TWI506020B - Mek雜環抑制劑及其使用方法 - Google Patents
Mek雜環抑制劑及其使用方法 Download PDFInfo
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- TWI506020B TWI506020B TW101118139A TW101118139A TWI506020B TW I506020 B TWI506020 B TW I506020B TW 101118139 A TW101118139 A TW 101118139A TW 101118139 A TW101118139 A TW 101118139A TW I506020 B TWI506020 B TW I506020B
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- compound
- fluoro
- methyl
- dihydropyridine
- dimethyl
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- C07—ORGANIC CHEMISTRY
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- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68233505P | 2005-05-18 | 2005-05-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201302708A TW201302708A (zh) | 2013-01-16 |
| TWI506020B true TWI506020B (zh) | 2015-11-01 |
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Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW101118140A TW201238952A (en) | 2005-05-18 | 2006-05-17 | Heterocyclic inhibitors of MEK and methods of use thereof |
| TW095117459A TWI441637B (zh) | 2005-05-18 | 2006-05-17 | Mek雜環抑制劑及其使用方法 |
| TW101118139A TWI506020B (zh) | 2005-05-18 | 2006-05-17 | Mek雜環抑制劑及其使用方法 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW101118140A TW201238952A (en) | 2005-05-18 | 2006-05-17 | Heterocyclic inhibitors of MEK and methods of use thereof |
| TW095117459A TWI441637B (zh) | 2005-05-18 | 2006-05-17 | Mek雜環抑制劑及其使用方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7517994B2 (en) * | 2003-11-19 | 2009-04-14 | Array Biopharma Inc. | Heterocyclic inhibitors of MEK and methods of use thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2005000818A1 (en) * | 2003-06-27 | 2005-01-06 | Warner-Lambert Company Llc | 5-substituted-4-`(substituted phenyl)!amino!-2-pyridone deviatives for use as mek inhibitors |
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