TWI506020B - Mek雜環抑制劑及其使用方法 - Google Patents

Mek雜環抑制劑及其使用方法 Download PDF

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Publication number
TWI506020B
TWI506020B TW101118139A TW101118139A TWI506020B TW I506020 B TWI506020 B TW I506020B TW 101118139 A TW101118139 A TW 101118139A TW 101118139 A TW101118139 A TW 101118139A TW I506020 B TWI506020 B TW I506020B
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Taiwan
Prior art keywords
compound
fluoro
methyl
dihydropyridine
dimethyl
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TW101118139A
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English (en)
Chinese (zh)
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TW201302708A (zh
Inventor
Allison L Marlow
Eli M Wallace
Jeongbeob Seo
Joseph P Lyssikatos
Hong Woon Yang
Jim Blake
Richard Anthony Storey
Rebecca Jane Booth
John David Pittam
John Leonard
Mark Richard Fielding
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Array Biopharma Inc
Astrazeneca Ab
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Application filed by Array Biopharma Inc, Astrazeneca Ab filed Critical Array Biopharma Inc
Publication of TW201302708A publication Critical patent/TW201302708A/zh
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    • C07D237/00Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/24Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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TW101118139A 2005-05-18 2006-05-17 Mek雜環抑制劑及其使用方法 TWI506020B (zh)

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TW101118140A TW201238952A (en) 2005-05-18 2006-05-17 Heterocyclic inhibitors of MEK and methods of use thereof
TW095117459A TWI441637B (zh) 2005-05-18 2006-05-17 Mek雜環抑制劑及其使用方法
TW101118139A TWI506020B (zh) 2005-05-18 2006-05-17 Mek雜環抑制劑及其使用方法

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