PL145104B1 - Method of obtaining novel concentrated two-ring derivatives of imidazole - Google Patents

Method of obtaining novel concentrated two-ring derivatives of imidazole Download PDF

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Publication number
PL145104B1
PL145104B1 PL1985259306A PL25930685A PL145104B1 PL 145104 B1 PL145104 B1 PL 145104B1 PL 1985259306 A PL1985259306 A PL 1985259306A PL 25930685 A PL25930685 A PL 25930685A PL 145104 B1 PL145104 B1 PL 145104B1
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PL
Poland
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compounds
tetrahydroimidazo
pyridine
cyanophenyl
formula
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PL1985259306A
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English (en)
Polish (pl)
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
PL1985259306A 1984-06-20 1985-06-20 Method of obtaining novel concentrated two-ring derivatives of imidazole PL145104B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/622,421 US4617307A (en) 1984-06-20 1984-06-20 Substituted imidazo[1,5-A]pyridine derivatives as aromatase inhibitors

Publications (1)

Publication Number Publication Date
PL145104B1 true PL145104B1 (en) 1988-08-31

Family

ID=24494112

Family Applications (6)

Application Number Title Priority Date Filing Date
PL1985259306A PL145104B1 (en) 1984-06-20 1985-06-20 Method of obtaining novel concentrated two-ring derivatives of imidazole
PL1985259307A PL145105B1 (en) 1984-06-20 1985-06-20 Method of obtaining novel concentrated two-ring derivatives of imidazole
PL1985259303A PL145103B1 (en) 1984-06-20 1985-06-20 Method of obtaining novel concentrated two-ring derivatives of imidazole
PL1985259305A PL145814B1 (en) 1984-06-20 1985-06-20 Method of obtaining novel condensed derivatives of double-ring imidazole
PL1985254099A PL145087B1 (en) 1984-06-20 1985-06-20 Method of obtaining novel derivatives of imidazo /1,5-a/ pyridine
PL1985259304A PL145348B1 (en) 1984-06-20 1985-06-20 Method of obtaining novel condensed disubstituted imidazole derivatives

Family Applications After (5)

Application Number Title Priority Date Filing Date
PL1985259307A PL145105B1 (en) 1984-06-20 1985-06-20 Method of obtaining novel concentrated two-ring derivatives of imidazole
PL1985259303A PL145103B1 (en) 1984-06-20 1985-06-20 Method of obtaining novel concentrated two-ring derivatives of imidazole
PL1985259305A PL145814B1 (en) 1984-06-20 1985-06-20 Method of obtaining novel condensed derivatives of double-ring imidazole
PL1985254099A PL145087B1 (en) 1984-06-20 1985-06-20 Method of obtaining novel derivatives of imidazo /1,5-a/ pyridine
PL1985259304A PL145348B1 (en) 1984-06-20 1985-06-20 Method of obtaining novel condensed disubstituted imidazole derivatives

Country Status (31)

Country Link
US (1) US4617307A (enEXAMPLES)
EP (1) EP0165904B1 (enEXAMPLES)
JP (1) JPS6112688A (enEXAMPLES)
KR (1) KR900008566B1 (enEXAMPLES)
AT (1) ATE62415T1 (enEXAMPLES)
AU (1) AU589565B2 (enEXAMPLES)
BG (7) BG60262B2 (enEXAMPLES)
CA (1) CA1276633C (enEXAMPLES)
CS (1) CS268672B2 (enEXAMPLES)
CY (1) CY1750A (enEXAMPLES)
DD (1) DD237510A5 (enEXAMPLES)
DE (1) DE3582452D1 (enEXAMPLES)
DK (1) DK170302B1 (enEXAMPLES)
DZ (1) DZ799A1 (enEXAMPLES)
ES (6) ES8702406A1 (enEXAMPLES)
FI (1) FI80694C (enEXAMPLES)
GR (1) GR851487B (enEXAMPLES)
HK (1) HK23494A (enEXAMPLES)
HU (1) HU202529B (enEXAMPLES)
IE (1) IE58070B1 (enEXAMPLES)
IL (1) IL75546A (enEXAMPLES)
MA (1) MA20459A1 (enEXAMPLES)
MX (1) MX9203369A (enEXAMPLES)
NO (1) NO162467C (enEXAMPLES)
NZ (1) NZ212483A (enEXAMPLES)
PH (1) PH23390A (enEXAMPLES)
PL (6) PL145104B1 (enEXAMPLES)
PT (1) PT80661B (enEXAMPLES)
RO (1) RO92583A (enEXAMPLES)
SU (6) SU1433413A3 (enEXAMPLES)
ZA (1) ZA854615B (enEXAMPLES)

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US4728645A (en) * 1982-12-21 1988-03-01 Ciba-Geigy Corporation Substituted imidazo[1,5-A]pyridine derivatives and other substituted bicyclic derivatives, useful as aromatase inhibitors
GB8510541D0 (en) * 1985-04-25 1985-05-30 Wyeth John & Brother Ltd Heterocyclic compounds
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US4978672A (en) * 1986-03-07 1990-12-18 Ciba-Geigy Corporation Alpha-heterocyclc substituted tolunitriles
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GB8820730D0 (en) * 1988-09-02 1988-10-05 Erba Carlo Spa Substituted 5 6 7 8-tetrahydroimidazo/1.5-a/pyridines & process for their preparation
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JP2022507958A (ja) 2018-11-27 2022-01-18 ノバルティス アーゲー 代謝障害の治療用のプロタンパク質転換酵素サブチリシン／ケキシン９型（ｐｃｓｋ９）阻害薬としての環状四量体化合物
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US4409226A (en) * 1981-10-05 1983-10-11 Schering Corporation Imidazo[1,5-a]pyridines
US4470986A (en) * 1982-12-21 1984-09-11 Ciba-Geigy Corporation Certain imidazo (1,5-A) pyridine aliphatic carboxylic acid derivatives and their use as selective thromboxane inhibitors
US4588732A (en) * 1982-12-21 1986-05-13 Ciba-Geigy Corporation Certain imidazo(1,5-a)pyridine derivatives and their use as thromboxane synthetase inhibitors

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HK23494A (en) 1994-03-25
EP0165904A2 (de) 1985-12-27
PL145087B1 (en) 1988-08-31
IE851520L (en) 1985-12-20
ES8800681A1 (es) 1987-11-16
US4617307A (en) 1986-10-14
BG60307B2 (en) 1994-07-25
KR900008566B1 (ko) 1990-11-24
BG60262B1 (bg) 1994-03-31
NO162467C (no) 1990-01-10
FI852399L (fi) 1985-12-21
EP0165904B1 (de) 1991-04-10
DK277685A (da) 1985-12-21
IE58070B1 (en) 1993-06-30
CS268672B2 (en) 1990-04-11
NZ212483A (en) 1988-10-28
ES555538A0 (es) 1988-03-16
MA20459A1 (fr) 1985-12-31
DK277685D0 (da) 1985-06-19
ES555539A0 (es) 1988-04-01
ZA854615B (en) 1986-02-26
HU202529B (en) 1991-03-28
RO92583A (ro) 1987-11-30
DZ799A1 (fr) 2004-09-13
FI80694B (fi) 1990-03-30
EP0165904A3 (en) 1987-09-09
SU1436879A3 (ru) 1988-11-07
BG60352B2 (bg) 1994-11-30
CA1276633C (en) 1990-11-20
FI852399A0 (fi) 1985-06-17
PL145348B1 (en) 1988-09-30
SU1482530A3 (ru) 1989-05-23
ES8802048A1 (es) 1988-03-16
BG60306B2 (bg) 1994-07-25
NO852474L (no) 1985-12-23
JPS6112688A (ja) 1986-01-21
BG60305B2 (bg) 1994-07-25
PH23390A (en) 1989-07-26
SU1433413A3 (ru) 1988-10-23
ES8801262A1 (es) 1987-12-16
MX9203369A (es) 1992-09-01
ES555541A0 (es) 1987-11-16
ES8702406A1 (es) 1987-01-01
PT80661B (en) 1987-05-04
ES544344A0 (es) 1987-01-01
SU1436878A3 (ru) 1988-11-07
IL75546A0 (en) 1985-10-31
PL254099A1 (en) 1986-09-09
BG60262B2 (en) 1994-03-31
PT80661A (en) 1985-07-01
ES8802049A1 (es) 1988-03-16
AU4385785A (en) 1986-01-02
ES555542A0 (es) 1988-03-16
SU1443802A3 (ru) 1988-12-07
SU1436880A3 (ru) 1988-11-07
CY1750A (en) 1994-06-03
KR860000299A (ko) 1986-01-27
HUT37936A (en) 1986-03-28
PL145105B1 (en) 1988-08-31
PL145814B1 (en) 1988-11-30
DE3582452D1 (de) 1991-05-16
IL75546A (en) 1990-01-18
AU589565B2 (en) 1989-10-19
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BG60353B2 (bg) 1994-11-30
NO162467B (no) 1989-09-25
CS444985A2 (en) 1989-07-12
PL145103B1 (en) 1988-08-31
GR851487B (enEXAMPLES) 1985-11-25
DK170302B1 (da) 1995-07-31
ES8802155A1 (es) 1988-04-01
FI80694C (fi) 1990-07-10
ES555540A0 (es) 1987-12-16
ATE62415T1 (de) 1991-04-15
JPH047746B2 (enEXAMPLES) 1992-02-12
DD237510A5 (de) 1986-07-16

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