PT582368E - Derivados de tienobenzodiazepina para o tratamento de doencas de cns - Google Patents
Derivados de tienobenzodiazepina para o tratamento de doencas de cns Download PDFInfo
- Publication number
- PT582368E PT582368E PT93304102T PT93304102T PT582368E PT 582368 E PT582368 E PT 582368E PT 93304102 T PT93304102 T PT 93304102T PT 93304102 T PT93304102 T PT 93304102T PT 582368 E PT582368 E PT 582368E
- Authority
- PT
- Portugal
- Prior art keywords
- methyl
- alkyl
- compounds
- thieno
- piperazinyl
- Prior art date
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- 201000010099 disease Diseases 0.000 title description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title description 5
- 150000001875 compounds Chemical class 0.000 claims abstract description 40
- 150000003839 salts Chemical class 0.000 claims abstract description 16
- 239000001257 hydrogen Substances 0.000 claims abstract description 8
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 8
- 125000000217 alkyl group Chemical group 0.000 claims description 7
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
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- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract description 8
- 125000000304 alkynyl group Chemical group 0.000 abstract description 3
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- 125000000753 cycloalkyl group Chemical group 0.000 abstract description 2
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- -1 for example Chemical group 0.000 description 16
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- 230000001419 dependent effect Effects 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000003818 flash chromatography Methods 0.000 description 1
- 230000009969 flowable effect Effects 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 125000001153 fluoro group Chemical group F* 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 229960003878 haloperidol Drugs 0.000 description 1
- UWYVPFMHMJIBHE-OWOJBTEDSA-N hydroxymaleic acid group Chemical group O/C(/C(=O)O)=C/C(=O)O UWYVPFMHMJIBHE-OWOJBTEDSA-N 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000007972 injectable composition Substances 0.000 description 1
- 239000000543 intermediate Substances 0.000 description 1
- INQOMBQAUSQDDS-UHFFFAOYSA-N iodomethane Chemical compound IC INQOMBQAUSQDDS-UHFFFAOYSA-N 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000011344 liquid material Substances 0.000 description 1
- 159000000002 lithium salts Chemical group 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 230000006984 memory degeneration Effects 0.000 description 1
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- 208000023060 memory loss Diseases 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical group COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
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- 238000002156 mixing Methods 0.000 description 1
- 229960005181 morphine Drugs 0.000 description 1
- KVBGVZZKJNLNJU-UHFFFAOYSA-N naphthalene-2-sulfonic acid Chemical compound C1=CC=CC2=CC(S(=O)(=O)O)=CC=C21 KVBGVZZKJNLNJU-UHFFFAOYSA-N 0.000 description 1
- 239000003176 neuroleptic agent Substances 0.000 description 1
- 230000000701 neuroleptic effect Effects 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 229960002715 nicotine Drugs 0.000 description 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 208000019906 panic disease Diseases 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 235000011007 phosphoric acid Nutrition 0.000 description 1
- 150000003016 phosphoric acids Chemical class 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 229940069328 povidone Drugs 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 201000000980 schizophrenia Diseases 0.000 description 1
- 239000012056 semi-solid material Substances 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 208000011117 substance-related disease Diseases 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000007916 tablet composition Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- FKHIFSZMMVMEQY-UHFFFAOYSA-N talc Chemical compound [Mg+2].[O-][Si]([O-])=O FKHIFSZMMVMEQY-UHFFFAOYSA-N 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- 125000004953 trihalomethyl group Chemical group 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Anesthesiology (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929211379A GB9211379D0 (en) | 1992-05-29 | 1992-05-29 | Pharmaceutical compounds |
| GB939309025A GB9309025D0 (en) | 1993-04-30 | 1993-04-30 | Pharmaceutical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT582368E true PT582368E (pt) | 2001-05-31 |
Family
ID=26300951
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT93304102T PT582368E (pt) | 1992-05-29 | 1993-05-26 | Derivados de tienobenzodiazepina para o tratamento de doencas de cns |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0582368B1 (enExample) |
| JP (1) | JP3219541B2 (enExample) |
| CN (1) | CN1043994C (enExample) |
| AT (1) | ATE198891T1 (enExample) |
| AU (1) | AU668159B2 (enExample) |
| CA (1) | CA2097016A1 (enExample) |
| CZ (1) | CZ282783B6 (enExample) |
| DE (1) | DE69329887T2 (enExample) |
| DK (1) | DK0582368T3 (enExample) |
| ES (1) | ES2153373T3 (enExample) |
| FI (1) | FI101538B (enExample) |
| GR (1) | GR3035587T3 (enExample) |
| HU (1) | HU218278B (enExample) |
| IL (1) | IL105827A (enExample) |
| MX (1) | MX9303124A (enExample) |
| MY (1) | MY109943A (enExample) |
| NO (1) | NO305125B1 (enExample) |
| NZ (1) | NZ247703A (enExample) |
| PT (1) | PT582368E (enExample) |
| RU (1) | RU2125574C1 (enExample) |
| TW (1) | TW268005B (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5457101A (en) * | 1994-06-03 | 1995-10-10 | Eli Lilly And Company | Thieno[1,5]benzoidiazepine use |
| US5574028A (en) * | 1994-10-31 | 1996-11-12 | Eli Lilly And Company | Method for treating anxiety |
| CR5278A (es) | 1995-03-24 | 1996-07-04 | Lilly Co Eli | Formulacion oral de 2-metil-tieno-benzodiacepina |
| EG23659A (en) * | 1995-03-24 | 2007-03-26 | Lilly Co Eli | Process and crystal forms of methyl-thieno-benzodiazepine |
| EG24221A (en) * | 1995-03-24 | 2008-11-10 | Lilly Co Eli | Process for preparing olanzapine |
| US5891461A (en) * | 1995-09-14 | 1999-04-06 | Cygnus, Inc. | Transdermal administration of olanzapine |
| PL329221A1 (en) * | 1996-03-25 | 1999-03-15 | Lilly Co Eli | Method of relieving hemicrania pains |
| NZ332039A (en) * | 1996-03-25 | 2000-06-23 | Lilly Co Eli | Method for treating pain using olanzapine and NSAIDs |
| CZ298198A3 (cs) * | 1996-03-25 | 1999-06-16 | Eli Lilly And Company | Farmaceutický přípravek |
| ZA978515B (en) * | 1996-09-23 | 1999-03-23 | Lilly Co Eli | Intermediates and process for preparing olanzapine |
| TR199900639T2 (xx) | 1996-09-23 | 1999-06-21 | Eli Lilly And Company | Olanzapin dihidrat D. |
| CN1230883A (zh) * | 1996-09-24 | 1999-10-06 | 伊莱利利公司 | 包衣颗粒制剂 |
| RU2185383C1 (ru) * | 2001-05-22 | 2002-07-20 | Институт молекулярной генетики РАН | ВЫСОКОМЕЧЕННЫЙ ТРИТИЕМ 2-МЕТИЛ-4-(4-МЕТИЛ-1-ПИПЕРАЗИНИЛ)-10Н-ТИЕНО[2,3-b][1,5]БЕНЗОДИАЗЕПИН |
| CN104736566A (zh) | 2012-08-21 | 2015-06-24 | 奥索临床诊断有限公司 | 帕潘立酮半抗原的抗体及其用途 |
| CN104822660A (zh) | 2012-08-21 | 2015-08-05 | 詹森药业有限公司 | 阿立哌唑半抗原及其在免疫测定中的应用 |
| CN104755928B (zh) | 2012-08-21 | 2017-05-10 | 詹森药业有限公司 | 奥氮平的抗体及其用途 |
| ES2666000T3 (es) | 2012-08-21 | 2018-04-30 | Janssen Pharmaceutica, N.V. | Anticuerpos para aripiprazol y uso de los mismos |
| ES2822004T3 (es) | 2012-08-21 | 2021-04-28 | Janssen Pharmaceutica Nv | Anticuerpos contra quetiapina y uso de los mismos |
| ES2926662T3 (es) | 2012-08-21 | 2022-10-27 | Janssen Pharmaceutica Nv | Anticuerpos contra haptenos de risperidona y uso de los mismos |
| AU2013305965B2 (en) | 2012-08-21 | 2017-08-24 | Saladax Biomedical Inc. | Antibodies to paliperidone and use thereof |
| AU2013306018B2 (en) * | 2012-08-21 | 2017-08-10 | Saladax Biomedical Inc. | Haptens of olanzapine |
| PT3663317T (pt) | 2012-08-21 | 2023-01-23 | Janssen Pharmaceutica Nv | Anticorpos para haptenos de quetiapina e sua utilização |
| PL2888258T3 (pl) | 2012-08-21 | 2019-10-31 | Janssen Pharmaceutica Nv | Hapteny paliperydonu |
| EP2888263B1 (en) | 2012-08-21 | 2018-05-09 | Janssen Pharmaceutica NV | Haptens of risperidone and paliperidone |
| EP3305784B1 (en) | 2012-08-21 | 2020-08-12 | Janssen Pharmaceutica NV | Haptens of quetiapine for use in immunoassays |
| ES2691092T3 (es) | 2012-08-21 | 2018-11-23 | Janssen Pharmaceutica Nv | Anticuerpos contra la risperidona y uso de los mismos |
| EP3581195B1 (en) | 2012-08-21 | 2025-10-01 | Janssen Pharmaceutica NV | Antibodies to olanzapine haptens and use thereof |
| US9611332B2 (en) | 2012-08-21 | 2017-04-04 | Janssen Pharmaceutica Nv | Antibodies to aripiprazole haptens and use thereof |
| WO2017106501A1 (en) | 2015-12-17 | 2017-06-22 | Janssen Pharmaceutica Nv | Antibodies to risperidone and use thereof |
| EP3390455A1 (en) | 2015-12-17 | 2018-10-24 | Janssen Pharmaceutica NV | Antibodies to quetiapine and use thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH569730A5 (enExample) * | 1972-04-04 | 1975-11-28 | Wander Ag Dr A | |
| US3962248A (en) * | 1972-04-04 | 1976-06-08 | Sandoz, Inc. | Process for making 11-piperazino-diazepines, oxazepines, thiazepines and azepines |
| SU629879A3 (ru) * | 1974-11-26 | 1978-10-25 | Лилли Индастриз Лимитед, (Фирма) | Способ получени тиено(1,5) бензодиазепинов или их солей |
| US4061752A (en) * | 1975-08-06 | 1977-12-06 | Sandoz Ltd. | 6-Piperazino-11-methylene-dibenzazepines[b,e] |
| FI762646A7 (enExample) * | 1975-09-24 | 1977-03-25 | Sandoz Ag | |
| CH624682A5 (enExample) * | 1976-11-10 | 1981-08-14 | Sandoz Ag | |
| US4761411A (en) * | 1983-05-18 | 1988-08-02 | Hoechst-Roussel Pharmaceuticals Inc. | Dihydrobenzopyrrolobenzodiazepines useful for treating pyschoses |
| GB9009229D0 (en) * | 1990-04-25 | 1990-06-20 | Lilly Industries Ltd | Pharmaceutical compounds |
-
1993
- 1993-05-26 CA CA002097016A patent/CA2097016A1/en not_active Abandoned
- 1993-05-26 NZ NZ247703A patent/NZ247703A/en unknown
- 1993-05-26 EP EP93304102A patent/EP0582368B1/en not_active Expired - Lifetime
- 1993-05-26 AT AT93304102T patent/ATE198891T1/de not_active IP Right Cessation
- 1993-05-26 PT PT93304102T patent/PT582368E/pt unknown
- 1993-05-26 AU AU39807/93A patent/AU668159B2/en not_active Ceased
- 1993-05-26 NO NO931917A patent/NO305125B1/no not_active IP Right Cessation
- 1993-05-26 TW TW082104161A patent/TW268005B/zh active
- 1993-05-26 DK DK93304102T patent/DK0582368T3/da active
- 1993-05-26 DE DE69329887T patent/DE69329887T2/de not_active Expired - Fee Related
- 1993-05-26 ES ES93304102T patent/ES2153373T3/es not_active Expired - Lifetime
- 1993-05-27 MX MX9303124A patent/MX9303124A/es not_active IP Right Cessation
- 1993-05-28 HU HU9301579A patent/HU218278B/hu not_active IP Right Cessation
- 1993-05-28 RU RU93005057A patent/RU2125574C1/ru active
- 1993-05-28 IL IL10582793A patent/IL105827A/xx not_active IP Right Cessation
- 1993-05-28 JP JP12642993A patent/JP3219541B2/ja not_active Expired - Fee Related
- 1993-05-28 CN CN93108212A patent/CN1043994C/zh not_active Expired - Fee Related
- 1993-05-28 CZ CZ931024A patent/CZ282783B6/cs not_active IP Right Cessation
- 1993-05-28 MY MYPI93001036A patent/MY109943A/en unknown
- 1993-05-28 FI FI932445A patent/FI101538B/fi active
-
2001
- 2001-03-15 GR GR20010400431T patent/GR3035587T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| MY109943A (en) | 1997-10-31 |
| IL105827A (en) | 1997-02-18 |
| CZ102493A3 (en) | 1993-12-15 |
| CN1085903A (zh) | 1994-04-27 |
| GR3035587T3 (en) | 2001-06-29 |
| ES2153373T3 (es) | 2001-03-01 |
| DK0582368T3 (da) | 2001-02-05 |
| CZ282783B6 (cs) | 1997-10-15 |
| FI932445L (fi) | 1993-11-30 |
| JP3219541B2 (ja) | 2001-10-15 |
| NZ247703A (en) | 1995-07-26 |
| ATE198891T1 (de) | 2001-02-15 |
| EP0582368B1 (en) | 2001-01-24 |
| JPH0687862A (ja) | 1994-03-29 |
| AU3980793A (en) | 1993-12-02 |
| HUT66180A (en) | 1994-09-28 |
| AU668159B2 (en) | 1996-04-26 |
| HU218278B (en) | 2000-07-28 |
| EP0582368A1 (en) | 1994-02-09 |
| MX9303124A (es) | 1993-11-01 |
| NO305125B1 (no) | 1999-04-06 |
| FI101538B1 (fi) | 1998-07-15 |
| IL105827A0 (en) | 1993-09-22 |
| HU9301579D0 (en) | 1993-09-28 |
| TW268005B (enExample) | 1996-01-11 |
| CN1043994C (zh) | 1999-07-07 |
| DE69329887D1 (de) | 2001-03-01 |
| FI101538B (fi) | 1998-07-15 |
| NO931917D0 (no) | 1993-05-26 |
| CA2097016A1 (en) | 1993-11-30 |
| NO931917L (no) | 1993-11-30 |
| RU2125574C1 (ru) | 1999-01-27 |
| FI932445A0 (fi) | 1993-05-28 |
| DE69329887T2 (de) | 2001-05-23 |
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