PT85353B - Processo de preparacao de composicoes farmaceuticas de libertacao controlada e de matriz a base de alcool alifatico e resina acrilica - Google Patents
Processo de preparacao de composicoes farmaceuticas de libertacao controlada e de matriz a base de alcool alifatico e resina acrilica Download PDFInfo
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- PT85353B PT85353B PT85353A PT8535387A PT85353B PT 85353 B PT85353 B PT 85353B PT 85353 A PT85353 A PT 85353A PT 8535387 A PT8535387 A PT 8535387A PT 85353 B PT85353 B PT 85353B
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- process according
- acrylic resin
- weight
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- matrix
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Classifications
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        - A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
 
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        - A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
 
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        - A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
 
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        - A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
 
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        - A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
 
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        - A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/14—Antitussive agents
 
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        - A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
 
- 
        - A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
 
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        - A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
 
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        - A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
 
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        - A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
 
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        - A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
 
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title | 
|---|---|---|---|
| US06/887,340 US4861598A (en) | 1986-07-18 | 1986-07-18 | Controlled release bases for pharmaceuticals | 
Publications (2)
| Publication Number | Publication Date | 
|---|---|
| PT85353A PT85353A (en) | 1987-08-01 | 
| PT85353B true PT85353B (pt) | 1990-04-30 | 
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date | 
|---|---|---|---|
| PT85353A PT85353B (pt) | 1986-07-18 | 1987-07-17 | Processo de preparacao de composicoes farmaceuticas de libertacao controlada e de matriz a base de alcool alifatico e resina acrilica | 
Country Status (22)
| Country | Link | 
|---|---|
| US (1) | US4861598A (forum.php) | 
| EP (1) | EP0253104B1 (forum.php) | 
| JP (2) | JP2511054B2 (forum.php) | 
| KR (1) | KR930008954B1 (forum.php) | 
| CN (1) | CN1029770C (forum.php) | 
| AT (1) | ATE62404T1 (forum.php) | 
| AU (1) | AU596183B2 (forum.php) | 
| CA (1) | CA1296633C (forum.php) | 
| DE (1) | DE3769221D1 (forum.php) | 
| DK (1) | DK175627B1 (forum.php) | 
| DZ (1) | DZ1112A1 (forum.php) | 
| EG (1) | EG18574A (forum.php) | 
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| MX (1) | MX163284A (forum.php) | 
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Families Citing this family (145)
| Publication number | Priority date | Publication date | Assignee | Title | 
|---|---|---|---|---|
| US4970075A (en) * | 1986-07-18 | 1990-11-13 | Euroceltique, S.A. | Controlled release bases for pharmaceuticals | 
| US5266331A (en) * | 1991-11-27 | 1993-11-30 | Euroceltique, S.A. | Controlled release oxycodone compositions | 
| US5478577A (en) * | 1993-11-23 | 1995-12-26 | Euroceltique, S.A. | Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level | 
| US5968551A (en) * | 1991-12-24 | 1999-10-19 | Purdue Pharma L.P. | Orally administrable opioid formulations having extended duration of effect | 
| US5958459A (en) * | 1991-12-24 | 1999-09-28 | Purdue Pharma L.P. | Opioid formulations having extended controlled released | 
| US5681585A (en) * | 1991-12-24 | 1997-10-28 | Euro-Celtique, S.A. | Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer | 
| US20080075781A1 (en) * | 1992-11-25 | 2008-03-27 | Purdue Pharma Lp | Controlled release oxycodone compositions | 
| NZ260408A (en) | 1993-05-10 | 1996-05-28 | Euro Celtique Sa | Controlled release preparation comprising tramadol | 
| US20070275062A1 (en) * | 1993-06-18 | 2007-11-29 | Benjamin Oshlack | Controlled release oxycodone compositions | 
| IL109944A (en) * | 1993-07-01 | 1998-12-06 | Euro Celtique Sa | Sustained release dosage unit forms containing morphine and a method of preparing these sustained release dosage unit forms | 
| IL110014A (en) * | 1993-07-01 | 1999-11-30 | Euro Celtique Sa | Solid controlled-release oral dosage forms of opioid analgesics | 
| US7740881B1 (en) | 1993-07-01 | 2010-06-22 | Purdue Pharma Lp | Method of treating humans with opioid formulations having extended controlled release | 
| US5879705A (en) * | 1993-07-27 | 1999-03-09 | Euro-Celtique S.A. | Sustained release compositions of morphine and a method of preparing pharmaceutical compositions | 
| EP2036558A3 (en) * | 1993-10-07 | 2010-04-28 | Euro-Celtique S.A. | Orally administrable opioid formulations having extended duration of effect | 
| KR100354702B1 (ko) * | 1993-11-23 | 2002-12-28 | 유로-셀티크 소시에떼 아노뉨 | 약학조성물의제조방법및서방형조성물 | 
| US5891471A (en) * | 1993-11-23 | 1999-04-06 | Euro-Celtique, S.A. | Pharmaceutical multiparticulates | 
| US5843480A (en) * | 1994-03-14 | 1998-12-01 | Euro-Celtique, S.A. | Controlled release diamorphine formulation | 
| US5430021A (en) * | 1994-03-18 | 1995-07-04 | Pharmavene, Inc. | Hydrophobic drug delivery systems | 
| US5484608A (en) * | 1994-03-28 | 1996-01-16 | Pharmavene, Inc. | Sustained-release drug delivery system | 
| ES2097087B1 (es) * | 1994-08-01 | 1997-12-16 | Univ Sevilla | Sistema de liberacion controlada de morfina y otros farmacos solubles en agua por complejacion con sustancias polimericas. | 
| GB9422154D0 (en) * | 1994-11-03 | 1994-12-21 | Euro Celtique Sa | Pharmaceutical compositions and method of producing the same | 
| US5965161A (en) † | 1994-11-04 | 1999-10-12 | Euro-Celtique, S.A. | Extruded multi-particulates | 
| US20020006438A1 (en) * | 1998-09-25 | 2002-01-17 | Benjamin Oshlack | Sustained release hydromorphone formulations exhibiting bimodal characteristics | 
| GB9519363D0 (en) | 1995-09-22 | 1995-11-22 | Euro Celtique Sa | Pharmaceutical formulation | 
| US5811126A (en) * | 1995-10-02 | 1998-09-22 | Euro-Celtique, S.A. | Controlled release matrix for pharmaceuticals | 
| JPH1050306A (ja) * | 1996-07-31 | 1998-02-20 | Toyota Autom Loom Works Ltd | 水素吸蔵合金電極の製造方法 | 
| US6375957B1 (en) | 1997-12-22 | 2002-04-23 | Euro-Celtique, S.A. | Opioid agonist/opioid antagonist/acetaminophen combinations | 
| NZ505193A (en) | 1997-12-22 | 2003-03-28 | Euro Celtique S | Opioid agonist/antagonist combinations | 
| WO2000016776A1 (fr) * | 1998-09-18 | 2000-03-30 | Takeda Chemical Industries, Ltd. | Preparations a administrer par voie buccale a liberation lente | 
| US6806294B2 (en) | 1998-10-15 | 2004-10-19 | Euro-Celtique S.A. | Opioid analgesic | 
| DE19918325A1 (de) | 1999-04-22 | 2000-10-26 | Euro Celtique Sa | Verfahren zur Herstellung von Arzneiformen mit regulierter Wirkstofffreisetzung mittels Extrusion | 
| US10179130B2 (en) | 1999-10-29 | 2019-01-15 | Purdue Pharma L.P. | Controlled release hydrocodone formulations | 
| CA2389235C (en) * | 1999-10-29 | 2007-07-17 | Euro-Celtique, S.A. | Controlled release hydrocodone formulations | 
| BR0108379A (pt) | 2000-02-08 | 2002-11-05 | Euro Celtique Sa | Composições de liberação controlada contendo agonista e antagonista opióide, método para a preparação de uma formulação em dosagem de analgésico opióide de liberação controlada com potência analgésica aumentada e sistema de administração através da derme para um analgésico opióide | 
| ES2312413T3 (es) | 2000-02-08 | 2009-03-01 | Euro-Celtique S.A. | Composiciones de liberacion controlada que contienen un agonista y antagonista de opioide. | 
| US6716449B2 (en) | 2000-02-08 | 2004-04-06 | Euro-Celtique S.A. | Controlled-release compositions containing opioid agonist and antagonist | 
| KR100968128B1 (ko) | 2000-10-30 | 2010-07-06 | 유로-셀티크 소시에떼 아노뉨 | 서방성 하이드로코돈 제형 | 
| US20110104214A1 (en) | 2004-04-15 | 2011-05-05 | Purdue Pharma L.P. | Once-a-day oxycodone formulations | 
| UA81224C2 (uk) * | 2001-05-02 | 2007-12-25 | Euro Celtic S A | Дозована форма оксикодону та її застосування | 
| US20030065002A1 (en) | 2001-05-11 | 2003-04-03 | Endo Pharmaceuticals, Inc. | Abuse-resistant controlled-release opioid dosage form | 
| US20030129234A1 (en) * | 2001-07-06 | 2003-07-10 | Penwest Pharmaceuticals Company | Methods of making sustained release formulations of oxymorphone | 
| US8329216B2 (en) * | 2001-07-06 | 2012-12-11 | Endo Pharmaceuticals Inc. | Oxymorphone controlled release formulations | 
| AU2002318211B2 (en) | 2001-07-06 | 2007-07-12 | Endo Pharmaceuticals, Inc. | Parenteral administration of 6-hydroxy-oxymorphone for use as an analgesic | 
| DE60230632D1 (de) | 2001-07-18 | 2009-02-12 | Euro Celtique Sa | Pharmazeutische kombinationen von oxycodon und naloxon | 
| CA2457361C (en) | 2001-08-06 | 2008-11-04 | Christopher Breder | Opioid agonist formulations with releasable and sequestered antagonist | 
| AU2002324624A1 (en) | 2001-08-06 | 2003-02-24 | Euro-Celtique S.A. | Sequestered antagonist formulations | 
| US20030044458A1 (en) | 2001-08-06 | 2003-03-06 | Curtis Wright | Oral dosage form comprising a therapeutic agent and an adverse-effect agent | 
| US20030068375A1 (en) | 2001-08-06 | 2003-04-10 | Curtis Wright | Pharmaceutical formulation containing gelling agent | 
| JP2005523876A (ja) * | 2001-09-26 | 2005-08-11 | ペンウェスト ファーマシューティカルズ カンパニー | 乱用の可能性が低減したオピオイド製剤 | 
| JP4755810B2 (ja) | 2002-04-05 | 2011-08-24 | ユーロ−セルティーク エス.エイ. | オキシコドン及びナロキソンを含有する医薬製剤 | 
| GB0209265D0 (en) | 2002-04-23 | 2002-06-05 | Novartis Ag | Organic compounds | 
| DE60325715D1 (de) * | 2002-04-29 | 2009-02-26 | Alza Corp | Methoden und darreichungsformen zur kontrollierten freisetzung von oxykodon | 
| US20050106249A1 (en) * | 2002-04-29 | 2005-05-19 | Stephen Hwang | Once-a-day, oral, controlled-release, oxycodone dosage forms | 
| CN1671358A (zh) * | 2002-05-31 | 2005-09-21 | 阿尔扎公司 | 用于渗透传递可变剂量的羟考酮的剂型和组合物 | 
| US20040001889A1 (en) | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations | 
| AU2003247876B2 (en) | 2002-07-05 | 2006-10-05 | Collegium Pharmaceutical, Inc | Abuse-deterrent pharmaceutical compositions of opiods and other drugs | 
| US8557291B2 (en) * | 2002-07-05 | 2013-10-15 | Collegium Pharmaceutical, Inc. | Abuse-deterrent pharmaceutical compositions of opioids and other drugs | 
| US10004729B2 (en) | 2002-07-05 | 2018-06-26 | Collegium Pharmaceutical, Inc. | Tamper-resistant pharmaceutical compositions of opioids and other drugs | 
| US8840928B2 (en) * | 2002-07-05 | 2014-09-23 | Collegium Pharmaceutical, Inc. | Tamper-resistant pharmaceutical compositions of opioids and other drugs | 
| CA2498798A1 (en) * | 2002-09-20 | 2004-04-01 | Alpharma, Inc. | Sustained-release opioid formulations and methods of use | 
| AU2003270778B2 (en) | 2002-09-20 | 2009-10-08 | Alpharma Pharmaceuticals, Llc | Sequestering subunit and related compositions and methods | 
| US20040110781A1 (en) * | 2002-12-05 | 2004-06-10 | Harmon Troy M. | Pharmaceutical compositions containing indistinguishable drug components | 
| SI1575569T1 (sl) | 2002-12-13 | 2010-12-31 | Durect Corp | Oralni sistem dostave zdravila, ki obsega visokoviskozne tekoče nosilne materiale | 
| US20040202717A1 (en) | 2003-04-08 | 2004-10-14 | Mehta Atul M. | Abuse-resistant oral dosage forms and method of use thereof | 
| MY135852A (en) | 2003-04-21 | 2008-07-31 | Euro Celtique Sa | Pharmaceutical products | 
| EP1479381A1 (en) * | 2003-05-19 | 2004-11-24 | Euro-Celtique S.A. | Pharmaceutical dosage form comprising a solid solution | 
| US20060165790A1 (en) * | 2003-06-27 | 2006-07-27 | Malcolm Walden | Multiparticulates | 
| TWI357815B (en) * | 2003-06-27 | 2012-02-11 | Euro Celtique Sa | Multiparticulates | 
| EP1663229B1 (en) | 2003-09-25 | 2010-04-14 | Euro-Celtique S.A. | Pharmaceutical combinations of hydrocodone and naltrexone | 
| CA2874604A1 (en) * | 2003-10-03 | 2005-04-21 | Elite Laboratories Inc. | Extended release formulations of opioids and method of use thereof | 
| JP5646126B2 (ja) | 2003-12-11 | 2014-12-24 | サノビオン ファーマシューティカルズ インクSunovion Pharmaceuticals Inc. | 鎮静剤と神経伝達物質調節剤の併用、および睡眠の質の向上方法および鬱の治療方法 | 
| RS50817B (sr) * | 2004-03-30 | 2010-08-31 | Euro-Celtique S.A. | Dozni oblik otporan na promene koji sadrži adsorbenti i sredstvo sa suprotnim dejstvom | 
| TWI483944B (zh) | 2004-03-30 | 2015-05-11 | Euro Celtique Sa | 含有小於25ppm14-羥可待因酮之羥可酮鹽酸鹽組成物、醫藥劑型、延遲釋出口服劑型及醫藥上可以接受的包裝 | 
| US20050226929A1 (en) * | 2004-04-12 | 2005-10-13 | Jianbo Xie | Controlled release opioid analgesic formulation | 
| US20050266082A1 (en) * | 2004-05-26 | 2005-12-01 | Patel Satishkumar A | Preparation of stable paroxetine HC1 ER tablets using a melt granulation process | 
| EP1604666A1 (en) | 2004-06-08 | 2005-12-14 | Euro-Celtique S.A. | Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD) | 
| EP1604667A1 (en) | 2004-06-08 | 2005-12-14 | Euro-Celtique S.A. | Opioids for the treatment of the restless leg syndrome | 
| LT1765292T (lt) | 2004-06-12 | 2018-01-10 | Collegium Pharmaceutical, Inc. | Nuo piktnaudžiavimo apsaugotos vaistų formos | 
| US9308164B2 (en) | 2004-06-30 | 2016-04-12 | Sovereign Pharmaceuticals, Llc | Hyoscyamine dosage form | 
| GB2418854B (en) | 2004-08-31 | 2009-12-23 | Euro Celtique Sa | Multiparticulates | 
| LT2767292T (lt) * | 2004-09-17 | 2016-12-12 | Durect Corporation | Palaikomosios vietinės anestezijos mišinys su saib | 
| TWI369203B (en) | 2004-11-22 | 2012-08-01 | Euro Celtique Sa | Methods for purifying trans-(-)-△9-tetrahydrocannabinol and trans-(+)-△9-tetrahydrocannabinol | 
| CN101132772B (zh) * | 2005-01-28 | 2012-05-09 | 欧洲凯尔特公司 | 耐醇剂型 | 
| EP1702558A1 (en) | 2005-02-28 | 2006-09-20 | Euro-Celtique S.A. | Method and device for the assessment of bowel function | 
| EP1695700A1 (en) * | 2005-02-28 | 2006-08-30 | Euro-Celtique S.A. | Dosage form containing oxycodone and naloxone | 
| US20090214640A1 (en) * | 2005-03-04 | 2009-08-27 | Intelgenx Cporp. | Delayed release pharmaceutical oral dosage form and method of making same | 
| MY148074A (en) * | 2005-05-10 | 2013-02-28 | Novartis Ag | Pharmaceutical compositions comprising imatinib and a release retardant | 
| JP2008542419A (ja) | 2005-06-09 | 2008-11-27 | ユーロ−セルティーク エス.エイ. | 神経刺激性ステロイドの医薬組成物及びその使用 | 
| TWI366460B (en) | 2005-06-16 | 2012-06-21 | Euro Celtique Sa | Cannabinoid active pharmaceutical ingredient for improved dosage forms | 
| EP2502621A1 (en) | 2005-06-27 | 2012-09-26 | Valeant International (Barbados) SRL | Crystalline forms of bupropion HBr | 
| US20070027105A1 (en) | 2005-07-26 | 2007-02-01 | Alza Corporation | Peroxide removal from drug delivery vehicle | 
| EP1813276A1 (en) * | 2006-01-27 | 2007-08-01 | Euro-Celtique S.A. | Tamper resistant dosage forms | 
| US20070190141A1 (en) * | 2006-02-16 | 2007-08-16 | Aaron Dely | Extended release opiate composition | 
| US20070212414A1 (en) * | 2006-03-08 | 2007-09-13 | Penwest Pharmaceuticals Co. | Ethanol-resistant sustained release formulations | 
| US20070281016A1 (en) * | 2006-06-06 | 2007-12-06 | Endo Pharmaceuticals Inc., A Delaware Corporation | Sustained release oxycodone composition with acrylic polymer and surfactant | 
| US20070281017A1 (en) * | 2006-06-06 | 2007-12-06 | Endo Pharmaceuticals Inc., A Delaware Corporation | Sustained release oxycodone composition with acrylic polymer and metal hydroxide | 
| US20080069891A1 (en) * | 2006-09-15 | 2008-03-20 | Cima Labs, Inc. | Abuse resistant drug formulation | 
| AU2007261451A1 (en) | 2006-06-19 | 2007-12-27 | Alpharma Pharmaceuticals, Llc | Pharmaceutical compositions | 
| EP2068840A2 (en) * | 2006-07-21 | 2009-06-17 | LAB International SRL | Hydrophobic abuse deterrent delivery system | 
| AU2007285845A1 (en) * | 2006-08-16 | 2008-02-21 | Auspex Pharmaceuticals, Inc. | Preparation and utility of opioid analgesics | 
| SA07280459B1 (ar) | 2006-08-25 | 2011-07-20 | بيورديو فارما إل. بي. | أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني | 
| US8445018B2 (en) | 2006-09-15 | 2013-05-21 | Cima Labs Inc. | Abuse resistant drug formulation | 
| PT2117521E (pt) | 2006-11-03 | 2012-09-10 | Durect Corp | Sistemas de administração transdérmica que compreendem bupivacaína | 
| US20080220064A1 (en) * | 2006-12-06 | 2008-09-11 | Ramesh Ketkar Anant | Extended release matrix formulations of morphine | 
| GB0624880D0 (en) * | 2006-12-14 | 2007-01-24 | Johnson Matthey Plc | Improved method for making analgesics | 
| US8202542B1 (en) | 2007-05-31 | 2012-06-19 | Tris Pharma | Abuse resistant opioid drug-ion exchange resin complexes having hybrid coatings | 
| US20090124650A1 (en) * | 2007-06-21 | 2009-05-14 | Endo Pharmaceuticals, Inc. | Method of Treating Pain Utilizing Controlled Release Oxymorphone Pharmaceutical Compositions and Instructions on Effects of Alcohol | 
| US8415401B2 (en) | 2007-12-06 | 2013-04-09 | Durect Corporation | Oral pharmaceutical dosage forms | 
| US8623418B2 (en) | 2007-12-17 | 2014-01-07 | Alpharma Pharmaceuticals Llc | Pharmaceutical composition | 
| US20090246276A1 (en) | 2008-01-28 | 2009-10-01 | Graham Jackson | Pharmaceutical Compositions | 
| US20100003322A1 (en) * | 2008-07-03 | 2010-01-07 | Lai Felix S | Enteric coated hydrophobic matrix formulation | 
| US20100260844A1 (en) | 2008-11-03 | 2010-10-14 | Scicinski Jan J | Oral pharmaceutical dosage forms | 
| KR20140141727A (ko) | 2009-03-10 | 2014-12-10 | 유로-셀티큐 에스.에이. | 옥시코돈 및 날록손을 포함하는 즉시 방출 제약 조성물 | 
| FR2946533A1 (fr) | 2009-06-12 | 2010-12-17 | Ethypharm Sa | Reduction des fluctuations plasmatiques d'opioides. | 
| US10668060B2 (en) | 2009-12-10 | 2020-06-02 | Collegium Pharmaceutical, Inc. | Tamper-resistant pharmaceutical compositions of opioids and other drugs | 
| MX2012012991A (es) | 2010-05-11 | 2012-11-30 | Cima Labs Inc | Formas de dosificacion oral de liberacion prolongada resistentes al alcohol y que contienen metoprolol. | 
| KR101647267B1 (ko) | 2010-12-22 | 2016-08-09 | 퍼듀 퍼머 엘피 | 케이싱된 탬퍼 저항성 제어 방출 투여 형태 | 
| PH12013501345A1 (en) | 2010-12-23 | 2022-10-24 | Purdue Pharma Lp | Tamper resistant solid oral dosage forms | 
| US20130143867A1 (en) | 2011-12-02 | 2013-06-06 | Sychroneuron Inc. | Acamprosate formulations, methods of using the same, and combinations comprising the same | 
| CH708257B1 (de) | 2012-04-17 | 2019-05-15 | Purdue Pharma Lp | Zusammensetzung zur Behandlung einer Opioid-induzierten unerwünschten pharmakodynamischen Reaktion. | 
| TWI643860B (zh) | 2012-07-16 | 2018-12-11 | 羅德科技公司 | 改良之類鴉片合成方法 | 
| JP6236446B2 (ja) | 2012-07-16 | 2017-11-22 | ローズ テクノロジーズ | 改善されたオピオイド合成方法 | 
| PE20151301A1 (es) | 2013-02-05 | 2015-09-16 | Purdue Pharma Lp | Formulaciones farmaceuticas resistentes a la manipulacion indebida | 
| US10751287B2 (en) | 2013-03-15 | 2020-08-25 | Purdue Pharma L.P. | Tamper resistant pharmaceutical formulations | 
| US9555113B2 (en) | 2013-03-15 | 2017-01-31 | Durect Corporation | Compositions with a rheological modifier to reduce dissolution variability | 
| EP3878445A3 (en) | 2013-06-05 | 2021-10-27 | Synchroneuron Inc. | Acamprosate formulations, methods of using the same, and combinations comprising the same | 
| US10071089B2 (en) | 2013-07-23 | 2018-09-11 | Euro-Celtique S.A. | Combination of oxycodone and naloxone for use in treating pain in patients suffering from pain and a disease resulting in intestinal dysbiosis and/or increasing the risk for intestinal bacterial translocation | 
| WO2015015146A1 (en) | 2013-08-02 | 2015-02-05 | Johnson Matthey Public Limited Company | Process for the preparation of oxymorphone | 
| CN106029670A (zh) | 2014-01-15 | 2016-10-12 | 罗德科技公司 | 改进的羟考酮合成的方法 | 
| US9938285B2 (en) | 2014-01-15 | 2018-04-10 | Rhodes Technologies | Process for improved oxymorphone synthesis | 
| US9062063B1 (en) | 2014-03-21 | 2015-06-23 | Johnson Matthey Public Limited Company | Forms of oxymorphone hydrochloride | 
| US9849124B2 (en) | 2014-10-17 | 2017-12-26 | Purdue Pharma L.P. | Systems and methods for treating an opioid-induced adverse pharmacodynamic response | 
| US9918979B2 (en) | 2015-01-29 | 2018-03-20 | Johnson Matthey Public Limited Company | Process of preparing low ABUK oxymorphone hydrochloride | 
| US9943513B1 (en) | 2015-10-07 | 2018-04-17 | Banner Life Sciences Llc | Opioid abuse deterrent dosage forms | 
| CA3003950C (en) | 2015-10-23 | 2020-05-12 | Kashiv Pharma Llc | Enhanced abuse-deterrent formulations of oxycodone | 
| US10335405B1 (en) | 2016-05-04 | 2019-07-02 | Patheon Softgels, Inc. | Non-burst releasing pharmaceutical composition | 
| US9737530B1 (en) | 2016-06-23 | 2017-08-22 | Collegium Pharmaceutical, Inc. | Process of making stable abuse-deterrent oral formulations | 
| CA3028450A1 (en) | 2016-07-06 | 2018-01-11 | Durect Corporation | Oral dosage form with drug composition, barrier layer and drug layer | 
| US10335375B2 (en) | 2017-05-30 | 2019-07-02 | Patheon Softgels, Inc. | Anti-overingestion abuse deterrent compositions | 
| WO2019006404A1 (en) | 2017-06-30 | 2019-01-03 | Purdue Pharma L.P. | METHOD OF TREATMENT AND DOSAGE FORMS | 
| AU2018360383A1 (en) | 2017-11-02 | 2020-05-21 | Natureceuticals Sdn. Bhd. | Extract of orthosiphon stamineus, formulations, and uses thereof | 
| EP3727384A4 (en) | 2017-12-20 | 2021-11-03 | Purdue Pharma L.P. | ABUSE-DISSUASIVE MORPHINE SULPHATE FORMES | 
| CN115666621A (zh) | 2020-01-13 | 2023-01-31 | 度勒科特公司 | 具有减少的杂质的持续释放药物递送系统及相关方法 | 
| JP2024503402A (ja) | 2021-01-12 | 2024-01-25 | デュレクト コーポレーション | 徐放性薬物送達システム及び関連の方法 | 
| KR20230000634U (ko) | 2021-09-16 | 2023-03-23 | 장상환 | 분리가능한 쇠스랑 | 
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title | 
|---|---|---|---|---|
| US2805977A (en) | 1955-01-04 | 1957-09-10 | Smith Kline French Lab | Sustained release pharmaceutical preparation | 
| GB1405088A (en) * | 1971-06-03 | 1975-09-03 | Mundipharma Ag | Slow release formulation | 
| US3965256A (en) * | 1972-05-16 | 1976-06-22 | Synergistics | Slow release pharmaceutical compositions | 
| SE418247B (sv) * | 1975-11-17 | 1981-05-18 | Haessle Ab | Sett att framstella kroppar med reglerad frigoring av en aktiv komponent | 
| SE7813246L (sv) * | 1978-12-22 | 1980-06-23 | Haessle Ab | Fast farmaceutisk beredning innehallande kroppar med flera ytskikt | 
| SE8003805L (sv) * | 1980-05-21 | 1981-11-22 | Haessle Ab | En farmaceutisk beredning med forbettrade utlosningsegenskap | 
| ATE14379T1 (de) * | 1981-04-27 | 1985-08-15 | Haessle Ab | Pharmazeutisches praeparat. | 
| DE3124983A1 (de) * | 1981-06-25 | 1983-01-20 | Meditest Inst Fuer Medizinisch | Arzneiformen zur oralen verabreichung | 
| US4443428A (en) * | 1982-06-21 | 1984-04-17 | Euroceltique, S.A. | Extended action controlled release compositions | 
| DK58983D0 (da) * | 1983-02-11 | 1983-02-11 | Leo Pharm Prod Ltd | Farmaceutisk praeparat | 
| JPS6143108A (ja) * | 1984-08-03 | 1986-03-01 | Nippon Shinyaku Co Ltd | 医薬品製剤及びその製造法 | 
| NL8500724A (nl) * | 1985-03-13 | 1986-10-01 | Univ Groningen | Inrichtingen voor geregelde afgifte van werkzame stoffen, alsmede werkwijze ter vervaardiging daarvan. | 
- 
        1986
        - 1986-07-18 US US06/887,340 patent/US4861598A/en not_active Expired - Lifetime
 
- 
        1987
        - 1987-05-20 IL IL82604A patent/IL82604A/xx not_active IP Right Cessation
- 1987-05-22 ES ES198787107438T patent/ES2033259T3/es not_active Expired - Lifetime
- 1987-05-22 NZ NZ220406A patent/NZ220406A/xx unknown
- 1987-05-22 AT AT87107438T patent/ATE62404T1/de not_active IP Right Cessation
- 1987-05-22 DE DE8787107438T patent/DE3769221D1/de not_active Expired - Lifetime
- 1987-05-22 EP EP87107438A patent/EP0253104B1/en not_active Expired - Lifetime
- 1987-05-25 MX MX6617A patent/MX163284A/es unknown
- 1987-05-26 AU AU73403/87A patent/AU596183B2/en not_active Expired
- 1987-05-27 CA CA000538065A patent/CA1296633C/en not_active Expired - Lifetime
- 1987-06-01 IN IN427/CAL/87A patent/IN166546B/en unknown
- 1987-06-05 ZA ZA874038A patent/ZA874038B/xx unknown
- 1987-06-23 CN CN87104429A patent/CN1029770C/zh not_active Expired - Lifetime
- 1987-07-01 FI FI872917A patent/FI87045C/fi not_active IP Right Cessation
- 1987-07-13 EG EG410/87A patent/EG18574A/xx active
- 1987-07-15 DK DK198703676A patent/DK175627B1/da not_active IP Right Cessation
- 1987-07-15 JP JP62175018A patent/JP2511054B2/ja not_active Expired - Lifetime
- 1987-07-16 KR KR1019870007755A patent/KR930008954B1/ko not_active Expired - Lifetime
- 1987-07-17 NO NO872989A patent/NO169998C/no not_active IP Right Cessation
- 1987-07-17 PT PT85353A patent/PT85353B/pt unknown
- 1987-07-18 DZ DZ870126A patent/DZ1112A1/fr active
 
- 
        1991
        - 1991-04-16 GR GR91400498T patent/GR3001788T3/el unknown
 
- 
        1995
        - 1995-08-02 JP JP7197755A patent/JP2661646B2/ja not_active Expired - Lifetime
 
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