EA202091963A1 - СИНЕРГИЧЕСКИЙ ПРОТИВООПУХОЛЕВЫЙ ЭФФЕКТ ИНГИБИТОРА Bcl-2 В СОЧЕТАНИИ С РИТУКСИМАБОМ И/ИЛИ БЕНДАМУСТИНОМ ИЛИ ИНГИБИТОРА Bcl-2 В СОЧЕТАНИИ С CHOP - Google Patents
СИНЕРГИЧЕСКИЙ ПРОТИВООПУХОЛЕВЫЙ ЭФФЕКТ ИНГИБИТОРА Bcl-2 В СОЧЕТАНИИ С РИТУКСИМАБОМ И/ИЛИ БЕНДАМУСТИНОМ ИЛИ ИНГИБИТОРА Bcl-2 В СОЧЕТАНИИ С CHOPInfo
- Publication number
- EA202091963A1 EA202091963A1 EA202091963A EA202091963A EA202091963A1 EA 202091963 A1 EA202091963 A1 EA 202091963A1 EA 202091963 A EA202091963 A EA 202091963A EA 202091963 A EA202091963 A EA 202091963A EA 202091963 A1 EA202091963 A1 EA 202091963A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- bcl
- inhibitor
- combination
- chop
- bendamustin
- Prior art date
Links
- 239000012664 BCL-2-inhibitor Substances 0.000 title abstract 3
- 229940123711 Bcl2 inhibitor Drugs 0.000 title abstract 3
- 230000000259 anti-tumor effect Effects 0.000 title 1
- 229960004641 rituximab Drugs 0.000 title 1
- 230000002195 synergetic effect Effects 0.000 title 1
- 239000013066 combination product Substances 0.000 abstract 4
- 229940127555 combination product Drugs 0.000 abstract 4
- 206010072579 Granulomatosis with polyangiitis Diseases 0.000 abstract 2
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 2
- 102100021569 Apoptosis regulator Bcl-2 Human genes 0.000 abstract 1
- 108091008038 CHOP Proteins 0.000 abstract 1
- 102100021246 DDIT3 upstream open reading frame protein Human genes 0.000 abstract 1
- 101000971171 Homo sapiens Apoptosis regulator Bcl-2 Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- YTKUWDBFDASYHO-UHFFFAOYSA-N bendamustine Chemical compound ClCCN(CCCl)C1=CC=C2N(C)C(CCCC(O)=O)=NC2=C1 YTKUWDBFDASYHO-UHFFFAOYSA-N 0.000 abstract 1
- 229960002707 bendamustine Drugs 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 206010063344 microscopic polyangiitis Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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Abstract
В данном документе представлен комбинированный продукт, содержащий ингибитор Bcl-2, антитело к CD20 и/или бендамустин, или комбинированный продукт, содержащий ингибитор Bcl-2 и CHOP, при этом комбинированный продукт предусматривает применение комбинированного продукта для предупреждения и/или лечения заболевания (например, рака, ревматоидного артрита (RA), гранулематоза с полиангиитом (GPA) и микроскопического полиангиита).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810867252 | 2018-07-31 | ||
PCT/CN2019/097028 WO2020024826A1 (en) | 2018-07-31 | 2019-07-22 | Synergistic antitumor effect of bcl-2 inhibitor combined with rituximab and/or bendamustine or bcl-2 inhibitor combined with chop |
Publications (1)
Publication Number | Publication Date |
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EA202091963A1 true EA202091963A1 (ru) | 2021-05-13 |
Family
ID=69231401
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA202091963A EA202091963A1 (ru) | 2018-07-31 | 2019-07-22 | СИНЕРГИЧЕСКИЙ ПРОТИВООПУХОЛЕВЫЙ ЭФФЕКТ ИНГИБИТОРА Bcl-2 В СОЧЕТАНИИ С РИТУКСИМАБОМ И/ИЛИ БЕНДАМУСТИНОМ ИЛИ ИНГИБИТОРА Bcl-2 В СОЧЕТАНИИ С CHOP |
Country Status (15)
Country | Link |
---|---|
US (1) | US11554127B2 (ru) |
EP (1) | EP3672591B1 (ru) |
JP (1) | JP2021516262A (ru) |
KR (1) | KR20200139139A (ru) |
CN (1) | CN110772640B (ru) |
AU (1) | AU2019315466B2 (ru) |
BR (1) | BR112020019134A2 (ru) |
CA (1) | CA3092753C (ru) |
EA (1) | EA202091963A1 (ru) |
GE (1) | GEP20237460B (ru) |
IL (1) | IL277309A (ru) |
MX (1) | MX2020009759A (ru) |
TW (1) | TWI726362B (ru) |
UA (1) | UA125241C2 (ru) |
WO (1) | WO2020024826A1 (ru) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
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CN110772640B (zh) | 2018-07-31 | 2023-02-03 | 苏州亚盛药业有限公司 | Bcl-2抑制剂与利妥昔单抗和/或苯达莫司汀或与CHOP联合的协同抗肿瘤作用 |
CN110772521A (zh) | 2018-07-31 | 2020-02-11 | 苏州亚盛药业有限公司 | Bcl-2抑制剂或Bcl-2/Bcl-xL抑制剂与BTK抑制剂的组合产品及其用途 |
WO2020024834A1 (en) | 2018-07-31 | 2020-02-06 | Ascentage Pharma (Suzhou) Co., Ltd. | Combination product of bcl-2 inhibitor and chemotherapeutic agent and use thereof in the prevention and/or treatment of diseases |
MX2020009757A (es) | 2018-07-31 | 2020-10-08 | Ascentage Pharma Suzhou Co Ltd | Producto combinado de inhibidor de bcl-2 e inhibidor de mdm2 y uso de este en la prevencion y/o tratamiento de enfermedades. |
WO2021110097A1 (en) * | 2019-12-03 | 2021-06-10 | Ascentage Pharma (Suzhou) Co., Ltd. | N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors |
US20220323465A1 (en) * | 2019-12-04 | 2022-10-13 | Ascentage Pharma (Suzhou) Co., Ltd. | Pharmaceutical combination and use thereof |
JP2023545498A (ja) * | 2020-10-16 | 2023-10-30 | リキュリウム アイピー ホールディングス リミテッド ライアビリティー カンパニー | Bcl-2阻害剤と化学療法剤との組み合わせ |
CN114681458B (zh) * | 2020-12-28 | 2023-07-18 | 苏州亚盛药业有限公司 | 治疗多发性硬化症的方法 |
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CN105061315B (zh) | 2015-08-06 | 2017-10-24 | 大连理工大学 | 一类1,5‑二苯基吡唑‑3‑羧酸类化合物及其应用 |
KR20180041677A (ko) | 2015-08-28 | 2018-04-24 | 노파르티스 아게 | Mdm2 억제제 및 그의 조합물 |
KR102429704B1 (ko) * | 2016-08-05 | 2022-08-04 | 더 리젠츠 오브 더 유니버시티 오브 미시건 | Bcl-2 억제제로서의 n-(페닐설포닐)벤즈아미드 및 관련 화합물 |
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CN110772521A (zh) | 2018-07-31 | 2020-02-11 | 苏州亚盛药业有限公司 | Bcl-2抑制剂或Bcl-2/Bcl-xL抑制剂与BTK抑制剂的组合产品及其用途 |
MX2020009757A (es) * | 2018-07-31 | 2020-10-08 | Ascentage Pharma Suzhou Co Ltd | Producto combinado de inhibidor de bcl-2 e inhibidor de mdm2 y uso de este en la prevencion y/o tratamiento de enfermedades. |
CN110772640B (zh) | 2018-07-31 | 2023-02-03 | 苏州亚盛药业有限公司 | Bcl-2抑制剂与利妥昔单抗和/或苯达莫司汀或与CHOP联合的协同抗肿瘤作用 |
US20210275522A1 (en) * | 2018-11-23 | 2021-09-09 | Ascentage Pharma (Suzhou) Co., Ltd. | Pharmaceutical compositions and use thereof |
TWI770503B (zh) * | 2019-05-13 | 2022-07-11 | 大陸商蘇州亞盛藥業有限公司 | 用於預測bcl-2/bcl-xl抑制劑對癌症的功效的方法和組合物 |
WO2021110097A1 (en) * | 2019-12-03 | 2021-06-10 | Ascentage Pharma (Suzhou) Co., Ltd. | N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors |
CN112168830B (zh) * | 2019-07-02 | 2022-01-25 | 苏州亚盛药业有限公司 | 一种含有mTOR抑制剂的药物组合及其应用 |
TW202114664A (zh) * | 2019-07-31 | 2021-04-16 | 大陸商蘇州亞盛藥業有限公司 | Bcl-2/Bcl-xL抑制劑與化療藥的組合產品及其在預防和/或治療疾病中的用途 |
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2019
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- 2019-07-22 US US16/648,593 patent/US11554127B2/en active Active
- 2019-07-22 EP EP19845466.2A patent/EP3672591B1/en active Active
- 2019-07-22 UA UAA202005954A patent/UA125241C2/uk unknown
- 2019-07-22 BR BR112020019134-5A patent/BR112020019134A2/pt not_active IP Right Cessation
- 2019-07-22 MX MX2020009759A patent/MX2020009759A/es unknown
- 2019-07-22 EA EA202091963A patent/EA202091963A1/ru unknown
- 2019-07-22 JP JP2020570625A patent/JP2021516262A/ja active Pending
- 2019-07-22 CA CA3092753A patent/CA3092753C/en active Active
- 2019-07-22 GE GEAP201915446A patent/GEP20237460B/en unknown
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CA3092753C (en) | 2023-10-17 |
TWI726362B (zh) | 2021-05-01 |
EP3672591A4 (en) | 2021-01-13 |
US11554127B2 (en) | 2023-01-17 |
CA3092753A1 (en) | 2020-02-06 |
MX2020009759A (es) | 2020-10-08 |
US20210361678A1 (en) | 2021-11-25 |
AU2019315466A1 (en) | 2020-09-24 |
KR20200139139A (ko) | 2020-12-11 |
GEP20237460B (en) | 2023-01-25 |
CN110772640B (zh) | 2023-02-03 |
EP3672591A1 (en) | 2020-07-01 |
IL277309A (en) | 2020-10-29 |
BR112020019134A2 (pt) | 2021-02-09 |
JP2021516262A (ja) | 2021-07-01 |
WO2020024826A1 (en) | 2020-02-06 |
EP3672591B1 (en) | 2024-02-14 |
CN110772640A (zh) | 2020-02-11 |
UA125241C2 (uk) | 2022-02-02 |
TW202019409A (zh) | 2020-06-01 |
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