2 (en) 2008-12-04 2013-10-15 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US20100160322A1 (en) * 2008-12-04 2010-06-24 Abbott Laboratories Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US8586754B2 (en) 2008-12-05 2013-11-19 Abbvie Inc. BCL-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
US8563735B2 (en) 2008-12-05 2013-10-22 Abbvie Inc. Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
ES2588374T3 (en) 2008-12-05 2016-11-02 Abbvie Inc. Sulfonamide derivatives as selective apoptosis inducing agents for bcl-2 for the treatment of cancer and immune diseases
DK2511264T3 (en) * 2009-01-19 2015-06-22 Abbvie Inc Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US8546399B2 (en) 2009-05-26 2013-10-01 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
US20220315555A1 (en) 2009-05-26 2022-10-06 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
SG175253A1 (en) 2009-05-26 2011-11-28 Abbott Lab Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US9034875B2 (en) 2009-05-26 2015-05-19 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
TWI520960B (en) 2010-05-26 2016-02-11 艾伯維有限公司 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
MX2020004501A (en) 2010-06-03 2021-11-09 Pharmacyclics Llc The use of inhibitors of bruton's tyrosine kinase (btk).
TWI535712B (en) 2010-08-06 2016-06-01 阿斯特捷利康公司 Chemical compounds
AU2011319842B2 (en) 2010-10-29 2014-05-29 Abbvie Inc. Solid dispersions containing an apoptosis-inducing agent
UA113500C2 (en) * 2010-10-29 2017-02-10 MEL EXTRUSION SOLID DISPERSIONS CONTAINING AN APOPTOSIS-INDUCING AGENT
NZ610151A (en) 2010-11-23 2015-06-26 Abbvie Inc Salts and crystalline forms of an apoptosis-inducing agent
NZ708508A (en) 2010-11-23 2016-06-24 Abbvie Bahamas Ltd Methods of treatment using selective bcl-2 inhibitors
CN103380110A (en) 2011-02-15 2013-10-30 宇部兴产株式会社 Industrial methods for producing arylsulfur pentafluorides
CN102241649A (en) * 2011-07-08 2011-11-16 陈飞 Method for preparing tetrahydro-3-furanmethanol
CN103958508B (en) 2011-10-14 2019-02-12 艾伯维公司 For treating cancer and the immune cell death inducer with autoimmune disease
WO2013185202A1 (en) * 2012-06-14 2013-12-19 Beta Pharma Canada Inc Apoptosis inducers
BR112015001690A2 (en) 2012-07-24 2017-11-07 Pharmacyclics Inc mutations associated with resistance to bruton tyrosine kinase inhibitors (btk)
US8883784B2 (en) * 2012-08-13 2014-11-11 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
KR102158467B1 (en) 2012-09-07 2020-09-25 제넨테크, 인크. Combination therapy of a type ii anti-cd20 antibody with a selective bcl-2 inhibitor
LT6064B (en) 2012-10-15 2014-08-25 Vilniaus Universitetas Fluorinated benzenesulfonamides as inhibitors of carbonic anhydrase
DK2914296T4 (en) * 2012-11-01 2022-01-03 Infinity Pharmaceuticals Inc Treatment of cancers using PI3 kinase isoform modulators
US20150283142A1 (en) * 2013-03-15 2015-10-08 Infinity Pharmaceuticals, Inc. Treatment of cancers using pi3 kinase isoform modulators
AR095265A1 (en) 2013-03-13 2015-09-30 Abbvie Inc PROCESSES FOR THE PREPARATION OF AN APOPTOSIS INDUCTIVE AGENT
US20140275082A1 (en) * 2013-03-14 2014-09-18 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
EP2983670A4 (en) * 2013-04-08 2017-03-08 Pharmacyclics LLC Ibrutinib combination therapy
TWI594975B (en) 2013-04-24 2017-08-11 第一三共股份有限公司 Compound having di-carboxylic moiety
US9238652B2 (en) 2014-03-04 2016-01-19 Abbvie Inc. Processes for the preparation of an apoptosis-inducing agent
EP3708170A1 (en) 2014-05-05 2020-09-16 BioVentures, LLC Compositions and methods for inhibiting antiapoptotic bcl-2 proteins as anti-aging agents
CA2955972A1 (en) 2014-07-22 2016-01-28 Bioventures, Llc. Compositions and methods for selectively depleting senescent cells
CN104163798A (en) * 2014-07-29 2014-11-26 苏州康润医药有限公司 Synthesis method of 3-amino-8-trifluoromethyl quinoline
RS62713B1 (en) 2014-08-11 2022-01-31 Acerta Pharma Bv Therapeutic combinations of a btk inhibitor and a bcl-2 inhibitor
RU2020134082A (en) 2014-10-06 2020-11-27 Вертекс Фармасьютикалз Инкорпорейтед MODULATORS OF THE TRANSMEMBRANE CONDUCTIVITY REGULATOR IN FLUISCIDOSIS
US10195213B2 (en) 2015-03-13 2019-02-05 Unity Biotechnology, Inc. Chemical entities that kill senescent cells for use in treating age-related disease
BR112017028012A2 (en) 2015-07-07 2018-08-28 Genentech Inc THERAPY COMBINED WITH AN ANTIBODY-ANTI-HER2 DRUG CONJUGATE AND A BCL-2 INHIBITOR
WO2017063572A1 (en) * 2015-10-13 2017-04-20 苏州晶云药物科技有限公司 Novel crystal form of cell apoptosis inducing agent and preparation method thereof
JP6944936B2 (en) 2015-12-04 2021-10-06 ポートラ ファーマシューティカルズ, インコーポレイテッド Serduratinib for treating blood cancer
EP3426655A1 (en) 2016-03-10 2019-01-16 Assia Chemical Industries Ltd. Solid state forms of venetoclax and processes for preparation of venetoclax
WO2017160954A1 (en) 2016-03-15 2017-09-21 Seattle Genetics, Inc. Combinations of pbd-based antibody drug conjugates with bcl-2 inhibitors
RU2766259C2 (en) 2016-03-15 2022-02-10 Оризон Дженомикс, С.А. Combinations of lsd1 inhibitors for treating haematological malignant diseases
KR20230042756A (en) 2016-03-15 2023-03-29 오리존 지노믹스 에스.에이. Combinations of lsd1 inhibitors for use in the treatment of solid tumors
ES2946970T3 (en) 2016-03-31 2023-07-28 Vertex Pharma Transmembrane conductance regulator of cystic fibrosis modulators
CA3018991A1 (en) 2016-04-21 2017-10-26 Bioventures, Llc Compounds that induce degradation of anti-apoptotic bcl-2 family proteins and the uses thereof
EP4129999A1 (en) * 2016-08-05 2023-02-08 The Regents Of The University Of Michigan N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors
WO2018041248A1 (en) * 2016-09-01 2018-03-08 北京赛林泰医药技术有限公司 Bcl-2 selective inhibitor and preparation and use thereof
HRP20211683T1 (en) 2016-09-30 2022-03-04 Vertex Pharmaceuticals Incorporated Modulator of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
CN106749233B (en) * 2016-11-24 2020-04-21 中山大学 Sulfonamide derivatives and application thereof
CN110267948B (en) 2016-12-09 2023-12-08 弗特克斯药品有限公司 Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and methods for preparing the modulators
CN110177788B (en) * 2017-01-07 2023-03-24 重庆复创医药研究有限公司 Compounds as BCL-2 selective apoptosis inducers
JOP20190191A1 (en) 2017-02-22 2019-08-08 Astrazeneca Ab Therapeutic dendrimers
WO2018167652A1 (en) * 2017-03-13 2018-09-20 Laurus Labs Limited Process for preparation of amorphous form of venetoclax
BR112019021434A2 (en) * 2017-04-18 2020-05-05 Fochon Pharmaceuticals Ltd apoptosis-inducing agents
CN107089981A (en) * 2017-04-24 2017-08-25 杭州科耀医药科技有限公司 A kind of inhibitor Venetoclax of BCL 2 synthetic method
AU2018279646B2 (en) 2017-06-08 2023-04-06 Vertex Pharmaceuticals Incorporated Methods of treatment for cystic fibrosis
JP7374496B2 (en) 2017-06-26 2023-11-07 深▲チェン▼市塔吉瑞生物医薬有限公司 N-benzenesulfonylbenzamide compounds, compositions and uses thereof for inhibiting Bcl-2 protein
WO2019018395A1 (en) 2017-07-17 2019-01-24 Vertex Pharmaceuticals Incorporated Methods of treatment for cystic fibrosis
CN110891608A (en) 2017-07-26 2020-03-17 豪夫迈·罗氏有限公司 Combination therapy with BET inhibitors and Bcl-2 inhibitors
JP2020528061A (en) 2017-07-26 2020-09-17 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト Combination therapy with BET inhibitor, Bcl-2 inhibitor and anti-CD20 antibody
EP3661915B1 (en) 2017-08-02 2022-03-09 Vertex Pharmaceuticals Incorporated Processes for preparing pyrrolidine compounds
CA3073445A1 (en) 2017-08-23 2019-02-28 Newave Pharmaceutical Inc. Condensed heterocyclic derivatives as bcl-2 inhibitors for the treatment of neoplastic diseases
EP3697774A1 (en) 2017-10-19 2020-08-26 Vertex Pharmaceuticals Incorporated Crystalline forms and compositions of cftr modulators
CN108037196B (en) * 2017-11-23 2020-06-23 中山奕安泰医药科技有限公司 Detection method of 3-nitro-4- [ [ (tetrahydro-2H-pyran-4-yl) methyl ] amino ] benzenesulfonamide
CA3085006A1 (en) 2017-12-08 2019-06-13 Vertex Pharmaceuticals Incorporated Processes for making modulators of cystic fibrosis transmembrane conductance regulator
CA3087261A1 (en) 2018-01-10 2019-07-18 Recurium Ip Holdings, Llc Benzamide compounds
JP7385284B2 (en) 2018-01-22 2023-11-22 バイオベンチャーズ・リミテッド・ライアビリティ・カンパニー BCL-2 proteolytic agents for cancer treatment
TWI810243B (en) 2018-02-05 2023-08-01 美商維泰克斯製藥公司 Pharmaceutical compositions for treating cystic fibrosis
MX2020008569A (en) 2018-02-16 2020-09-21 Abbvie Inc Selective bcl-2 inhibitors in combination with an anti-pd-1 or an anti-pd-l1 antibody for the treatment of cancers.
WO2019178433A1 (en) 2018-03-15 2019-09-19 Abbvie Inc. Abbv-621 in combination with anti-cancer agents for the treatment of pancreatic cancer
WO2019185025A1 (en) * 2018-03-30 2019-10-03 正大天晴药业集团股份有限公司 Trifluoromethyl-substituted sulfonamide as bcl-2-selective inhibitor
EP3774825A1 (en) 2018-04-13 2021-02-17 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
CN117430601A (en) * 2018-04-29 2024-01-23 百济神州有限公司 Bcl-2 inhibitors
EP3788035A2 (en) 2018-05-04 2021-03-10 Portola Pharmaceuticals, Inc. Solid forms of cerdulatinib
WO2020023435A1 (en) 2018-07-24 2020-01-30 Albany Molecular Research, Inc. Venetoclax basic salts and processes for the purification of venetoclax
TW202023568A (en) 2018-07-30 2020-07-01 瑞典商阿斯特捷利康公司 Combination therapy for treating cancer
CN110776507B (en) 2018-07-31 2020-12-18 苏州亚盛药业有限公司 Combination of a Bcl-2 inhibitor and a chemotherapeutic agent and its use for the prevention and/or treatment of diseases
UA126098C2 (en) 2018-07-31 2022-08-10 Есентейдж Фарма (Сучжоу) Ко., Лтд. Combination product of bcl-2 inhibitor and mdm2 inhibitor and use thereof inthe prevention and/or treatment of diseases
CN114522167A (en) 2018-07-31 2022-05-24 苏州亚盛药业有限公司 Bcl-2 inhibitor or Bcl-2/Bcl-xL inhibitor and BTK inhibitor combination product and application thereof
EA202091963A1 (en) 2018-07-31 2021-05-13 Эсентейдж Фарма (Сучжоу) Ко., Лтд. SYNERGIC ANTITUMOR EFFECT OF Bcl-2 INHIBITOR IN COMBINATION WITH RITUXIMAB AND / OR BENDAMUSTIN OR Bcl-2 INHIBITOR IN COMBINATION WITH CHOP
US11903950B2 (en) 2018-08-22 2024-02-20 Newave Pharmaceutical Inc. BCL-2 inhibitors
US20220002290A1 (en) * 2018-10-29 2022-01-06 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Trifluoromethyl-substituted sulfonamide as bcl-2-selective inhibitor
CN109438441A (en) * 2018-11-30 2019-03-08 重庆三圣实业股份有限公司 It is a kind of dimension how the preparation method and products thereof of appropriate drawing
CN109320516A (en) * 2018-11-30 2019-02-12 重庆三圣实业股份有限公司 A kind of how appropriate preparation method and products thereof for drawing intermediate of dimension
WO2020232214A1 (en) 2019-05-14 2020-11-19 Abbvie Inc. Treating acute myeloid leukemia (aml) with mivebresib, a bromodomain inhibitor
WO2020234445A1 (en) 2019-05-23 2020-11-26 F. Hoffmann-La Roche Ag Combination therapy with a bet inhibitor and a bcl-2 inhibitor
US20220220110A1 (en) * 2019-05-24 2022-07-14 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Methyl- and trifluoromethyl-containing disubstituted sulfonamide selective bcl-2 inhibitor
WO2021037933A1 (en) 2019-08-28 2021-03-04 Astrazeneca Ab Combination of azd2811 nanoparticles, 5-azacitidine and venetoclax for use in the treatment of cancer
CN112661751A (en) * 2019-10-16 2021-04-16 南京天印健华医药科技有限公司 Heterocyclic compounds as BCL-2 inhibitors
EP4051676A4 (en) * 2019-10-28 2023-11-22 BeiGene, Ltd. Bcl-2 inhibitors
WO2021110102A1 (en) * 2019-12-02 2021-06-10 Beigene, Ltd. Methods of cancer treatment using bcl-2 inhibitor
US20230174528A1 (en) 2020-04-29 2023-06-08 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Crystal of trifluoromethyl/chloro disubstituted sulfonamide selective bcl-2 inhibitor
CN111848607B (en) * 2020-07-22 2023-03-17 长沙创新药物工业技术研究院有限公司 Novel BCL-2/BCL-XL inhibitor, pharmaceutical composition and application
WO2022037683A1 (en) * 2020-08-21 2022-02-24 Ascentage Pharma (Suzhou) Co., Ltd. Compositions and methods for treating non-alcoholic steatohepatitis
CN114478520A (en) * 2020-10-28 2022-05-13 杭州和正医药有限公司 Bcl-2 protein apoptosis inducer and application thereof
CN114736203A (en) * 2021-01-07 2022-07-12 南京天印健华医药科技有限公司 Heterocyclic compounds as BCL-2 inhibitors
JP2024510434A (en) 2021-03-19 2024-03-07 エイル セラピューティクス,インコーポレイテッド Compounds with ((3-nitrophenyl)sulfonyl)acetamide as BCL-2 inhibitors
CN117616023A (en) * 2021-04-13 2024-02-27 爱新医药科技(香港)有限公司 BCL-2 or BCL-2/BCL-XL modulators and uses thereof
CN117377672A (en) 2021-06-04 2024-01-09 正大天晴药业集团股份有限公司 Phosphate esters of trifluoromethyl substituted sulfonamides
CA3230314A1 (en) * 2021-08-31 2023-03-09 Beigene Switzerland Gmbh Solid forms of bcl-2 inhibitors, method of preparation, and use thereof
IT202100025976A1 (en) 2021-10-06 2023-04-06 Univ Degli Studi Di Perugia Combination of active substances for the treatment of acute myeloid leukemia (AML) with nucleophosmin (NPM1) mutation
WO2023107606A1 (en) 2021-12-09 2023-06-15 University Of Florida Research Foundation, Incorporated Bcl-xl/bcl-2 dual degraders for treatment of cancers
WO2024012557A1 (en) * 2022-07-15 2024-01-18 Berrybio (Hong Kong) Limited Anti-apoptotic bcl-2 family protein degraders, pharmaceutical compositions, and therapeutic applications
WO2024017354A1 (en) * 2022-07-21 2024-01-25 Beigene, Ltd. Methods of treating multiple myeloma using bcl-2 inhibitor
CN115260191B (en) * 2022-09-29 2022-12-27 上海睿跃生物科技有限公司 Piperidine compound and preparation method and application thereof
KR102598137B1 (en) 2022-11-24 2023-11-06 율촌화학 주식회사 High-barrier biodegradable film and preparation method thereof

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2579596B1 (en) * 1985-03-26 1987-11-20 Inst Nat Sante Rech Med (IMIDAZOLYL-4) PIPERIDINES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
CA1338238C (en) * 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
CA2016710A1 (en) * 1989-05-15 1990-11-15 Prasun K. Chakravarty Substituted benzimidazoles as angiotensin ii antagonists
GB9110625D0 (en) * 1991-05-16 1991-07-03 Glaxo Group Ltd Chemical compounds
PT672031E (en) * 1992-12-02 2003-06-30 Pfizer DIETERES OF CATECOL AS SELECTIVE INHIBITORS OF PDE IV
MY115155A (en) 1993-09-09 2003-04-30 Upjohn Co Substituted oxazine and thiazine oxazolidinone antimicrobials.
EP1019385B1 (en) 1995-09-15 2004-01-14 PHARMACIA & UPJOHN COMPANY Aminoaryl oxazolidinone n-oxides
AU732406B2 (en) * 1997-10-03 2001-04-26 Merck Frosst Canada & Co. Aryl thiophene derivatives as PDE IV inhibitors
US20030220234A1 (en) 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
EP2002837A1 (en) 1998-07-06 2008-12-17 Bristol-Myers Squibb Company Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
DE19830430A1 (en) * 1998-07-08 2000-01-13 Hoechst Marion Roussel De Gmbh New sulfur-substituted sulfonylamino-carboxylic acid N-arylamide derivatives useful as guanylate cyclase activators in treatment of e.g. cardiovascular disorders, asthma and diabetes
GB9918037D0 (en) 1999-07-30 1999-09-29 Biochemie Gmbh Organic compounds
CN1217936C (en) * 1999-12-28 2005-09-07 卫材株式会社 Heterocyclic compounds having sulfonic acid
GB2361003A (en) * 2000-04-07 2001-10-10 Astrazeneca Ab Novel compounds
US6720338B2 (en) * 2000-09-20 2004-04-13 Abbott Laboratories N-acylsulfonamide apoptosis promoters
US20020055631A1 (en) * 2000-09-20 2002-05-09 Augeri David J. N-acylsulfonamide apoptosis promoters
AR031130A1 (en) * 2000-09-20 2003-09-10 Abbott Lab PROMOTING N-ACILSULFONAMIDS OF APOPTOSIS
US6995162B2 (en) 2001-01-12 2006-02-07 Amgen Inc. Substituted alkylamine derivatives and methods of use
KR100880760B1 (en) 2001-06-06 2009-02-02 일라이 릴리 앤드 캄파니 Benzoylsulfonamides and Sulfonylbenzamidines for Use as Antitumour Agents
US20030059489A1 (en) 2001-09-24 2003-03-27 Canolio Inc. Genital lubricating compositions and uses thereof
WO2003026587A2 (en) * 2001-09-26 2003-04-03 Bristol-Myers Squibb Company Compounds useful for treating hepatitus c virus
FR2836914B1 (en) * 2002-03-11 2008-03-14 Aventis Pharma Sa SUBSTITUTED INDAZOLES, COMPOSITIONS CONTAINING SAME, METHOD OF MANUFACTURE AND USE
GB0215650D0 (en) * 2002-07-05 2002-08-14 Cyclacel Ltd Bisarylsufonamide compounds
US6995787B2 (en) 2002-08-21 2006-02-07 Adams Steven L Sports projectile and camera apparatus
JP4336678B2 (en) 2003-09-04 2009-09-30 株式会社日立超エル・エス・アイ・システムズ Semiconductor device
US7767684B2 (en) * 2003-11-13 2010-08-03 Abbott Laboratories Apoptosis promoters
US7642260B2 (en) * 2003-11-13 2010-01-05 Abbott Laboratories, Inc. Apoptosis promoters
WO2005049593A2 (en) * 2003-11-13 2005-06-02 Abbott Laboratories N-acylsulfonamide apoptosis promoters
US7973161B2 (en) * 2003-11-13 2011-07-05 Abbott Laboratories Apoptosis promoters
US8614318B2 (en) * 2003-11-13 2013-12-24 Abbvie Inc. Apoptosis promoters
US7307163B2 (en) 2004-04-19 2007-12-11 Symed Labs Limited Process for the preparation of linezolid and related compounds
JP5064213B2 (en) * 2004-06-17 2012-10-31 インフィニティ・ディスカバリー・インコーポレイテッド Compounds and methods for inhibiting the interaction of a BCL protein with a binding partner
US7429661B2 (en) 2004-07-20 2008-09-30 Symed Labs Limited Intermediates for linezolid and related compounds
US7361764B2 (en) * 2004-07-27 2008-04-22 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
WO2006039164A2 (en) 2004-09-29 2006-04-13 Amr Technology, Inc. Novel cyclosporin analogues and their pharmaceutical uses
US8624027B2 (en) * 2005-05-12 2014-01-07 Abbvie Inc. Combination therapy for treating cancer and diagnostic assays for use therein
US7390799B2 (en) * 2005-05-12 2008-06-24 Abbott Laboratories Apoptosis promoters
MX2007014327A (en) 2005-05-16 2008-02-11 Irm Llc Pyrrolopyridine derivatives as protein kinase inhibitors.
TW200716636A (en) 2005-05-31 2007-05-01 Speedel Experimenta Ag Heterocyclic spiro-compounds
DK1893612T3 (en) 2005-06-22 2011-11-21 Plexxikon Inc Pyrrole [2,3-B] pyridine derivatives as protein kinase inhibitors
US7514068B2 (en) 2005-09-14 2009-04-07 Concert Pharmaceuticals Inc. Biphenyl-pyrazolecarboxamide compounds
US20070115787A1 (en) * 2005-11-23 2007-05-24 Seagate Technology Llc Planar optical device for generating optical nanojets
CN101534904B (en) * 2006-09-05 2013-11-06 Abbvie公司 BCL inhibitors treating platelet excess
US8796267B2 (en) 2006-10-23 2014-08-05 Concert Pharmaceuticals, Inc. Oxazolidinone derivatives and methods of use
WO2008064116A2 (en) * 2006-11-16 2008-05-29 Abbott Laboratories Method of preventing or treating organ, hematopoietic stem cell or bone marrow transplant rejection
EP2121641B1 (en) 2007-02-15 2014-09-24 F. Hoffmann-La Roche AG 2-aminooxazolines as taar1 ligands
US8536157B2 (en) 2007-04-13 2013-09-17 The University Of Melbourne Non-steroidal compounds
KR20100105802A (en) 2007-04-19 2010-09-29 콘서트 파마슈티컬즈, 인크. Deuterated morpholinyl compounds
US7531685B2 (en) 2007-06-01 2009-05-12 Protia, Llc Deuterium-enriched oxybutynin
US20090131485A1 (en) 2007-09-10 2009-05-21 Concert Pharmaceuticals, Inc. Deuterated pirfenidone
US20090118238A1 (en) 2007-09-17 2009-05-07 Protia, Llc Deuterium-enriched alendronate
US20090088416A1 (en) 2007-09-26 2009-04-02 Protia, Llc Deuterium-enriched lapaquistat
US20090082471A1 (en) 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched fingolimod
EP2209774A1 (en) 2007-10-02 2010-07-28 Concert Pharmaceuticals Inc. Pyrimidinedione derivatives
US20090098118A1 (en) * 2007-10-15 2009-04-16 Thomas Friess Combination therapy of a type ii anti-cd20 antibody with an anti-bcl-2 active agent
WO2009051782A1 (en) 2007-10-18 2009-04-23 Concert Pharmaceuticals Inc. Deuterated etravirine
US20090105338A1 (en) 2007-10-18 2009-04-23 Protia, Llc Deuterium-enriched gabexate mesylate
WO2009055006A1 (en) 2007-10-26 2009-04-30 Concert Pharmaceuticals, Inc. Deuterated darunavir
US8168784B2 (en) * 2008-06-20 2012-05-01 Abbott Laboratories Processes to make apoptosis promoters
US8557983B2 (en) * 2008-12-04 2013-10-15 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
UA108193C2 (en) 2008-12-04 2015-04-10 APOPTOZINDUCE FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTO-IMMUNE DISEASES
US20100160322A1 (en) * 2008-12-04 2010-06-24 Abbott Laboratories Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US8586754B2 (en) * 2008-12-05 2013-11-19 Abbvie Inc. BCL-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
ES2588374T3 (en) 2008-12-05 2016-11-02 Abbvie Inc. Sulfonamide derivatives as selective apoptosis inducing agents for bcl-2 for the treatment of cancer and immune diseases
US8563735B2 (en) * 2008-12-05 2013-10-22 Abbvie Inc. Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
WO2010077740A2 (en) 2008-12-09 2010-07-08 Cytokine Pharmasciences, Inc. Novel antiviral compounds, compositions, and methods of use
WO2010072734A2 (en) 2008-12-23 2010-07-01 The Provost Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin Targeting prodrugs and compositions for the treatment of gastrointestinal diseases
DK2511264T3 (en) * 2009-01-19 2015-06-22 Abbvie Inc Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
AU2010204555B2 (en) * 2009-01-19 2013-03-07 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US8546399B2 (en) 2009-05-26 2013-10-01 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
SG175253A1 (en) 2009-05-26 2011-11-28 Abbott Lab Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases

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