RS50817B - Dozni oblik otporan na promene koji sadrži adsorbenti i sredstvo sa suprotnim dejstvom - Google Patents

Dozni oblik otporan na promene koji sadrži adsorbenti i sredstvo sa suprotnim dejstvom

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Publication number
RS50817B
RS50817B RSP-2009/0145A RSP20090145A RS50817B RS 50817 B RS50817 B RS 50817B RS P20090145 A RSP20090145 A RS P20090145A RS 50817 B RS50817 B RS 50817B
Authority
RS
Serbia
Prior art keywords
dosage form
adsorbent
adverse agent
tamper resistant
pharmaceutical compositions
Prior art date
Application number
RSP-2009/0145A
Other languages
English (en)
Inventor
Osvaldo Abreu
Original Assignee
Euro-Celtique S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro-Celtique S.A. filed Critical Euro-Celtique S.A.
Publication of RS50817B publication Critical patent/RS50817B/sr

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    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
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Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1525851A (zh) * 2001-05-11 2004-09-01 ������ҩ�����޹�˾ 抗滥用阿片样物质控释剂型
US20030157168A1 (en) 2001-08-06 2003-08-21 Christopher Breder Sequestered antagonist formulations
WO2004112756A1 (en) 2003-06-26 2004-12-29 Isa Odidi Proton pump-inhibitor-containing capsules which comprise subunits differently structured for a delayed release of the active ingredient
PT1729730E (pt) 2004-03-30 2009-04-06 Euro Celtique Sa Forma de dosagem resistente às violações que compreende um adsorvente e um agente adverso
US8394409B2 (en) 2004-07-01 2013-03-12 Intellipharmaceutics Corp. Controlled extended drug release technology
US10624858B2 (en) 2004-08-23 2020-04-21 Intellipharmaceutics Corp Controlled release composition using transition coating, and method of preparing same
EP1802258A4 (en) 2004-09-13 2015-09-23 Chrono Therapeutics Inc BIOSYNCHRONE TRANSDERMAL MEDICINES
US8252321B2 (en) 2004-09-13 2012-08-28 Chrono Therapeutics, Inc. Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like
US10064828B1 (en) 2005-12-23 2018-09-04 Intellipharmaceutics Corp. Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems
US8202535B2 (en) 2006-01-06 2012-06-19 Acelrx Pharmaceuticals, Inc. Small-volume oral transmucosal dosage forms
US8252329B2 (en) 2007-01-05 2012-08-28 Acelrx Pharmaceuticals, Inc. Bioadhesive drug formulations for oral transmucosal delivery
US8865743B2 (en) 2006-01-06 2014-10-21 Acelrx Pharmaceuticals, Inc. Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain
US9561188B2 (en) 2006-04-03 2017-02-07 Intellipharmaceutics Corporation Controlled release delivery device comprising an organosol coat
US10960077B2 (en) 2006-05-12 2021-03-30 Intellipharmaceutics Corp. Abuse and alcohol resistant drug composition
CA2673837C (en) * 2007-01-05 2015-11-24 Acelrx Pharmaceuticals, Inc. Storage and dispensing devices for administration of oral transmucosal dosage forms
EP2219612A4 (en) 2007-12-17 2013-10-30 Paladin Labs Inc CONTROLLED RELEASE FORMULATION AVOIDING IMPROPER USES
PL2379111T3 (pl) * 2008-12-12 2013-08-30 Paladin Labs Inc Preparaty leków narkotycznych o obniżonym potencjale uzależniającym
EP2367541B1 (en) * 2008-12-16 2014-07-16 Paladin Labs Inc. Misuse preventative, controlled release formulation
CA2841785A1 (en) 2011-07-06 2013-01-10 The Parkinson's Institute Compositions and methods for treatment of symptoms in parkinson's disease patients
CN102697660B (zh) * 2012-06-04 2014-02-12 贵州景峰注射剂有限公司 一种去除微丸丸间静电的方法
WO2014022541A1 (en) * 2012-08-01 2014-02-06 Acura Pharmaceuticals, Inc. Stabilization of one-pot methamphetamine synthesis systems
WO2014197137A1 (en) * 2013-04-29 2014-12-11 Howard Brooks-Korn Diversion-resistant formulation
US9770514B2 (en) 2013-09-03 2017-09-26 ExxPharma Therapeutics LLC Tamper-resistant pharmaceutical dosage forms
CA2929866A1 (en) * 2013-12-23 2015-07-02 Purdue Pharma L.P. Opioid antagonist formulations
US10744131B2 (en) 2013-12-31 2020-08-18 Kashiv Biosciences, Llc Abuse-resistant drug formulations
JP2018511355A (ja) 2015-01-28 2018-04-26 クロノ セラピューティクス インコーポレイテッドＣｈｒｏｎｏ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． 薬剤送達方法及びシステム
US10679516B2 (en) 2015-03-12 2020-06-09 Morningside Venture Investments Limited Craving input and support system
US20170050173A1 (en) * 2015-08-19 2017-02-23 The Decaf Company, Llc Programmable mip catch and release technology
US9943513B1 (en) 2015-10-07 2018-04-17 Banner Life Sciences Llc Opioid abuse deterrent dosage forms
US10335405B1 (en) 2016-05-04 2019-07-02 Patheon Softgels, Inc. Non-burst releasing pharmaceutical composition
JP2020503950A (ja) 2017-01-06 2020-02-06 クロノ セラピューティクス インコーポレイテッドＣｈｒｏｎｏ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． 経皮薬剤送達の装置及び方法
CA3050250A1 (en) * 2017-01-13 2018-07-19 Kashiv Biosciences, Llc Opioid agonist / antagonist combination dosage forms
US10335375B2 (en) 2017-05-30 2019-07-02 Patheon Softgels, Inc. Anti-overingestion abuse deterrent compositions
CN107693361B (zh) * 2017-09-13 2024-04-26 北京化工大学 一种高效缓释纳米药物的制备装置
AU2019279884A1 (en) 2018-05-29 2020-12-10 Morningside Venture Investments Limited Drug delivery methods and systems
EP3610860A1 (en) * 2018-08-15 2020-02-19 Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen Composition of carbon dioxide absorbent or adsorbent, whereby the said composition contains a polymeric coating selected from silicone rubber and cellulose
CN113976075B (zh) * 2021-10-19 2023-09-19 恒枫食品科技有限公司 一种脱除溶液中咖啡因用的材料及系统
DE102021127957A1 (de) 2021-10-27 2023-04-27 Rheinisch-Westfälische Technische Hochschule Aachen, Körperschaft des öffentlichen Rechts Umhüllte Wirkstoffformulierung zu kontrollierten in vivo-Aufnahme von CO2
KR20240095253A (ko) 2021-10-27 2024-06-25 오11 바이오메디컬 게엠베하 Co2의 제어된 생체내 흡수를 위한 코팅된 활성 성분 제형

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3493657A (en) 1961-03-14 1970-02-03 Mozes Juda Lewenstein Therapeutic compositions of n-allyl-14-hydroxy - dihydronormorphinane and morphine
US3642986A (en) * 1970-04-01 1972-02-15 William Arthur Welch Aspirin-charcoal compositions
US3773955A (en) 1970-08-03 1973-11-20 Bristol Myers Co Analgetic compositions
US3966940A (en) 1973-11-09 1976-06-29 Bristol-Myers Company Analgetic compositions
US4761284A (en) 1977-12-27 1988-08-02 Kureha Kagaku Kogy Kabushiki Kaisha Antidote including activated carbon particles
JPS54154515A (en) * 1978-05-24 1979-12-05 Kureha Chem Ind Co Ltd Slowly releasing drug
JPS5646807A (en) * 1979-09-27 1981-04-28 Japan Atom Energy Res Inst Production of composition of complex gradually releasing physiologically active substance
US4457933A (en) 1980-01-24 1984-07-03 Bristol-Myers Company Prevention of analgesic abuse
JPS608220A (ja) * 1983-06-28 1985-01-17 Takeda Chem Ind Ltd 難溶性結晶薬物の非晶質化方法および混合粉砕物
DE3485000D1 (de) 1983-06-28 1991-10-10 Takeda Chemical Industries Ltd Gemahlene mischung.
GB8332556D0 (en) 1983-12-06 1984-01-11 Reckitt & Colmann Prod Ltd Analgesic compositions
US4673565A (en) 1985-05-03 1987-06-16 E. I. Du Pont De Nemours And Company Pharmaceutical compositions containing hollow fine tubular drug delivery systems
US4594249A (en) 1985-06-14 1986-06-10 21St Century Marketing, Inc. Method of altering intoxicating effects of alcohol
US5316759A (en) 1986-03-17 1994-05-31 Robert J. Schaap Agonist-antagonist combination to reduce the use of nicotine and other drugs
US4861598A (en) * 1986-07-18 1989-08-29 Euroceltique, S.A. Controlled release bases for pharmaceuticals
US4970075A (en) 1986-07-18 1990-11-13 Euroceltique, S.A. Controlled release bases for pharmaceuticals
GB8626098D0 (en) 1986-10-31 1986-12-03 Euro Celtique Sa Controlled release hydromorphone composition
US5200193A (en) 1987-04-22 1993-04-06 Mcneilab, Inc. Pharmaceutical sustained release matrix and process
DE3812567A1 (de) 1988-04-15 1989-10-26 Basf Ag Verfahren zur herstellung pharmazeutischer mischungen
DE3830353A1 (de) 1988-09-07 1990-03-15 Basf Ag Verfahren zur kontinuierlichen herstellung von festen pharmazeutischen formen
FR2677886B1 (fr) 1991-06-18 1995-03-31 Adir Comprime matriciel permettant la liberation prolongee d'indapamide apres administration par voie orale.
US5266331A (en) 1991-11-27 1993-11-30 Euroceltique, S.A. Controlled release oxycodone compositions
US5656295A (en) 1991-11-27 1997-08-12 Euro-Celtique, S.A. Controlled release oxycodone compositions
US5968551A (en) 1991-12-24 1999-10-19 Purdue Pharma L.P. Orally administrable opioid formulations having extended duration of effect
US5472712A (en) 1991-12-24 1995-12-05 Euroceltique, S.A. Controlled-release formulations coated with aqueous dispersions of ethylcellulose
US5478577A (en) 1993-11-23 1995-12-26 Euroceltique, S.A. Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
JPH068220A (ja) 1992-06-23 1994-01-18 Kubota Corp 無機質板の乾式製法における給水方法及びその装置
US5324351A (en) 1992-08-13 1994-06-28 Euroceltique Aqueous dispersions of zein and preparation thereof
US5879705A (en) 1993-07-27 1999-03-09 Euro-Celtique S.A. Sustained release compositions of morphine and a method of preparing pharmaceutical compositions
DE4325465B4 (de) * 1993-07-29 2004-03-04 Zenz, Michael, Prof. Dr.med. Orales pharmazeutisches Präparat für die Schmerztherapie
US5492692A (en) 1993-08-17 1996-02-20 University Of Kentucky Research Foundation Coated products with potent anti-HIV and antimicrobial properties
US5559158A (en) 1993-10-01 1996-09-24 Abbott Laboratories Pharmaceutical composition
US5451409A (en) 1993-11-22 1995-09-19 Rencher; William F. Sustained release matrix system using hydroxyethyl cellulose and hydroxypropyl cellulose polymer blends
US5965161A (en) 1994-11-04 1999-10-12 Euro-Celtique, S.A. Extruded multi-particulates
US6007843A (en) 1995-09-29 1999-12-28 Lam Pharmaceuticals Corp. Sustained release delivery system
DE19539361A1 (de) 1995-10-23 1997-04-24 Basf Ag Verfahren zur Herstellung von mehrschichtigen, festen Arzneiformen zur oralen oder rektalen Verabreichung
US5846971A (en) * 1996-06-28 1998-12-08 Schering Corporation Oral antifungal composition
IN183097B (sr) 1997-03-27 1999-09-04 Rajiv Indravadan Dr Modi
RS50070B (sr) * 1997-12-22 2009-01-22 Euro-Celtique S.A., Oralni dozni oblik sa kombinacijom opijatnog agonista i antagonista
EP1041988A4 (en) 1997-12-22 2002-03-13 Euro Celtique Sa METHOD FOR PREVENTING ABUSE OF OPIOID DOSES FORMS
AU755855B2 (en) 1998-06-16 2002-12-19 Merck Sharp & Dohme Limited Triazolo-pyridine derivatives as ligands for GABA receptors
US6306132B1 (en) * 1999-06-17 2001-10-23 Vivant Medical Modular biopsy and microwave ablation needle delivery apparatus adapted to in situ assembly and method of use
FR2795326B1 (fr) 1999-06-28 2001-08-31 Adir Composition pharmaceutique solide thermoformable a liberation controlee
US6353145B1 (en) * 1999-09-24 2002-03-05 Glenda Church Charcoal poultice
EP2517710B1 (en) * 2000-02-08 2015-03-25 Euro-Celtique S.A. Tamper-resistant oral opioid agonist formulations
DE10006033B4 (de) 2000-02-10 2005-11-10 Professor Dr. Magnus von Knebel Doeberitz Chirurgische Universitätsklinik Sektion für Molekulare Diagnostik und Therapie Immunisierung eines Individuums gegen Carcinome und ihre Vorstufen
ATE293439T1 (de) 2000-12-07 2005-05-15 Warner Lambert Co Verfahren und system zur gleichmä igen arzneistoffabgabe
RU2003122515A (ru) * 2000-12-22 2005-01-27 Эспен Аэроджелз, Инк. (Us) Порошок аэрогеля, включающий терапевтические средства
MXPA03006251A (es) 2001-01-12 2004-10-15 Innovation Ventures Llc Composicion a base de carbon vegetal activado y metodo para reducir sintomas de resaca asociados con el consumo de bebidas que contienen alcohol.
JP2002310357A (ja) * 2001-04-18 2002-10-23 Toray Ind Inc 自在継手および浄水器
AU2002303718B2 (en) 2001-05-11 2008-02-28 Endo Pharmaceuticals, Inc. Abuse-resistant opioid dosage form
CN1525851A (zh) 2001-05-11 2004-09-01 ������ҩ�����޹�˾ 抗滥用阿片样物质控释剂型
US20030044458A1 (en) 2001-08-06 2003-03-06 Curtis Wright Oral dosage form comprising a therapeutic agent and an adverse-effect agent
DE60232417D1 (de) 2001-08-06 2009-07-02 Euro Celtique Sa Opioid-agonist-formulierungen mit freisetzbarem und sequestriertem antagonist
EP1414418A1 (en) 2001-08-06 2004-05-06 Euro-Celtique S.A. Compositions and methods to prevent abuse of opioids
US20030157168A1 (en) 2001-08-06 2003-08-21 Christopher Breder Sequestered antagonist formulations
US20030229111A1 (en) * 2002-03-14 2003-12-11 Benjamin Oshlack Naltrexone hydrochloride compositions
ES2281851T3 (es) 2003-12-09 2007-10-01 Euro-Celtique S.A. Forma de dosis co-extruida resistente a la manipulacion conteniendo un agente activo y un agente adverso y proceso para preparar el mismo.
PT1729730E (pt) 2004-03-30 2009-04-06 Euro Celtique Sa Forma de dosagem resistente às violações que compreende um adsorvente e um agente adverso
US20100303935A1 (en) * 2009-05-29 2010-12-02 Squires Meryl J Medicinal Composition

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DK1729730T3 (da) 2009-03-23
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WO2005097075A2 (en) 2005-10-20
IL178175A0 (en) 2006-12-31
CY1108947T1 (el) 2014-07-02
MXPA06011122A (es) 2007-03-21
US20070207089A1 (en) 2007-09-06
IL178175A (en) 2010-05-17
PL1729730T3 (pl) 2009-06-30
CA2557839C (en) 2011-05-10
US20130017255A1 (en) 2013-01-17
AU2005231146A1 (en) 2005-10-20
NZ549479A (en) 2010-06-25
US8298579B2 (en) 2012-10-30
ES2321012T3 (es) 2009-06-01
US9795681B2 (en) 2017-10-24
PT1729730E (pt) 2009-04-06
DE602005012244D1 (de) 2009-02-26
KR100963914B1 (ko) 2010-06-17
NO20064924L (no) 2006-12-21
WO2005097075A3 (en) 2006-08-03
JP2007530684A (ja) 2007-11-01
US20140256764A1 (en) 2014-09-11
KR101053558B1 (ko) 2011-08-03
AU2005231146B2 (en) 2008-12-11
JP2011093927A (ja) 2011-05-12
SI1729730T1 (sl) 2009-06-30
EP1729730B1 (en) 2009-01-07
CA2557839A1 (en) 2005-10-20
CN1938004B (zh) 2011-12-21
KR20060135043A (ko) 2006-12-28
KR20080095309A (ko) 2008-10-28
EP1729730A2 (en) 2006-12-13
CN1938004A (zh) 2007-03-28
BRPI0508769A (pt) 2007-08-28
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