EA201990183A1 - Аденовирус, вооруженный биспецифичным активатором т-клеток (bite) - Google Patents

Аденовирус, вооруженный биспецифичным активатором т-клеток (bite)

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Publication number
EA201990183A1
EA201990183A1 EA201990183A EA201990183A EA201990183A1 EA 201990183 A1 EA201990183 A1 EA 201990183A1 EA 201990183 A EA201990183 A EA 201990183A EA 201990183 A EA201990183 A EA 201990183A EA 201990183 A1 EA201990183 A1 EA 201990183A1
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Eurasian Patent Office
Prior art keywords
bite
specific
virus
cell activator
armed
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EA201990183A
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English (en)
Inventor
Брайан Роберт Чемпион
Элис Клэр Ноэль Бромли
Джошуа Дэвид Фридман
Керри Дэвид Фишер
Леонард Уильям Сеймур
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Псайоксус Терапьютикс Лимитед
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Priority claimed from PCT/EP2017/071674 external-priority patent/WO2018041838A1/en
Publication of EA201990183A1 publication Critical patent/EA201990183A1/ru

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Abstract

Модифицированный аденовирус, в частности enadenotucirev (EnAd), вооруженный биспецифичным активатором T-клеток (BiTE), содержащим по меньшей мере два связывающих домена, причем по меньшей мере один из доменов является специфичным к поверхностному антигену на представляющей интерес T-клетке. Также предложена композиция, например фармацевтический состав, содержащий указанный вирус, применение указанного вируса и составов, содержащих указанный вирус, для лечения, например лечения рака. В настоящем изобретении предложены также способы получения указанного вируса.
EA201990183A 2017-08-28 2017-08-29 Аденовирус, вооруженный биспецифичным активатором т-клеток (bite) EA201990183A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1713765.4A GB201713765D0 (en) 2017-08-28 2017-08-28 Modified adenovirus
PCT/EP2017/071674 WO2018041838A1 (en) 2016-08-29 2017-08-29 Adenovirus armed with bispecific t cell engager (bite)

Publications (1)

Publication Number Publication Date
EA201990183A1 true EA201990183A1 (ru) 2019-07-31

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Application Number Title Priority Date Filing Date
EA201990183A EA201990183A1 (ru) 2017-08-28 2017-08-29 Аденовирус, вооруженный биспецифичным активатором т-клеток (bite)
EA202090124A EA202090124A1 (ru) 2017-08-28 2018-08-28 Аденовирус, вооруженный биспецифическим рекрутером t-клеток (bite)

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US (2) US11840702B2 (ru)
EP (1) EP3675904A1 (ru)
JP (1) JP7280244B2 (ru)
KR (1) KR20200037826A (ru)
CN (1) CN111712257B (ru)
AU (1) AU2018322776B2 (ru)
BR (1) BR112020003842A2 (ru)
CA (1) CA3073480A1 (ru)
CO (1) CO2020001930A2 (ru)
EA (2) EA201990183A1 (ru)
GB (1) GB201713765D0 (ru)
IL (1) IL272872B (ru)
MX (1) MX2020002158A (ru)
MY (1) MY197586A (ru)
PH (1) PH12020500386A1 (ru)
SA (1) SA520411426B1 (ru)
SG (1) SG11202001537QA (ru)
UA (1) UA126972C2 (ru)
WO (1) WO2019043020A1 (ru)
ZA (1) ZA202000388B (ru)

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CN115161293A (zh) * 2021-04-01 2022-10-11 南京惟亚德生物医药有限公司 一种编码双特异性t细胞衔接子的溶瘤痘苗病毒及其制备方法和应用
WO2024022602A1 (en) 2022-07-28 2024-02-01 Akamis Bio Ltd Virus encoding transgenes to complement cellular therapy
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