PL316006A1 - 2-heteroaryl-5,11-dihydro-6h-dipyrido[3,2-b',3'-e][1,4] diazepines and their application in preventing and treating hiv infections - Google Patents

2-heteroaryl-5,11-dihydro-6h-dipyrido[3,2-b',3'-e][1,4] diazepines and their application in preventing and treating hiv infections

Info

Publication number
PL316006A1
PL316006A1 PL95316006A PL31600695A PL316006A1 PL 316006 A1 PL316006 A1 PL 316006A1 PL 95316006 A PL95316006 A PL 95316006A PL 31600695 A PL31600695 A PL 31600695A PL 316006 A1 PL316006 A1 PL 316006A1
Authority
PL
Poland
Prior art keywords
dipyrido
diazepines
dihydro
heteroaryl
preventing
Prior art date
Application number
PL95316006A
Other versions
PL181323B1 (en
Inventor
Karl D Hargrave
Terence A Kelly
Suresh R Kapadia
John R Proudfoot
Daniel W Mcneil
Usha R Patel
Mario G Cardozo
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of PL316006A1 publication Critical patent/PL316006A1/en
Publication of PL181323B1 publication Critical patent/PL181323B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B57/00—Other synthetic dyes of known constitution

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Disclosed are novel 2-heteroaryl-5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepines of formula (1), wherein Z is an oxygen or sulfur atom, =NCN or a group of the formula =NOR<10> wherein R<10> is alkyl of 1 to 3 carbon atoms; Ar is a group of formulae (I, II, III, IV or V). These compounds are useful in the prevention or treatment of HIV infections.
PL95316006A 1994-02-18 1995-02-17 2-heteroaryl-5,11-dihydro-6h-dipyrido[3,2-b',3'-e][1,4] diazepines and their application in preventing and treating hiv infections PL181323B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19824294A 1994-02-18 1994-02-18
US35641594A 1994-12-14 1994-12-14
PCT/US1995/001993 WO1995022545A1 (en) 1994-02-18 1995-02-17 2-HETEROARYL-5,11-DIHYDRO-6H-DIPYRIDO[3,2-b:2',3'-e][1,4]DIAZEPINES AND THEIR USE IN THE PREVENTION OR TREATMENT OF HIV INFECTION

Publications (2)

Publication Number Publication Date
PL316006A1 true PL316006A1 (en) 1996-12-23
PL181323B1 PL181323B1 (en) 2001-07-31

Family

ID=26893601

Family Applications (1)

Application Number Title Priority Date Filing Date
PL95316006A PL181323B1 (en) 1994-02-18 1995-02-17 2-heteroaryl-5,11-dihydro-6h-dipyrido[3,2-b',3'-e][1,4] diazepines and their application in preventing and treating hiv infections

Country Status (15)

Country Link
EP (1) EP0745083B1 (en)
JP (1) JPH09509179A (en)
KR (1) KR970701190A (en)
CN (1) CN1043347C (en)
AT (1) ATE166353T1 (en)
AU (1) AU690646B2 (en)
CA (1) CA2183571A1 (en)
CO (1) CO4340691A1 (en)
DE (1) DE69502587T2 (en)
DK (1) DK0745083T3 (en)
ES (1) ES2118575T3 (en)
PL (1) PL181323B1 (en)
RU (1) RU2142464C1 (en)
TW (1) TW327171B (en)
WO (1) WO1995022545A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5705499A (en) * 1995-10-06 1998-01-06 Boehringer Ingelheim Pharmaceuticals, Inc. 8-arylalkyl- and 8-arylheteroalkyl-5,11-dihydro-6H-dipyrido 3,2-B:2',3'-e! 1!diazepines and their use in the treatment of HIV-1 infection
US5747488A (en) * 1996-01-30 1998-05-05 Boehringer Ingelheim Pharmaceuticals, Inc. 2-aryl-5,11-dihydro-6H-dipyrido 3,2-B:2',3'-E! 1, 4!diazepines and their use in the treatment of HIV infection
US6514977B1 (en) 1997-05-22 2003-02-04 G.D. Searle & Company Substituted pyrazoles as p38 kinase inhibitors
EP1019394A1 (en) 1997-05-22 2000-07-19 G.D. Searle & Co. PYRAZOLE DERIVATIVES AS p38 KINASE INHIBITORS
US6979686B1 (en) 2001-12-07 2005-12-27 Pharmacia Corporation Substituted pyrazoles as p38 kinase inhibitors
US6716836B2 (en) * 2001-03-22 2004-04-06 Boehringer Ingelheim (Canada) Ltd. Non-nucleoside reverse transcriptase inhibitors
AU2005233642A1 (en) * 2004-04-13 2005-10-27 Astellas Pharma Inc. Polycyclic pyridines as potassium ion channel modulators
SI1753764T1 (en) 2004-06-09 2009-02-28 Glaxo Group Ltd Pyrrolopyridine derivatives
EP2514751A1 (en) 2005-11-15 2012-10-24 Vertex Pharmaceuticals, Inc. Azaindazoles useful as inhibitor of kinases
WO2014060381A1 (en) 2012-10-18 2014-04-24 Bayer Cropscience Ag Heterocyclic compounds as pesticides
BR112015009751A2 (en) 2012-10-31 2017-07-11 Bayer Cropscience Ag new heterocyclic compounds as pesticides

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2019812C (en) * 1989-06-28 2000-11-21 Gunther Schmidt (Deceased) Novel 5,11-dihydro-6h-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-ones and their use in the prevention or treatment of aids
CA2030056C (en) * 1989-11-17 1995-10-17 Karl D. Hargrave 5,11-dihydro-6h-dipyrido[3,2-b:2',3'-e][1,4]diazepines and their use in the prevention or treatment of hiv infection
ATE143018T1 (en) * 1991-02-07 1996-10-15 Boehringer Ingelheim Pharma PYRIDOBENZODIAZEPINES, DIPYRIDO-(3,2-B:2',3'-3> (1,4>-DIAZEPINES AND THEIR USE IN THE PREVENTION AND TREATMENT OF AIDS

Also Published As

Publication number Publication date
RU2142464C1 (en) 1999-12-10
WO1995022545A1 (en) 1995-08-24
DE69502587T2 (en) 1998-11-26
CO4340691A1 (en) 1996-07-30
CA2183571A1 (en) 1995-08-24
AU690646B2 (en) 1998-04-30
CN1138861A (en) 1996-12-25
AU1845795A (en) 1995-09-04
KR970701190A (en) 1997-03-17
EP0745083A1 (en) 1996-12-04
CN1043347C (en) 1999-05-12
TW327171B (en) 1998-02-21
MX9603359A (en) 1998-07-31
EP0745083B1 (en) 1998-05-20
ATE166353T1 (en) 1998-06-15
PL181323B1 (en) 2001-07-31
DE69502587D1 (en) 1998-06-25
JPH09509179A (en) 1997-09-16
DK0745083T3 (en) 1999-01-25
ES2118575T3 (en) 1998-09-16

Similar Documents

Publication Publication Date Title
AU7578894A (en) Methods for inhibiting smooth muscle cell proliferation and restinosis
ZA944739B (en) Amide and urea derivatives having anti-hypercholesteremic activity their preparation and their therapeutic uses
PL316006A1 (en) 2-heteroaryl-5,11-dihydro-6h-dipyrido[3,2-b&#39;,3&#39;-e][1,4] diazepines and their application in preventing and treating hiv infections
BG102759A (en) Therapeutical form for diabetes
ATE91128T1 (en) 5,11-DIHYDRO-6H-DIPYRIDO (3,2-B:2&#39;,3&#39;-E&gt;DIAZEPIN- 6-ONE AND ITS USE IN THE PREVENTION AND TREATMENT OF AIDS.
HUT64026A (en) Process for producing 4-alkyl-3-amino-2-chloropyridines
GR3022398T3 (en) Method for the preparation of 3-amino-2-chloro-4-alkylpyridines
GR3021428T3 (en) Pyridobenzodiazepines, dipyrido [3,2-b:2&#39;,3&#39;-e] [1,4]diazepines and their use in the prevention or treatment of HIV infection
GR3022788T3 (en) Benzo(b)thiophen-3-yl-piperazines, a process for their preparation and their use as medicaments
WO1988000587A3 (en) 5-HETERO- OR ARYL-SUBSTITUTED-IMIDAZO[2,1-a]ISOQUINOLINES
WO1996000726A3 (en) New brefeldin a derivatives and their utility in the treatment of cancer
DK0598396T3 (en) Improved process for preparing 3-amino-2-chloro-4-alkylpyridines
MX9702941A (en) Di-tert-butylphenol compounds with heterocyclic moiety, useful as anti-inflammatory agents.