PL1805199T3 - Sposoby amplifikacji kwasu nukleinowego - Google Patents

Sposoby amplifikacji kwasu nukleinowego

Info

Publication number
PL1805199T3
PL1805199T3 PL05810422T PL05810422T PL1805199T3 PL 1805199 T3 PL1805199 T3 PL 1805199T3 PL 05810422 T PL05810422 T PL 05810422T PL 05810422 T PL05810422 T PL 05810422T PL 1805199 T3 PL1805199 T3 PL 1805199T3
Authority
PL
Poland
Prior art keywords
pcr
late
following
detection during
fluorescent dna
Prior art date
Application number
PL05810422T
Other languages
English (en)
Inventor
Lawrence J Wangh
John Rice
Aquiles J Sanchez
Kenneth Pierce
Jesse Salk
Arthur Reis
Cristina Hartshorn
Original Assignee
Univ Brandeis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36203686&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL1805199(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Brandeis filed Critical Univ Brandeis
Publication of PL1805199T3 publication Critical patent/PL1805199T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6851—Quantitative amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
PL05810422T 2004-10-18 2005-10-17 Sposoby amplifikacji kwasu nukleinowego PL1805199T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US61965404P 2004-10-18 2004-10-18
EP05810422A EP1805199B1 (en) 2004-10-18 2005-10-17 Methods for nucleic acid amplification
PCT/US2005/037667 WO2006044994A2 (en) 2004-10-18 2005-10-17 Primers, probes and methods for nucleic acid amplification

Publications (1)

Publication Number Publication Date
PL1805199T3 true PL1805199T3 (pl) 2011-06-30

Family

ID=36203686

Family Applications (1)

Application Number Title Priority Date Filing Date
PL05810422T PL1805199T3 (pl) 2004-10-18 2005-10-17 Sposoby amplifikacji kwasu nukleinowego

Country Status (18)

Country Link
US (3) US7632642B2 (pl)
EP (3) EP2927238B1 (pl)
JP (2) JP5543065B2 (pl)
KR (3) KR101424812B1 (pl)
CN (1) CN101076607B (pl)
AT (1) ATE494295T1 (pl)
AU (1) AU2005295298B2 (pl)
BR (1) BRPI0517105B1 (pl)
CA (3) CA2996947C (pl)
DE (1) DE602005025791D1 (pl)
DK (1) DK1805199T3 (pl)
ES (3) ES2359322T3 (pl)
HK (1) HK1106251A1 (pl)
NO (1) NO20072506L (pl)
PL (1) PL1805199T3 (pl)
PT (1) PT1805199E (pl)
RU (1) RU2460804C2 (pl)
WO (1) WO2006044994A2 (pl)

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2359322T3 (es) 2004-10-18 2011-05-20 Brandeis University Procedimiento para la amplificación de ácidos nucleicos.
CN100487432C (zh) * 2006-06-22 2009-05-13 上海交通大学 采用分子信标对核酸信号进行恒温放大与检测的方法
CN101802224A (zh) 2007-07-12 2010-08-11 史密斯探测公司 光纤检测系统
US8592182B2 (en) 2007-10-23 2013-11-26 Stratos Genomics Inc. High throughput nucleic acid sequencing by spacing
US8538733B2 (en) * 2008-01-25 2013-09-17 Life Technologies Corporation Methods for the analysis of dissociation melt curve data
US20100129796A1 (en) * 2008-11-24 2010-05-27 Micah Halpern Dye probe fluorescence resonance energy transfer genotyping
WO2010076189A1 (en) * 2008-12-30 2010-07-08 Stmicroelectronics S.R.L. Method, microreactor and apparatus for carrying out real-time nucleic acid amplification
FR2940805B1 (fr) * 2009-01-05 2015-10-16 Biomerieux Sa Procede d'amplification et/ou de detection d'acides nucleiques, kits et utilisations de ce procede
JP5423006B2 (ja) * 2009-01-20 2014-02-19 ソニー株式会社 プライマー評価方法、プライマー評価プログラム及びリアルタイムｐｃｒ装置
US8039215B2 (en) * 2009-03-10 2011-10-18 Roche Molecular Systems, Inc. Multiplex quantitative nucleic acid amplification and melting assay
AU2010224100B2 (en) * 2009-03-12 2015-10-22 Brandeis University Reagents and methods for PCR
US8674080B2 (en) * 2009-04-09 2014-03-18 Roche Molecular Systems, Inc. Dye composition for liquid transfer control
FI20095514A0 (fi) * 2009-05-07 2009-05-07 Expression Analytics Oy Menetelmä, laitteisto ja tietokoneohjelmatuote PCR-tuotteiden kvantifioimiseksi
DE102009026651A1 (de) * 2009-06-02 2011-02-17 Großmann, Kay, Dr. rer. nat. (Chemie) Verfahren und Messvorrichtung zur qualitativen und quantitativen Analyse von Körperflüssigkeiten
AR077841A1 (es) 2009-08-11 2011-09-28 Univ Brandeis Metodos kits y composiciones de deteccion de acido nucleico a multiples temperaturas, con sonda unica
AR077840A1 (es) * 2009-08-11 2011-09-28 Univ Brandeis Ensayos de deteccion e identificacion de especies y tipos de staphylococcus
US8853373B2 (en) * 2009-08-14 2014-10-07 Hitachi, Ltd. Method and reagent for gene sequence analysis
EP2980224B1 (en) 2009-10-21 2019-07-03 Brandeis University Kits for analyzing single-stranded nucleic acid sequences
CA2778249C (en) * 2009-11-03 2018-12-04 Htg Molecular Diagnostics, Inc. Quantitative nuclease protection sequencing (qnps)
EP2569447A4 (en) * 2010-05-14 2013-11-27 Fluidigm Corp ANALYZES FOR DETECTION OF GENOTYPE, MUTATIONS, AND / OR ANEUPLOIDIE
IT1405994B1 (it) * 2010-06-22 2014-02-06 Euroclone Spa Metodo ad elevata sensibilita' per rilevare un acido nucleico target in un campione
WO2012024642A1 (en) * 2010-08-20 2012-02-23 Life Technologies Corporation Quantitative real-time pcr assay using fret dual-labeled primers
US9850529B2 (en) 2010-09-08 2017-12-26 Brandeis University Compositions and methods for nucleic acid based diagnostic assays for variable sequence targets
WO2012040387A1 (en) 2010-09-24 2012-03-29 The Board Of Trustees Of The Leland Stanford Junior University Direct capture, amplification and sequencing of target dna using immobilized primers
US20130295570A1 (en) * 2010-10-07 2013-11-07 Brandeis University Compositions and methods for nucleic acid based diagnostic assays
GB201017978D0 (en) * 2010-10-25 2010-12-08 Oxitec Ltd Multiplex amplification and detection
WO2012064978A2 (en) 2010-11-10 2012-05-18 Brandeis University Compositions, methods, and kits for detecting and identifying mycobacteria
EP2646575B1 (en) 2010-12-03 2017-05-31 Brandeis University Detecting mutations in dna
US20140004504A1 (en) * 2010-12-10 2014-01-02 Brandeis University Compositions and methods for the detection and analysis of african swine fever virus
EP3839064A1 (en) 2010-12-27 2021-06-23 Abbott Molecular Inc. Systems for quantitating high titer samples by digital pcr
WO2012095748A2 (en) * 2011-01-14 2012-07-19 Smiths Detection - Watford Limited Single tube quantitative polymerase chain reaction (pcr)
CN103649335B (zh) 2011-05-04 2015-11-25 Htg分子诊断有限公司 定量核酸酶保护测定（qnpa）和测序（qnps）的改进
WO2013019759A1 (en) * 2011-07-30 2013-02-07 The Regents Of The University Of California Enzymatic preparation of 10 base to 50 kb double-strand dna reagent for sequencing with a nanopore-polymerase sequencing device
US20130052650A1 (en) 2011-08-29 2013-02-28 Thermo Fisher Scientific Inc. Dye blends
CN102321765B (zh) * 2011-09-08 2014-04-02 厦门基科生物科技有限公司 一种实时荧光pcr方法及用途
DK2756101T3 (en) 2011-09-15 2018-08-27 David A Shafer PROBLEMS: ANTISON DETAIL COMPOSITIONS FOR DETECTING HIGH OR SPECIFIC DNA OR RNA
BR112014019168B1 (pt) 2012-02-03 2021-10-05 California Institute Of Technology Método capaz de detectar de forma não degenerada presença ou ausência de analitos em um único volume de amostra e método de detecção da presença ou ausência de cada analito dentre uma pluralidade de analitos
US9127317B2 (en) 2012-03-02 2015-09-08 Winthrop-University Hospital Method for using probe based PCR detection to measure the levels of circulating demethylated β cell derived DNA as a measure of β cell loss in diabetes
CN102643910B (zh) * 2012-04-10 2014-10-15 中国人民解放军第三军医大学第一附属医院 非对称多色荧光发夹探针链反应在病原菌检测中的应用
CN108753932B (zh) * 2012-08-03 2022-12-02 加州理工学院 Pcr中具有减少的硬件和要求的多重化和定量
US20150218625A1 (en) * 2012-09-17 2015-08-06 Brandeis University Combination of dsdna binding dye and probes for characterization of ssdna sequences
CA2902207A1 (en) * 2013-02-21 2014-08-28 Toma Biosciences, Inc. Methods, compositions, and kits for nucleic acid analysis
US11254977B2 (en) 2013-03-12 2022-02-22 Life Technologies Corporation Universal reporter-based genotyping methods and materials
WO2015023677A1 (en) * 2013-08-12 2015-02-19 Bio-Rad Laboratories, Inc. Amplification reporter with base-pairing oligomers
CN105745334B (zh) * 2013-09-30 2019-12-10 吴迪 通过使用邻近条形编码分析分子复合物的概况的方法
US10501783B2 (en) 2013-12-11 2019-12-10 Qiagen Gmbh Nucleic acid detection and quantification
WO2015138343A1 (en) 2014-03-10 2015-09-17 Click Diagnostics, Inc. Cartridge-based thermocycler
GB201411567D0 (en) 2014-06-30 2014-08-13 Epistem Ltd Quantification methods
US20170247745A1 (en) * 2014-09-12 2017-08-31 Click Diagnostics, Inc. Multiplex optical detection
RU2717655C2 (ru) 2014-10-10 2020-03-24 Рутгерс, Зе Стейт Юниверсити Оф Нью-Джерси Праймеры и зонды для полимеразной цепной реакции для обнаружения mycobacterium tuberculosis
KR102019506B1 (ko) 2014-12-09 2019-09-19 주식회사 씨젠 타겟 핵산 서열에 대한 시그널의 구별
WO2016100335A1 (en) * 2014-12-19 2016-06-23 Brandeis University Mispriming prevention reagents
US9623415B2 (en) 2014-12-31 2017-04-18 Click Diagnostics, Inc. Devices and methods for molecular diagnostic testing
WO2016115001A2 (en) * 2015-01-12 2016-07-21 Life Technologies Corporation Methods, systems and compositions thereof for nucleic acid library quality control and quantification
KR102165931B1 (ko) * 2015-09-24 2020-10-14 주식회사 씨젠 타겟 분석물질의 존재 또는 부존재를 결정하기 위한 다중 데이터 세트 분석법
WO2017087943A1 (en) 2015-11-20 2017-05-26 Brandeis University Amplifying and detecting coconut cadang-cadang viroid rna
WO2017197040A1 (en) 2016-05-11 2017-11-16 Click Diagnostics, Inc. Devices and methods for nucleic acid extraction
WO2017209563A1 (en) * 2016-06-02 2017-12-07 Seegene, Inc. . Method for detecting a target analyte in a sample using a signal change-amount data set
EP3478857A1 (en) 2016-06-29 2019-05-08 Click Diagnostics, Inc. Devices and methods for the detection of molecules using a flow cell
EP3610031A4 (en) * 2017-04-11 2020-11-18 Nugen Technologies, Inc. LIBRARY QUANTIFICATION AND QUALIFICATION
US20190093155A1 (en) * 2017-05-25 2019-03-28 Roche Molecular Systems, Inc. Multiplex Nucleic Acid Amplification Assay
KR102380264B1 (ko) * 2017-08-31 2022-03-29 주식회사 씨젠 다이머-형성 프라이머 쌍을 이용한 구성요소의 성능 평가
CA3078976A1 (en) 2017-11-09 2019-05-16 Visby Medical, Inc. Portable molecular diagnostic device and methods for the detection of target viruses
CN108570495A (zh) * 2018-01-15 2018-09-25 新开源博畅（武汉）生物科技有限公司 一种hla高分辨基因位点的快速扩增诊断试剂盒及扩增方法
CN108624664B (zh) * 2018-01-16 2020-08-28 武汉菲思特生物科技有限公司 一种急性肝损伤的早期诊断标志物的快速扩增方法
AU2019209444A1 (en) * 2018-01-22 2020-07-30 Luminex Corporation Methods and compositions for discrete melt analysis
CA3095112A1 (en) * 2018-04-20 2019-10-24 Seegene, Inc. Method and apparatus for detecting a plurality of target nucleic acid sequences in sample
CN109321672B (zh) * 2018-10-30 2021-07-06 中国农业大学 核苷酸组合物、试剂盒及检测方法
WO2021011850A2 (en) * 2019-07-17 2021-01-21 Chao Chien Chung Amplification assay for the detection of anaplasma phagocytophilum
CN110568175A (zh) * 2019-09-06 2019-12-13 成都理工大学 一种基于核酸染料诱导纳米金快速聚集检测dna的方法
CA3155451A1 (en) 2019-09-23 2021-04-01 Universiteit Gent Probe and method for str-genotyping
WO2021138544A1 (en) 2020-01-03 2021-07-08 Visby Medical, Inc. Devices and methods for antibiotic susceptibility testing
US20230242971A1 (en) * 2020-05-08 2023-08-03 Roche Sequencing Solutions, Inc. Removal of excess oligonucleotides from a reation mixture
CN111961717B (zh) * 2020-08-28 2023-08-01 南方医科大学 单管同时检测缺失型和非缺失型α-地中海贫血基因的荧光PCR试剂盒
CN111909990B (zh) * 2020-08-28 2023-11-28 亚能生物技术（深圳）有限公司 单管同时检测基因的缺失突变和点突变的荧光pcr检测方法
EP4388132A1 (en) * 2021-08-19 2024-06-26 Luminex Corporation Digital amplification assay analysis method
WO2023248310A1 (ja) * 2022-06-20 2023-12-28 株式会社日立ハイテク プライマー、ｄｎａ検出方法およびｄｎａ検出キット

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US5066584A (en) 1988-09-23 1991-11-19 Cetus Corporation Methods for generating single stranded dna by the polymerase chain reaction
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
US5994056A (en) * 1991-05-02 1999-11-30 Roche Molecular Systems, Inc. Homogeneous methods for nucleic acid amplification and detection
US5756285A (en) * 1991-09-27 1998-05-26 Amersham Life Science, Inc. DNA cycle sequencing
US5925517A (en) 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
US5538848A (en) 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
US5716784A (en) * 1996-02-05 1998-02-10 The Perkin-Elmer Corporation Fluorescence detection assay for homogeneous PCR hybridization systems
AU713667B2 (en) 1996-04-12 1999-12-09 Phri Properties, Inc. Detection probes, kits and assays
CA2257109C (en) * 1996-06-04 2009-10-06 University Of Utah Research Foundation Monitoring hybridization during pcr
US5935791A (en) * 1997-09-23 1999-08-10 Becton, Dickinson And Company Detection of nucleic acids by fluorescence quenching
GB9725197D0 (en) 1997-11-29 1998-01-28 Secr Defence Detection system
US6140054A (en) 1998-09-30 2000-10-31 University Of Utah Research Foundation Multiplex genotyping using fluorescent hybridization probes
US6277607B1 (en) 1999-05-24 2001-08-21 Sanjay Tyagi High specificity primers, amplification methods and kits
WO2001013086A2 (en) 1999-08-13 2001-02-22 Brandeis University Detection of nucleic acids
US6472156B1 (en) 1999-08-30 2002-10-29 The University Of Utah Homogeneous multiplex hybridization analysis by color and Tm
JP4919568B2 (ja) * 1999-10-22 2012-04-18 ピーエイチアールアイ プロパティーズ，インコーポレイテッド 短い配列の変異体を検出するためのアッセイ
US20030082550A1 (en) * 2000-09-08 2003-05-01 Hans-Ulrich Thomann Mutations of the cyclooxygenase-2 gene
US7267945B2 (en) * 2001-03-26 2007-09-11 Applera Corporation Methods of determining the presence of polynucleotides employing amplification
GB0112868D0 (en) * 2001-05-25 2001-07-18 Secr Defence Detection system
RU2004100107A (ru) * 2001-06-08 2005-06-10 Шанхай Мендель Дна Сентер Ко., Лтд (Cn) Низкотемпературное циклическое удлинение днк с высокой специфичностью праймирования
US20030108906A1 (en) * 2001-07-27 2003-06-12 Brooksbank Robert Alan Identification and use of molecules implicated in pain
EP1444365A4 (en) * 2001-10-25 2005-07-20 Gorilla Genomics Inc ASYMMETRIC PCR WITH NUCLEASE-FREE POLYMERASE OR NUCLEASERESISTENT MOLECULAR BEACONS
WO2003045233A1 (en) 2001-11-21 2003-06-05 Optiscan Biomedical Corporation Method and apparatus for improving the accuracy of alternative site analyte concentration measurements
US7198897B2 (en) 2001-12-19 2007-04-03 Brandeis University Late-PCR
JP2004024035A (ja) * 2002-06-21 2004-01-29 Tosoh Corp 核酸の検出方法
EP1394271B1 (en) * 2002-09-02 2007-11-14 Toyo Boseki Kabushiki Kaisha Method for identifying nucleotide polymorphisms using resonance energy transfer
AU2003297297A1 (en) * 2002-11-22 2004-06-18 North Shore-Long Island Jewish Research Institute Elf3 gene compositions and methods
US20040175704A1 (en) * 2003-03-06 2004-09-09 Stratagene Compositions and methods for polynucleotide sequence detection
ATE557100T1 (de) * 2003-12-03 2012-05-15 Abbott Lab Doppelsträngige lineare nukleinsäuresonde und deren verwendung
CN104774931B (zh) * 2004-03-31 2017-11-10 综合医院公司 测定癌症对表皮生长因子受体靶向性治疗反应性的方法
ES2359322T3 (es) * 2004-10-18 2011-05-20 Brandeis University Procedimiento para la amplificación de ácidos nucleicos.

Also Published As

Publication number Publication date
RU2460804C2 (ru) 2012-09-10
EP2351766B1 (en) 2014-12-03
KR101447405B1 (ko) 2014-10-06
KR20130021465A (ko) 2013-03-05
AU2005295298B2 (en) 2011-07-14
ES2668467T3 (es) 2018-05-18
EP1805199B1 (en) 2011-01-05
JP2014110793A (ja) 2014-06-19
DK1805199T3 (da) 2011-04-26
CN101076607B (zh) 2013-04-24
WO2006044994A2 (en) 2006-04-27
EP2927238A1 (en) 2015-10-07
KR101424812B1 (ko) 2014-08-07
CA2584569A1 (en) 2006-04-27
BRPI0517105A (pt) 2008-09-30
BRPI0517105B1 (pt) 2015-06-23
JP2008516612A (ja) 2008-05-22
CN101076607A (zh) 2007-11-21
RU2007118545A (ru) 2008-11-27
EP2351766A2 (en) 2011-08-03
HK1106251A1 (en) 2008-03-07
CA2584569C (en) 2014-09-30
CA2855748C (en) 2018-08-28
KR101347951B1 (ko) 2014-01-07
US20120040352A1 (en) 2012-02-16
AU2005295298A1 (en) 2006-04-27
US20060177841A1 (en) 2006-08-10
EP1805199A4 (en) 2008-07-16
JP5860484B2 (ja) 2016-02-16
EP2927238B1 (en) 2018-01-17
US7632642B2 (en) 2009-12-15
EP1805199A2 (en) 2007-07-11
PT1805199E (pt) 2011-04-11
DE602005025791D1 (de) 2011-02-17
ATE494295T1 (de) 2011-01-15
KR20130113541A (ko) 2013-10-15
ES2359322T3 (es) 2011-05-20
WO2006044994A3 (en) 2007-03-08
US20130095479A1 (en) 2013-04-18
KR20070090159A (ko) 2007-09-05
US9745624B2 (en) 2017-08-29
NO20072506L (no) 2007-07-11
EP2351766A3 (en) 2012-03-21
JP5543065B2 (ja) 2014-07-09
CA2855748A1 (en) 2006-04-27
ES2529204T3 (es) 2015-02-17
CA2996947A1 (en) 2006-04-27
CA2996947C (en) 2019-02-26

Similar Documents

Publication Publication Date Title
HK1106251A1 (en) Methods for nucleic acid amplification
JP2985446B2 (ja) 核酸の検出及び測定方法
JP4982387B2 (ja) 微生物のゲノムｄｎａを同定するデバイスおよび方法
EP1578952A4 (en) DIRECT SNP DETECTION WITH UNAMPLIFIED DNA
AU3360101A (en) Method for quickly detecting microbial dna/rna, kit therefor and the use of saidmethod
Treerattrakoon et al. Rolling circle amplification and graphene-based sensor-on-a-chip for sensitive detection of serum circulating miRNAs
CN112852921A (zh) 一种基于即时检测试纸条的核酸检测方法、检测探针及其试剂盒
CN111270007A (zh) 猪瘟病毒检测用引物、微流控芯片、系统及其应用
EP1829964A4 (en) METHOD OF STUDYING A SEQUENCE OF A GENE
Delespaux et al. PCR-RFLP using Ssu-rDNA amplification: applicability for the diagnosis of mixed infections with different trypanosome species in cattle
Wang et al. Establishment of an ultrasensitive and visual detection platform for Neospora caninum based-on the RPA-CRISPR/Cas12a system
JP2002027993A (ja) 特定の核酸を検出定量するための等長プライマー伸長法およびキット
WO2015170190A2 (en) Devices and kits for measuring biological results
CA2601671A1 (en) Nucleic acid detection
JP2003174900A (ja) ピロリン酸と核酸の定量方法およびその装置
EP0877094A2 (en) Detection and quantification of one or more nucleotide sequence target analytes in a sample using spatially localized target analyte replication
KR101334072B1 (ko) 핵산 정량 방법 및 키트
US20130115616A1 (en) Detection of nucleic acids by agglutination
Doellinger et al. Comparison of real-time PCR and MassTag PCR for the multiplex detection of highly pathogenic agents
CN113684259B (zh) 基于非标记探针熔解技术检测cyp2d6基因拷贝数的方法、引物对与非标记探针组合及试剂盒
CN102936622A (zh) 环介导等温扩增技术检测西伯利亚立克次体的非诊断性方法
Powell et al. Tissue source attribution using the PyroMark® Q48 Autoprep System: Sperm identification in forensic casework
Odin et al. Rapid method for relative gene expression determination in human tissues using automated capillary gel electrophoresis and multicolor detection
JP2009005713A (ja) 核酸の検出方法
WO2005001124A3 (en) Methods of nucleic acid analysis