NL300873I2 - Venetoclax - Google Patents
Venetoclax Download PDFInfo
- Publication number
- NL300873I2 NL300873I2 NL300873C NL300873C NL300873I2 NL 300873 I2 NL300873 I2 NL 300873I2 NL 300873 C NL300873 C NL 300873C NL 300873 C NL300873 C NL 300873C NL 300873 I2 NL300873 I2 NL 300873I2
- Authority
- NL
- Netherlands
- Prior art keywords
- venetoclax
- Prior art date
Links
- LQBVNQSMGBZMKD-UHFFFAOYSA-N venetoclax Chemical compound C=1C=C(Cl)C=CC=1C=1CC(C)(C)CCC=1CN(CC1)CCN1C(C=C1OC=2C=C3C=CNC3=NC=2)=CC=C1C(=O)NS(=O)(=O)C(C=C1[N+]([O-])=O)=CC=C1NCC1CCOCC1 LQBVNQSMGBZMKD-UHFFFAOYSA-N 0.000 title 1
- 229960001183 venetoclax Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- AIDS & HIV (AREA)
- Molecular Biology (AREA)
- Transplantation (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Indole Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18120309P | 2009-05-26 | 2009-05-26 | |
| PCT/US2010/036198 WO2010138588A2 (en) | 2009-05-26 | 2010-05-26 | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL300873I2 true NL300873I2 (nl) | 2017-10-24 |
Family
ID=42677657
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL300873C NL300873I2 (nl) | 2009-05-26 | 2017-05-16 | Venetoclax |
Country Status (43)
Families Citing this family (111)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100160322A1 (en) | 2008-12-04 | 2010-06-24 | Abbott Laboratories | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| US8557983B2 (en) | 2008-12-04 | 2013-10-15 | Abbvie Inc. | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| US8586754B2 (en) | 2008-12-05 | 2013-11-19 | Abbvie Inc. | BCL-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases |
| US8563735B2 (en) | 2008-12-05 | 2013-10-22 | Abbvie Inc. | Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases |
| ME02642B (me) * | 2008-12-05 | 2017-06-20 | Abbvie Inc | Sulfonamid derivati i kao BCL- 2 selektivni agensi za induciranje apoptoze namijenjeni liječenju raka i imunih bolesti |
| ES2536090T3 (es) * | 2009-01-19 | 2015-05-20 | Abbvie Inc. | Agentes inductores de la apoptosis para el tratamiento del cáncer y enfermedades inmunitarias y autoinmunitarias |
| US20220315555A1 (en) | 2009-05-26 | 2022-10-06 | Abbvie Inc. | Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases |
| PL2435432T6 (pl) * | 2009-05-26 | 2024-02-12 | Abbvie Ireland Unlimited Company | Środki wywołujące apoptozę do leczenia raka oraz chorób immunologicznych i autoimmunologicznych |
| US8546399B2 (en) * | 2009-05-26 | 2013-10-01 | Abbvie Inc. | Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases |
| US9034875B2 (en) | 2009-05-26 | 2015-05-19 | Abbvie Inc. | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| TWI520960B (zh) * | 2010-05-26 | 2016-02-11 | 艾伯維有限公司 | 用於治療癌症及免疫及自體免疫疾病之細胞凋亡誘導劑 |
| CA3240281A1 (en) | 2010-06-03 | 2011-12-08 | Pharmacyclics Llc | Use of inhibitors of bruton's tyrosine kinase (btk) in the treatment of follicular lymphoma |
| TWI535712B (zh) | 2010-08-06 | 2016-06-01 | 阿斯特捷利康公司 | 化合物 |
| UA113500C2 (xx) * | 2010-10-29 | 2017-02-10 | Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб | |
| RU2598345C2 (ru) * | 2010-10-29 | 2016-09-20 | Эббви Инк. | Твердые дисперсии, содержащие средства, вызывающие апоптоз |
| AU2011332043C1 (en) | 2010-11-23 | 2016-11-10 | Abbvie Inc. | Salts and crystalline forms of an apoptosis-inducing agent |
| WO2012071374A1 (en) | 2010-11-23 | 2012-05-31 | Abbott Laboratories | Methods of treatment using selective bcl-2 inhibitors |
| US9108910B2 (en) | 2011-02-15 | 2015-08-18 | Ube Industries, Ltd. | Industrial methods for producing arylsulfur pentafluorides |
| CN102241649A (zh) * | 2011-07-08 | 2011-11-16 | 陈飞 | 3-四氢呋喃甲醇的制备方法 |
| US8940737B2 (en) | 2011-10-14 | 2015-01-27 | Abbvie Inc. | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| WO2013185202A1 (en) * | 2012-06-14 | 2013-12-19 | Beta Pharma Canada Inc | Apoptosis inducers |
| EP2877598A1 (en) | 2012-07-24 | 2015-06-03 | Pharmacyclics, Inc. | Mutations associated with resistance to inhibitors of bruton's tyrosine kinase (btk) |
| ES2677480T3 (es) * | 2012-08-13 | 2018-08-02 | Abbvie Inc. | Agentes que inducen apoptosis |
| CN111481552A (zh) | 2012-09-07 | 2020-08-04 | 吉宁特有限公司 | II型抗CD20抗体与选择性Bcl-2抑制剂的组合治疗 |
| LT6064B (lt) | 2012-10-15 | 2014-08-25 | Vilniaus Universitetas | Fluorinti benzensulfonamidai kaip karboanhidrazės inhibitoriai |
| US20150283142A1 (en) * | 2013-03-15 | 2015-10-08 | Infinity Pharmaceuticals, Inc. | Treatment of cancers using pi3 kinase isoform modulators |
| MX2020009849A (es) * | 2012-11-01 | 2021-09-13 | Infinity Pharmaceuticals Inc | Tratamiento de canceres utilizando moduladores de las isoformas de pi3 cinasa. |
| US9006438B2 (en) | 2013-03-13 | 2015-04-14 | Abbvie Inc. | Processes for the preparation of an apoptosis-inducing agent |
| US20140275082A1 (en) | 2013-03-14 | 2014-09-18 | Abbvie Inc. | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| KR20150141971A (ko) * | 2013-04-08 | 2015-12-21 | 파마싸이클릭스 엘엘씨 | 이브루티닙 병용 요법 |
| TWI594975B (zh) | 2013-04-24 | 2017-08-11 | 第一三共股份有限公司 | 二羧酸化合物 |
| US9238652B2 (en) | 2014-03-04 | 2016-01-19 | Abbvie Inc. | Processes for the preparation of an apoptosis-inducing agent |
| EP3708170A1 (en) | 2014-05-05 | 2020-09-16 | BioVentures, LLC | Compositions and methods for inhibiting antiapoptotic bcl-2 proteins as anti-aging agents |
| JP2017522388A (ja) | 2014-07-22 | 2017-08-10 | バイオベンチャーズ・リミテッド・ライアビリティ・カンパニーＢｉｏＶｅｎｔｕｒｅｓ， ＬＬＣ | 老化細胞を選択的に枯渇させるための組成物及び方法 |
| CN104163798A (zh) * | 2014-07-29 | 2014-11-26 | 苏州康润医药有限公司 | 3-氨基-8-三氟甲基喹啉的合成方法 |
| LT3179991T (lt) | 2014-08-11 | 2021-11-10 | Acerta Pharma B.V. | Terapiniai btk inhibitoriaus ir bcl-2 inhibitoriaus deriniai |
| CN112250627B (zh) | 2014-10-06 | 2024-02-02 | 弗特克斯药品有限公司 | 囊性纤维化跨膜转导调节因子调节剂 |
| US10195213B2 (en) | 2015-03-13 | 2019-02-05 | Unity Biotechnology, Inc. | Chemical entities that kill senescent cells for use in treating age-related disease |
| SI3319995T1 (sl) | 2015-07-07 | 2019-07-31 | F. Hoffmann-La Roche Ag | Kombinirana terapija s konjugatom protitelo anti-HER-2 in zdravilo ter zaviralcem bcl-2 |
| WO2017063572A1 (zh) * | 2015-10-13 | 2017-04-20 | 苏州晶云药物科技有限公司 | 细胞凋亡诱导剂的新晶型及其制备方法 |
| CN108367006B (zh) | 2015-12-04 | 2021-12-31 | 博尔托拉制药公司 | 用于治疗血液癌症的赛度替尼 |
| US11001582B2 (en) | 2016-03-10 | 2021-05-11 | Assia Chemical Industries Ltd. | Solid state forms of Venetoclax and processes for preparation of Venetoclax |
| MX2018011102A (es) | 2016-03-15 | 2019-01-10 | Oryzon Genomics Sa | Combinaciones de inhibidores de desmetilasa-1 especifica de lisina (lsd1) para uso en el tratamiento de tumores solidos. |
| BR112018068532A2 (pt) | 2016-03-15 | 2019-01-29 | Oryzon Genomics Sa | combinações de inibidores de lsd1 para o tratamento de malignidades hematológicas |
| EP3442584B1 (en) | 2016-03-15 | 2021-07-28 | Seagen Inc. | Combinations of pbd-based antibody drug conjugates with bcl-2 inhibitors |
| WO2017173274A1 (en) | 2016-03-31 | 2017-10-05 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
| CN109152933B (zh) * | 2016-04-21 | 2022-12-02 | 生物风险投资有限责任公司 | 诱导抗细胞凋亡bcl-2家族蛋白的降解的化合物及其用途 |
| RS61821B1 (sr) * | 2016-08-05 | 2021-06-30 | Univ Michigan Regents | Derivati n-(fenilsulfonil)benzamida kao bcl-2 inhibitori |
| CN109641897B (zh) * | 2016-09-01 | 2021-12-07 | 北京赛林泰医药技术有限公司 | Bcl-2选择性抑制剂及其制备和用途 |
| RS62670B1 (sr) | 2016-09-30 | 2021-12-31 | Vertex Pharma | Modulator transmembranskog regulatora provodnosti cistične fibroze, farmaceutske kompozicije, metode lečenja i proces izrade modulatora |
| CN106749233B (zh) * | 2016-11-24 | 2020-04-21 | 中山大学 | 一类磺酰胺衍生物及其应用 |
| MX2019006637A (es) | 2016-12-09 | 2019-08-21 | Vertex Pharma | Modulador del regulador de conductancia transmembrana de fibrosis quistica composiciones farmaceuticas metodos de tratamiento y proceso para producir el modulador. |
| WO2018127130A1 (en) * | 2017-01-07 | 2018-07-12 | Shanghai Fochon Pharmaceutical Co., Ltd. | Compounds as bcl-2-selective apoptosis-inducing agents |
| JOP20190191A1 (ar) | 2017-02-22 | 2019-08-08 | Astrazeneca Ab | وحدات شجرية علاجية |
| WO2018167652A1 (en) * | 2017-03-13 | 2018-09-20 | Laurus Labs Limited | Process for preparation of amorphous form of venetoclax |
| SI3612531T1 (sl) * | 2017-04-18 | 2022-11-30 | Shanghai Fochon Pharmaceutical Co., Ltd. | Sredstva, ki sprožajo apoptozo |
| CN107089981A (zh) * | 2017-04-24 | 2017-08-25 | 杭州科耀医药科技有限公司 | 一种BCL‑2抑制剂Venetoclax的合成方法 |
| AU2018279646B2 (en) | 2017-06-08 | 2023-04-06 | Vertex Pharmaceuticals Incorporated | Methods of treatment for cystic fibrosis |
| CN108658983B (zh) | 2017-06-26 | 2019-12-20 | 深圳市塔吉瑞生物医药有限公司 | 用于抑制Bcl-2蛋白的N-苯磺酰基苯甲酰胺类化合物及其组合物及应用 |
| MA49631A (fr) | 2017-07-17 | 2020-05-27 | Vertex Pharma | Méthodes de traitement de la fibrose kystique |
| JP2020528061A (ja) | 2017-07-26 | 2020-09-17 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | ＢＥＴ阻害剤、Ｂｃｌ−２阻害剤及び抗ＣＤ２０抗体を用いた併用療法 |
| EP3658188A1 (en) | 2017-07-26 | 2020-06-03 | H. Hoffnabb-La Roche Ag | Combination therapy with a bet inhibitor and a bcl-2 inhibitor |
| CA3071278A1 (en) | 2017-08-02 | 2019-02-07 | Vertex Pharmaceuticals Incorporated | Processes for preparing pyrrolidine compounds |
| CN111448198B (zh) | 2017-08-23 | 2023-02-03 | 广州麓鹏制药有限公司 | 作为治疗新生性疾病的Bcl-2抑制剂的缩合杂环衍生物 |
| CA3078893A1 (en) | 2017-10-19 | 2019-04-25 | Vertex Pharmaceuticals Incorporated | Crystalline forms and compositions of cftr modulators |
| CN108037196B (zh) * | 2017-11-23 | 2020-06-23 | 中山奕安泰医药科技有限公司 | 一种3-硝基-4-[[(四氢-2h-吡喃-4-基)甲基]氨基]苯磺酰胺的检测方法 |
| MX2020005753A (es) | 2017-12-08 | 2020-08-20 | Vertex Pharma | Procesos para producir moduladores de regulador de conductancia transmembranal de fibrosis quistica. |
| AU2019207611A1 (en) | 2018-01-10 | 2020-07-09 | Recurium Ip Holdings, Llc | Benzamide compounds |
| CA3088253A1 (en) | 2018-01-22 | 2019-07-25 | Bioventures, Llc | Bcl-2 proteins degraders for cancer treatment |
| TWI810243B (zh) | 2018-02-05 | 2023-08-01 | 美商維泰克斯製藥公司 | 用於治療囊腫纖化症之醫藥組合物 |
| MX2020008569A (es) | 2018-02-16 | 2020-09-21 | Abbvie Inc | Inhibidores selectivos de bcl-2 en combinacion con un anticuerpo anti-pd-1 o anti-pd-l1 para el tratamiento de tipos de cancer. |
| WO2019178433A1 (en) | 2018-03-15 | 2019-09-19 | Abbvie Inc. | Abbv-621 in combination with anti-cancer agents for the treatment of pancreatic cancer |
| WO2019185025A1 (zh) * | 2018-03-30 | 2019-10-03 | 正大天晴药业集团股份有限公司 | 三氟甲基取代的磺酰胺类选择性bcl-2抑制剂 |
| WO2019200246A1 (en) | 2018-04-13 | 2019-10-17 | Alexander Russell Abela | Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator |
| BR112020022092A2 (pt) | 2018-04-29 | 2021-02-02 | Beigene, Ltd. | compostos, método para tratar doenças apoptóticas desreguladas e composição farmacêutica |
| US10865198B2 (en) | 2018-05-04 | 2020-12-15 | Alexion Pharmaceuticals, Inc. | Solid forms of cerdulatinib |
| US12084423B2 (en) | 2018-05-18 | 2024-09-10 | Bioventures, Llc | Piperlongumine analogues and uses thereof |
| WO2020023435A1 (en) | 2018-07-24 | 2020-01-30 | Albany Molecular Research, Inc. | Venetoclax basic salts and processes for the purification of venetoclax |
| TW202023568A (zh) | 2018-07-30 | 2020-07-01 | 瑞典商阿斯特捷利康公司 | 用於治療癌症之組合療法 |
| AU2019315466B2 (en) * | 2018-07-31 | 2022-05-19 | Ascentage Pharma (Suzhou) Co., Ltd. | Synergistic antitumor effect of Bcl-2 inhibitor combined with rituximab and/or bendamustine or Bcl-2 inhibitor combined with CHOP |
| CN110772521A (zh) | 2018-07-31 | 2020-02-11 | 苏州亚盛药业有限公司 | Bcl-2抑制剂或Bcl-2/Bcl-xL抑制剂与BTK抑制剂的组合产品及其用途 |
| US11491167B2 (en) | 2018-07-31 | 2022-11-08 | Ascentage Pharma (Suzhou) Co., Ltd. | Combination product of Bcl-2 inhibitor and chemotherapeutic agent and use thereof in the prevention and/or treatment of diseases |
| GEP20237458B (en) | 2018-07-31 | 2023-01-10 | Ascentage Pharma Suzhou Co Ltd | Combination product of bcl-2 inhibitor and mdm2 inhibitor and use thereof in the prevention and/or treatment of diseases |
| WO2020041406A1 (en) | 2018-08-22 | 2020-02-27 | Newave Pharmaceutical Inc. | Bcl-2 inhibitors |
| CN116199686A (zh) * | 2018-10-29 | 2023-06-02 | 正大天晴药业集团股份有限公司 | 三氟甲基取代的磺酰胺类化合物 |
| CN109438441A (zh) * | 2018-11-30 | 2019-03-08 | 重庆三圣实业股份有限公司 | 一种维奈妥拉的制备方法及其产品 |
| CN109320516A (zh) * | 2018-11-30 | 2019-02-12 | 重庆三圣实业股份有限公司 | 一种维奈妥拉中间体的制备方法及其产品 |
| WO2020232214A1 (en) | 2019-05-14 | 2020-11-19 | Abbvie Inc. | Treating acute myeloid leukemia (aml) with mivebresib, a bromodomain inhibitor |
| WO2020234445A1 (en) | 2019-05-23 | 2020-11-26 | F. Hoffmann-La Roche Ag | Combination therapy with a bet inhibitor and a bcl-2 inhibitor |
| CN113825754B (zh) * | 2019-05-24 | 2023-09-22 | 正大天晴药业集团股份有限公司 | 包括甲基和三氟甲基的双取代磺酰胺类选择性bcl-2抑制剂 |
| WO2021037933A1 (en) | 2019-08-28 | 2021-03-04 | Astrazeneca Ab | Combination of azd2811 nanoparticles, 5-azacitidine and venetoclax for use in the treatment of cancer |
| CN112661751B (zh) * | 2019-10-16 | 2024-06-14 | 南京天印健华医药科技有限公司 | 作为bcl-2抑制剂的杂环化合物 |
| US20230002369A1 (en) * | 2019-10-28 | 2023-01-05 | Beigene, Ltd. | Bcl-2 INHIBITORS |
| WO2021110102A1 (en) * | 2019-12-02 | 2021-06-10 | Beigene, Ltd. | Methods of cancer treatment using bcl-2 inhibitor |
| TW202144350A (zh) | 2020-04-29 | 2021-12-01 | 大陸商正大天晴藥業集團股份有限公司 | 三氟甲基和氯雙取代的磺醯胺類選擇性bcl-2抑制劑的晶體 |
| CN111848607B (zh) * | 2020-07-22 | 2023-03-17 | 长沙创新药物工业技术研究院有限公司 | 一种新型bcl-2/bcl-xl抑制剂、药物组合物及用途 |
| CN114057728A (zh) * | 2020-08-06 | 2022-02-18 | 北京诺诚健华医药科技有限公司 | 作为bcl-2抑制剂的杂环化合物 |
| CN114073703B (zh) * | 2020-08-21 | 2022-12-30 | 苏州亚盛药业有限公司 | 用于治疗非酒精性脂肪肝炎的组合物和方法 |
| WO2022089463A1 (zh) * | 2020-10-28 | 2022-05-05 | 杭州和正医药有限公司 | Bcl-2蛋白凋亡诱导剂及应用 |
| CN114736203A (zh) * | 2021-01-07 | 2022-07-12 | 南京天印健华医药科技有限公司 | 作为bcl-2抑制剂的杂环化合物 |
| CN117642157A (zh) | 2021-03-19 | 2024-03-01 | 伊尔治疗学股份有限公司 | 具有((3-硝基苯基)磺酰基)乙酰胺作为bcl-2抑制剂的化合物 |
| WO2022218311A1 (en) * | 2021-04-13 | 2022-10-20 | Appicine Therapeutics (Hk) Limited | Modulators of bcl-2 or bcl-2/bcl-xl and uses thereof |
| CN117377672A (zh) | 2021-06-04 | 2024-01-09 | 正大天晴药业集团股份有限公司 | 三氟甲基取代的磺酰胺类化合物的磷酸酯 |
| AU2022336557A1 (en) * | 2021-08-31 | 2024-03-21 | Beigene Switzerland Gmbh | Solid forms of bcl-2 inhibitors, method of preparation, and use thereof |
| IT202100025976A1 (it) | 2021-10-06 | 2023-04-06 | Univ Degli Studi Di Perugia | Combinazione di principi attivi per il trattamento della leucemia acuta mieloide (LAM) con mutazione della nucleofosmina (NPM1) |
| CN118660886A (zh) | 2021-12-09 | 2024-09-17 | 佛罗里达大学研究基金公司 | 用于治疗癌症的bcl-xl/bcl-2双重降解剂 |
| WO2024012557A1 (en) * | 2022-07-15 | 2024-01-18 | Berrybio (Hong Kong) Limited | Anti-apoptotic bcl-2 family protein degraders, pharmaceutical compositions, and therapeutic applications |
| WO2024017354A1 (en) * | 2022-07-21 | 2024-01-25 | Beigene, Ltd. | Methods of treating multiple myeloma using bcl-2 inhibitor |
| CN115260191B (zh) * | 2022-09-29 | 2022-12-27 | 上海睿跃生物科技有限公司 | 哌啶类化合物及其制备方法和应用 |
| KR102598137B1 (ko) | 2022-11-24 | 2023-11-06 | 율촌화학 주식회사 | 고차단성 생분해 필름 및 이의 제조방법 |
| EP4421075A1 (en) | 2023-02-27 | 2024-08-28 | KRKA, d.d., Novo mesto | Process for the preparation of venetoclax and intermediates used therein |
Family Cites Families (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2579596B1 (fr) * | 1985-03-26 | 1987-11-20 | Inst Nat Sante Rech Med | (imidazolyl-4) piperidines, leur preparation et leur application en therapeutique |
| CA1338238C (en) * | 1988-01-07 | 1996-04-09 | David John Carini | Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids |
| EP0400835A1 (en) * | 1989-05-15 | 1990-12-05 | Merck & Co. Inc. | Substituted benzimidazoles as angiotensin II antagonists |
| GB9110625D0 (en) * | 1991-05-16 | 1991-07-03 | Glaxo Group Ltd | Chemical compounds |
| DE69332762T2 (de) * | 1992-12-02 | 2003-08-14 | Pfizer Inc., New York | Cathecoldiether als selektive pde iv hemmungsmittel |
| MY115155A (en) | 1993-09-09 | 2003-04-30 | Upjohn Co | Substituted oxazine and thiazine oxazolidinone antimicrobials. |
| JPH11512429A (ja) | 1995-09-15 | 1999-10-26 | ファルマシア・アンド・アップジョン・カンパニー | アミノアリールオキサゾリジノン ｎ−オキシド |
| WO1999018099A1 (en) * | 1997-10-03 | 1999-04-15 | Merck Frosst Canada & Co. | Aryl thiophene derivatives as pde iv inhibitors |
| US20030220234A1 (en) | 1998-11-02 | 2003-11-27 | Selvaraj Naicker | Deuterated cyclosporine analogs and their use as immunodulating agents |
| RU2001103044A (ru) | 1998-07-06 | 2003-08-10 | Бристол-Маерс Сквибб Ко. (Us) | Бенилсульфонамиды в качестве двойных антагонистов ангиотензиновых эндотелиновых рецепторов |
| DE19830430A1 (de) * | 1998-07-08 | 2000-01-13 | Hoechst Marion Roussel De Gmbh | Schwefelsubstituierte Sulfonylamino-carbonsäure-N-arylamide, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| GB9918037D0 (en) | 1999-07-30 | 1999-09-29 | Biochemie Gmbh | Organic compounds |
| WO2001047891A1 (fr) * | 1999-12-28 | 2001-07-05 | Eisai Co., Ltd. | Composes heterocylciques contenant des groupes de sulfamide |
| GB2361003A (en) * | 2000-04-07 | 2001-10-10 | Astrazeneca Ab | Novel compounds |
| AR031130A1 (es) * | 2000-09-20 | 2003-09-10 | Abbott Lab | N-acilsulfonamidas promotoras de la apoptosis |
| US20020055631A1 (en) * | 2000-09-20 | 2002-05-09 | Augeri David J. | N-acylsulfonamide apoptosis promoters |
| US6720338B2 (en) * | 2000-09-20 | 2004-04-13 | Abbott Laboratories | N-acylsulfonamide apoptosis promoters |
| US6995162B2 (en) | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
| SK14642003A3 (sk) | 2001-06-06 | 2004-12-01 | Eli Lilly And Company | Benzoylsulfónamidy a sulfonylbenzamidíny ako protinádorové činidlá |
| US20030059489A1 (en) | 2001-09-24 | 2003-03-27 | Canolio Inc. | Genital lubricating compositions and uses thereof |
| EP1429759A4 (en) * | 2001-09-26 | 2004-12-15 | Bristol Myers Squibb Co | COMPOUNDS FOR TREATING HEPATITIS C VIRUS |
| FR2836914B1 (fr) * | 2002-03-11 | 2008-03-14 | Aventis Pharma Sa | Indazoles substitues, compositions les contenant, procede de fabrication et utilisation |
| GB0215650D0 (en) * | 2002-07-05 | 2002-08-14 | Cyclacel Ltd | Bisarylsufonamide compounds |
| US6995787B2 (en) | 2002-08-21 | 2006-02-07 | Adams Steven L | Sports projectile and camera apparatus |
| JP4336678B2 (ja) | 2003-09-04 | 2009-09-30 | 株式会社日立超エル・エス・アイ・システムズ | 半導体装置 |
| US8614318B2 (en) * | 2003-11-13 | 2013-12-24 | Abbvie Inc. | Apoptosis promoters |
| WO2005049593A2 (en) * | 2003-11-13 | 2005-06-02 | Abbott Laboratories | N-acylsulfonamide apoptosis promoters |
| US7973161B2 (en) * | 2003-11-13 | 2011-07-05 | Abbott Laboratories | Apoptosis promoters |
| US7642260B2 (en) * | 2003-11-13 | 2010-01-05 | Abbott Laboratories, Inc. | Apoptosis promoters |
| US7767684B2 (en) * | 2003-11-13 | 2010-08-03 | Abbott Laboratories | Apoptosis promoters |
| DE602004009344T2 (de) | 2004-04-19 | 2008-07-10 | Symed Labs Ltd., Hyderabad | Neues verfahren zur herstellung von linezolid und verwandten verbindungen |
| RU2416606C2 (ru) * | 2004-06-17 | 2011-04-20 | Инфинити Дискавери, Инк. | Соединения и способы для ингибирования взаимодействия bcl белков с компонентами по связыванию |
| ATE429423T1 (de) | 2004-07-20 | 2009-05-15 | Symed Labs Ltd | Neue zwischenprodukte für linezolid und verwandte verbindungen |
| US7361764B2 (en) * | 2004-07-27 | 2008-04-22 | Sgx Pharmaceuticals, Inc. | Pyrrolo-pyridine kinase modulators |
| US7511013B2 (en) | 2004-09-29 | 2009-03-31 | Amr Technology, Inc. | Cyclosporin analogues and their pharmaceutical uses |
| WO2007040650A2 (en) * | 2005-05-12 | 2007-04-12 | Abbott Laboratories | Apoptosis promoters |
| US8624027B2 (en) * | 2005-05-12 | 2014-01-07 | Abbvie Inc. | Combination therapy for treating cancer and diagnostic assays for use therein |
| BRPI0610828A2 (pt) | 2005-05-16 | 2010-07-27 | Irm Llc | compostos e composições como inibidores de proteìna quinase |
| TW200716636A (en) | 2005-05-31 | 2007-05-01 | Speedel Experimenta Ag | Heterocyclic spiro-compounds |
| AU2006261993B2 (en) | 2005-06-22 | 2011-11-17 | Plexxikon, Inc. | Pyrrolo (2, 3-B) pyridine derivatives as protein kinase inhibitors |
| US7514068B2 (en) | 2005-09-14 | 2009-04-07 | Concert Pharmaceuticals Inc. | Biphenyl-pyrazolecarboxamide compounds |
| US20070115787A1 (en) * | 2005-11-23 | 2007-05-24 | Seagate Technology Llc | Planar optical device for generating optical nanojets |
| EP2061560A2 (en) | 2006-09-05 | 2009-05-27 | Abbott Laboratories | Bcl inhibitors for treating platelet excess |
| US8796267B2 (en) | 2006-10-23 | 2014-08-05 | Concert Pharmaceuticals, Inc. | Oxazolidinone derivatives and methods of use |
| WO2008064116A2 (en) * | 2006-11-16 | 2008-05-29 | Abbott Laboratories | Method of preventing or treating organ, hematopoietic stem cell or bone marrow transplant rejection |
| CA2676944C (en) | 2007-02-15 | 2016-01-19 | F. Hoffmann-La Roche Ag | 2-aminooxazolines as taar1 ligands |
| WO2008124878A1 (en) | 2007-04-13 | 2008-10-23 | Cryptopharma Pty Ltd | Non-steroidal compounds |
| EP2148867B1 (en) | 2007-04-19 | 2014-09-10 | Concert Pharmaceuticals Inc. | Deuterated morpholinyl compounds |
| US7531685B2 (en) | 2007-06-01 | 2009-05-12 | Protia, Llc | Deuterium-enriched oxybutynin |
| WO2009035598A1 (en) | 2007-09-10 | 2009-03-19 | Concert Pharmaceuticals, Inc. | Deuterated pirfenidone |
| US20090118238A1 (en) | 2007-09-17 | 2009-05-07 | Protia, Llc | Deuterium-enriched alendronate |
| US20090088416A1 (en) | 2007-09-26 | 2009-04-02 | Protia, Llc | Deuterium-enriched lapaquistat |
| US20090082471A1 (en) | 2007-09-26 | 2009-03-26 | Protia, Llc | Deuterium-enriched fingolimod |
| US20090137457A1 (en) | 2007-10-02 | 2009-05-28 | Concert Pharmaceuticals, Inc. | Pyrimidinedione derivatives |
| US20090098118A1 (en) * | 2007-10-15 | 2009-04-16 | Thomas Friess | Combination therapy of a type ii anti-cd20 antibody with an anti-bcl-2 active agent |
| US8410124B2 (en) | 2007-10-18 | 2013-04-02 | Concert Pharmaceuticals Inc. | Deuterated etravirine |
| US20090105338A1 (en) | 2007-10-18 | 2009-04-23 | Protia, Llc | Deuterium-enriched gabexate mesylate |
| CA2703591C (en) | 2007-10-26 | 2013-05-07 | Concert Pharmaceuticals, Inc. | Deuterated darunavir |
| US8168784B2 (en) * | 2008-06-20 | 2012-05-01 | Abbott Laboratories | Processes to make apoptosis promoters |
| US8557983B2 (en) * | 2008-12-04 | 2013-10-15 | Abbvie Inc. | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| US20100160322A1 (en) * | 2008-12-04 | 2010-06-24 | Abbott Laboratories | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| UA108193C2 (uk) * | 2008-12-04 | 2015-04-10 | Апоптозіндукуючий засіб для лікування раку і імунних і аутоімунних захворювань | |
| ME02642B (me) | 2008-12-05 | 2017-06-20 | Abbvie Inc | Sulfonamid derivati i kao BCL- 2 selektivni agensi za induciranje apoptoze namijenjeni liječenju raka i imunih bolesti |
| US8563735B2 (en) * | 2008-12-05 | 2013-10-22 | Abbvie Inc. | Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases |
| US8586754B2 (en) * | 2008-12-05 | 2013-11-19 | Abbvie Inc. | BCL-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases |
| US20110245156A1 (en) | 2008-12-09 | 2011-10-06 | Cytokine Pharmasciences, Inc. | Novel antiviral compounds, compositions, and methods of use |
| WO2010072734A2 (en) | 2008-12-23 | 2010-07-01 | The Provost Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin | Targeting prodrugs and compositions for the treatment of gastrointestinal diseases |
| BRPI1006115A8 (pt) * | 2009-01-19 | 2017-09-26 | Abbott Lab | "agentes indutores de apoptose para o tratamento de câncer e doenças autoimunes". |
| ES2536090T3 (es) * | 2009-01-19 | 2015-05-20 | Abbvie Inc. | Agentes inductores de la apoptosis para el tratamiento del cáncer y enfermedades inmunitarias y autoinmunitarias |
| US8546399B2 (en) * | 2009-05-26 | 2013-10-01 | Abbvie Inc. | Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases |
| PL2435432T6 (pl) * | 2009-05-26 | 2024-02-12 | Abbvie Ireland Unlimited Company | Środki wywołujące apoptozę do leczenia raka oraz chorób immunologicznych i autoimmunologicznych |
-
2010
- 2010-05-26 PL PL10721246.6T patent/PL2435432T6/pl unknown
- 2010-05-26 RU RU2014132884/04A patent/RU2573832C2/ru active
- 2010-05-26 TW TW104138114A patent/TWI561523B/zh active
- 2010-05-26 EP EP15167892.7A patent/EP2944638A1/en not_active Withdrawn
- 2010-05-26 CA CA3206963A patent/CA3206963A1/en active Pending
- 2010-05-26 BR BRPI1014359-9A patent/BRPI1014359B1/pt active IP Right Grant
- 2010-05-26 KR KR1020187032920A patent/KR102001418B1/ko active IP Right Grant
- 2010-05-26 NZ NZ595708A patent/NZ595708A/en unknown
- 2010-05-26 ME MEP-2015-124A patent/ME02205B/me unknown
- 2010-05-26 CN CN201510165051.4A patent/CN104876927B/zh active Active
- 2010-05-26 RS RS20150592A patent/RS54234B2/sr unknown
- 2010-05-26 AR ARP100101806A patent/AR076705A1/es active IP Right Grant
- 2010-05-26 KR KR1020197020313A patent/KR20190086591A/ko active IP Right Grant
- 2010-05-26 ES ES10721246T patent/ES2546294T7/es active Active
- 2010-05-26 PT PT107212466T patent/PT2435432E/pt unknown
- 2010-05-26 WO PCT/US2010/036198 patent/WO2010138588A2/en active Application Filing
- 2010-05-26 DK DK10721246.6T patent/DK2435432T6/da active
- 2010-05-26 EP EP19195104.5A patent/EP3656771A1/en not_active Withdrawn
- 2010-05-26 HU HUE10721246A patent/HUE027698T2/en unknown
- 2010-05-26 AU AU2010254160A patent/AU2010254160C1/en active Active
- 2010-05-26 HR HRP20151001TT patent/HRP20151001T4/hr unknown
- 2010-05-26 KR KR1020157014221A patent/KR101723378B1/ko active IP Right Review Request
- 2010-05-26 KR KR1020187011857A patent/KR101920202B1/ko active IP Right Grant
- 2010-05-26 CA CA2929347A patent/CA2929347A1/en not_active Abandoned
- 2010-05-26 BR BR122019016429-0A patent/BR122019016429B1/pt active IP Right Grant
- 2010-05-26 CR CR20170019A patent/CR20170019A/es unknown
- 2010-05-26 PE PE2011002025A patent/PE20120345A1/es active IP Right Grant
- 2010-05-26 MY MYPI2011005633A patent/MY155645A/en unknown
- 2010-05-26 EP EP10721246.6A patent/EP2435432B3/en active Active
- 2010-05-26 KR KR1020197033737A patent/KR20190130676A/ko active Application Filing
- 2010-05-26 CN CN201080023068.1A patent/CN102448959B/zh active Active
- 2010-05-26 CA CA3052016A patent/CA3052016A1/en not_active Abandoned
- 2010-05-26 SI SI201031011T patent/SI2435432T2/sl unknown
- 2010-05-26 IL IL299019A patent/IL299019A/en unknown
- 2010-05-26 UA UAA201115309A patent/UA106079C2/uk unknown
- 2010-05-26 RU RU2011152973A patent/RU2535347C3/ru active Protection Beyond IP Right Term
- 2010-05-26 TW TW099116922A patent/TWI476195B/zh active
- 2010-05-26 SG SG10201704742YA patent/SG10201704742YA/en unknown
- 2010-05-26 KR KR1020177008201A patent/KR20170037683A/ko active Application Filing
- 2010-05-26 TW TW103138402A patent/TWI537269B/zh active
- 2010-05-26 CN CN201910261444.3A patent/CN109897038B/zh active Active
- 2010-05-26 KR KR1020117030916A patent/KR101659583B1/ko active Protection Beyond IP Right Term
- 2010-05-26 CN CN201910270919.5A patent/CN109966294A/zh active Pending
- 2010-05-26 UY UY0001032668A patent/UY32668A/es active IP Right Grant
- 2010-05-26 SG SG2011075843A patent/SG175253A1/en unknown
- 2010-05-26 MX MX2011012257A patent/MX339469B/es active IP Right Grant
- 2010-05-26 KR KR1020237028352A patent/KR20230128571A/ko active Search and Examination
- 2010-05-26 CN CN201510215766.6A patent/CN104906100A/zh active Pending
- 2010-05-26 JP JP2012513209A patent/JP5747025B2/ja active Active
- 2010-05-26 CA CA2759182A patent/CA2759182C/en active Active
- 2010-11-22 US US12/951,344 patent/US8580794B2/en active Active
- 2010-11-23 UY UY0001033047A patent/UY33047A/es not_active Application Discontinuation
-
2011
- 2011-10-09 IL IL215644A patent/IL215644A/en active IP Right Grant
- 2011-11-17 MX MX2019012154A patent/MX2019012154A/es unknown
- 2011-11-22 CL CL2011002949A patent/CL2011002949A1/es unknown
- 2011-11-23 ZA ZA2011/08616A patent/ZA201108616B/en unknown
- 2011-11-25 DO DO2011000367A patent/DOP2011000367A/es unknown
- 2011-11-25 CR CR20110632A patent/CR20110632A/es unknown
- 2011-12-26 CO CO11178424A patent/CO6480950A2/es not_active Application Discontinuation
- 2011-12-26 EC EC2011011554A patent/ECSP11011554A/es unknown
-
2012
- 2012-04-19 HK HK12103892.9A patent/HK1163099A1/xx unknown
-
2015
- 2015-01-09 JP JP2015003098A patent/JP6038195B2/ja active Active
- 2015-02-10 PH PH12015500297A patent/PH12015500297A1/en unknown
- 2015-09-23 CY CY20151100832T patent/CY1117423T1/el unknown
- 2015-09-24 SM SM201500225T patent/SMT201500225B/xx unknown
- 2015-12-18 RU RU2015154494A patent/RU2628885C2/ru active
-
2016
- 2016-03-25 HK HK16103532.1A patent/HK1215576A1/zh unknown
- 2016-10-31 JP JP2016212548A patent/JP6353506B2/ja active Active
-
2017
- 2017-05-16 NL NL300873C patent/NL300873I2/nl unknown
- 2017-05-16 HU HUS1700021C patent/HUS1700021I1/hu unknown
- 2017-05-18 LT LTPA2017015C patent/LTC2435432I2/lt unknown
- 2017-05-25 CY CY2017019C patent/CY2017019I2/el unknown
- 2017-05-29 FI FIEP10721246.6T patent/FI2435432T6/fi active
- 2017-05-29 NO NO2017023C patent/NO2017023I1/no unknown
- 2017-08-07 IL IL253891A patent/IL253891A0/en unknown
- 2017-10-18 AR ARP170102895A patent/AR109974A2/es active IP Right Grant
-
2018
- 2018-04-18 JP JP2018079598A patent/JP2018138577A/ja not_active Ceased
- 2018-07-31 UY UY0001037825A patent/UY37825A/es active IP Right Grant
-
2019
- 2019-09-03 IL IL26909219A patent/IL269092A/en unknown
- 2019-10-17 JP JP2019189974A patent/JP2020023545A/ja not_active Ceased
-
2021
- 2021-09-01 IL IL286036A patent/IL286036A/en unknown
- 2021-12-09 JP JP2021199837A patent/JP2022033939A/ja not_active Ceased
-
2023
- 2023-01-10 JP JP2023001499A patent/JP2023040165A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NL300873I2 (nl) | Venetoclax | |
| DK2414015T3 (da) | Laryngoskopsystem | |
| DE112010004215A5 (de) | Hydrostataktor | |
| DE112010002949A5 (de) | Kupplungstastpunkte | |
| DK2411442T4 (da) | Umættet polyesterresin | |
| DK2430035T3 (da) | Uracylspipooxetannukleosider | |
| BRPI1008827A2 (pt) | deisobutenizador | |
| BRPI1014968A2 (pt) | subalargador | |
| DE112010002728A5 (de) | Turboinhalator | |
| DE112010004249A5 (de) | Spindelaktor | |
| DE112009005323A5 (de) | Hebelarmprüfmaschine | |
| DE112009005462T8 (de) | Lenkungsssteuervorrichtung | |
| BR112012004964A2 (pt) | girocóptero | |
| BRPI1008070A2 (pt) | tricianoboratos | |
| DK2483126T3 (da) | Skinnekøretøj | |
| DE112010004865T8 (de) | Lamellennassreibkupplung | |
| DK2506968T3 (da) | Faujasit-zeolit | |
| DE112010003255A5 (de) | Fördergutverteiler | |
| BRPI1010159A2 (pt) | bistuti | |
| DE602010000025D1 (de) | Fahrzeugsitzgurtvorrichtung | |
| FI20090100A0 (fi) | Biotinidaasimääritys | |
| BR112012003616A2 (pt) | metilpirroloprimidinacarboxamidas | |
| DE112010002351A5 (de) | Klemmorrichtung | |
| DE112010003843T8 (de) | Lastansteuervorrichtung | |
| DE202009005065U8 (de) | Kartonverschließmaschine |