PT1256585E - Processo para a preparacao de 9-(2-(dietilfosfonometoxi)-etil)-adenina - Google Patents

Processo para a preparacao de 9-(2-(dietilfosfonometoxi)-etil)-adenina

Info

Publication number
PT1256585E
PT1256585E PT02016429T PT02016429T PT1256585E PT 1256585 E PT1256585 E PT 1256585E PT 02016429 T PT02016429 T PT 02016429T PT 02016429 T PT02016429 T PT 02016429T PT 1256585 E PT1256585 E PT 1256585E
Authority
PT
Portugal
Prior art keywords
dyethyphofonomethoxy
eethyl
adenin
preparation
Prior art date
Application number
PT02016429T
Other languages
English (en)
Portuguese (pt)
Inventor
Murty N Arimilli
Ernest J Prisbe
Thomas T K Lee
Lawrence V Manes
John D Munger Jr
Lisa M Schultze
Daphne E Kelly
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26732226&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT1256585(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of PT1256585E publication Critical patent/PT1256585E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Transplanting Machines (AREA)
PT02016429T 1997-07-25 1998-07-23 Processo para a preparacao de 9-(2-(dietilfosfonometoxi)-etil)-adenina PT1256585E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5377197P 1997-07-25 1997-07-25
US90074597A 1997-07-25 1997-07-25

Publications (1)

Publication Number Publication Date
PT1256585E true PT1256585E (pt) 2005-01-31

Family

ID=26732226

Family Applications (3)

Application Number Title Priority Date Filing Date
PT02016429T PT1256585E (pt) 1997-07-25 1998-07-23 Processo para a preparacao de 9-(2-(dietilfosfonometoxi)-etil)-adenina
PT98937988T PT996430E (pt) 1997-07-25 1998-07-23 Composicoes de analogos nucleotidicos
PT02016428T PT1256584E (pt) 1997-07-25 1998-07-23 Processo para a preparacao de adefovir-dipivoxil

Family Applications After (2)

Application Number Title Priority Date Filing Date
PT98937988T PT996430E (pt) 1997-07-25 1998-07-23 Composicoes de analogos nucleotidicos
PT02016428T PT1256584E (pt) 1997-07-25 1998-07-23 Processo para a preparacao de adefovir-dipivoxil

Country Status (24)

Country Link
EP (1) EP0996430B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (4) JP3573713B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (3) KR100618663B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CN (2) CN1216062C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AR (1) AR016548A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (3) ATE277937T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU747163B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BR (1) BR9811552A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (3) CA2596320C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CO (1) CO4980869A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (3) DE69826735T2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK0996430T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (3) ES2229029T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HK (1) HK1046357B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ID (1) ID28006A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL133461A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IN (1) IN190037B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
MY (1) MY129451A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ501659A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (3) PT1256585E (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SI (2) SI1256584T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
TR (3) TR200000224T2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
TW (1) TW584635B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
WO (1) WO1999004774A2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0996430B1 (en) * 1997-07-25 2002-11-27 Gilead Sciences, Inc. Nucleotide analog compositions
US6635278B1 (en) * 1998-12-15 2003-10-21 Gilead Sciences, Inc. Pharmaceutical formulations
TWI230618B (en) * 1998-12-15 2005-04-11 Gilead Sciences Inc Pharmaceutical compositions of 9-[2-[[bis[(pivaloyloxy)methyl]phosphono]methoxy]ethyl]adenine and tablets or capsules containing the same
DK1301519T4 (da) 2000-07-21 2021-12-20 Gilead Sciences Inc Prodrugs af phosphonatnukleotidanaloger og fremgangsmåder til udvælgelse og fremstilling heraf
EP1532157A4 (en) 2002-05-13 2009-02-25 Metabasis Therapeutics Inc NEW PRODRUGS FROM PMEA TO PHOSPHONIC ACID BASE AND ITS ANALOG
NZ536327A (en) 2002-05-13 2007-08-31 Metabasis Therapeutics Inc PMEA and PMPA cyclic producing synthesis
WO2004043972A1 (fr) * 2002-11-12 2004-05-27 Tianjin Kinsly Pharmaceutical Co., Ltd. Nouvelle forme cristalline d'adefovir dipivoxil et sa composition
CN100383149C (zh) * 2002-11-12 2008-04-23 天津帝士力投资控股集团有限公司 一种新的晶状埃地双酯及其组合物
CN1303089C (zh) * 2002-11-19 2007-03-07 天津药物研究院 阿德福韦酯结晶形态及其制备方法
CN100415756C (zh) * 2003-10-14 2008-09-03 沈阳药科大学 草酸阿地福韦酯及其晶型和制备方法及用途
CN100358907C (zh) * 2004-03-31 2008-01-02 河北医科大学生物医学工程中心 一种非晶状阿德福韦酯的制备方法
CN100374118C (zh) * 2004-05-20 2008-03-12 江苏吴中中药研发有限公司 含有阿德福韦酯的滴丸剂及其制备方法
AU2005254940A1 (en) 2004-06-08 2005-12-29 Metabasis Therapeutics, Inc. Lewis acid mediated synthesis of cyclic esters
CN102240295B (zh) * 2005-06-13 2013-04-03 博瑞生物医药技术(苏州)有限公司 泰诺福韦衍生物及用途
CN100395248C (zh) * 2006-05-26 2008-06-18 华东理工大学 一种9-(二乙氧基磷酰基甲氧基乙基)-腺嘌啉的制备方法
ITMI20071594A1 (it) * 2007-08-02 2009-02-03 Solmag Spa Forma cristallina monoidrata di adefovir dipivoxil
CN101343290B (zh) * 2008-05-24 2011-02-02 广东肇庆星湖生物科技股份有限公司 一种阿德福韦酯无水结晶物的制备方法、所得的阿德福韦酯无水结晶物及其应用
WO2010005195A2 (ko) * 2008-07-07 2010-01-14 (주)아모레퍼시픽 아데포버 디피복실의 결정형 ｌ의 제조방법
KR20100031045A (ko) 2008-09-11 2010-03-19 씨제이제일제당 (주) 아데포비어 디피복실의 정제방법
WO2010032958A2 (ko) 2008-09-17 2010-03-25 씨제이제일제당 (주) 아데포비어 디피복실의 안정화된 고체 분산체 및 이의 제조 방법
KR20100032803A (ko) 2008-09-18 2010-03-26 씨제이제일제당 (주) 아데포비어디피복실의 개선된 제조방법
KR20100061401A (ko) * 2008-11-28 2010-06-07 (주)아모레퍼시픽 아데포버 디피복실의 결정형, 그 제조방법 및 그를 포함하는 약제학적 조성물
JP5642766B2 (ja) * 2009-03-26 2014-12-17 ダエウン ファーマシューティカル カンパニー リミテッド アデフォビルジピボキシルの新規結晶形及びその製造方法
KR20100113302A (ko) * 2009-04-13 2010-10-21 한미홀딩스 주식회사 결정형 아데포비어 디피복실의 제조방법 및 이에 사용되는 아데포비어 디피복실 부탄올레이트
KR101528754B1 (ko) * 2009-04-14 2015-06-17 중앙대학교 산학협력단 신규한 복합결정형의 화합물, 그 제조방법 및 이를 포함하는 약제학적 조성물
KR100971486B1 (ko) * 2009-06-11 2010-07-21 주식회사 셀트리온화학연구소 아데포비어 다이피복실 말론산염 및 이를 포함하는 약제학적 조성물
KR101089620B1 (ko) * 2009-07-20 2011-12-06 경희대학교 산학협력단 무수결정형 아데포비어 디피복실 및 이온성 액체를 사용한 이의 제조 방법
WO2011016611A2 (ko) * 2009-08-03 2011-02-10 제일약품주식회사 새로운 결정형을 갖는 아데포비어 디피복실, 이의 제조방법 및 이를 유효성분으로 함유하는 만성 ｂ형 간염의 예방 또는 치료용 조성물
KR101129575B1 (ko) * 2009-09-02 2012-03-28 경희대학교 산학협력단 반수화물 아데포비어 디피복실 및 이온성 액체를 사용한 이의 제조 방법
KR101048024B1 (ko) * 2009-10-09 2011-07-13 주식회사 삼오제약 9-(2-포스포닐메톡시에틸)아데닌, 아데포비아 디피복실 및 무정형 아데포비아 디피복실의 제조방법
EP2343056A1 (en) 2009-12-30 2011-07-13 Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi Producing stable adefovir dipivoxil solid dispersions
WO2012032541A1 (en) * 2010-09-06 2012-03-15 Matrix Laboratories Ltd "adefovir dipivoxil pseudopolymorph"
WO2012062835A1 (en) 2010-11-12 2012-05-18 Glaxo Wellcome Manufacturing Pte Ltd Novel pharmaceutical compositions
CN102250146A (zh) * 2011-05-27 2011-11-23 扬州三友合成化工有限公司 抗乙肝药物阿德福韦的一种合成方法
KR101357687B1 (ko) * 2011-11-25 2014-02-05 숭실대학교산학협력단 고분자 첨가제를 이용한 아데포비어 디피복실 복합체의 결정입자 제어방법 및 이의 응용
KR101258678B1 (ko) 2012-02-29 2013-04-26 제일약품주식회사 새로운 결정형을 갖는 아데포비어 디피복실, 이의 제조방법 및 이를 유효성분으로 함유하는 만성 β형 간염의 예방 또는 치료용 조성물
CN107312039B (zh) 2012-08-30 2019-06-25 江苏豪森药业集团有限公司 一种替诺福韦前药的制备方法
CN102816184B (zh) * 2012-09-07 2015-11-18 山东大学 (2-(2-氧基-4-硫代嘧啶)乙氧基)甲基膦酸酯类衍生物及其制备与应用
CN103709198A (zh) * 2012-09-28 2014-04-09 江苏天士力帝益药业有限公司 一种阿德福韦酯的结晶方法
CN103333208B (zh) * 2013-06-04 2016-05-11 广州晶莱医药科技有限公司 阿德福韦酯马来酸盐及其制备方法和组合物
AU2015217221A1 (en) 2014-02-13 2016-08-11 Ligand Pharmaceuticals, Inc. Prodrug compounds and their uses
CN106687118A (zh) 2014-07-02 2017-05-17 配体药物公司 前药化合物及其用途
EP3372227A1 (en) 2017-03-06 2018-09-12 MH10 Spolka z ograniczona odpowiedzialnoscia Tablet formulation of adefovir dipivoxil
JP2021509907A (ja) 2018-01-09 2021-04-08 リガンド・ファーマシューティカルズ・インコーポレイテッド アセタール化合物およびその治療的使用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0481214B1 (en) * 1990-09-14 1998-06-24 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Prodrugs of phosphonates
EP0632048B1 (en) * 1993-06-29 2001-03-21 Mitsubishi Chemical Corporation Phosphonate-nucleotide ester derivatives
JP4033494B2 (ja) * 1996-07-26 2008-01-16 ギリヤド サイエンシーズ， インコーポレイテッド ヌクレオチドアナログ
EP0996430B1 (en) * 1997-07-25 2002-11-27 Gilead Sciences, Inc. Nucleotide analog compositions

Also Published As

Publication number Publication date
JP2001512712A (ja) 2001-08-28
HK1091212A1 (en) 2007-01-12
HK1051694A1 (en) 2003-08-15
TR200000224T2 (tr) 2000-07-21
JP2005306879A (ja) 2005-11-04
MY129451A (en) 2007-04-30
CA2298057C (en) 2008-11-18
HK1046357A1 (en) 2003-01-10
JP2003342283A (ja) 2003-12-03
DK0996430T3 (da) 2003-03-10
CN1347695A (zh) 2002-05-08
HK1091211A1 (en) 2007-01-12
NZ501659A (en) 2004-12-24
SI1256585T1 (en) 2005-02-28
KR100618663B1 (ko) 2006-09-08
BR9811552A (pt) 2000-08-29
CN1274700C (zh) 2006-09-13
CN1216062C (zh) 2005-08-24
JP2009263389A (ja) 2009-11-12
WO1999004774A2 (en) 1999-02-04
ATE277936T1 (de) 2004-10-15
PT996430E (pt) 2003-03-31
ES2229029T3 (es) 2005-04-16
CA2596497A1 (en) 1999-02-04
AR016548A1 (es) 2001-07-25
PT1256584E (pt) 2004-12-31
AU8660998A (en) 1999-02-16
DE69826734D1 (de) 2004-11-04
TR200200137T2 (tr) 2002-09-23
CN1251592A (zh) 2000-04-26
DE69809749T2 (de) 2003-09-11
CA2596497C (en) 2008-12-23
ATE277937T1 (de) 2004-10-15
CA2298057A1 (en) 1999-02-04
KR100700087B1 (ko) 2007-03-28
DE69826735D1 (de) 2004-11-04
JP3573713B2 (ja) 2004-10-06
EP0996430A2 (en) 2000-05-03
KR20060038363A (ko) 2006-05-03
KR20060038364A (ko) 2006-05-03
IN190037B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 2003-05-31
TR200200117T2 (tr) 2002-06-21
EP0996430B1 (en) 2002-11-27
ES2187991T3 (es) 2003-06-16
IL133461A (en) 2005-05-17
CO4980869A1 (es) 2000-11-27
IL133461A0 (en) 2001-04-30
DE69826735T2 (de) 2005-10-06
KR20010014284A (ko) 2001-02-26
ATE228357T1 (de) 2002-12-15
WO1999004774A3 (en) 1999-04-15
SI1256584T1 (en) 2005-02-28
HK1051693A1 (en) 2003-08-15
ID28006A (id) 2001-05-03
KR100700089B1 (ko) 2007-03-28
ES2229030T3 (es) 2005-04-16
JP4452034B2 (ja) 2010-04-21
CA2596320A1 (en) 1999-02-04
HK1046357B (zh) 2007-08-24
AU747163B2 (en) 2002-05-09
DE69809749D1 (de) 2003-01-09
DE69826734T2 (de) 2005-10-06
CA2596320C (en) 2008-12-23
TW584635B (en) 2004-04-21

Similar Documents

Publication Publication Date Title
PT1256585E (pt) Processo para a preparacao de 9-(2-(dietilfosfonometoxi)-etil)-adenina
PT1003792E (pt) Um processo para a preparacao de polietileno
PT770615E (pt) Processo para a preparacao de di-haloazolopirimidinas
BR9706447A (pt) Processo para a preparação de oxo-álcoois superiores
BR9710457A (pt) Processo para a prepara-Æo de ciclohexanodimetanol
PT1147075E (pt) Processo para a preparacao de cloridrato de l-fenilefrina
BR9608471A (pt) Processo para a preparação de um composto
BRPI9814894B8 (pt) processo para a preparação de ácidos 8-metóxi-quinolonocarboxìlicos.
BR9711201A (pt) Processo para a prepara-ao de um composto
BR9706465A (pt) Processo para a preparação contínua de metilmercaptano
BR9500668A (pt) Processo para a preparaçao de compostos polialquil-1-oxa- diazaspirodecano
BR9500613A (pt) Processo para a preparação contínua de mononitrotoluenos
BR9703467A (pt) Processo para a preparação de derivados de dicetopirrolopirrol
PT877738E (pt) Processo para a preparacao de derivados de fenil-imidazolidina
PT1327637E (pt) Processo para a preparacao de l-ribose
PT1028960E (pt) Processo para a preparacao de derivados de tiazolidinodiona
BR9800557A (pt) Processo contínuo para preparação de 4-aminopiperidinas
BR9610887A (pt) Processo para a preparação de um composto
BR9609493A (pt) Processo para a preparação de um composto
BR9711732A (pt) Processo para a prepara-Æo de alfa -mega-amino-nitrilas alif ticas
BR9612457A (pt) Processo para a fabricação de felodipina
PT880498E (pt) Processo para a preparacao de compostos dicetonicos
PT973769E (pt) Processo para a preparacao de eprosartan
BR9804873A (pt) Processo para a produ-Æo de ironas
BR9608904A (pt) Processo para a preparação de um composto