ES2096086T3 - Metodo nuevo para preparar 3-amino-2-cloro-4-alquilpiridinas. - Google Patents

Metodo nuevo para preparar 3-amino-2-cloro-4-alquilpiridinas.

Info

Publication number
ES2096086T3
ES2096086T3 ES92914035T ES92914035T ES2096086T3 ES 2096086 T3 ES2096086 T3 ES 2096086T3 ES 92914035 T ES92914035 T ES 92914035T ES 92914035 T ES92914035 T ES 92914035T ES 2096086 T3 ES2096086 T3 ES 2096086T3
Authority
ES
Spain
Prior art keywords
amino
alkyl
piridines
chlorine
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92914035T
Other languages
English (en)
Inventor
Karl G Grozinger
Karl D Hargrave
Julian Adams
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BOEHRINGER INGELHEIM PHARMA
Boehringer Ingelheim Pharmaceuticals Inc
Original Assignee
BOEHRINGER INGELHEIM PHARMA
Boehringer Ingelheim Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BOEHRINGER INGELHEIM PHARMA, Boehringer Ingelheim Pharmaceuticals Inc filed Critical BOEHRINGER INGELHEIM PHARMA
Application granted granted Critical
Publication of ES2096086T3 publication Critical patent/ES2096086T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

UN PROCESO PARA LA PREPARACION DE UNA 3-AMINO-2-CLORO-4ALQUILPIRIDINA DE FORMULA (I), DONDE R ES ALQUILO DE UNO A TRES ATOMOS DE CARBONO, UN INTERMEDIARIO EN LA PREPARACION DE CIERTOS COMPUESTOS DE 5,11-DIHIDRO-6H-DIPIRIDO-[3,2-B:2'',3''E][1,4]DIAZEPINA UTILES EN LA PREVENCION Y TRATAMIENTO DE LA INFECCION POR HIV.
ES92914035T 1991-06-11 1992-05-29 Metodo nuevo para preparar 3-amino-2-cloro-4-alquilpiridinas. Expired - Lifetime ES2096086T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/714,129 US5200522A (en) 1991-06-11 1991-06-11 Method for preparing 3-amino-2-chloro-4-alkylpyridines

Publications (1)

Publication Number Publication Date
ES2096086T3 true ES2096086T3 (es) 1997-03-01

Family

ID=24868845

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92914035T Expired - Lifetime ES2096086T3 (es) 1991-06-11 1992-05-29 Metodo nuevo para preparar 3-amino-2-cloro-4-alquilpiridinas.

Country Status (14)

Country Link
US (1) US5200522A (es)
EP (1) EP0543000B1 (es)
JP (1) JP3133332B2 (es)
KR (1) KR100201724B1 (es)
AT (1) ATE146171T1 (es)
AU (1) AU654575B2 (es)
CA (1) CA2082629C (es)
DE (1) DE69215837T2 (es)
DK (1) DK0543000T3 (es)
ES (1) ES2096086T3 (es)
GR (1) GR3022726T3 (es)
HU (1) HU213258B (es)
MX (1) MX9202768A (es)
WO (1) WO1992022532A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU213257B (en) * 1991-06-11 1997-04-28 Boehringer Ingelheim Pharma Process for producing 4-alkyl-3-amino-2-chloropyridines
DK0598396T3 (da) * 1992-11-18 1998-11-23 Boehringer Ingelheim Pharma Forbedret fremgangsmåde til fremstilling af 3-amino-2-chlor-4-alkylpyridiner
US5654429A (en) * 1992-11-18 1997-08-05 Boehringer Ingelheim Pharma Method for the preparation of 3-amino-2-chloro-4-alkylpyridines
US5618942A (en) * 1993-09-03 1997-04-08 Luxembourg Industries (Pamol) Ltd. Production of 2,3,5,6-tetrachloropyridine
ATE192437T1 (de) * 1993-12-02 2000-05-15 Boehringer Ingelheim Pharma Verfahren zur herstellung von 3-amino-2-chlor-4- alkyl- bzw. 4-cycloalkyl-pyridine
PT1064265E (pt) * 1999-01-22 2004-07-30 Boehringer Ingelheim Pharma Sintese de 3-amino-2-cloro-4-metilpiridina a partir de malononitrilo e acetona
US6399781B1 (en) 2000-10-10 2002-06-04 Boehringer Ingelheim Chemicals, Inc. Process for making 3-amino-2-chloro-4-methylpyridine
CN100358871C (zh) * 2005-08-02 2008-01-02 江阴暨阳医药化工有限公司 氰乙酰胺和丙酮合成2-氯-3-氨基-4-甲基吡啶法
CN100460394C (zh) * 2007-01-08 2009-02-11 中国药科大学 一种3-氨基-4-甲基吡啶的制备方法
WO2012095691A1 (en) * 2011-01-15 2012-07-19 Jubilant Life Sciences Ltd. An improved process for producing aminopyridines
CN102532010B (zh) * 2011-12-25 2013-12-04 江苏新瀚有限公司 一种2-氯-3-氨基吡啶的制备方法
CN103664755B (zh) * 2013-12-31 2016-07-13 沈阳化工研究院有限公司 一种二氯甲基取代吡啶的制备方法
CN104356057B (zh) * 2014-11-12 2016-08-31 江苏中邦制药有限公司 一种3-氨基-4-甲基吡啶的制备方法
CN110015988B (zh) * 2018-01-10 2020-06-23 新发药业有限公司 一种3-氨基-4-甲基吡啶的制备方法
CN108558749A (zh) * 2018-05-12 2018-09-21 长乐智高生物科技有限公司 一种合成2,6-二羟基-3-氰基-4-三氟甲基吡啶的催化剂及其应用
CN109096182A (zh) * 2018-07-23 2018-12-28 湖北宇阳药业有限公司 一种奈韦拉平中间体的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3655679A (en) * 1969-06-25 1972-04-11 Merck & Co Inc Certain aryl pyridine carboxylic acid derivatives
US3703582A (en) * 1970-04-20 1972-11-21 Merck & Co Inc Aryl pyridine carboxylic acids in the treatment of inflammation
DE2310747A1 (de) * 1973-03-03 1974-09-12 Bayer Ag Verfahren zur herstellung von neuen amino-3,4-dihydropyridinen und ihre verwendung als arzneimittel
US4442100A (en) * 1979-12-11 1984-04-10 Bayer Aktiengesellschaft Substituted 2-amino-3,4-dihydropyridine derivatives, their production and their medicinal use
CA2030056C (en) * 1989-11-17 1995-10-17 Karl D. Hargrave 5,11-dihydro-6h-dipyrido[3,2-b:2',3'-e][1,4]diazepines and their use in the prevention or treatment of hiv infection
CA2052946A1 (en) * 1990-10-19 1992-04-20 Karl G. Grozinger Method for the preparation of 5,11-dihydro-6h-dipyrido ¬3,2-b:2', 3'-e| ¬1,4|diazepines

Also Published As

Publication number Publication date
KR930701406A (ko) 1993-06-11
EP0543000A1 (en) 1993-05-26
CA2082629A1 (en) 1992-12-12
AU654575B2 (en) 1994-11-10
WO1992022532A1 (en) 1992-12-23
DE69215837T2 (de) 1997-05-15
ATE146171T1 (de) 1996-12-15
JP3133332B2 (ja) 2001-02-05
US5200522A (en) 1993-04-06
AU2235192A (en) 1993-01-12
HU9300334D0 (en) 1993-05-28
EP0543000B1 (en) 1996-12-11
KR100201724B1 (ko) 1999-06-15
EP0543000A4 (es) 1994-03-16
DK0543000T3 (da) 1997-04-21
JPH06501028A (ja) 1994-01-27
DE69215837D1 (de) 1997-01-23
HUT64026A (en) 1993-11-29
GR3022726T3 (en) 1997-06-30
HU213258B (en) 1997-04-28
MX9202768A (es) 1993-01-01
CA2082629C (en) 2003-09-16

Similar Documents

Publication Publication Date Title
ES2096086T3 (es) Metodo nuevo para preparar 3-amino-2-cloro-4-alquilpiridinas.
KR910018387A (ko) 약제학적 화합물
NZ235892A (en) 1,2-benzisoxazole derivatives; pharmaceutical compositions and preparatory processes
SE8701605D0 (sv) Novel medicinal compounds
FI101538B (fi) Menetelmä uusien, terapeuttisesti käyttökelpoisten 2-metyyli-4-(4-mety yli-1-piperatsinyyli)-10H-tieno£2,3-b|£1,5|bentsodiatsepiinijohdannais ten valmistamiseksi
ES2094913T3 (es) Metodo para la preparacion de 3-amino-2-cloro-4-alquilpiridinas.
CA2014771A1 (en) 5,11-dihydro-6h-dipyrido[3,2-b:2'3'-e][1,4]diazepin-6-ones and their use in the prevention or treatment of aids
PL316006A1 (en) 2-heteroaryl-5,11-dihydro-6h-dipyrido[3,2-b',3'-e][1,4] diazepines and their application in preventing and treating hiv infections
EG16546A (en) Therapeutic agents
AU7819691A (en) {(1-arylpyrrolidin-2-yl)methyl}piperazine derivatives, their preparation and their application in therapeutics
ES2121916T3 (es) Metodo mejorado para la preparacion de 3-amino-2-cloro-4-alquilpiridinas.
HU913660D0 (en) The use of imidoazepine derivatives for treating of sleep impairments
GR80903B (en) Process for the preparation of novel thieno (2,3-b) pyrrole derivatives
GR3030952T3 (en) Salmycins, a process for their preparation and their use as a pharmaceutical.
IT1245631B (it) Impiego di composti macrolidi come agenti anti-infiammatori per il trattamento di malattie provocate da cessione di istamina

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 543000

Country of ref document: ES