PT2084174E - Preparação de nucleósidos de ribofuranosil pirimidinas - Google Patents
Preparação de nucleósidos de ribofuranosil pirimidinasInfo
- Publication number
- PT2084174E PT2084174E PT78393691T PT07839369T PT2084174E PT 2084174 E PT2084174 E PT 2084174E PT 78393691 T PT78393691 T PT 78393691T PT 07839369 T PT07839369 T PT 07839369T PT 2084174 E PT2084174 E PT 2084174E
- Authority
- PT
- Portugal
- Prior art keywords
- preparation
- nucleosides
- ribofuranosyl
- pyrimidines
- ribofuranosyl pyrimidines
- Prior art date
Links
- 239000002777 nucleoside Substances 0.000 title 1
- -1 nucleosides ribofuranosyl pyrimidines Chemical class 0.000 title 1
- 241000711549 Hepacivirus C Species 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 101800001554 RNA-directed RNA polymerase Proteins 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/02—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85096206P | 2006-10-10 | 2006-10-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2084174E true PT2084174E (pt) | 2013-10-08 |
Family
ID=39111500
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT78393691T PT2084174E (pt) | 2006-10-10 | 2007-10-05 | Preparação de nucleósidos de ribofuranosil pirimidinas |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US8912321B2 (enExample) |
| EP (1) | EP2084174B1 (enExample) |
| JP (1) | JP5252459B2 (enExample) |
| KR (1) | KR101057239B1 (enExample) |
| CN (1) | CN101600725B (enExample) |
| AU (1) | AU2007307057B2 (enExample) |
| BR (1) | BRPI0719174A2 (enExample) |
| CA (1) | CA2666098C (enExample) |
| DK (1) | DK2084174T3 (enExample) |
| ES (1) | ES2429290T3 (enExample) |
| GT (1) | GT200900080A (enExample) |
| IL (1) | IL198086A (enExample) |
| MX (1) | MX2009003795A (enExample) |
| PL (1) | PL2084174T3 (enExample) |
| PT (1) | PT2084174E (enExample) |
| RU (1) | RU2421461C2 (enExample) |
| SI (1) | SI2084174T1 (enExample) |
| WO (1) | WO2008045419A1 (enExample) |
Families Citing this family (80)
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| MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| ES2624353T3 (es) | 2002-11-15 | 2017-07-13 | Idenix Pharmaceuticals Llc | 2'-Metil nucleósidos en combinación con interferón y mutación de Flaviviridae |
| EP4032897B1 (en) | 2003-05-30 | 2025-01-29 | Gilead Pharmasset LLC | Modified fluorinated nucleoside analogues |
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| CN101057259B (zh) | 2004-11-16 | 2010-11-03 | 汤姆森许可贸易公司 | 基于预计算的变换系数的胶片颗粒仿真方法 |
| CN101138247B (zh) | 2004-11-16 | 2010-05-26 | 汤姆森特许公司 | 位精度仿真的胶片颗粒补充增强信息消息插入方法及系统 |
| MX2007005651A (es) | 2004-11-17 | 2007-06-05 | Thomson Licensing | Metodo de simulacion de grano de pelicula exacto de bits con base en coeficientes transformados pre-computados. |
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| PL3290428T3 (pl) | 2010-03-31 | 2022-02-07 | Gilead Pharmasset Llc | Tabletka zawierająca krystaliczny (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian izopropylu |
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| PT3042910T (pt) | 2010-11-30 | 2019-04-16 | Gilead Pharmasset Llc | 2'-espiro-nucleósidos para utilização na terapia da hepatite c |
| US9243025B2 (en) | 2011-03-31 | 2016-01-26 | Idenix Pharmaceuticals, Llc | Compounds and pharmaceutical compositions for the treatment of viral infections |
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| CN103450148B (zh) * | 2012-06-04 | 2018-06-12 | 浙江九洲药业股份有限公司 | 一种五元环硫酸酯化合物的合成方法 |
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| EP3650014B1 (en) | 2013-08-27 | 2021-10-06 | Gilead Pharmasset LLC | Combination formulation of two antiviral compounds |
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| CN106554333B (zh) * | 2015-09-29 | 2018-11-30 | 江苏福瑞生物医药有限公司 | 一种药物中间体的合成方法 |
| CN106608896B (zh) * | 2015-10-26 | 2019-08-27 | 江苏福瑞康泰药业有限公司 | 一种药物中间体的合成方法 |
| CN105418547A (zh) * | 2015-11-17 | 2016-03-23 | 海门慧聚药业有限公司 | 索非布韦关键中间体的制备 |
| CN105503983B (zh) * | 2015-12-17 | 2019-06-28 | 江苏阿尔法药业有限公司 | 索菲布韦中间体及其衍生物的制备方法 |
| CN105566422B (zh) * | 2015-12-29 | 2019-06-25 | 江苏阿尔法药业有限公司 | 索菲布韦中间体或其衍生物的制备方法 |
| US11192914B2 (en) | 2016-04-28 | 2021-12-07 | Emory University | Alkyne containing nucleotide and nucleoside therapeutic compositions and uses related thereto |
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| PL3512863T3 (pl) | 2016-09-07 | 2022-04-04 | Atea Pharmaceuticals, Inc. | 2'-Podstawione-N6-podstawione nukleotydy purynowe do leczenia zakażeń wirusem RNA |
| IL295609B2 (en) | 2017-02-01 | 2023-11-01 | Atea Pharmaceuticals Inc | Nucleotide hemisulfate salt for the treatment of hepatitis C virus |
| CN106810515A (zh) * | 2017-02-06 | 2017-06-09 | 抚州市星辰药业有限公司 | 一种合成索非布韦的中间体化合物及其合成方法 |
| CN109422789A (zh) * | 2017-08-28 | 2019-03-05 | 常州制药厂有限公司 | 一种索非布韦的制备工艺改进方法 |
| CN112351799A (zh) | 2018-04-10 | 2021-02-09 | 阿堤亚制药公司 | 具有硬化的hcv感染患者的治疗 |
| CN108675984A (zh) * | 2018-06-22 | 2018-10-19 | 江苏阿尔法药业有限公司 | 索非布韦中间体的制备方法 |
| CN111606961A (zh) * | 2019-02-26 | 2020-09-01 | 顾世海 | 一种(2’r)-2’-脱氧-2’-氟-2’-甲基脲苷的工艺生产方法 |
| CN111040010A (zh) * | 2019-12-23 | 2020-04-21 | 上海红蓝医药科技有限公司 | 一种索非布韦中间体的合成方法 |
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|---|---|---|---|---|
| KR850002973A (ko) * | 1983-10-03 | 1985-05-28 | 구라바야시 이꾸시로 | 시티딘 유도체의 제조방법 |
| JP2559917B2 (ja) * | 1990-06-15 | 1996-12-04 | 三共株式会社 | ピリミジンヌクレオシド誘導体 |
| US5637688A (en) * | 1994-12-13 | 1997-06-10 | Eli Lilly And Company | Process for preparing 1-(2'-deoxy-2'-difluoro-d-ribofuranosyl)-4-aminopyrimidin-2-one hydrochloride |
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-
2007
- 2007-10-05 WO PCT/US2007/021548 patent/WO2008045419A1/en not_active Ceased
- 2007-10-05 RU RU2009117396/04A patent/RU2421461C2/ru not_active IP Right Cessation
- 2007-10-05 SI SI200731311T patent/SI2084174T1/sl unknown
- 2007-10-05 EP EP07839369.1A patent/EP2084174B1/en active Active
- 2007-10-05 AU AU2007307057A patent/AU2007307057B2/en active Active
- 2007-10-05 CN CN200780037855.XA patent/CN101600725B/zh active Active
- 2007-10-05 PT PT78393691T patent/PT2084174E/pt unknown
- 2007-10-05 BR BRPI0719174A patent/BRPI0719174A2/pt not_active IP Right Cessation
- 2007-10-05 ES ES07839369T patent/ES2429290T3/es active Active
- 2007-10-05 MX MX2009003795A patent/MX2009003795A/es active IP Right Grant
- 2007-10-05 CA CA2666098A patent/CA2666098C/en active Active
- 2007-10-05 DK DK07839369.1T patent/DK2084174T3/da active
- 2007-10-05 PL PL07839369T patent/PL2084174T3/pl unknown
- 2007-10-05 US US12/444,608 patent/US8912321B2/en active Active
- 2007-10-05 KR KR1020097008991A patent/KR101057239B1/ko active Active
- 2007-10-05 JP JP2009532372A patent/JP5252459B2/ja active Active
- 2007-10-10 US US11/973,748 patent/US20080139802A1/en not_active Abandoned
-
2009
- 2009-04-07 IL IL198086A patent/IL198086A/en active IP Right Grant
- 2009-04-13 GT GT200900080A patent/GT200900080A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2429290T3 (es) | 2013-11-14 |
| IL198086A0 (en) | 2009-12-24 |
| EP2084174B1 (en) | 2013-07-31 |
| HK1133889A1 (en) | 2010-04-09 |
| BRPI0719174A2 (pt) | 2017-06-13 |
| US8912321B2 (en) | 2014-12-16 |
| CN101600725B (zh) | 2014-11-26 |
| KR101057239B1 (ko) | 2011-08-16 |
| GT200900080A (es) | 2012-04-10 |
| US20080139802A1 (en) | 2008-06-12 |
| MX2009003795A (es) | 2009-06-18 |
| SI2084174T1 (sl) | 2013-10-30 |
| KR20090060460A (ko) | 2009-06-12 |
| JP2010505954A (ja) | 2010-02-25 |
| RU2421461C2 (ru) | 2011-06-20 |
| IL198086A (en) | 2012-03-29 |
| CN101600725A (zh) | 2009-12-09 |
| CA2666098A1 (en) | 2008-04-17 |
| RU2009117396A (ru) | 2010-11-20 |
| AU2007307057B2 (en) | 2011-09-15 |
| PL2084174T3 (pl) | 2013-12-31 |
| DK2084174T3 (da) | 2013-11-04 |
| US20100056770A1 (en) | 2010-03-04 |
| AU2007307057A1 (en) | 2008-04-17 |
| CA2666098C (en) | 2012-09-25 |
| WO2008045419A1 (en) | 2008-04-17 |
| EP2084174A1 (en) | 2009-08-05 |
| JP5252459B2 (ja) | 2013-07-31 |
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