AR113429A1 - Terapia combinada de agonistas de icos dirigidos a tumores con moléculas biespecíficas de linfocitos t - Google Patents
Terapia combinada de agonistas de icos dirigidos a tumores con moléculas biespecíficas de linfocitos tInfo
- Publication number
- AR113429A1 AR113429A1 ARP180103770A ARP180103770A AR113429A1 AR 113429 A1 AR113429 A1 AR 113429A1 AR P180103770 A ARP180103770 A AR P180103770A AR P180103770 A ARP180103770 A AR P180103770A AR 113429 A1 AR113429 A1 AR 113429A1
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- Prior art keywords
- binding
- antigen
- molecules
- icus
- lymphocytes
- Prior art date
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3007—Carcino-embryonic Antigens
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3053—Skin, nerves, brain
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
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- Animal Behavior & Ethology (AREA)
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- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
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- General Chemical & Material Sciences (AREA)
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- Oncology (AREA)
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- Neurology (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La presente se refiere a moléculas de unión a ICOS agonistas que comprenden al menos un dominio de unión a antígeno que se une a un antígeno asociado con tumores y a su uso en combinación con moléculas biespecíficas de linfocitos T en el tratamiento del cáncer, a las moléculas de unión a ICOS agonistas en sí, a composiciones farmacéuticas que comprenden estas moléculas y a métodos para usar las mismas. Reivindicación 1: Una molécula de unión a ICOS agonista que comprende al menos un dominio de unión a antígeno capaz de unirse de manera específica a un antígeno asociado a tumores para usarse en un método para el tratamiento o retraso de la progresión de cánceres, en donde la molécula de unión a ICOS agonista que comprende al menos un dominio de unión a antígeno capaz de unirse de manera específica a un antígeno asociado a tumores se usa en combinación con un anticuerpo biespecífico anti-CD3 de activación de linfocitos T, específico para un antígeno asociado a tumores.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP17209444.3A EP3502140A1 (en) | 2017-12-21 | 2017-12-21 | Combination therapy of tumor targeted icos agonists with t-cell bispecific molecules |
Publications (1)
Publication Number | Publication Date |
---|---|
AR113429A1 true AR113429A1 (es) | 2020-04-29 |
Family
ID=60702548
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP180103770A AR113429A1 (es) | 2017-12-21 | 2018-12-20 | Terapia combinada de agonistas de icos dirigidos a tumores con moléculas biespecíficas de linfocitos t |
Country Status (13)
Country | Link |
---|---|
US (2) | US20200306373A1 (es) |
EP (2) | EP3502140A1 (es) |
JP (1) | JP2021506293A (es) |
KR (1) | KR20200104332A (es) |
CN (1) | CN111465619A (es) |
AR (1) | AR113429A1 (es) |
AU (1) | AU2018392753A1 (es) |
BR (1) | BR112020012105A2 (es) |
CA (1) | CA3084114A1 (es) |
IL (1) | IL275316A (es) |
MX (1) | MX2020006116A (es) |
TW (1) | TW201936639A (es) |
WO (1) | WO2019122049A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
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EP3619235A1 (en) | 2017-04-11 | 2020-03-11 | Inhibrx, Inc. | Multispecific polypeptide constructs having constrained cd3 binding and methods of using the same |
CN112789294A (zh) * | 2018-07-24 | 2021-05-11 | 印希比股份有限公司 | 含有受限cd3结合结构域和受体结合区的多特异性多肽构建体及其使用方法 |
US20200223925A1 (en) * | 2018-12-21 | 2020-07-16 | Hoffmann-La Roche Inc. | Tumor-targeted superagonistic cd28 antigen binding molecules |
WO2020260326A1 (en) * | 2019-06-27 | 2020-12-30 | F. Hoffmann-La Roche Ag | Novel icos antibodies and tumor-targeted antigen binding molecules comprising them |
EP4136112A1 (en) * | 2020-04-14 | 2023-02-22 | GlaxoSmithKline Intellectual Property Development Limited | Combination treatment for cancer |
CN114539416A (zh) * | 2020-11-26 | 2022-05-27 | 盛禾(中国)生物制药有限公司 | 一种双特异性抗体的层析纯化工艺 |
CN113603789A (zh) * | 2021-07-30 | 2021-11-05 | 宝诺威(苏州)生物技术有限公司 | 一种定向定量标记生物素的抗体及其制备方法与应用 |
CN117940460A (zh) * | 2021-09-08 | 2024-04-26 | 上海齐鲁制药研究中心有限公司 | 双特异性抗原结合分子及其应用 |
WO2023219120A1 (ja) * | 2022-05-12 | 2023-11-16 | アステラス製薬株式会社 | 抗cd37-抗cd3二重特異性抗体 |
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MX2017006571A (es) | 2014-11-20 | 2017-09-29 | Hoffmann La Roche | Moleculas de union a antigeno biespecificas activadoras de celulas t. |
EP3245227A4 (en) * | 2015-01-14 | 2018-07-25 | Compass Therapeutics LLC | Multispecific immunomodulatory antigen-binding constructs |
CN114773486A (zh) * | 2015-04-17 | 2022-07-22 | 高山免疫科学股份有限公司 | 具有可调的亲和力的免疫调节蛋白 |
WO2017055398A2 (en) * | 2015-10-02 | 2017-04-06 | F. Hoffmann-La Roche Ag | Bispecific antibodies specific for a costimulatory tnf receptor |
EP3231813A1 (en) * | 2016-03-29 | 2017-10-18 | F. Hoffmann-La Roche AG | Trimeric costimulatory tnf family ligand-containing antigen binding molecules |
EP3464367B1 (en) * | 2016-05-27 | 2020-09-09 | AbbVie Biotherapeutics Inc. | Bispecific binding proteins binding an immunomodulatory protein and a tumor antigen |
CN106589129B (zh) * | 2016-12-30 | 2021-03-05 | 上海近岸生物科技有限公司 | 一种结合cd19、cd3和cd28的三功能分子及其应用 |
US11535666B2 (en) * | 2016-12-30 | 2022-12-27 | Cytocares (Shanghai) Inc. | Trifunctional molecule and application thereof |
-
2017
- 2017-12-21 EP EP17209444.3A patent/EP3502140A1/en not_active Ceased
-
2018
- 2018-12-20 AR ARP180103770A patent/AR113429A1/es unknown
- 2018-12-20 MX MX2020006116A patent/MX2020006116A/es unknown
- 2018-12-20 EP EP18833865.1A patent/EP3728325A1/en active Pending
- 2018-12-20 CN CN201880080713.XA patent/CN111465619A/zh active Pending
- 2018-12-20 KR KR1020207020455A patent/KR20200104332A/ko active Search and Examination
- 2018-12-20 WO PCT/EP2018/086046 patent/WO2019122049A1/en unknown
- 2018-12-20 TW TW107146130A patent/TW201936639A/zh unknown
- 2018-12-20 AU AU2018392753A patent/AU2018392753A1/en active Pending
- 2018-12-20 JP JP2020533564A patent/JP2021506293A/ja active Pending
- 2018-12-20 CA CA3084114A patent/CA3084114A1/en active Pending
- 2018-12-20 BR BR112020012105-3A patent/BR112020012105A2/pt unknown
-
2020
- 2020-06-11 IL IL275316A patent/IL275316A/en unknown
- 2020-06-17 US US16/903,756 patent/US20200306373A1/en not_active Abandoned
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2023
- 2023-03-06 US US18/178,874 patent/US20230355754A1/en active Pending
Also Published As
Publication number | Publication date |
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US20230355754A1 (en) | 2023-11-09 |
TW201936639A (zh) | 2019-09-16 |
EP3502140A1 (en) | 2019-06-26 |
CA3084114A1 (en) | 2018-12-20 |
BR112020012105A2 (pt) | 2020-11-24 |
IL275316A (en) | 2020-07-30 |
KR20200104332A (ko) | 2020-09-03 |
US20200306373A1 (en) | 2020-10-01 |
JP2021506293A (ja) | 2021-02-22 |
WO2019122049A1 (en) | 2019-06-27 |
EP3728325A1 (en) | 2020-10-28 |
CN111465619A (zh) | 2020-07-28 |
AU2018392753A1 (en) | 2020-06-11 |
MX2020006116A (es) | 2020-08-24 |
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