PH12962A - Stable tetracycline antibiotic composition - Google Patents

Stable tetracycline antibiotic composition

Info

Publication number
PH12962A
PH12962A PH20970A PH20970A PH12962A PH 12962 A PH12962 A PH 12962A PH 20970 A PH20970 A PH 20970A PH 20970 A PH20970 A PH 20970A PH 12962 A PH12962 A PH 12962A
Authority
PH
Philippines
Prior art keywords
antibiotic composition
tetracycline antibiotic
stable tetracycline
stable
composition
Prior art date
Application number
PH20970A
Other languages
English (en)
Inventor
W Armstrong
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PH12962A publication Critical patent/PH12962A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Hydrogenated Pyridines (AREA)
PH20970A 1977-04-27 1978-04-03 Stable tetracycline antibiotic composition PH12962A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/791,627 US4126680A (en) 1977-04-27 1977-04-27 Tetracycline antibiotic compositions

Publications (1)

Publication Number Publication Date
PH12962A true PH12962A (en) 1979-10-19

Family

ID=25154289

Family Applications (1)

Application Number Title Priority Date Filing Date
PH20970A PH12962A (en) 1977-04-27 1978-04-03 Stable tetracycline antibiotic composition

Country Status (38)

Country Link
US (1) US4126680A (de)
JP (1) JPS53136514A (de)
AR (1) AR217844A1 (de)
AT (1) AT360148B (de)
AU (1) AU503139B1 (de)
BE (1) BE866419A (de)
BG (1) BG47943A3 (de)
CA (1) CA1100875A (de)
CH (1) CH630260A5 (de)
CS (1) CS199527B2 (de)
DD (1) DD135445A5 (de)
DE (1) DE2817335C3 (de)
DK (1) DK155977C (de)
EG (1) EG14348A (de)
ES (1) ES468749A1 (de)
FI (1) FI781300A (de)
FR (1) FR2388561A1 (de)
GB (1) GB1563478A (de)
GR (1) GR70062B (de)
HU (1) HU179050B (de)
IE (1) IE47049B1 (de)
IL (1) IL54581A0 (de)
IN (1) IN148197B (de)
IT (1) IT1094557B (de)
LU (1) LU79547A1 (de)
MX (1) MX6087E (de)
NL (1) NL7804455A (de)
NO (1) NO148280C (de)
NZ (1) NZ187046A (de)
OA (1) OA05949A (de)
PH (1) PH12962A (de)
PL (1) PL110459B1 (de)
PT (1) PT67895B (de)
RO (2) RO75099A (de)
SE (1) SE443507B (de)
YU (1) YU87178A (de)
ZA (1) ZA782400B (de)
ZM (1) ZM3878A1 (de)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
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US4386083A (en) * 1980-04-10 1983-05-31 Walter Hacke Injectable oxytetracycline compositions
US4399127A (en) * 1980-04-10 1983-08-16 Diamond Shamrock Corporation Injectable oxytetracycline compositions
US5589470A (en) * 1990-02-26 1996-12-31 Trustees Of Tufts College Reducing tetracycline resistance in living cells
US4806529A (en) * 1982-11-18 1989-02-21 Trustees Of Tufts College, Tufts University Tetracycline activity enhancement
US5064821A (en) * 1982-11-18 1991-11-12 Trustees Of Tufts College Method and compositions for overcoming tetracycline resistance within living cells
US4769232A (en) * 1984-03-22 1988-09-06 Pfizer Inc. Parenteral formulations of indolmycin
US6756365B2 (en) * 1991-11-06 2004-06-29 Trustees Of Tufts College Reducing tetracycline resistance in living cells
EP0621033A1 (de) * 1993-04-20 1994-10-26 Nostras S.A. Oxytetracycline und Glycofurol enthaltendes antibiotisches Präparat
US6500812B2 (en) 1999-09-14 2002-12-31 Paratek Pharmaceuticals, Inc. 13-substituted methacycline compounds
US6849615B2 (en) 1999-09-14 2005-02-01 Paratek Pharmaceuticals, Inc. 13-substituted methacycline compounds
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
EP1666453A1 (de) 1999-09-14 2006-06-07 Trustees Of Tufts College Verfahren zur Herstellung von substituierten Tetracyclinen mit Hilfe von auf Übergangsmetalle basierten ChemienT
WO2001052858A1 (en) * 2000-01-24 2001-07-26 Trustees Of Tufts College Tetracycline compounds for treatment of cryptosporidium parvum related disorders
US6818634B2 (en) * 2000-03-31 2004-11-16 Paratek Pharmaceuticals, Inc. 7-and 9-carbamate, urea, thiourea, thiocarbamate, and heteroaryl-amino substituted tetracycline compounds
EP1286954B1 (de) * 2000-05-15 2004-04-14 Paratek Pharmaceuticals, Inc. 7-substituierte kondensierte ring-tetrazyclin- verbindungen
US20040224927A1 (en) * 2000-06-16 2004-11-11 Trustees Of Tufts College 7-N-substituted phenyl tetracycline compounds
US20020132798A1 (en) 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
US20020128238A1 (en) 2000-06-16 2002-09-12 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
US7094806B2 (en) * 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
US20050143353A1 (en) * 2000-07-07 2005-06-30 Paratek Pharmaceuticals, Inc. 13-Substituted methacycline compounds
CN100473644C (zh) 2000-07-07 2009-04-01 塔夫茨大学信托人 9-取代的二甲胺四环素化合物
EP1303479B1 (de) 2000-07-07 2011-04-06 Trustees Of Tufts College 7-, 8- und 9-substitutierte tetracyclinverbindungen
CN102336679A (zh) 2000-07-07 2012-02-01 塔夫茨大学信托人 7-取代的四环素化合物
WO2002004405A2 (en) 2000-07-07 2002-01-17 Trustees Of Tufts College 13-substituted methacycline compounds
AU2002250331A1 (en) * 2001-03-13 2002-09-24 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
JP2005506291A (ja) 2001-03-13 2005-03-03 パラテック ファーマシューティカルズ， インク． ７，９−置換テトラサイクリン化合物
US7553828B2 (en) * 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
WO2002072031A2 (en) 2001-03-14 2002-09-19 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds as synergistic antifungal agents
EP1379255A2 (de) 2001-03-14 2004-01-14 Paratek Pharmaceuticals, Inc. Substituierte tetracyclin-verbindungen als antimykotische mittel
US8088820B2 (en) * 2001-04-24 2012-01-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
CA2444899C (en) 2001-04-24 2011-06-21 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
EP2995610A1 (de) 2002-01-08 2016-03-16 Paratek Pharmaceuticals, Inc. 4-dedimethylamino-tetracyclin-verbindungen
EP2311451A1 (de) 2002-03-08 2011-04-20 Paratek Pharmaceuticals, Inc. Aminomethyl-substituierte Tetracyclin-Verbindungen
IL164180A0 (en) 2002-03-21 2005-12-18 Paratek Pharm Innc Substituted tetracycline compounds
CA2492273C (en) 2002-07-12 2013-02-05 Paratek Pharmaceuticals, Inc. 3, 10, and 12a substituted tetracycline compounds
EP2277504A1 (de) 2002-10-24 2011-01-26 Paratek Pharmaceuticals, Inc. Substituierte Tetracyclin-Verbindungen zur Behandlung von Malaria
EA201001081A1 (ru) 2003-07-09 2011-02-28 Пэрэтек Фамэсьютикэлс, Инк. Соединения тетрациклина, фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния у субъекта
EP2292590A3 (de) 2003-07-09 2012-05-02 Paratek Pharmaceuticals, Inc. Prodrugs aus 9-Aminomethyl-Tetracyclinverbindungen
CN1893956A (zh) * 2003-07-25 2007-01-10 沃纳奇尔科特公司 多西环素金属络合物固体剂型
JP5010284B2 (ja) * 2004-01-15 2012-08-29 パラテック ファーマシューティカルズ インコーポレイテッド テトラサイクリン化合物の芳香族ａ環誘導体
TWI261038B (en) * 2004-08-11 2006-09-01 Bo-Cheng Chen Bicycle gear-shifting handgrip
EP2284156A3 (de) 2004-10-25 2011-09-21 Paratek Pharmaceuticals, Inc. Substituierte Tetracyclin-Verbindungen
EP2301912A3 (de) 2004-10-25 2012-07-11 Paratek Pharmaceuticals, Inc. 4-Aminotetracycline und Verfahren zu ihrer Verwendung
JP2008530023A (ja) 2005-02-04 2008-08-07 パラテック ファーマシューティカルズ インコーポレイテッド テトラサイクリン化合物の１１ａ，１２−誘導体
US7919483B2 (en) * 2005-06-24 2011-04-05 Medicis Pharmaceutical Corporation Method for the treatment of acne
US20080242642A1 (en) 2007-04-02 2008-10-02 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US8722650B1 (en) 2005-06-24 2014-05-13 Medicis Pharmaceutical Corporation Extended-release minocycline dosage forms
US7541347B2 (en) * 2007-04-02 2009-06-02 Medicis Pharmaceutical Coropration Minocycline oral dosage forms for the treatment of acne
US20080241235A1 (en) * 2007-04-02 2008-10-02 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US8252776B2 (en) 2007-04-02 2012-08-28 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US7544373B2 (en) * 2007-04-02 2009-06-09 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
EP1991236A2 (de) 2006-01-24 2008-11-19 Paratek Pharmaceuticals, Inc. Verfahren zur erhöhung der oralen bioverfügbarkeit von tetracyclinen
US20070244335A1 (en) * 2006-04-17 2007-10-18 Teva Pharmaceutical Industries Ltd. Isolation of tetracycline derivatives
EP2857386B1 (de) * 2006-04-24 2017-02-22 Teva Pharmaceutical Industries Ltd Kristalline Tigecylinformen und Verfahren zur Herstellung davon
US8198470B2 (en) * 2006-04-24 2012-06-12 Teva Pharmaceutical Industries Ltd. Crystalline form II of tigecycline and processes for preparation thereof
EP2431469A3 (de) * 2006-05-15 2012-05-30 Paratek Pharmaceuticals, Inc. Verfahren zur Regelung der Genexpression oder von Genprodukten mit substituierten Tetracyclinverbindungen
ES2315123B1 (es) * 2006-09-25 2009-12-30 Divasa-Farmavic, S.A. Composiciones farmaceuticas estables de tetraciclinas en solucion, procedimiento para su obtencion y sus usos.
WO2008045507A2 (en) 2006-10-11 2008-04-17 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of bacillus anthracis infections
EP2452935A3 (de) 2006-12-21 2012-08-29 Paratek Pharmaceuticals, Inc. Tetracyxlin-Derivate zur Behandlung bakterieller, viraler und parasitärer Infektionen
CA2892739A1 (en) 2006-12-21 2008-07-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of inflammatory skin disorders
JP5395052B2 (ja) * 2007-03-23 2014-01-22 モレキュラー リサーチ センター インコーポレイテッド 炎症を処置するための組成物および方法
AU2012230089B2 (en) * 2007-03-23 2013-11-21 Molecular Research Center, Inc. Anti-inflammatory compositions comprising tetracyclines and use thereof in therapy
US20080241197A1 (en) * 2007-04-02 2008-10-02 Medicis Pharmaceutical Corporation Minocycline dosage forms for the treatment of acne
EP2144614A1 (de) 2007-04-12 2010-01-20 Paratek Pharmaceuticals, Inc. Verfahren zur behandlung von spinaler muskelatrophie mittels tetracyclinverbindungen
AU2008246119A1 (en) * 2007-04-27 2008-11-06 Paratek Pharmaceuticals, Inc. Methods for synthesizing and purifying aminoalkyl tetracycline compounds
BRPI0823405A2 (pt) 2007-07-06 2012-12-25 Paratek Pharm Innc mÉtodos para sintetizar compostos de tetraciclina substituÍda
WO2009111064A2 (en) 2008-03-05 2009-09-11 Paratek Pharmaceuticals, Inc. Minocycline compounds and methods of use thereof
PT2271348T (pt) 2008-03-28 2018-04-16 Paratek Pharm Innc Formulação de comprimido oral de composto de tetraciclina
CA2721399A1 (en) * 2008-04-14 2009-10-22 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
TW202332671A (zh) 2008-05-23 2023-08-16 美商Ｐｒｔｋ Ｓｐｖ２公司 四環素化合物之甲苯磺酸鹽及同素異形體
WO2010017310A1 (en) 2008-08-06 2010-02-11 Medicis Pharmaceutical Corporation Method for the treatment of acne and certain dosage forms thereof
EA201170425A1 (ru) * 2008-09-19 2011-10-31 Паратек Фармасьютикалс, Инк. Тетрациклиновые соединения для лечения ревматоидного артрита и связанные с ними способы лечения
AU2010233089B2 (en) 2009-04-10 2016-05-26 Tufts Medical Center, Inc. Par-1 activation by metalloproteinase-1 (MMP-1)
EP3574908B8 (de) 2011-05-12 2024-09-11 Almirall LLC Pharmazeutische zubereiting für orale verabreichung mit kristallinen salzen von (4s, 4as, 5ar, 12as)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacen-2-carbonsäureamid
US9561241B1 (en) 2011-06-28 2017-02-07 Medicis Pharmaceutical Corporation Gastroretentive dosage forms for minocycline
ES2611185T3 (es) * 2013-05-20 2017-05-05 Fundación Comunidad Valenciana Centro De Investigación Principe Felipe Conjugados polímero-fármaco para el tratamiento de la amiloidosis
JP6793715B2 (ja) 2015-03-23 2020-12-02 バイオファーミクス・インコーポレイテッドＢｉｏＰｈａｒｍＸ， Ｉｎｃ． テトラサイクリンの皮膚用医薬組成物
EP3534908A4 (de) 2016-11-01 2020-05-27 Paratek Pharmaceuticals, Inc. 9-aminomethyl-minocyclin-verbindungen und verwendung davon in der behandlung von ambulant erworbener bakterieller pneumonie (cabp)
JP2020527607A (ja) 2017-07-21 2020-09-10 アルミラール・リミテッド・ライアビリティ・カンパニーＡｌｍｉｒａｌｌ， Ｌｌｃ 非炎症性病変の処置
CN113655052B (zh) * 2021-08-03 2023-12-12 哈尔滨工程大学 基于高活性MgO对四环素类抗生素可视化检测的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1913323A (en) * 1931-02-28 1933-06-06 Hoffmann La Roche Stable concentrated solution for therapeutic purposes
DE647766C (de) * 1931-03-01 1937-07-12 Hoffmanni La Roche & Co Akt Ge Verfahren zur Darstellung haltbarer, konzentrierter, waessriger Loesungen der Cinchonaalkaloide
GB381012A (en) * 1931-12-04 1932-09-29 Andrew Home Morton Process for the manufacture of stable concentrated solutions for therapeutic use
DE662812C (de) * 1931-12-08 1938-07-22 Hoffmanni La Roche & Co Akt Ge Verfahren zur Herstellung haltbarer, waessriger Arzneimittelloesungen
DE673500C (de) * 1933-01-15 1939-03-23 Hoffmann La Roche & Co Akt Ges Verfahren zur Herstellung von haltbaren Loesungen schwer loeslicher Arzneimittel
GB1019164A (en) * 1963-01-30 1966-02-02 Chugai Pharmaceutical Co Ltd Hemostatic preparation for injection and process for the production thereof
DK129969B (da) * 1973-01-11 1974-12-09 Rosco Ak Fremgangsmåde til fremstilling af en klar, stabil, i det væsentlige vandig opløsning af oxytetracyclin.
GB1508601A (en) * 1974-01-19 1978-04-26 Norbrook Labor Ltd Oxytetracycline solution
US4018889A (en) * 1976-01-02 1977-04-19 Pfizer Inc. Oxytetracycline compositions

Also Published As

Publication number Publication date
DE2817335B2 (de) 1981-06-11
IT7822720A0 (it) 1978-04-26
EG14348A (en) 1984-09-30
IE47049B1 (en) 1983-12-14
AR217844A1 (es) 1980-04-30
GR70062B (de) 1982-07-26
FR2388561A1 (fr) 1978-11-24
PT67895A (en) 1978-05-01
CH630260A5 (fr) 1982-06-15
ES468749A1 (es) 1979-01-01
DD135445A5 (de) 1979-05-09
ZA782400B (en) 1979-04-25
JPS53136514A (en) 1978-11-29
PL206050A1 (pl) 1979-03-26
SE7801816L (sv) 1978-10-28
OA05949A (fr) 1981-06-30
US4126680A (en) 1978-11-21
ZM3878A1 (en) 1978-11-21
AT360148B (de) 1980-12-29
BG47943A3 (en) 1990-10-15
CS199527B2 (en) 1980-07-31
CA1100875A (en) 1981-05-12
LU79547A1 (fr) 1979-11-07
RO75099A (ro) 1980-12-30
NO781457L (no) 1978-10-30
NZ187046A (en) 1980-03-05
YU87178A (en) 1984-04-30
DK182578A (da) 1978-10-28
DE2817335C3 (de) 1982-04-22
NO148280C (no) 1983-09-21
NL7804455A (nl) 1978-10-31
PL110459B1 (en) 1980-07-31
IL54581A0 (en) 1978-07-31
IE780828L (en) 1978-10-27
FR2388561B1 (de) 1980-07-18
IT1094557B (it) 1985-08-02
PT67895B (en) 1979-11-14
DK155977B (da) 1989-06-12
HU179050B (en) 1982-08-28
DE2817335A1 (de) 1978-11-16
NO148280B (no) 1983-06-06
GB1563478A (en) 1980-03-26
RO77953A (ro) 1981-12-25
DK155977C (da) 1989-10-30
FI781300A (fi) 1978-10-28
MX6087E (es) 1984-11-08
AU503139B1 (en) 1979-08-23
IN148197B (de) 1980-11-29
JPS5632290B2 (de) 1981-07-27
ATA300478A (de) 1980-05-15
SE443507B (sv) 1986-03-03
BE866419A (fr) 1978-10-26

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