ES2094913T3 - Metodo para la preparacion de 3-amino-2-cloro-4-alquilpiridinas. - Google Patents

Metodo para la preparacion de 3-amino-2-cloro-4-alquilpiridinas.

Info

Publication number
ES2094913T3
ES2094913T3 ES92912917T ES92912917T ES2094913T3 ES 2094913 T3 ES2094913 T3 ES 2094913T3 ES 92912917 T ES92912917 T ES 92912917T ES 92912917 T ES92912917 T ES 92912917T ES 2094913 T3 ES2094913 T3 ES 2094913T3
Authority
ES
Spain
Prior art keywords
preparation
amino
alkyl
piridines
chlorine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92912917T
Other languages
English (en)
Inventor
Karl G Grozinger
Karl D Hargrave
Julian Adams
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BOEHRINGER INGELHEIM PHARMA
Boehringer Ingelheim Pharmaceuticals Inc
Original Assignee
BOEHRINGER INGELHEIM PHARMA
Boehringer Ingelheim Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24870473&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2094913(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by BOEHRINGER INGELHEIM PHARMA, Boehringer Ingelheim Pharmaceuticals Inc filed Critical BOEHRINGER INGELHEIM PHARMA
Application granted granted Critical
Publication of ES2094913T3 publication Critical patent/ES2094913T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/53—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

UN PROCESO PARA LA PREPARACION DE LA FORMULA 3 2 CLORO A TRES ATOMOS DE CARBONO, UN INTERMEDIARIO EN LA PREPARACION DE CIERTOS COMPUESTOS DE 5,11 ,3''-E][1,4] DIAZEPINA UTILES EN LA PREVENCION Y TRATAMIENTO DE LA INFECCION VIH.
ES92912917T 1991-06-11 1992-05-29 Metodo para la preparacion de 3-amino-2-cloro-4-alquilpiridinas. Expired - Lifetime ES2094913T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US71454991A 1991-06-11 1991-06-11

Publications (1)

Publication Number Publication Date
ES2094913T3 true ES2094913T3 (es) 1997-02-01

Family

ID=24870473

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92912917T Expired - Lifetime ES2094913T3 (es) 1991-06-11 1992-05-29 Metodo para la preparacion de 3-amino-2-cloro-4-alquilpiridinas.

Country Status (14)

Country Link
US (1) US5668287A (es)
EP (1) EP0551459B1 (es)
JP (1) JP3133331B2 (es)
KR (1) KR100201725B1 (es)
AT (1) ATE145397T1 (es)
AU (1) AU652656B2 (es)
CA (1) CA2082801C (es)
DE (1) DE69215346T2 (es)
DK (1) DK0551459T3 (es)
ES (1) ES2094913T3 (es)
GR (1) GR3022398T3 (es)
HU (1) HU213257B (es)
MX (1) MX9202769A (es)
WO (1) WO1992022531A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE170512T1 (de) * 1992-11-18 1998-09-15 Boehringer Ingelheim Pharma Verbesserte methode zur herstellung von 4-alkyl-3-amino-2-chlor-pyridinen
PT682655E (pt) * 1993-12-02 2000-08-31 Boehringer Ingelheim Pharma Processo para a preparacao de 3-amino-2-cloro-4-alquilo ou -4-ciclo-alquilpiridinas
ATE264306T1 (de) * 1999-01-22 2004-04-15 Boehringer Ingelheim Pharma Synthese von 3-amino-2-chlor-4-methylpyridin aus malonsäuresäurenitril und aceton
ES2251964T3 (es) * 1999-01-22 2006-05-16 Boehringer Ingelheim Pharmaceuticals Inc. Sintesis de 3-amino-2-cloro-4-metilpiridina a partir de acetona y cianoacetato de etilo.
US6399781B1 (en) 2000-10-10 2002-06-04 Boehringer Ingelheim Chemicals, Inc. Process for making 3-amino-2-chloro-4-methylpyridine
JP2002322152A (ja) * 2001-04-24 2002-11-08 Koei Chem Co Ltd シアノピリジン類の製造方法
CN100358871C (zh) * 2005-08-02 2008-01-02 江阴暨阳医药化工有限公司 氰乙酰胺和丙酮合成2-氯-3-氨基-4-甲基吡啶法
EP2604175B1 (en) 2011-12-13 2019-11-20 EndoChoice Innovation Center Ltd. Removable tip endoscope
JP2022547007A (ja) * 2019-09-11 2022-11-10 キラル クエスト （スーチョウ） カンパニー、リミテッド Ｋｒａｓ阻害剤である複素環式中間体に適用される合成方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2372690A (en) * 1940-11-15 1945-04-03 Merck & Co Inc Intermediates for the production of vitamin b6 and processes of preparing the same
US3703582A (en) * 1970-04-20 1972-11-21 Merck & Co Inc Aryl pyridine carboxylic acids in the treatment of inflammation
DE2310747A1 (de) * 1973-03-03 1974-09-12 Bayer Ag Verfahren zur herstellung von neuen amino-3,4-dihydropyridinen und ihre verwendung als arzneimittel
US4442100A (en) * 1979-12-11 1984-04-10 Bayer Aktiengesellschaft Substituted 2-amino-3,4-dihydropyridine derivatives, their production and their medicinal use
US4395554A (en) * 1981-12-01 1983-07-26 Mobil Oil Corporation Process for producing alpha-picoline
EP0407346A3 (en) * 1989-07-07 1991-10-02 Ciba-Geigy Ag Aminopyridines
CA2030056C (en) * 1989-11-17 1995-10-17 Karl D. Hargrave 5,11-dihydro-6h-dipyrido[3,2-b:2',3'-e][1,4]diazepines and their use in the prevention or treatment of hiv infection
CA2052946A1 (en) * 1990-10-19 1992-04-20 Karl G. Grozinger Method for the preparation of 5,11-dihydro-6h-dipyrido ¬3,2-b:2', 3'-e| ¬1,4|diazepines
US5200522A (en) * 1991-06-11 1993-04-06 Boehringer Ingelheim Pharmaceuticals, Inc. Method for preparing 3-amino-2-chloro-4-alkylpyridines

Also Published As

Publication number Publication date
AU652656B2 (en) 1994-09-01
WO1992022531A1 (en) 1992-12-23
US5668287A (en) 1997-09-16
CA2082801C (en) 2003-07-08
DE69215346T2 (de) 1997-04-30
EP0551459A4 (es) 1994-03-16
EP0551459B1 (en) 1996-11-20
EP0551459A1 (en) 1993-07-21
AU2180792A (en) 1993-01-12
HUT64027A (en) 1993-11-29
KR100201725B1 (ko) 1999-06-15
JP3133331B2 (ja) 2001-02-05
HU213257B (en) 1997-04-28
HU9300337D0 (en) 1993-05-28
JPH06500800A (ja) 1994-01-27
DE69215346D1 (de) 1997-01-02
CA2082801A1 (en) 1992-12-12
DK0551459T3 (da) 1997-04-07
GR3022398T3 (en) 1997-04-30
KR930701405A (ko) 1993-06-11
MX9202769A (es) 1993-01-01
ATE145397T1 (de) 1996-12-15

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