AR016548A1 - Compuestos de analogos de nucleotidos, un metodo para su preparacion, una composicion que los comprende, un producto producido mediante el proceso de comprimir una mezcla y un metodo para preparar 9-[2-(dietilfosfonometoxi)etil]adenina. - Google Patents

Compuestos de analogos de nucleotidos, un metodo para su preparacion, una composicion que los comprende, un producto producido mediante el proceso de comprimir una mezcla y un metodo para preparar 9-[2-(dietilfosfonometoxi)etil]adenina.

Info

Publication number
AR016548A1
AR016548A1 ARP980103692A ARP980103692A AR016548A1 AR 016548 A1 AR016548 A1 AR 016548A1 AR P980103692 A ARP980103692 A AR P980103692A AR P980103692 A ARP980103692 A AR P980103692A AR 016548 A1 AR016548 A1 AR 016548A1
Authority
AR
Argentina
Prior art keywords
ethyl
dietilphosphonometoxy
nucleotid
aden
compressing
Prior art date
Application number
ARP980103692A
Other languages
English (en)
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26732226&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR016548(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of AR016548A1 publication Critical patent/AR016548A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Transplanting Machines (AREA)

Abstract

Se describen formas cristalinas de 9-[2-[[bis(pivaloiloxi)-metoxi]fosfinil]metoxi]etil]adenina (adefovir dipivoxil) y métodos para preparar los cristales.Las composiciones y métodos de la presente invencion tienen propiedades deseables para la síntesis a gran escala de adefovir dipivoxil cristalino o para suformulacion en dosificaciones terapéuticas. Las composiciones de la invencion incluyen una forma cristalina anhidra de adefovir dipivoxil.
ARP980103692A 1997-07-25 1998-07-27 Compuestos de analogos de nucleotidos, un metodo para su preparacion, una composicion que los comprende, un producto producido mediante el proceso de comprimir una mezcla y un metodo para preparar 9-[2-(dietilfosfonometoxi)etil]adenina. AR016548A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5377197P 1997-07-25 1997-07-25
US90074597A 1997-07-25 1997-07-25

Publications (1)

Publication Number Publication Date
AR016548A1 true AR016548A1 (es) 2001-07-25

Family

ID=26732226

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP980103692A AR016548A1 (es) 1997-07-25 1998-07-27 Compuestos de analogos de nucleotidos, un metodo para su preparacion, una composicion que los comprende, un producto producido mediante el proceso de comprimir una mezcla y un metodo para preparar 9-[2-(dietilfosfonometoxi)etil]adenina.

Country Status (24)

Country Link
EP (1) EP0996430B1 (es)
JP (4) JP3573713B2 (es)
KR (3) KR100700087B1 (es)
CN (2) CN1274700C (es)
AR (1) AR016548A1 (es)
AT (3) ATE228357T1 (es)
AU (1) AU747163B2 (es)
BR (1) BR9811552A (es)
CA (3) CA2596320C (es)
CO (1) CO4980869A1 (es)
DE (3) DE69826735T2 (es)
DK (1) DK0996430T3 (es)
ES (3) ES2229029T3 (es)
HK (5) HK1046357B (es)
ID (1) ID28006A (es)
IL (1) IL133461A (es)
IN (1) IN190037B (es)
MY (1) MY129451A (es)
NZ (1) NZ501659A (es)
PT (3) PT1256584E (es)
SI (2) SI1256584T1 (es)
TR (3) TR200200117T2 (es)
TW (1) TW584635B (es)
WO (1) WO1999004774A2 (es)

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US6635278B1 (en) * 1998-12-15 2003-10-21 Gilead Sciences, Inc. Pharmaceutical formulations
HRP20160074B1 (hr) 2000-07-21 2021-09-03 Gilead Sciences, Inc. Prolijekovi koji su fosfonatni analozi nukleotida i metode njihovog odabira te njihova priprava
NZ536328A (en) 2002-05-13 2007-11-30 Metabasis Therapeutics Inc Novel phosphonic acid based prodrugs of PMEA and its analogues
EP1504014B1 (en) 2002-05-13 2015-12-02 Metabasis Therapeutics, Inc. Process for preparation of cyclic prodrugs of pmea and pmpa
US7417036B2 (en) 2002-11-12 2008-08-26 Tianjin Kinsly Pharmaceutical Co. Ltd. Crystal form of adefovir dipivoxil and its preparation
CN100383149C (zh) * 2002-11-12 2008-04-23 天津帝士力投资控股集团有限公司 一种新的晶状埃地双酯及其组合物
CN1303089C (zh) * 2002-11-19 2007-03-07 天津药物研究院 阿德福韦酯结晶形态及其制备方法
CN100415756C (zh) * 2003-10-14 2008-09-03 沈阳药科大学 草酸阿地福韦酯及其晶型和制备方法及用途
CN100358907C (zh) * 2004-03-31 2008-01-02 河北医科大学生物医学工程中心 一种非晶状阿德福韦酯的制备方法
CN100374118C (zh) * 2004-05-20 2008-03-12 江苏吴中中药研发有限公司 含有阿德福韦酯的滴丸剂及其制备方法
RU2006138907A (ru) 2004-06-08 2008-07-20 Метабазис Терапеутикс Синтез сложных циклических эфиров с применением кислоты льюиса
CN102228463B (zh) * 2005-06-13 2012-12-19 博瑞生物医药技术(苏州)有限公司 泰诺福韦的晶体
CN100395248C (zh) * 2006-05-26 2008-06-18 华东理工大学 一种9-(二乙氧基磷酰基甲氧基乙基)-腺嘌啉的制备方法
ITMI20071594A1 (it) * 2007-08-02 2009-02-03 Solmag Spa Forma cristallina monoidrata di adefovir dipivoxil
CN101343290B (zh) * 2008-05-24 2011-02-02 广东肇庆星湖生物科技股份有限公司 一种阿德福韦酯无水结晶物的制备方法、所得的阿德福韦酯无水结晶物及其应用
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KR20100032803A (ko) * 2008-09-18 2010-03-26 씨제이제일제당 (주) 아데포비어디피복실의 개선된 제조방법
KR20100061401A (ko) * 2008-11-28 2010-06-07 (주)아모레퍼시픽 아데포버 디피복실의 결정형, 그 제조방법 및 그를 포함하는 약제학적 조성물
US9169257B2 (en) 2009-03-26 2015-10-27 Daewoong Pharmaceutical Co., Ltd. Crystal forms of adefovir dipivoxil and processes for preparing the same
KR20100113302A (ko) * 2009-04-13 2010-10-21 한미홀딩스 주식회사 결정형 아데포비어 디피복실의 제조방법 및 이에 사용되는 아데포비어 디피복실 부탄올레이트
KR101528754B1 (ko) * 2009-04-14 2015-06-17 중앙대학교 산학협력단 신규한 복합결정형의 화합물, 그 제조방법 및 이를 포함하는 약제학적 조성물
KR100971486B1 (ko) * 2009-06-11 2010-07-21 주식회사 셀트리온화학연구소 아데포비어 다이피복실 말론산염 및 이를 포함하는 약제학적 조성물
KR101089620B1 (ko) * 2009-07-20 2011-12-06 경희대학교 산학협력단 무수결정형 아데포비어 디피복실 및 이온성 액체를 사용한 이의 제조 방법
WO2011016611A2 (ko) * 2009-08-03 2011-02-10 제일약품주식회사 새로운 결정형을 갖는 아데포비어 디피복실, 이의 제조방법 및 이를 유효성분으로 함유하는 만성 ｂ형 간염의 예방 또는 치료용 조성물
KR101129575B1 (ko) * 2009-09-02 2012-03-28 경희대학교 산학협력단 반수화물 아데포비어 디피복실 및 이온성 액체를 사용한 이의 제조 방법
KR101048024B1 (ko) * 2009-10-09 2011-07-13 주식회사 삼오제약 9-(2-포스포닐메톡시에틸)아데닌, 아데포비아 디피복실 및 무정형 아데포비아 디피복실의 제조방법
EP2343056A1 (en) 2009-12-30 2011-07-13 Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi Producing stable adefovir dipivoxil solid dispersions
WO2012032541A1 (en) * 2010-09-06 2012-03-15 Matrix Laboratories Ltd "adefovir dipivoxil pseudopolymorph"
WO2012062835A1 (en) 2010-11-12 2012-05-18 Glaxo Wellcome Manufacturing Pte Ltd Novel pharmaceutical compositions
CN102250146A (zh) * 2011-05-27 2011-11-23 扬州三友合成化工有限公司 抗乙肝药物阿德福韦的一种合成方法
KR101357687B1 (ko) * 2011-11-25 2014-02-05 숭실대학교산학협력단 고분자 첨가제를 이용한 아데포비어 디피복실 복합체의 결정입자 제어방법 및 이의 응용
KR101258678B1 (ko) 2012-02-29 2013-04-26 제일약품주식회사 새로운 결정형을 갖는 아데포비어 디피복실, 이의 제조방법 및 이를 유효성분으로 함유하는 만성 β형 간염의 예방 또는 치료용 조성물
CN107312039B (zh) 2012-08-30 2019-06-25 江苏豪森药业集团有限公司 一种替诺福韦前药的制备方法
CN102816184B (zh) * 2012-09-07 2015-11-18 山东大学 (2-(2-氧基-4-硫代嘧啶)乙氧基)甲基膦酸酯类衍生物及其制备与应用
CN103709198A (zh) * 2012-09-28 2014-04-09 江苏天士力帝益药业有限公司 一种阿德福韦酯的结晶方法
CN103333208B (zh) * 2013-06-04 2016-05-11 广州晶莱医药科技有限公司 阿德福韦酯马来酸盐及其制备方法和组合物
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Also Published As

Publication number Publication date
KR20010014284A (ko) 2001-02-26
ES2187991T3 (es) 2003-06-16
IL133461A (en) 2005-05-17
WO1999004774A2 (en) 1999-02-04
CA2298057C (en) 2008-11-18
PT1256584E (pt) 2004-12-31
JP3573713B2 (ja) 2004-10-06
CN1216062C (zh) 2005-08-24
DE69809749T2 (de) 2003-09-11
CO4980869A1 (es) 2000-11-27
HK1051693A1 (en) 2003-08-15
CA2596497A1 (en) 1999-02-04
CA2596497C (en) 2008-12-23
ATE277937T1 (de) 2004-10-15
KR100618663B1 (ko) 2006-09-08
KR20060038363A (ko) 2006-05-03
DE69826735T2 (de) 2005-10-06
CN1251592A (zh) 2000-04-26
CA2596320C (en) 2008-12-23
HK1046357A1 (en) 2003-01-10
JP2001512712A (ja) 2001-08-28
ES2229030T3 (es) 2005-04-16
HK1046357B (zh) 2007-08-24
CN1274700C (zh) 2006-09-13
PT1256585E (pt) 2005-01-31
WO1999004774A3 (en) 1999-04-15
ATE228357T1 (de) 2002-12-15
IN190037B (es) 2003-05-31
SI1256585T1 (en) 2005-02-28
MY129451A (en) 2007-04-30
TR200200117T2 (tr) 2002-06-21
NZ501659A (en) 2004-12-24
ATE277936T1 (de) 2004-10-15
KR20060038364A (ko) 2006-05-03
JP4452034B2 (ja) 2010-04-21
CA2298057A1 (en) 1999-02-04
HK1051694A1 (en) 2003-08-15
EP0996430B1 (en) 2002-11-27
TR200000224T2 (tr) 2000-07-21
AU747163B2 (en) 2002-05-09
PT996430E (pt) 2003-03-31
DE69826734T2 (de) 2005-10-06
JP2009263389A (ja) 2009-11-12
CA2596320A1 (en) 1999-02-04
HK1091212A1 (en) 2007-01-12
IL133461A0 (en) 2001-04-30
DE69809749D1 (de) 2003-01-09
ES2229029T3 (es) 2005-04-16
EP0996430A2 (en) 2000-05-03
TR200200137T2 (tr) 2002-09-23
DE69826734D1 (de) 2004-11-04
CN1347695A (zh) 2002-05-08
HK1091211A1 (en) 2007-01-12
AU8660998A (en) 1999-02-16
DK0996430T3 (da) 2003-03-10
JP2005306879A (ja) 2005-11-04
KR100700087B1 (ko) 2007-03-28
BR9811552A (pt) 2000-08-29
KR100700089B1 (ko) 2007-03-28
DE69826735D1 (de) 2004-11-04
TW584635B (en) 2004-04-21
ID28006A (id) 2001-05-03
JP2003342283A (ja) 2003-12-03
SI1256584T1 (en) 2005-02-28

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