PT1922307E - Inibidores heterocíclicos de mek e seus métodos de utilização - Google Patents

Inibidores heterocíclicos de mek e seus métodos de utilização Download PDF

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Publication number
PT1922307E
PT1922307E PT06836069T PT06836069T PT1922307E PT 1922307 E PT1922307 E PT 1922307E PT 06836069 T PT06836069 T PT 06836069T PT 06836069 T PT06836069 T PT 06836069T PT 1922307 E PT1922307 E PT 1922307E
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PT
Portugal
Prior art keywords
compound
oxo
fluoro
carboxamide
dihydropyridine
Prior art date
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PT06836069T
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English (en)
Portuguese (pt)
Inventor
John David Pittam
Allison L Marlow
Eli Wallace
Jeongbeob Seo
Joseph P Lyssikatos
Hong Woon Yang
Jim Blake
Richard Anthony Storey
Rebecca Jane Booth
John Leonard
Mark Richard Fielding
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Astrazeneca Ab
Array Biopharma Inc
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Application filed by Astrazeneca Ab, Array Biopharma Inc filed Critical Astrazeneca Ab
Publication of PT1922307E publication Critical patent/PT1922307E/pt

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
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    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
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PT06836069T 2005-05-18 2006-05-17 Inibidores heterocíclicos de mek e seus métodos de utilização PT1922307E (pt)

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