PL366102A1 - Prepart małych dawek entekawiru i jego zastosowanie - Google Patents

Prepart małych dawek entekawiru i jego zastosowanie

Info

Publication number
PL366102A1
PL366102A1 PL01366102A PL36610201A PL366102A1 PL 366102 A1 PL366102 A1 PL 366102A1 PL 01366102 A PL01366102 A PL 01366102A PL 36610201 A PL36610201 A PL 36610201A PL 366102 A1 PL366102 A1 PL 366102A1
Authority
PL
Poland
Prior art keywords
low dose
dose entecavir
entecavir formulation
formulation
low
Prior art date
Application number
PL01366102A
Other languages
English (en)
Other versions
PL201411B1 (pl
Inventor
Richard J. Colonno
Omar L. Sprockel
Abizer Harianawala
Diuyakant Desai
Michael G. Fakes
Original Assignee
Bristol-Myers Squibb Company Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26881354&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL366102(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol-Myers Squibb Company Co filed Critical Bristol-Myers Squibb Company Co
Publication of PL366102A1 publication Critical patent/PL366102A1/pl
Publication of PL201411B1 publication Critical patent/PL201411B1/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/485—Inorganic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
PL366102A 2000-02-29 2001-01-26 Zastosowanie entekawiru do wytwarzania kompozycji farmaceutycznej PL201411B1 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18567200P 2000-02-29 2000-02-29
US22131300P 2000-07-28 2000-07-28

Publications (2)

Publication Number Publication Date
PL366102A1 true PL366102A1 (pl) 2005-01-24
PL201411B1 PL201411B1 (pl) 2009-04-30

Family

ID=26881354

Family Applications (1)

Application Number Title Priority Date Filing Date
PL366102A PL201411B1 (pl) 2000-02-29 2001-01-26 Zastosowanie entekawiru do wytwarzania kompozycji farmaceutycznej

Country Status (35)

Country Link
US (1) US6627224B2 (pl)
EP (2) EP1267880B2 (pl)
JP (3) JP5140222B2 (pl)
KR (1) KR100757155B1 (pl)
AR (1) AR027965A1 (pl)
AT (1) ATE312613T1 (pl)
AU (1) AU2001229775A1 (pl)
BG (1) BG65815B1 (pl)
BR (1) BRPI0108435B8 (pl)
CA (1) CA2401569C (pl)
CO (1) CO5261593A1 (pl)
CZ (1) CZ303395B6 (pl)
DE (1) DE60115870T3 (pl)
DK (1) DK1267880T4 (pl)
EA (1) EA006181B1 (pl)
EE (1) EE05442B1 (pl)
EG (1) EG24408A (pl)
ES (1) ES2253403T5 (pl)
GE (1) GEP20053504B (pl)
HK (1) HK1048771A1 (pl)
HR (1) HRP20020649A2 (pl)
HU (1) HU230698B1 (pl)
IL (1) IL150447A0 (pl)
MX (1) MXPA02008359A (pl)
MY (1) MY127422A (pl)
NO (1) NO324014B1 (pl)
NZ (1) NZ520024A (pl)
PE (1) PE20020770A1 (pl)
PL (1) PL201411B1 (pl)
RS (1) RS51561B (pl)
SI (1) SI1267880T2 (pl)
SK (1) SK288008B6 (pl)
TW (1) TWI287988B (pl)
UA (1) UA84534C2 (pl)
WO (1) WO2001064221A1 (pl)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ303395B6 (cs) * 2000-02-29 2012-08-29 Bristol-Myers Squibb Co. Farmaceutický prostredek s nízkou dávkou entekaviru
TWI275392B (en) * 2002-04-08 2007-03-11 Bristol Myers Squibb Co Low dose liquid entecavir formulations and use
AR040588A1 (es) 2002-07-26 2005-04-13 Schering Corp Formulacion farmaceutica que comprende un inhibidor de la absorcion del colesterol y un inhibidor de una hmg- co a reductasa
IN2012DN00604A (pl) * 2002-12-11 2015-08-21 Bristol Myers Squibb Co
US20040224916A1 (en) 2003-01-14 2004-11-11 Gilead Sciences, Inc. Compositions and methods for combination antiviral therapy
BRPI0416566A (pt) 2003-11-17 2007-01-23 Biomarin Pharm Inc tratamento de fenilcetonúrias com bh4
MXPA06005545A (es) * 2003-11-18 2006-08-17 Boehringer Ingelheim Int Preparacion farmaceutica solida.
US7511139B2 (en) * 2004-06-04 2009-03-31 Bristol-Myers Squibb Company Process for the preparation of entecavir and novel intermediates thereof via carbon-silicon oxidation
JP4756153B2 (ja) * 2004-08-27 2011-08-24 富士製薬工業株式会社 低成分含量の錠剤の製造方法
CN101027043A (zh) * 2004-09-23 2007-08-29 Fmc有限公司 涂料组合物
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
CN101245068A (zh) * 2007-02-14 2008-08-20 浙江医药股份有限公司新昌制药厂 结晶型态的恩替卡韦及其制备方法和其药物组合物及用途
TW200904405A (en) * 2007-03-22 2009-02-01 Bristol Myers Squibb Co Pharmaceutical formulations containing an SGLT2 inhibitor
CA2778273A1 (en) * 2009-10-28 2011-05-12 Mcneil-Ppc, Inc. Fast dissolving/disintegrating coating compositions
EA201290556A1 (ru) * 2009-12-23 2013-01-30 Рациофарм Гмбх Оральная лекарственная форма, включающая энтекавир
DE102009060194A1 (de) 2009-12-23 2011-06-30 ratiopharm GmbH, 89079 Orale Darreichungsform umfassend Entecavir
US9168269B2 (en) 2010-02-18 2015-10-27 The Trustees Of Princeton University Inhibitors of long and very long chain fatty acid metabolism as broad spectrum anti-virals
JP5933523B2 (ja) 2010-03-31 2016-06-08 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． １−アミノ−２−シクロプロピルエチルボロン酸の誘導体
WO2012048455A1 (zh) * 2010-10-12 2012-04-19 武汉大学 一种抗病毒透皮吸收贴片及其制备方法
EP2508172A1 (en) 2011-04-06 2012-10-10 Zentiva, a.s. Stable and uniform formulations of entecavir and preparation method thereof
KR101594820B1 (ko) * 2011-06-16 2016-02-17 건일제약 주식회사 엔테카비르를 함유하는 미립구 및 이의 제조방법
KR101439635B1 (ko) 2011-11-01 2014-09-11 대원제약주식회사 안정성이 향상된 엔테카비어를 함유하는 약학적 조성물 및 그 제조방법
WO2013072937A2 (en) * 2011-11-14 2013-05-23 Hetero Research Foundation Fast release solid oral compositions of entecavir
EP2644197A1 (en) * 2012-03-26 2013-10-02 Sanovel Ilac Sanayi ve Ticaret A.S. Novel Pharmaceutical Compositions of Entecavir
EP2644196B1 (en) * 2012-03-26 2019-09-18 Arven Ilac Sanayi ve Ticaret A.S. Pharmaceutical compositions of Entecavir
KR101285008B1 (ko) * 2012-04-18 2013-07-10 제일약품주식회사 저용량 엔테카비어의 경구투여 제제의 제조방법
CA2779052A1 (en) * 2012-05-31 2013-11-30 Pharmascience Inc. Pharmaceutical composition of entecavir and process of manufacturing
CN103908436B (zh) * 2012-12-29 2016-02-10 安徽贝克生物制药有限公司 一种速释型恩替卡韦组合物
KR101512895B1 (ko) 2013-08-09 2015-04-16 대화제약 주식회사 엔테카비어를 포함하는 약학적 조성물의 제조방법
EP3158998A4 (en) * 2014-06-20 2018-02-14 CTC Bio, Inc. Pharmaceutical preparation containing entecavir as active ingredient, and preparation method therefor
KR102671429B1 (ko) 2015-09-30 2024-05-30 주식회사 다이셀 복용 용이성 고형 제제용 입자 조성물 및 상기 입자 조성물을 포함하는 복용 용이성 고형 제제
KR20230112817A (ko) 2022-01-21 2023-07-28 한림대학교 산학협력단 피루브산 및 pdk 억제제를 포함하는 뇌질환의 예방 또는 치료용 조성물

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US4513008A (en) * 1982-07-30 1985-04-23 The Vinoxen Company, Inc. Virucidal compositions and therapy
US4489026A (en) * 1982-09-07 1984-12-18 The Upjohn Company Process for preparing solid unit dosage forms of ultra-low dose drugs
US4631284A (en) * 1984-11-19 1986-12-23 Mallinckrodt, Inc. Acetaminophen compositions containing low doses of chlorpheniramine maleate, method for preparing same and tablets formed therefrom
US5206244A (en) * 1990-10-18 1993-04-27 E. R. Squibb & Sons, Inc. Hydroxymethyl (methylenecyclopentyl) purines and pyrimidines
JPH08208478A (ja) * 1994-10-14 1996-08-13 Japan Energy Corp 抗エイズ薬製剤およびその製造方法
ES2201298T3 (es) * 1996-04-04 2004-03-16 Felix Specht Procedimiento para la obtencion de sistemas pulverulentos de libre fluencia con baja dosificacion y/o directamente compactables.
AU4090697A (en) 1996-09-03 1998-03-26 Bristol-Myers Squibb Company Improved process for preparing the antiviral agent {1s-(1alpha, 3alpha, 4beta)}-2-amino-1,9-dihydro-9-{4-hydroxy-3-(hydroxymethyl)-2 -methylenecyclopentyl}-6h-purin-6-one
CA2340156C (en) * 1998-08-10 2007-10-23 Novirio Pharmaceuticals Limited .beta.-l-2'-deoxy-nucleosides for the treatment of hepatitis b
US5997905A (en) * 1998-09-04 1999-12-07 Mcneil-Ppc Preparation of pharmaceutically active particles
GB9820416D0 (en) 1998-09-18 1998-11-11 Glaxo Group Ltd Antiviral combinations
GB9820417D0 (en) 1998-09-18 1998-11-11 Glaxo Group Ltd Antiviral combinations
GB9820420D0 (en) 1998-09-18 1998-11-11 Glaxo Group Ltd Antiviral combinations
US6432966B2 (en) † 1999-10-29 2002-08-13 Smithkline Beecham Corporation Antiviral combinations
CZ303395B6 (cs) * 2000-02-29 2012-08-29 Bristol-Myers Squibb Co. Farmaceutický prostredek s nízkou dávkou entekaviru

Also Published As

Publication number Publication date
BG65815B1 (bg) 2010-01-29
EG24408A (en) 2009-05-20
HUP0500558A3 (en) 2012-08-28
DK1267880T4 (da) 2010-05-17
SI1267880T2 (sl) 2010-04-30
JP5140222B2 (ja) 2013-02-06
MY127422A (en) 2006-11-30
EP1642582A1 (en) 2006-04-05
IL150447A0 (en) 2002-12-01
PE20020770A1 (es) 2002-09-06
TWI287988B (en) 2007-10-11
JP2004503467A (ja) 2004-02-05
NO20024099L (no) 2002-08-28
SK11652002A3 (sk) 2003-09-11
MXPA02008359A (es) 2003-02-12
EA006181B1 (ru) 2005-10-27
SI1267880T1 (sl) 2006-06-30
KR20020082230A (ko) 2002-10-30
UA84534C2 (uk) 2008-11-10
PL201411B1 (pl) 2009-04-30
DK1267880T3 (da) 2006-03-06
KR100757155B1 (ko) 2007-09-07
BR0108435A (pt) 2004-06-15
DE60115870D1 (de) 2006-01-19
NO20024099D0 (no) 2002-08-28
HK1048771A1 (zh) 2003-04-17
ES2253403T5 (es) 2010-04-22
HU230698B1 (hu) 2017-09-28
NZ520024A (en) 2005-03-24
ATE312613T1 (de) 2005-12-15
EA200200812A1 (ru) 2003-12-25
AR027965A1 (es) 2003-04-16
ES2253403T3 (es) 2006-06-01
EE200200484A (et) 2004-04-15
EP1267880B1 (en) 2005-12-14
JP2012255017A (ja) 2012-12-27
EP1267880B2 (en) 2010-01-20
BRPI0108435B1 (pt) 2019-02-05
HRP20020649A2 (en) 2004-12-31
CO5261593A1 (es) 2003-03-31
AU2001229775A1 (en) 2001-09-12
YU63002A (sh) 2005-03-15
US6627224B2 (en) 2003-09-30
EP1267880A1 (en) 2003-01-02
US20010033864A1 (en) 2001-10-25
BG106905A (bg) 2003-04-30
WO2001064221A1 (en) 2001-09-07
JP2015178523A (ja) 2015-10-08
GEP20053504B (en) 2005-05-10
HUP0500558A2 (hu) 2005-09-28
CA2401569C (en) 2009-08-18
JP5921746B2 (ja) 2016-05-24
BRPI0108435B8 (pt) 2021-05-25
DE60115870T2 (de) 2006-08-17
DE60115870T3 (de) 2010-07-29
RS51561B (sr) 2011-08-31
NO324014B1 (no) 2007-07-30
CZ303395B6 (cs) 2012-08-29
SK288008B6 (sk) 2012-10-02
CA2401569A1 (en) 2001-09-07
EE05442B1 (et) 2011-08-15

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