PL99816B1 - Sposob wytwarzania nowych 5,9 beta-dwupodstawionych 2-tetrahydrofurfurylo-6,7-benzomorfanow - Google Patents
Sposob wytwarzania nowych 5,9 beta-dwupodstawionych 2-tetrahydrofurfurylo-6,7-benzomorfanow Download PDFInfo
- Publication number
- PL99816B1 PL99816B1 PL1975190659A PL19065975A PL99816B1 PL 99816 B1 PL99816 B1 PL 99816B1 PL 1975190659 A PL1975190659 A PL 1975190659A PL 19065975 A PL19065975 A PL 19065975A PL 99816 B1 PL99816 B1 PL 99816B1
- Authority
- PL
- Poland
- Prior art keywords
- compounds
- acid
- tetrahydrofurfuryl
- hydroxy
- benzomorphan
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2437610A DE2437610A1 (de) | 1974-08-05 | 1974-08-05 | Neue 5,9-beta-disubstituierte 2-tetrahydrofurfuryl-6,7-benzomorphane, deren saeureadditionssalze, ihre verwendung als arzneimittel und verfahren zu deren herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL99816B1 true PL99816B1 (pl) | 1978-08-31 |
Family
ID=5922448
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL1975190659A PL99816B1 (pl) | 1974-08-05 | 1975-08-04 | Sposob wytwarzania nowych 5,9 beta-dwupodstawionych 2-tetrahydrofurfurylo-6,7-benzomorfanow |
| PL1975182528A PL99838B1 (pl) | 1974-08-05 | 1975-08-04 | Sposob wytwarzania nowych 5,9 beta-dwupodstawionych 2-tetrahydrofurfurylo-6,7-benzomorfanow |
| PL1975190658A PL99819B1 (pl) | 1974-08-05 | 1975-08-04 | Sposob wytwarzania nowych 5,9 beta-dwupodstawionych 2-tetrahydrofurfurylo-6,7-benzomorfanow |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL1975182528A PL99838B1 (pl) | 1974-08-05 | 1975-08-04 | Sposob wytwarzania nowych 5,9 beta-dwupodstawionych 2-tetrahydrofurfurylo-6,7-benzomorfanow |
| PL1975190658A PL99819B1 (pl) | 1974-08-05 | 1975-08-04 | Sposob wytwarzania nowych 5,9 beta-dwupodstawionych 2-tetrahydrofurfurylo-6,7-benzomorfanow |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US3982005A (OSRAM) |
| JP (1) | JPS60358B2 (OSRAM) |
| AT (1) | AT348140B (OSRAM) |
| BE (1) | BE832099R (OSRAM) |
| BG (3) | BG25089A3 (OSRAM) |
| CA (1) | CA1049008A (OSRAM) |
| CH (7) | CH613963A5 (OSRAM) |
| CS (1) | CS189717B2 (OSRAM) |
| DD (1) | DD122685A5 (OSRAM) |
| DE (1) | DE2437610A1 (OSRAM) |
| DK (1) | DK138992C (OSRAM) |
| ES (6) | ES452765A1 (OSRAM) |
| FI (1) | FI63229C (OSRAM) |
| FR (1) | FR2320096A2 (OSRAM) |
| GB (1) | GB1513950A (OSRAM) |
| HU (1) | HU177952B (OSRAM) |
| IE (1) | IE42216B1 (OSRAM) |
| IL (1) | IL47860A (OSRAM) |
| LU (1) | LU73138A1 (OSRAM) |
| NL (1) | NL7509249A (OSRAM) |
| NO (1) | NO143460C (OSRAM) |
| PH (1) | PH13687A (OSRAM) |
| PL (3) | PL99816B1 (OSRAM) |
| RO (3) | RO67390A (OSRAM) |
| SE (1) | SE425392B (OSRAM) |
| SU (3) | SU591147A3 (OSRAM) |
| ZA (1) | ZA754997B (OSRAM) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4087532A (en) * | 1974-03-09 | 1978-05-02 | Boehringer Ingelheim Gmbh | Analgesically useful 2-tetrahydrofurfuryl-5-lower alkyl-2-oxy-6,7-benzomorphans and salts thereof |
| GB1575009A (en) * | 1976-06-21 | 1980-09-17 | Acf Chemiefarma Nv | 6,7-benzomorphan derivatives |
| DE2716687A1 (de) * | 1977-04-15 | 1978-10-19 | Boehringer Sohn Ingelheim | 2'-hydroxy-2-(5-isoxazolylmethyl)-6,7benzomorphane, deren saeureadditionssalze und diese enthaltende arzneimittel |
| NL7804509A (nl) * | 1978-04-26 | 1979-10-30 | Acf Chemiefarma Nv | Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan. |
| DE2828039A1 (de) * | 1978-06-26 | 1980-01-10 | Boehringer Sohn Ingelheim | 2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphane deren saeureadditionssalze diese enthaltende arzneimittel und verfahren zu deren herstellung |
| JPS5636521A (en) * | 1979-08-31 | 1981-04-09 | Shin Etsu Chem Co Ltd | Production of alkenyloxy group-containing organopolysiloxane |
| JP5470557B2 (ja) | 2007-07-26 | 2014-04-16 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の阻害剤の合成 |
| JP5769970B2 (ja) | 2007-11-16 | 2015-08-26 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ベンゾモルファン及び関連骨格のアリール−及びヘテロアリールカルボニル誘導体、かかる化合物を含有する医薬及びこれらの使用 |
| WO2009075835A1 (en) | 2007-12-11 | 2009-06-18 | Vitae Pharmaceutical, Inc | CYCLIC UREA INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE 1 |
| TW200934490A (en) | 2008-01-07 | 2009-08-16 | Vitae Pharmaceuticals Inc | Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1 |
| CA2712500A1 (en) | 2008-01-24 | 2009-07-30 | Vitae Pharmaceuticals, Inc. | Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| US8598160B2 (en) | 2008-02-15 | 2013-12-03 | Vitae Pharmaceuticals, Inc. | Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| KR20110002492A (ko) | 2008-05-01 | 2011-01-07 | 비타이 파마슈티컬즈, 인코포레이티드 | 11베타-하이드록시스테로이드 탈수소효소 1의 고리형 억제제 |
| CA2723034A1 (en) | 2008-05-01 | 2009-11-05 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| WO2009134392A1 (en) | 2008-05-01 | 2009-11-05 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| EP2288596B1 (en) | 2008-05-13 | 2016-11-30 | Boehringer Ingelheim International GmbH | Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use |
| EP2324017B1 (en) | 2008-07-25 | 2014-12-31 | Boehringer Ingelheim International GmbH | INHIBITORS OF 11beta-HYDROXYSTEROID DEHYDROGENASE 1 |
| KR20110050459A (ko) | 2008-07-25 | 2011-05-13 | 비타이 파마슈티컬즈, 인코포레이티드 | 11베타-하이드록시스테로이드 탈수소효소 1의 고리형 억제제 |
| US8680093B2 (en) | 2009-04-30 | 2014-03-25 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| WO2011011123A1 (en) | 2009-06-11 | 2011-01-27 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure |
| UY33001A (es) | 2009-11-06 | 2011-05-31 | Boehringer Ingelheim Int | Derivados arilo y heteroarilcarbonilo de hexahidroindenopiridina y octahidrobenzoquinolina |
| EP2582698B1 (en) | 2010-06-16 | 2016-09-14 | Vitae Pharmaceuticals, Inc. | Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use |
| TWI537258B (zh) | 2010-11-05 | 2016-06-11 | 百靈佳殷格翰國際股份有限公司 | 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物 |
| WO2013025664A1 (en) | 2011-08-17 | 2013-02-21 | Boehringer Ingelheim International Gmbh | Indenopyridine derivatives |
| WO2022113437A1 (ja) | 2020-11-26 | 2022-06-02 | 信越化学工業株式会社 | 室温硬化性オルガノポリシロキサン組成物及び物品並びに加水分解性オルガノシラン化合物及びその製造方法 |
| US20240352196A1 (en) | 2021-09-03 | 2024-10-24 | Shin-Etsu Chemical Co., Ltd. | Organopolysiloxane compound, room temperature-curable organopolysiloxane composition, and article |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE582575A (OSRAM) * | 1958-09-22 | |||
| US3700734A (en) * | 1969-01-23 | 1972-10-24 | Merck & Co Inc | 2{40 -hydroxy-2,3,5-trimethyl-6,7-benzomorphan |
| DE2105743C3 (de) * | 1971-02-08 | 1979-11-29 | Boehringer Sohn Ingelheim | 2-(Furylmethyl)- a -5,9-dialkyl -6,7benzomorphane, Verfahren zu ihrer Herstellung und deren Verwendung |
| CS166801B2 (OSRAM) * | 1971-02-08 | 1976-03-29 | Boehringer Sohn Ingelheim | |
| DE2200596A1 (de) * | 1972-01-07 | 1973-07-12 | Boehringer Sohn Ingelheim | N-(furyl-methyl)-2'-hydroxy-5-phenyl6,7-benzomorphane, deren saeureadditionssalze sowie verfahren zu deren herstellung |
| DE2217420C3 (de) * | 1972-04-12 | 1981-03-12 | C.H. Boehringer Sohn, 6507 Ingelheim | N-Thienylmethyl-Heterocyclen, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zubereitungen |
| DE2229695A1 (de) * | 1972-06-19 | 1974-01-31 | Boehringer Sohn Ingelheim | 2-(heteroaryl-methyl)-5,9 beta-dialkyl6,7-benzomorphane, deren saeureadditionssalze sowie verfahren zu deren herstellung |
-
1974
- 1974-08-05 DE DE2437610A patent/DE2437610A1/de not_active Ceased
-
1975
- 1975-07-08 AT AT523775A patent/AT348140B/de not_active IP Right Cessation
- 1975-07-25 SU SU752162235A patent/SU591147A3/ru active
- 1975-07-30 JP JP50092995A patent/JPS60358B2/ja not_active Expired
- 1975-07-30 US US05/600,374 patent/US3982005A/en not_active Expired - Lifetime
- 1975-07-30 RO RO7583017A patent/RO67390A/ro unknown
- 1975-07-31 RO RO7593232A patent/RO72735A/ro unknown
- 1975-07-31 RO RO7593231A patent/RO72736A/ro unknown
- 1975-07-31 CH CH1002475A patent/CH613963A5/xx not_active IP Right Cessation
- 1975-08-01 CA CA75232728A patent/CA1049008A/en not_active Expired
- 1975-08-02 BG BG031842A patent/BG25089A3/xx unknown
- 1975-08-02 BG BG031843A patent/BG25090A3/xx unknown
- 1975-08-02 BG BG030726A patent/BG25088A3/xx unknown
- 1975-08-04 HU HU75BO1566A patent/HU177952B/hu unknown
- 1975-08-04 PL PL1975190659A patent/PL99816B1/pl unknown
- 1975-08-04 DD DD187666A patent/DD122685A5/xx unknown
- 1975-08-04 DK DK352875A patent/DK138992C/da active
- 1975-08-04 ZA ZA754997A patent/ZA754997B/xx unknown
- 1975-08-04 NO NO752731A patent/NO143460C/no unknown
- 1975-08-04 PL PL1975182528A patent/PL99838B1/pl unknown
- 1975-08-04 NL NL7509249A patent/NL7509249A/xx not_active Application Discontinuation
- 1975-08-04 GB GB32576/75A patent/GB1513950A/en not_active Expired
- 1975-08-04 SE SE7508789A patent/SE425392B/xx not_active IP Right Cessation
- 1975-08-04 PH PH17443A patent/PH13687A/en unknown
- 1975-08-04 IL IL47860A patent/IL47860A/xx unknown
- 1975-08-04 CS CS755425A patent/CS189717B2/cs unknown
- 1975-08-04 FI FI752211A patent/FI63229C/fi not_active IP Right Cessation
- 1975-08-04 PL PL1975190658A patent/PL99819B1/pl unknown
- 1975-08-04 BE BE158924A patent/BE832099R/xx not_active IP Right Cessation
- 1975-08-04 LU LU73138A patent/LU73138A1/xx unknown
- 1975-08-05 IE IE1738/75A patent/IE42216B1/en unknown
- 1975-08-05 FR FR7524380A patent/FR2320096A2/fr active Granted
-
1976
- 1976-04-16 SU SU762346107A patent/SU587858A3/ru active
- 1976-04-16 SU SU762346108A patent/SU587859A3/ru active
- 1976-10-27 ES ES452765A patent/ES452765A1/es not_active Expired
- 1976-10-27 ES ES452767A patent/ES452767A1/es not_active Expired
- 1976-10-27 ES ES452764A patent/ES452764A1/es not_active Expired
- 1976-10-27 ES ES452763A patent/ES452763A1/es not_active Expired
- 1976-10-27 ES ES452766A patent/ES452766A1/es not_active Expired
- 1976-10-27 ES ES452768A patent/ES452768A1/es not_active Expired
-
1979
- 1979-04-26 CH CH393179A patent/CH615677A5/de not_active IP Right Cessation
- 1979-04-26 CH CH393479A patent/CH615679A5/de not_active IP Right Cessation
- 1979-04-26 CH CH393679A patent/CH615680A5/de not_active IP Right Cessation
- 1979-04-26 CH CH393279A patent/CH615678A5/de not_active IP Right Cessation
- 1979-04-26 CH CH393379A patent/CH616420A5/de not_active IP Right Cessation
- 1979-04-26 CH CH393579A patent/CH616421A5/de not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PL99816B1 (pl) | Sposob wytwarzania nowych 5,9 beta-dwupodstawionych 2-tetrahydrofurfurylo-6,7-benzomorfanow | |
| US4293556A (en) | Analgesic 2-(2-alkoxy-ethyl)-2'-hydroxy-6,7-benzomorphans and salts thereof | |
| CA1049511A (en) | 2-tetrahydrofurfuryl-6,7-benzomorphanes, their acid addition salts, their use as pharmaceuticals and processes for their production | |
| PL92052B1 (OSRAM) | ||
| SK279168B6 (sk) | Bicyklické 1-azacykloalkány, farmaceutické prostri | |
| WO1988007530A1 (en) | Psychotropic bicyclic imides | |
| EP1648893B1 (en) | Nicotine addiction reducing heteroaryl fused azapolycyclic compounds | |
| PL116941B1 (en) | Process for manufacturing novel derivatives of cyproheptadine | |
| US4087532A (en) | Analgesically useful 2-tetrahydrofurfuryl-5-lower alkyl-2-oxy-6,7-benzomorphans and salts thereof | |
| US3823150A (en) | 2-(furfuryl-methyl)-6,7-benzomorphans and acid addition salts thereof | |
| HUT54151A (en) | Process fopr producing new (r)-(-)-3-quinuclidinone derivatives and pharmaceutical compositions comprising such compounds | |
| US3378561A (en) | 1-beta-arylthioethyltetrahydro-isoquinolines | |
| US4977176A (en) | Pilocarpine compounds which are used as pharmaceutical agents | |
| US4835174A (en) | Pilocarpine derivatives | |
| US3864347A (en) | {60 {8 3(R)-alkyl-4(R) piperidyl methyl{9 -{62 -(6,7 substituted-4 quinolyl)-2-alkanoyloxy propane and racemates | |
| KR810000890B1 (ko) | 2-테트라하이드로푸르푸릴-6,7-벤조모르판류의 제조방법 | |
| Meese et al. | Synthesis of deuterated 1, 2, 3, 4‐tetrahydroisoquinolines | |
| AT350198B (de) | Verfahren zur herstellung neuer 5,9-beta- disubstituierter 2-tetrahydrofurfuryl-6,7- benzomorphane und deren saeureadditionssalzen |