CA2666098C - Preparation of nucleosides ribofuranosyl pyrimidines - Google Patents

Preparation of nucleosides ribofuranosyl pyrimidines Download PDF

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Publication number
CA2666098C
CA2666098C CA2666098A CA2666098A CA2666098C CA 2666098 C CA2666098 C CA 2666098C CA 2666098 A CA2666098 A CA 2666098A CA 2666098 A CA2666098 A CA 2666098A CA 2666098 C CA2666098 C CA 2666098C
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CA
Canada
Prior art keywords
formula
aryl
methyl
process according
fluoro
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CA2666098A
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English (en)
French (fr)
Other versions
CA2666098A1 (en
Inventor
Steven D. Axt
Keshab Sarma
Justin Vitale
Jiang Zhu
Bruce Ross
Suguna Rachakonda
Qingwu Jin
Byoung-Kwon Chun
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F Hoffmann La Roche AG
Gilead Pharmasset LLC
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F Hoffmann La Roche AG
Pharmasset Inc
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Publication of CA2666098A1 publication Critical patent/CA2666098A1/en
Application granted granted Critical
Publication of CA2666098C publication Critical patent/CA2666098C/en
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Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/02—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CA2666098A 2006-10-10 2007-10-05 Preparation of nucleosides ribofuranosyl pyrimidines Active CA2666098C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US85096206P 2006-10-10 2006-10-10
US60/850,962 2006-10-10
PCT/US2007/021548 WO2008045419A1 (en) 2006-10-10 2007-10-05 Preparation of nucleosides ribofuranosyl pyrimidines

Publications (2)

Publication Number Publication Date
CA2666098A1 CA2666098A1 (en) 2008-04-17
CA2666098C true CA2666098C (en) 2012-09-25

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA2666098A Active CA2666098C (en) 2006-10-10 2007-10-05 Preparation of nucleosides ribofuranosyl pyrimidines

Country Status (18)

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US (2) US8912321B2 (enExample)
EP (1) EP2084174B1 (enExample)
JP (1) JP5252459B2 (enExample)
KR (1) KR101057239B1 (enExample)
CN (1) CN101600725B (enExample)
AU (1) AU2007307057B2 (enExample)
BR (1) BRPI0719174A2 (enExample)
CA (1) CA2666098C (enExample)
DK (1) DK2084174T3 (enExample)
ES (1) ES2429290T3 (enExample)
GT (1) GT200900080A (enExample)
IL (1) IL198086A (enExample)
MX (1) MX2009003795A (enExample)
PL (1) PL2084174T3 (enExample)
PT (1) PT2084174E (enExample)
RU (1) RU2421461C2 (enExample)
SI (1) SI2084174T1 (enExample)
WO (1) WO2008045419A1 (enExample)

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Also Published As

Publication number Publication date
GT200900080A (es) 2012-04-10
EP2084174B1 (en) 2013-07-31
US20100056770A1 (en) 2010-03-04
ES2429290T3 (es) 2013-11-14
PT2084174E (pt) 2013-10-08
US20080139802A1 (en) 2008-06-12
EP2084174A1 (en) 2009-08-05
JP2010505954A (ja) 2010-02-25
SI2084174T1 (sl) 2013-10-30
US8912321B2 (en) 2014-12-16
MX2009003795A (es) 2009-06-18
CA2666098A1 (en) 2008-04-17
CN101600725A (zh) 2009-12-09
DK2084174T3 (da) 2013-11-04
KR101057239B1 (ko) 2011-08-16
CN101600725B (zh) 2014-11-26
KR20090060460A (ko) 2009-06-12
BRPI0719174A2 (pt) 2017-06-13
AU2007307057B2 (en) 2011-09-15
IL198086A (en) 2012-03-29
PL2084174T3 (pl) 2013-12-31
JP5252459B2 (ja) 2013-07-31
HK1133889A1 (en) 2010-04-09
AU2007307057A1 (en) 2008-04-17
IL198086A0 (en) 2009-12-24
RU2009117396A (ru) 2010-11-20
WO2008045419A1 (en) 2008-04-17
RU2421461C2 (ru) 2011-06-20

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