IL105827A - 10-substituted 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno [2,3-b][1,5] benzodiazepines their preparation and pharmaceutical compositions containing them - Google Patents
10-substituted 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno [2,3-b][1,5] benzodiazepines their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL105827A IL105827A IL10582793A IL10582793A IL105827A IL 105827 A IL105827 A IL 105827A IL 10582793 A IL10582793 A IL 10582793A IL 10582793 A IL10582793 A IL 10582793A IL 105827 A IL105827 A IL 105827A
- Authority
- IL
- Israel
- Prior art keywords
- methyl
- benzodiazepines
- thieno
- piperazinyl
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Anesthesiology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929211379A GB9211379D0 (en) | 1992-05-29 | 1992-05-29 | Pharmaceutical compounds |
GB939309025A GB9309025D0 (en) | 1993-04-30 | 1993-04-30 | Pharmaceutical compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
IL105827A0 IL105827A0 (en) | 1993-09-22 |
IL105827A true IL105827A (en) | 1997-02-18 |
Family
ID=26300951
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL10582793A IL105827A (en) | 1992-05-29 | 1993-05-28 | 10-substituted 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno [2,3-b][1,5] benzodiazepines their preparation and pharmaceutical compositions containing them |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP0582368B1 (xx) |
JP (1) | JP3219541B2 (xx) |
CN (1) | CN1043994C (xx) |
AT (1) | ATE198891T1 (xx) |
AU (1) | AU668159B2 (xx) |
CA (1) | CA2097016A1 (xx) |
CZ (1) | CZ282783B6 (xx) |
DE (1) | DE69329887T2 (xx) |
DK (1) | DK0582368T3 (xx) |
ES (1) | ES2153373T3 (xx) |
FI (1) | FI101538B1 (xx) |
GR (1) | GR3035587T3 (xx) |
HU (1) | HU218278B (xx) |
IL (1) | IL105827A (xx) |
MX (1) | MX9303124A (xx) |
MY (1) | MY109943A (xx) |
NO (1) | NO305125B1 (xx) |
NZ (1) | NZ247703A (xx) |
PT (1) | PT582368E (xx) |
RU (1) | RU2125574C1 (xx) |
TW (1) | TW268005B (xx) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5457101A (en) * | 1994-06-03 | 1995-10-10 | Eli Lilly And Company | Thieno[1,5]benzoidiazepine use |
US5574028A (en) * | 1994-10-31 | 1996-11-12 | Eli Lilly And Company | Method for treating anxiety |
EG23659A (en) * | 1995-03-24 | 2007-03-26 | Lilly Co Eli | Process and crystal forms of methyl-thieno-benzodiazepine |
CR5278A (es) * | 1995-03-24 | 1996-07-04 | Lilly Co Eli | Formulacion oral de 2-metil-tieno-benzodiacepina |
EG24221A (en) * | 1995-03-24 | 2008-11-10 | Lilly Co Eli | Process for preparing olanzapine |
US5891461A (en) * | 1995-09-14 | 1999-04-06 | Cygnus, Inc. | Transdermal administration of olanzapine |
IL126203A (en) * | 1996-03-25 | 2002-12-01 | Lilly Co Eli | A synergistic painkiller that contains olenzapine and another painkiller |
CN1219878A (zh) * | 1996-03-25 | 1999-06-16 | 伊莱利利公司 | 治疗疼痛的方法 |
EA000769B1 (ru) * | 1996-03-25 | 2000-04-24 | Эли Лилли Энд Компани | Способ лечения при боли, вызванной мигренью |
KR100516088B1 (ko) * | 1996-09-23 | 2005-09-22 | 일라이 릴리 앤드 캄파니 | 올란자핀 이수화물 d |
ZA978515B (en) * | 1996-09-23 | 1999-03-23 | Lilly Co Eli | Intermediates and process for preparing olanzapine |
JP2001501207A (ja) * | 1996-09-24 | 2001-01-30 | イーライ・リリー・アンド・カンパニー | コーティングされた粒子製剤 |
EP3556759B1 (en) | 2012-08-21 | 2023-11-29 | Janssen Pharmaceutica NV | Haptens of paliperidone |
AU2013305938B2 (en) | 2012-08-21 | 2017-08-17 | Saladax Biomedical Inc. | Antibodies to paliperidone haptens and use thereof |
CA2882490A1 (en) | 2012-08-21 | 2014-02-27 | Ortho-Clinical Diagnostics, Inc. | Antibodies to paliperidone and use thereof |
CA2882615C (en) | 2012-08-21 | 2019-07-09 | Ortho-Clinical Diagnostics, Inc. | Antibodies to quetiapine and use thereof |
PT3663317T (pt) | 2012-08-21 | 2023-01-23 | Janssen Pharmaceutica Nv | Anticorpos para haptenos de quetiapina e sua utilização |
ES2701062T3 (es) | 2012-08-21 | 2019-02-20 | Janssen Pharmaceutica Nv | Haptenos de olanzapina |
EP3321254B1 (en) | 2012-08-21 | 2020-08-12 | Janssen Pharmaceutica NV | Haptens of aripiprazole and their use in immunoassays |
WO2014031656A1 (en) | 2012-08-21 | 2014-02-27 | Ortho-Clinical Diagnostics, Inc | Antibodies to olanzapine haptens and use thereof |
PT2888593T (pt) | 2012-08-21 | 2018-12-12 | Janssen Pharmaceutica Nv | Anticorpos contra risperidona e utilizações dos mesmos |
WO2014031662A2 (en) | 2012-08-21 | 2014-02-27 | Ortho-Clinical Diagnostics, Inc | Antibodies to olanzapine and use thereof |
JP6389176B2 (ja) | 2012-08-21 | 2018-09-12 | ヤンセン ファーマシューティカ エヌ.ベー. | アリピプラゾールハプテンに対する抗体及びその使用 |
JP6131500B2 (ja) | 2012-08-21 | 2017-05-24 | ヤンセン ファーマシューティカ エヌ.ベー. | リスペリドン及びパリペリドンのハプテン |
PL2888257T3 (pl) | 2012-08-21 | 2018-02-28 | Janssen Pharmaceutica Nv | Hapteny kwetiapiny do zastosowania w testach immunologicznych |
PL2888284T3 (pl) | 2012-08-21 | 2023-02-27 | Janssen Pharmaceutica Nv | Przeciwciała przeciwko haptenom rysperydonu i ich zastosowanie |
PL3354751T3 (pl) | 2012-08-21 | 2020-03-31 | Janssen Pharmaceutica Nv | Przeciwciała dla arypiprazolu i ich zastosowanie |
CN108368180B (zh) | 2015-12-17 | 2022-07-26 | 詹森药业有限公司 | 喹硫平的抗体及其用途 |
CN108431040B (zh) | 2015-12-17 | 2022-07-26 | 詹森药业有限公司 | 利培酮的抗体及其用途 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SU629879A3 (ru) * | 1974-11-26 | 1978-10-25 | Лилли Индастриз Лимитед, (Фирма) | Способ получени тиено(1,5) бензодиазепинов или их солей |
DE2641378A1 (de) * | 1975-09-24 | 1977-04-07 | Sandoz Ag | Neue organische verbindungen, ihre verwendung und herstellung |
GB9009229D0 (en) * | 1990-04-25 | 1990-06-20 | Lilly Industries Ltd | Pharmaceutical compounds |
-
1993
- 1993-05-26 NO NO931917A patent/NO305125B1/no not_active IP Right Cessation
- 1993-05-26 DK DK93304102T patent/DK0582368T3/da active
- 1993-05-26 TW TW082104161A patent/TW268005B/zh active
- 1993-05-26 EP EP93304102A patent/EP0582368B1/en not_active Expired - Lifetime
- 1993-05-26 PT PT93304102T patent/PT582368E/pt unknown
- 1993-05-26 ES ES93304102T patent/ES2153373T3/es not_active Expired - Lifetime
- 1993-05-26 CA CA002097016A patent/CA2097016A1/en not_active Abandoned
- 1993-05-26 DE DE69329887T patent/DE69329887T2/de not_active Expired - Fee Related
- 1993-05-26 AU AU39807/93A patent/AU668159B2/en not_active Ceased
- 1993-05-26 NZ NZ247703A patent/NZ247703A/en unknown
- 1993-05-26 AT AT93304102T patent/ATE198891T1/de not_active IP Right Cessation
- 1993-05-27 MX MX9303124A patent/MX9303124A/es not_active IP Right Cessation
- 1993-05-28 CN CN93108212A patent/CN1043994C/zh not_active Expired - Fee Related
- 1993-05-28 CZ CZ931024A patent/CZ282783B6/cs not_active IP Right Cessation
- 1993-05-28 RU RU93005057A patent/RU2125574C1/ru active
- 1993-05-28 FI FI932445A patent/FI101538B1/fi active
- 1993-05-28 HU HU9301579A patent/HU218278B/hu not_active IP Right Cessation
- 1993-05-28 JP JP12642993A patent/JP3219541B2/ja not_active Expired - Fee Related
- 1993-05-28 MY MYPI93001036A patent/MY109943A/en unknown
- 1993-05-28 IL IL10582793A patent/IL105827A/xx not_active IP Right Cessation
-
2001
- 2001-03-15 GR GR20010400431T patent/GR3035587T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
RU2125574C1 (ru) | 1999-01-27 |
ES2153373T3 (es) | 2001-03-01 |
FI101538B (fi) | 1998-07-15 |
GR3035587T3 (en) | 2001-06-29 |
TW268005B (xx) | 1996-01-11 |
JP3219541B2 (ja) | 2001-10-15 |
FI932445A0 (fi) | 1993-05-28 |
JPH0687862A (ja) | 1994-03-29 |
FI101538B1 (fi) | 1998-07-15 |
DK0582368T3 (da) | 2001-02-05 |
EP0582368A1 (en) | 1994-02-09 |
NO931917L (no) | 1993-11-30 |
HU218278B (en) | 2000-07-28 |
DE69329887D1 (de) | 2001-03-01 |
FI932445A (fi) | 1993-11-30 |
NO931917D0 (no) | 1993-05-26 |
CZ282783B6 (cs) | 1997-10-15 |
CN1085903A (zh) | 1994-04-27 |
MY109943A (en) | 1997-10-31 |
PT582368E (pt) | 2001-05-31 |
NZ247703A (en) | 1995-07-26 |
HUT66180A (en) | 1994-09-28 |
CN1043994C (zh) | 1999-07-07 |
EP0582368B1 (en) | 2001-01-24 |
AU668159B2 (en) | 1996-04-26 |
CA2097016A1 (en) | 1993-11-30 |
MX9303124A (es) | 1993-11-01 |
HU9301579D0 (en) | 1993-09-28 |
AU3980793A (en) | 1993-12-02 |
NO305125B1 (no) | 1999-04-06 |
ATE198891T1 (de) | 2001-02-15 |
DE69329887T2 (de) | 2001-05-23 |
IL105827A0 (en) | 1993-09-22 |
CZ102493A3 (en) | 1993-12-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
HC | Change of name of proprietor(s) | ||
KB | Patent renewed | ||
RH1 | Patent not in force |