JP5252459B2 - リボフラノシルピリミジンヌクレオシドの調製 - Google Patents

リボフラノシルピリミジンヌクレオシドの調製 Download PDF

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JP5252459B2
JP5252459B2 JP2009532372A JP2009532372A JP5252459B2 JP 5252459 B2 JP5252459 B2 JP 5252459B2 JP 2009532372 A JP2009532372 A JP 2009532372A JP 2009532372 A JP2009532372 A JP 2009532372A JP 5252459 B2 JP5252459 B2 JP 5252459B2
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aryl
formula
methyl
fluoro
tetrahydrofuran
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JP2010505954A (ja
JP2010505954A5 (enExample
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スティーブン， ディー． アクスト，
ケシャブ サルマ，
ジャスティン ヴィターレ，
ジャン ジュ，
ブルース ロス，
スグナ ラチャコンダ，
キンウー ジン，
ビョン−クォン チュン，
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ギリアド ファーマセット エルエルシー
エフ． ホフマン ラ−ロシュ アーゲー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/02—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP2009532372A 2006-10-10 2007-10-05 リボフラノシルピリミジンヌクレオシドの調製 Active JP5252459B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US85096206P 2006-10-10 2006-10-10
US60/850,962 2006-10-10
PCT/US2007/021548 WO2008045419A1 (en) 2006-10-10 2007-10-05 Preparation of nucleosides ribofuranosyl pyrimidines

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JP2010505954A JP2010505954A (ja) 2010-02-25
JP2010505954A5 JP2010505954A5 (enExample) 2013-04-04
JP5252459B2 true JP5252459B2 (ja) 2013-07-31

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US (2) US8912321B2 (enExample)
EP (1) EP2084174B1 (enExample)
JP (1) JP5252459B2 (enExample)
KR (1) KR101057239B1 (enExample)
CN (1) CN101600725B (enExample)
AU (1) AU2007307057B2 (enExample)
BR (1) BRPI0719174A2 (enExample)
CA (1) CA2666098C (enExample)
DK (1) DK2084174T3 (enExample)
ES (1) ES2429290T3 (enExample)
GT (1) GT200900080A (enExample)
IL (1) IL198086A (enExample)
MX (1) MX2009003795A (enExample)
PL (1) PL2084174T3 (enExample)
PT (1) PT2084174E (enExample)
RU (1) RU2421461C2 (enExample)
SI (1) SI2084174T1 (enExample)
WO (1) WO2008045419A1 (enExample)

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US9117261B2 (en) 2004-11-16 2015-08-25 Thomson Licensing Film grain SEI message insertion for bit-accurate simulation in a video system
US9177364B2 (en) 2004-11-16 2015-11-03 Thomson Licensing Film grain simulation method based on pre-computed transform coefficients
US10715834B2 (en) 2007-05-10 2020-07-14 Interdigital Vc Holdings, Inc. Film grain simulation based on pre-computed transform coefficients

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ES2725457T3 (es) * 2004-09-14 2019-09-24 Gilead Pharmasset Llc Preparación de ribofuranosil pirimidinas y purinas 2'fluoro-2'-alquil-sustituidas u otras opcionalmente sustituidas y sus derivados
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
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MX2011006890A (es) 2008-12-23 2011-07-20 Pharmasset Inc Analogos de nucleosidos.
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
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PL3290428T3 (pl) 2010-03-31 2022-02-07 Gilead Pharmasset Llc Tabletka zawierająca krystaliczny (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian izopropylu
AP2012006535A0 (en) 2010-03-31 2012-10-31 Gilead Pharmasset Llc Stereoselective synthesis of phosphorous containing actives
JP5716500B2 (ja) * 2010-06-03 2015-05-13 セントラル硝子株式会社 （２Ｒ）−２−フルオロ−２−Ｃ−メチル−Ｄ−リボノ−γ−ラクトン類前駆体の製造方法
ES2716158T3 (es) 2010-11-30 2019-06-10 Gilead Pharmasset Llc 2'-spiro-nucleótidos para el tratamiento de hepatitis C
US9243025B2 (en) 2011-03-31 2016-01-26 Idenix Pharmaceuticals, Llc Compounds and pharmaceutical compositions for the treatment of viral infections
US9403863B2 (en) 2011-09-12 2016-08-02 Idenix Pharmaceuticals Llc Substituted carbonyloxymethylphosphoramidate compounds and pharmaceutical compositions for the treatment of viral infections
HRP20180237T4 (hr) 2011-09-16 2020-12-11 Gilead Pharmasset Llc Metode za liječenje hcv-a
AR089650A1 (es) 2011-10-14 2014-09-10 Idenix Pharmaceuticals Inc Fosfatos 3,5-ciclicos sustituidos de compuestos de nucleotido de purina y composiciones farmaceuticas para el tratamiento de infecciones virales
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CN103450148B (zh) * 2012-06-04 2018-06-12 浙江九洲药业股份有限公司 一种五元环硫酸酯化合物的合成方法
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EA201690473A1 (ru) 2013-08-27 2017-03-31 ГАЙЛИД ФАРМАССЕТ ЭлЭлСи Комбинированный состав двух противовирусных соединений
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Cited By (4)

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Publication number Priority date Publication date Assignee Title
US9117261B2 (en) 2004-11-16 2015-08-25 Thomson Licensing Film grain SEI message insertion for bit-accurate simulation in a video system
US9177364B2 (en) 2004-11-16 2015-11-03 Thomson Licensing Film grain simulation method based on pre-computed transform coefficients
US9098916B2 (en) 2004-11-17 2015-08-04 Thomson Licensing Bit-accurate film grain simulation method based on pre-computed transformed coefficients
US10715834B2 (en) 2007-05-10 2020-07-14 Interdigital Vc Holdings, Inc. Film grain simulation based on pre-computed transform coefficients

Also Published As

Publication number Publication date
KR20090060460A (ko) 2009-06-12
PT2084174E (pt) 2013-10-08
ES2429290T3 (es) 2013-11-14
JP2010505954A (ja) 2010-02-25
US20080139802A1 (en) 2008-06-12
SI2084174T1 (sl) 2013-10-30
CA2666098C (en) 2012-09-25
DK2084174T3 (da) 2013-11-04
RU2421461C2 (ru) 2011-06-20
MX2009003795A (es) 2009-06-18
BRPI0719174A2 (pt) 2017-06-13
WO2008045419A1 (en) 2008-04-17
GT200900080A (es) 2012-04-10
EP2084174A1 (en) 2009-08-05
KR101057239B1 (ko) 2011-08-16
AU2007307057A1 (en) 2008-04-17
CN101600725B (zh) 2014-11-26
CN101600725A (zh) 2009-12-09
IL198086A0 (en) 2009-12-24
US8912321B2 (en) 2014-12-16
HK1133889A1 (en) 2010-04-09
RU2009117396A (ru) 2010-11-20
US20100056770A1 (en) 2010-03-04
EP2084174B1 (en) 2013-07-31
PL2084174T3 (pl) 2013-12-31
IL198086A (en) 2012-03-29
CA2666098A1 (en) 2008-04-17
AU2007307057B2 (en) 2011-09-15

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