PT1256584E - Processo para a preparacao de adefovir-dipivoxil - Google Patents
Processo para a preparacao de adefovir-dipivoxilInfo
- Publication number
- PT1256584E PT1256584E PT02016428T PT02016428T PT1256584E PT 1256584 E PT1256584 E PT 1256584E PT 02016428 T PT02016428 T PT 02016428T PT 02016428 T PT02016428 T PT 02016428T PT 1256584 E PT1256584 E PT 1256584E
- Authority
- PT
- Portugal
- Prior art keywords
- dipivoxyl
- adefovir
- preparation
- Prior art date
Links
- WOZSCQDILHKSGG-UHFFFAOYSA-N adefovir depivoxil Chemical compound N1=CN=C2N(CCOCP(=O)(OCOC(=O)C(C)(C)C)OCOC(=O)C(C)(C)C)C=NC2=C1N WOZSCQDILHKSGG-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Transplanting Machines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90074597A | 1997-07-25 | 1997-07-25 | |
| US5377197P | 1997-07-25 | 1997-07-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1256584E true PT1256584E (pt) | 2004-12-31 |
Family
ID=26732226
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT02016428T PT1256584E (pt) | 1997-07-25 | 1998-07-23 | Processo para a preparacao de adefovir-dipivoxil |
| PT02016429T PT1256585E (pt) | 1997-07-25 | 1998-07-23 | Processo para a preparacao de 9-(2-(dietilfosfonometoxi)-etil)-adenina |
| PT98937988T PT996430E (pt) | 1997-07-25 | 1998-07-23 | Composicoes de analogos nucleotidicos |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT02016429T PT1256585E (pt) | 1997-07-25 | 1998-07-23 | Processo para a preparacao de 9-(2-(dietilfosfonometoxi)-etil)-adenina |
| PT98937988T PT996430E (pt) | 1997-07-25 | 1998-07-23 | Composicoes de analogos nucleotidicos |
Country Status (24)
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2596320C (en) * | 1997-07-25 | 2008-12-23 | Gilead Sciences, Inc. | Nucleotide analog compositions |
| US6635278B1 (en) * | 1998-12-15 | 2003-10-21 | Gilead Sciences, Inc. | Pharmaceutical formulations |
| TWI230618B (en) * | 1998-12-15 | 2005-04-11 | Gilead Sciences Inc | Pharmaceutical compositions of 9-[2-[[bis[(pivaloyloxy)methyl]phosphono]methoxy]ethyl]adenine and tablets or capsules containing the same |
| US20020119443A1 (en) | 2000-07-21 | 2002-08-29 | Gilead Sciences, Inc. | Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same |
| US7193081B2 (en) | 2002-05-13 | 2007-03-20 | Metabasis Therapeutics, Inc. | Process for preparation of cyclic prodrugs of PMEA and PMPA |
| JP4476811B2 (ja) | 2002-05-13 | 2010-06-09 | メタバシス・セラピューティクス・インコーポレイテッド | Ｐｍｅａおよびそのアナログの新規ホスホン酸系プロドラッグ |
| CN100383149C (zh) * | 2002-11-12 | 2008-04-23 | 天津帝士力投资控股集团有限公司 | 一种新的晶状埃地双酯及其组合物 |
| WO2004043972A1 (fr) * | 2002-11-12 | 2004-05-27 | Tianjin Kinsly Pharmaceutical Co., Ltd. | Nouvelle forme cristalline d'adefovir dipivoxil et sa composition |
| CN1303089C (zh) * | 2002-11-19 | 2007-03-07 | 天津药物研究院 | 阿德福韦酯结晶形态及其制备方法 |
| CN100415756C (zh) * | 2003-10-14 | 2008-09-03 | 沈阳药科大学 | 草酸阿地福韦酯及其晶型和制备方法及用途 |
| CN100358907C (zh) * | 2004-03-31 | 2008-01-02 | 河北医科大学生物医学工程中心 | 一种非晶状阿德福韦酯的制备方法 |
| CN100374118C (zh) * | 2004-05-20 | 2008-03-12 | 江苏吴中中药研发有限公司 | 含有阿德福韦酯的滴丸剂及其制备方法 |
| CN103374041B (zh) | 2004-06-08 | 2017-05-10 | 症变治疗公司 | 路易斯酸介导的环状酯的合成 |
| CN102228464B (zh) * | 2005-06-13 | 2013-06-05 | 博瑞生物医药技术(苏州)有限公司 | 泰诺福韦组合物 |
| CN100395248C (zh) * | 2006-05-26 | 2008-06-18 | 华东理工大学 | 一种9-(二乙氧基磷酰基甲氧基乙基)-腺嘌啉的制备方法 |
| ITMI20071594A1 (it) * | 2007-08-02 | 2009-02-03 | Solmag Spa | Forma cristallina monoidrata di adefovir dipivoxil |
| CN101343290B (zh) * | 2008-05-24 | 2011-02-02 | 广东肇庆星湖生物科技股份有限公司 | 一种阿德福韦酯无水结晶物的制备方法、所得的阿德福韦酯无水结晶物及其应用 |
| WO2010005195A2 (ko) * | 2008-07-07 | 2010-01-14 | (주)아모레퍼시픽 | 아데포버 디피복실의 결정형 ｌ의 제조방법 |
| KR20100031045A (ko) | 2008-09-11 | 2010-03-19 | 씨제이제일제당 (주) | 아데포비어 디피복실의 정제방법 |
| JP2012502902A (ja) * | 2008-09-17 | 2012-02-02 | シージェイ チェルジェダン コーポレイション | アデホビルジピボキシルの安定化した固体分散体及びその製造方法 |
| KR20100032803A (ko) * | 2008-09-18 | 2010-03-26 | 씨제이제일제당 (주) | 아데포비어디피복실의 개선된 제조방법 |
| KR20100061401A (ko) * | 2008-11-28 | 2010-06-07 | (주)아모레퍼시픽 | 아데포버 디피복실의 결정형, 그 제조방법 및 그를 포함하는 약제학적 조성물 |
| RU2485121C1 (ru) * | 2009-03-26 | 2013-06-20 | Даевунг Фармасьютикал Ко., Лтд. | Новые кристаллические формы адефовира дипивоксила и способы его получения |
| KR20100113302A (ko) * | 2009-04-13 | 2010-10-21 | 한미홀딩스 주식회사 | 결정형 아데포비어 디피복실의 제조방법 및 이에 사용되는 아데포비어 디피복실 부탄올레이트 |
| KR101528754B1 (ko) * | 2009-04-14 | 2015-06-17 | 중앙대학교 산학협력단 | 신규한 복합결정형의 화합물, 그 제조방법 및 이를 포함하는 약제학적 조성물 |
| KR100971486B1 (ko) * | 2009-06-11 | 2010-07-21 | 주식회사 셀트리온화학연구소 | 아데포비어 다이피복실 말론산염 및 이를 포함하는 약제학적 조성물 |
| KR101089620B1 (ko) * | 2009-07-20 | 2011-12-06 | 경희대학교 산학협력단 | 무수결정형 아데포비어 디피복실 및 이온성 액체를 사용한 이의 제조 방법 |
| WO2011016611A2 (ko) * | 2009-08-03 | 2011-02-10 | 제일약품주식회사 | 새로운 결정형을 갖는 아데포비어 디피복실, 이의 제조방법 및 이를 유효성분으로 함유하는 만성 ｂ형 간염의 예방 또는 치료용 조성물 |
| KR101129575B1 (ko) * | 2009-09-02 | 2012-03-28 | 경희대학교 산학협력단 | 반수화물 아데포비어 디피복실 및 이온성 액체를 사용한 이의 제조 방법 |
| KR101048024B1 (ko) * | 2009-10-09 | 2011-07-13 | 주식회사 삼오제약 | 9-(2-포스포닐메톡시에틸)아데닌, 아데포비아 디피복실 및 무정형 아데포비아 디피복실의 제조방법 |
| EP2343056A1 (en) | 2009-12-30 | 2011-07-13 | Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi | Producing stable adefovir dipivoxil solid dispersions |
| WO2012032541A1 (en) * | 2010-09-06 | 2012-03-15 | Matrix Laboratories Ltd | "adefovir dipivoxil pseudopolymorph" |
| CN103221037A (zh) | 2010-11-12 | 2013-07-24 | 葛兰素惠尔康制造业私人有限公司 | 新药物组合物 |
| CN102250146A (zh) * | 2011-05-27 | 2011-11-23 | 扬州三友合成化工有限公司 | 抗乙肝药物阿德福韦的一种合成方法 |
| KR101357687B1 (ko) * | 2011-11-25 | 2014-02-05 | 숭실대학교산학협력단 | 고분자 첨가제를 이용한 아데포비어 디피복실 복합체의 결정입자 제어방법 및 이의 응용 |
| KR101258678B1 (ko) | 2012-02-29 | 2013-04-26 | 제일약품주식회사 | 새로운 결정형을 갖는 아데포비어 디피복실, 이의 제조방법 및 이를 유효성분으로 함유하는 만성 β형 간염의 예방 또는 치료용 조성물 |
| CN107312039B (zh) | 2012-08-30 | 2019-06-25 | 江苏豪森药业集团有限公司 | 一种替诺福韦前药的制备方法 |
| CN102816184B (zh) * | 2012-09-07 | 2015-11-18 | 山东大学 | (2-(2-氧基-4-硫代嘧啶)乙氧基)甲基膦酸酯类衍生物及其制备与应用 |
| CN103709198A (zh) * | 2012-09-28 | 2014-04-09 | 江苏天士力帝益药业有限公司 | 一种阿德福韦酯的结晶方法 |
| CN103333208B (zh) * | 2013-06-04 | 2016-05-11 | 广州晶莱医药科技有限公司 | 阿德福韦酯马来酸盐及其制备方法和组合物 |
| CN114404427A (zh) | 2014-02-13 | 2022-04-29 | 配体药物公司 | 前药化合物及其用途 |
| CN106687118A (zh) | 2014-07-02 | 2017-05-17 | 配体药物公司 | 前药化合物及其用途 |
| EP3372227A1 (en) | 2017-03-06 | 2018-09-12 | MH10 Spolka z ograniczona odpowiedzialnoscia | Tablet formulation of adefovir dipivoxil |
| US11970482B2 (en) | 2018-01-09 | 2024-04-30 | Ligand Pharmaceuticals Inc. | Acetal compounds and therapeutic uses thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0481214B1 (en) * | 1990-09-14 | 1998-06-24 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic | Prodrugs of phosphonates |
| EP0632048B1 (en) * | 1993-06-29 | 2001-03-21 | Mitsubishi Chemical Corporation | Phosphonate-nucleotide ester derivatives |
| WO1998004569A1 (en) * | 1996-07-26 | 1998-02-05 | Gilead Sciences, Inc. | Nucleotide analogs |
| CA2596320C (en) * | 1997-07-25 | 2008-12-23 | Gilead Sciences, Inc. | Nucleotide analog compositions |
-
1998
- 1998-07-23 CA CA002596320A patent/CA2596320C/en not_active Expired - Lifetime
- 1998-07-23 AT AT98937988T patent/ATE228357T1/de active
- 1998-07-23 KR KR1019997012410A patent/KR100618663B1/ko not_active Expired - Lifetime
- 1998-07-23 KR KR1020057020625A patent/KR100700089B1/ko not_active Expired - Lifetime
- 1998-07-23 AU AU86609/98A patent/AU747163B2/en not_active Expired
- 1998-07-23 ES ES02016428T patent/ES2229029T3/es not_active Expired - Lifetime
- 1998-07-23 DE DE69826735T patent/DE69826735T2/de not_active Expired - Lifetime
- 1998-07-23 SI SI9830716T patent/SI1256585T1/xx unknown
- 1998-07-23 KR KR1020057020624A patent/KR100700087B1/ko not_active Expired - Lifetime
- 1998-07-23 ES ES98937988T patent/ES2187991T3/es not_active Expired - Lifetime
- 1998-07-23 SI SI9830712T patent/SI1256584T1/xx unknown
- 1998-07-23 IL IL13346198A patent/IL133461A/xx not_active IP Right Cessation
- 1998-07-23 DE DE69826734T patent/DE69826734T2/de not_active Expired - Lifetime
- 1998-07-23 DE DE69809749T patent/DE69809749T2/de not_active Expired - Lifetime
- 1998-07-23 ID IDW20000153A patent/ID28006A/id unknown
- 1998-07-23 CA CA002596497A patent/CA2596497C/en not_active Expired - Lifetime
- 1998-07-23 WO PCT/US1998/015304 patent/WO1999004774A2/en active IP Right Grant
- 1998-07-23 AT AT02016429T patent/ATE277937T1/de active
- 1998-07-23 TR TR2002/00117T patent/TR200200117T2/xx unknown
- 1998-07-23 BR BR9811552-9A patent/BR9811552A/pt not_active Application Discontinuation
- 1998-07-23 AT AT02016428T patent/ATE277936T1/de active
- 1998-07-23 PT PT02016428T patent/PT1256584E/pt unknown
- 1998-07-23 JP JP2000503833A patent/JP3573713B2/ja not_active Expired - Lifetime
- 1998-07-23 NZ NZ501659A patent/NZ501659A/xx not_active IP Right Cessation
- 1998-07-23 DK DK98937988T patent/DK0996430T3/da active
- 1998-07-23 TR TR2000/00224T patent/TR200000224T2/xx unknown
- 1998-07-23 CA CA002298057A patent/CA2298057C/en not_active Expired - Lifetime
- 1998-07-23 EP EP98937988A patent/EP0996430B1/en not_active Expired - Lifetime
- 1998-07-23 ES ES02016429T patent/ES2229030T3/es not_active Expired - Lifetime
- 1998-07-23 PT PT02016429T patent/PT1256585E/pt unknown
- 1998-07-23 PT PT98937988T patent/PT996430E/pt unknown
- 1998-07-23 CN CNB001370596A patent/CN1274700C/zh not_active Expired - Lifetime
- 1998-07-23 CN CN988037440A patent/CN1216062C/zh not_active Expired - Lifetime
- 1998-07-23 TR TR2002/00137T patent/TR200200137T2/xx unknown
- 1998-07-24 MY MYPI98003396A patent/MY129451A/en unknown
- 1998-07-24 IN IN2176DE1998 patent/IN190037B/en unknown
- 1998-07-24 TW TW087112169A patent/TW584635B/zh not_active IP Right Cessation
- 1998-07-24 CO CO98042226A patent/CO4980869A1/es unknown
- 1998-07-27 AR ARP980103692A patent/AR016548A1/es active IP Right Grant
-
2002
- 2002-09-06 HK HK02106589.2A patent/HK1046357B/zh not_active IP Right Cessation
-
2003
- 2003-05-26 JP JP2003148228A patent/JP4452034B2/ja not_active Expired - Lifetime
-
2005
- 2005-05-18 JP JP2005145754A patent/JP2005306879A/ja not_active Withdrawn
-
2009
- 2009-07-01 JP JP2009157357A patent/JP2009263389A/ja not_active Withdrawn
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT1256584E (pt) | Processo para a preparacao de adefovir-dipivoxil | |
| PT1003792E (pt) | Um processo para a preparacao de polietileno | |
| PT770615E (pt) | Processo para a preparacao de di-haloazolopirimidinas | |
| BR9706447A (pt) | Processo para a preparação de oxo-álcoois superiores | |
| BR9710457A (pt) | Processo para a prepara-Æo de ciclohexanodimetanol | |
| BR9608471A (pt) | Processo para a preparação de um composto | |
| BRPI9814894B8 (pt) | processo para a preparação de ácidos 8-metóxi-quinolonocarboxìlicos. | |
| PT1147075E (pt) | Processo para a preparacao de cloridrato de l-fenilefrina | |
| BR9711201A (pt) | Processo para a prepara-ao de um composto | |
| BR9706465A (pt) | Processo para a preparação contínua de metilmercaptano | |
| BR9500613A (pt) | Processo para a preparação contínua de mononitrotoluenos | |
| BR9500668A (pt) | Processo para a preparaçao de compostos polialquil-1-oxa- diazaspirodecano | |
| PT900254E (pt) | Processo para a preparacao de composicoes de betume | |
| PT1327637E (pt) | Processo para a preparacao de l-ribose | |
| PT877738E (pt) | Processo para a preparacao de derivados de fenil-imidazolidina | |
| BR9800557A (pt) | Processo contínuo para preparação de 4-aminopiperidinas | |
| PT1028960E (pt) | Processo para a preparacao de derivados de tiazolidinodiona | |
| BR9612457A (pt) | Processo para a fabricação de felodipina | |
| PT880498E (pt) | Processo para a preparacao de compostos dicetonicos | |
| PT973769E (pt) | Processo para a preparacao de eprosartan | |
| BR9804873A (pt) | Processo para a produ-Æo de ironas | |
| BR9805538B1 (pt) | processo para a preparação de ferro-succinilcaseìna. | |
| PT1200414E (pt) | Processo para a preparacao de pirimidnas substituidas | |
| PT970073E (pt) | Processo para a preparacao de eprosartan | |
| PT1012152E (pt) | Processo para a preparacao de oxazafosforina-2-aminas |